Beilstein Journal of Nanotechnology最新文献

{"title":"Recent advances in photothermal nanomaterials for ophthalmic applications.","authors":"Jiayuan Zhuang, Linhui Jia, Chenghao Li, Rui Yang, Jiapeng Wang, Wen-An Wang, Heng Zhou, Xiangxia Luo","doi":"10.3762/bjnano.16.16","DOIUrl":"10.3762/bjnano.16.16","url":null,"abstract":"<p><p>The human eye, with its remarkable resolution of up to 576 million pixels, grants us the ability to perceive the world with astonishing accuracy. Despite this, over 2 billion people globally suffer from visual impairments or blindness, primarily because of the limitations of current ophthalmic treatment technologies. This underscores an urgent need for more advanced therapeutic approaches to effectively halt or even reverse the progression of eye diseases. The rapid advancement of nanotechnology offers promising pathways for the development of novel ophthalmic therapies. Notably, photothermal nanomaterials, particularly well-suited for the transparent tissues of the eye, have emerged as a potential game changer. These materials enable precise and controllable photothermal therapy by effectively manipulating the distribution of the thermal field. Moreover, they extend beyond the conventional boundaries of thermal therapy, achieving unparalleled therapeutic effects through their diverse composite structures and demonstrating enormous potential in promoting retinal drug delivery and photoacoustic imaging. This paper provides a comprehensive summary of the structure-activity relationship between the photothermal properties of these nanomaterials and their innovative therapeutic mechanisms. We review the latest research on photothermal nanomaterial-based treatments for various eye diseases. Additionally, we discuss the current challenges and future perspectives in this field, with a focus on enhancing global visual health.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"195-215"},"PeriodicalIF":2.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the potential of rare earth elements in the development of new anticancer drugs: single molecule studies.","authors":"Josiane A D Batista, Rayane M de Oliveira, Carlos H M Lima, Milton L Lana Júnior, Virgílio C Dos Anjos, Maria J V Bell, Márcio S Rocha","doi":"10.3762/bjnano.16.15","DOIUrl":"10.3762/bjnano.16.15","url":null,"abstract":"<p><p>We use optical tweezers and atomic force microscopy to investigate the potential of rare earth elements to be used as anticancer agents in the development of new chemotherapeutic drugs by characterizing the binding of three rare earths (ytterbium, neodymium, and erbium) to double-stranded DNA, which is one of the main targets for these drugs inside cells. The three elements presented a significant interaction with the biopolymer in buffers of physiological relevance, typically binding with very high equilibrium association constants (10⁶ to 10⁷ M^-1) at the DNA grooves. Furthermore, neodymium and erbium can also induce a very strong compaction/condensation of the double helix at high concentrations, promoting DNA collapse at the single molecule level in a similar way to what occurs with classical DNA condensing agents such as polycations and depletants.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"187-194"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture.","authors":"Charlotte Skjold Qvist Christensen, Nicholas Hansen, Mahboubeh Motadayen, Nina Lock, Martin Lahn Henriksen, Jonathan Quinson","doi":"10.3762/bjnano.16.14","DOIUrl":"10.3762/bjnano.16.14","url":null,"abstract":"<p><p>Polymeric membranes offer an appealing solution for sustainable CO₂ capture, with potential for large-scale deployment. However, balancing high permeability and selectivity is an inherent challenge for pristine membranes. To address this challenge, the development of mixed matrix membranes (MMMs) is a promising strategy. MMMs are obtained by carefully integrating porous nano-fillers into polymeric matrices, enabling the simultaneous enhancement of selectivity and permeability. In particular, metal-organic frameworks (MOFs) have gained recognition as MMM fillers for CO₂ capture. Here, a review of the current state, recent advancements, and challenges in the fabrication and engineering of MMMs with MOFs for selective CO₂ capture is proposed. Key considerations and promising research directions to fully exploit the gas separation potential of MOF-based MMMs in CO₂ capture applications are highlighted.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"155-186"},"PeriodicalIF":2.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clays enhanced with niobium: potential in wastewater treatment and reuse as pigment with antibacterial activity.","authors":"Silvia Jaerger, Patricia Appelt, Mario Antônio Alves da Cunha, Fabián Ccahuana Ayma, Ricardo Schneider, Carla Bittencourt, Fauze Jacó Anaissi","doi":"10.3762/bjnano.16.13","DOIUrl":"10.3762/bjnano.16.13","url":null,"abstract":"<p><p>Bentonite clay sourced from the Guarapuava region, Brazil, was modified with niobium oxide (BEOx) and niobium phosphate (BEPh) to act as an adsorbent and photocatalyst in the remediation of wastewater containing methylene blue (MB) dye. Additionally, colored materials were evaluated for their potential as antibacterial hybrid pigments. The bentonite clay modified with niobium was prepared by a solution containing swelling clay mixed with niobium oxide (NbOx) and niobium phosphate (NbPh) in a water solution; after that, the suspension was calcinated. X-ray diffractometry, X-ray photoelectron spectroscopy, and laser-induced breakdown spectroscopy assessed the modifications induced by the incorporation of niobium compounds into the clay, confirming the presence of niobium in the bentonite clay. Following characterization, the BEOx and BEPh samples were used as adsorbents or photocatalysts for treating solutions containing the MB dye (400 mg·L^-1) at 25 °C. The results showed adsorption and photocatalysis efficiency above 94% for both samples. The blue-colored BEOx and BEPh samples were then applied as a hybrid pigment. The power pigment and its dispersion in colorless paint were evaluated by the CIEL*a*b* color space, and the Δ<i>E</i> parameters show values above 12, indicating a very strong color parameter difference. Subsequently, the efficacy of BEOx and BEPh as a hybrid pigment was assessed using the minimum inhibitory concentration (MIC) assay against two bacteria strains: <i>Bacillus cereus</i> (ATCC 10876) and <i>Proteus mirabilis</i> (ATCC 35649). The analysis revealed remarkable antibacterial activity against <i>Proteus mirabilis</i>, suggesting a preferential selectivity for Gram-negative bacteria.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"141-154"},"PeriodicalIF":2.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TiO₂ immobilized on 2D mordenite: effect of hydrolysis conditions on structural, textural, and optical characteristics of the nanocomposites.","authors":"Marina G Shelyapina, Rosario Isidro Yocupicio-Gaxiola, Gleb A Valkovsky, Vitalii Petranovskii","doi":"10.3762/bjnano.16.12","DOIUrl":"10.3762/bjnano.16.12","url":null,"abstract":"<p><p>A series of novel TiO₂/2D mordenite nanocomposites were synthetized by the introduction of titanium tetraethoxide (TEOT) into the interlamellar space of 2D mordenite, its subsequent hydrolysis in water or a solution of 70% ethanol in water for 6, 12, and 24 h, and calcination. The resulting TiO₂/2D mordenite materials were studied by a set of complementary characterization techniques, including XRD, SEM-EDX, TGA, N₂ sorption, NMR, XPS and UV-vis spectrometry. It was observed that treatment in 70% ethanol solution preserves the ordered layered structure of 2D mordenite because TEOT hydrolysis is slowed down. This, in turn, leads to higher mesoporosity after calcination due to anatase nanoparticles of about 4 nm preventing the collapse of the interlamellar space. Immobilization of TiO₂ on the zeolite surface is evidenced by the formation of Si-O-Ti bonds. The bandgap width of the synthetized nanocomposites was found to be sensitive to the hydrolysis medium.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"128-140"},"PeriodicalIF":2.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of organic and inorganic hole transport layers in double perovskite material-based solar cell.","authors":"Deepika K, Arjun Singh","doi":"10.3762/bjnano.16.11","DOIUrl":"10.3762/bjnano.16.11","url":null,"abstract":"<p><p>Perovskite solar cells (PSCs) are in the focus of the photovoltaic industry. Lead-free double perovskite solar cells (DPSCs) have become an essential alternative of lead-based PSCs as a promising photovoltaic material. The double perovskite layer is a remarkable choice as active layer because of intrinsic carrier stability, low exciton binding energy, and low toxicity. Herein, the optimization of a planar DPSC with a multifunctional double perovskite absorber layer, that is, La₂NiMnO₆ (LNMO), is studied with the organic and inorganic hole transport layers (HTLs) Cu₂O and PEDOT:PSS. Our study yields a significant improvement in the power conversion efficiency (PCE) of perovskite solar cells with two types of HTLs. The optimized devices achieved a maximum PCE of 27.84% and 27.38% for Cu₂O and PEDOT:PSS, respectively, with corresponding open-circuit voltages of 1.27 and 1.22 V, short-circuit current densities of 28.60 and 28.91 mA/cm², and fill factors of 76.31% and 77.15%, respectively. These results highlight the potential of these HTLs for enhanced device performance.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"119-127"},"PeriodicalIF":2.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy.","authors":"Naths Grazia Sukubo, Paolo Bigini, Annalisa Morelli","doi":"10.3762/bjnano.16.10","DOIUrl":"10.3762/bjnano.16.10","url":null,"abstract":"<p><p>In the coming decades, the development of nanocarriers (NCs) for targeted drug delivery will mark a significant advance in the field of pharmacology. NCs can improve drug solubility, ensure precise distribution, and enable passage across biological barriers. Despite these potential advantages, the interaction with many biological matrices, particularly with existing macrophages, must be considered. In this review, we will explore the dual role of macrophages in NC delivery, highlighting their physiological functions, the challenges posed by the mononuclear phagocyte system, and innovative strategies to exploit macrophage interactions for therapeutic advantage. Recent advancements in treating liver and lung diseases, particularly focusing on macrophage polarization and RNA-based therapies, have highlighted the potential developments in macrophage-NC interaction. Furthermore, we will delve into the intriguing potential of nanomedicine in neurology and traumatology, associated with macrophage interaction, and the exciting possibilities it holds for the future.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"97-118"},"PeriodicalIF":2.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling and simulation of carbon-nanocomposite-based gas sensors.","authors":"Roopa Hegde, Punya Prabha V, Shipra Upadhyay, Krishna S B","doi":"10.3762/bjnano.16.9","DOIUrl":"10.3762/bjnano.16.9","url":null,"abstract":"<p><p>This paper reports simulation of a carbon monoxide gas sensor using COMSOL Multiphysics whose active sensing material used is a carbon nanocomposite (i.e., 0.1 wt % of single-walled carbon nanotubes along with PEDOT:PSS (poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)) in an equal volume ratio of 1:1. Given the high cost associated with the development of these sensors, it becomes imperative to establish a mathematical model for economically predicting their behavior. The simulation using COMSOL Multiphysics is performed to obtain the surface coverage of the sensor by introducing carbon monoxide gas through a Gaussian pulse feed inlet at concentrations ranging from 1 to 7 ppm. The surface coverage over the range of 14% to 32.94% for the given range of concentrations is achieved giving the information of the amount of gas molecules adsorbed onto the surface of the sensing material at a given time. The surface coverage of the sensor is enhanced by using the nanocomposite materials which in turn enhances the sensitivity of the gas sensors.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"90-96"},"PeriodicalIF":2.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of ZnO nanoparticles synthesized using probiotic <i>Lactiplantibacillus plantarum</i> GP258.","authors":"Prashantkumar Siddappa Chakra, Aishwarya Banakar, Shriram Narayan Puranik, Vishwas Kaveeshwar, C R Ravikumar, Devaraja Gayathri","doi":"10.3762/bjnano.16.8","DOIUrl":"10.3762/bjnano.16.8","url":null,"abstract":"<p><p>The fundamental goal of our investigation is to employ a sustainable synthesis method for zinc oxide nanoparticles (ZnO NPs), utilizing lactic acid bacteria isolated from curd as the key biological agent. Bacteria function as agents for both reduction and capping processes, which aids the synthesis of ZnO NPs. Various characterization techniques including XRD, FTIR, UV-vis, TEM, SEM-EDX, and zeta potential measurements were employed to analyze the morphology, dimensions, and elemental composition of the generated nanoparticles. The experimental outcomes confirmed the presence of hexagonal wurtzite-structured ZnO NPs with an average size of 10 nm. The colloidal system demonstrated excellent stability with a zeta potential of -60 mV. Furthermore, the synthesized nanoparticles displayed significant antibacterial activity against selected human pathogens, with the biggest inhibition zone observed against <i>Staphylococcus aureus</i> (22 ± 0.57 mm) and the smallest inhibition zone observed against <i>Salmonella enterica serovar typhi</i> (3 ± 1 mm). MTT assay revealed the promising antiproliferative potential of ZnO NPs, with an average IC₅₀ value of 98.53 µg/mL. Additionally, the NPs were photocatalytically and electrochemically analyzed, indicating their potential use in cancer research as well as in coating and drug delivery applications.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"78-89"},"PeriodicalIF":2.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research.","authors":"Benjamin Punz, Maja Brajnik, Joh Dokler, Jaleesia D Amos, Litty Johnson, Katie Reilly, Anastasios G Papadiamantis, Amaia Green Etxabe, Lee Walker, Diego S T Martinez, Steffi Friedrichs, Klaus M Weltring, Nazende Günday-Türeli, Claus Svendsen, Christine Ogilvie Hendren, Mark R Wiesner, Martin Himly, Iseult Lynch, Thomas E Exner","doi":"10.3762/bjnano.16.7","DOIUrl":"10.3762/bjnano.16.7","url":null,"abstract":"<p><p>Nanosafety assessment, which seeks to evaluate the risks from exposure to nanoscale materials, spans materials synthesis and characterisation, exposure science, toxicology, and computational approaches, resulting in complex experimental workflows and diverse data types. Managing the data flows, with a focus on provenance (who generated the data and for what purpose) and quality (how was the data generated, using which protocol with which controls), as part of good research output management, is necessary to maximise the reuse potential and value of the data. Instance maps have been developed and evolved to visualise experimental nanosafety workflows and to bridge the gap between the theoretical principles of FAIR (Findable, Accessible, Interoperable and Re-usable) data and the everyday practice of experimental researchers. Instance maps are most effective when applied at the study design stage to associate the workflow with the nanomaterials, environmental conditions, method descriptions, protocols, biological and computational models to be used, and the data flows arising from study execution. Application of the InstanceMaps tool (described herein) to research workflows of increasing complexity is presented to demonstrate its utility, starting from (i) documentation of a nanomaterial's synthesis, functionalisation, and characterisation, over (ii) assessment of a nanomaterial's transformations in complex media, (iii) description of the culturing of ecotoxicity model organisms <i>Daphnia magna</i> and their use in standardised tests for nanomaterials ecotoxicity assessment, and (iv) visualisation of complex workflows in human immunotoxicity assessment using cell lines and primary cellular models, to (v) the use of the instance map approach for the coordination of materials and data flows in complex multipartner collaborative projects and for the demonstration of case studies. Finally, areas for future development of the instance map approach and the tool are highlighted.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"57-77"},"PeriodicalIF":2.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}