Beilstein Journal of Nanotechnology最新文献_第9页

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review 用于治疗利什曼病的姜黄素负载纳米结构系统：综述

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2024-01-04 DOI: 10.3762/bjnano.15.4

Douglas Dourado, Thayse Silva Medeiros, Éverton do Nascimento Alencar, Edijane Matos Sales, Fábio Rocha Formiga

{"title":"Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review","authors":"Douglas Dourado, Thayse Silva Medeiros, Éverton do Nascimento Alencar, Edijane Matos Sales, Fábio Rocha Formiga","doi":"10.3762/bjnano.15.4","DOIUrl":"https://doi.org/10.3762/bjnano.15.4","url":null,"abstract":"Leishmaniasis is a neglected tropical disease that has affected more than 350 million people worldwide and can manifest itself in three different forms: cutaneous, mucocutaneous, or visceral. Furthermore, the current treatment options have drawbacks which compromise efficacy and patient compliance. To face this global health concern, new alternatives for the treatment of leishmaniasis have been explored. Curcumin, a polyphenol obtained from the rhizome of turmeric, exhibits leishmanicidal activity against different species of Leishmania spp. Although its mechanism of action has not yet been fully elucidated, its leishmanicidal potential may be associated with its antioxidant and anti-inflammatory properties. However, it has limitations that compromise its clinical use. Conversely, nanotechnology has been used as a tool for solving biopharmaceutical challenges associated with drugs, such as curcumin. From a drug delivery standpoint, nanocarriers (1–1000 nm) can improve stability, increase solubility, promote intracellular delivery, and increase biological activity. Thus, this review offers a deep look into curcumin-loaded nanocarriers intended for the treatment of leishmaniasis.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"59 20","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139386786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators 使用 YBCO 振荡器测量带有集成冷电子波长计的二色性弓形天线阵列

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2024-01-04 DOI: 10.3762/bjnano.15.3

L. Revin, Dmitrii A Pimanov, A. Chiginev, A. V. Blagodatkin, V. Zbrozhek, Andrey V Samartsev, Anastasia N Orlova, D. Masterov, A. Parafin, Victoria Yu. Safonova, A. Gordeeva, A. Pankratov, L S Kuzmin, Anatolie S Sidorenko, Silvia Masi, P. de Bernardis

{"title":"Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators","authors":"L. Revin, Dmitrii A Pimanov, A. Chiginev, A. V. Blagodatkin, V. Zbrozhek, Andrey V Samartsev, Anastasia N Orlova, D. Masterov, A. Parafin, Victoria Yu. Safonova, A. Gordeeva, A. Pankratov, L S Kuzmin, Anatolie S Sidorenko, Silvia Masi, P. de Bernardis","doi":"10.3762/bjnano.15.3","DOIUrl":"https://doi.org/10.3762/bjnano.15.3","url":null,"abstract":"We consider properties of dichroic antenna arrays on a silicon substrate with integrated cold-electron bolometers to detect radiation at frequencies of 210 and 240 GHz. This frequency range is widely used in cosmic microwave background experiments in space, balloon, and ground-based missions such as BICEP Array, LSPE, LiteBIRD, QUBIC, Simons Observatory, and AliCPT. As a direct radiation detector, we use cold-electron bolometers, which have high sensitivity and a wide operating frequency range, as well as immunity to spurious cosmic rays. Their other advantages are the compact size of the order of a few micrometers and the effect of direct electron cooling, which can improve sensitivity in typical closed-loop cycle 3He cryostats for space applications. We study a novel concept of cold-electron bolometers with two SIN tunnel junctions and one SN contact. The amplitude–frequency characteristics measured with YBCO Josephson Junction oscillators show narrow peaks at 205 GHz for the 210 GHz array and at 225 GHz for the 240 GHz array; the separation of these two frequency bands is clearly visible. The noise equivalent power level at an operating point in the current bias mode is 5 × 10−16 W/√Hz.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"14 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnological approaches in the treatment of schistosomiasis: an overview. 治疗血吸虫病的纳米技术方法：概述。

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2024-01-03 eCollection Date: 2024-01-01 DOI: 10.3762/bjnano.15.2

Lucas Carvalho, Michelle Sarcinelli, Beatriz Patrício

{"title":"Nanotechnological approaches in the treatment of schistosomiasis: an overview.","authors":"Lucas Carvalho, Michelle Sarcinelli, Beatriz Patrício","doi":"10.3762/bjnano.15.2","DOIUrl":"10.3762/bjnano.15.2","url":null,"abstract":"Schistosomiasis causes over 200,000 deaths annually. The current treatment option, praziquantel, presents limitations, including low bioavailability and resistance. In this context, nanoparticles have emerged as a promising option for improving schistosomiasis treatment. Several narrative reviews have been published on this topic. Unfortunately, the lack of clear methodologies presented in these reviews leads to the exclusion of many important studies without apparent justification. This integrative review aims to examine works published in this area with a precise and reproducible method. To achieve this, three databases (i.e., Pubmed, Web of Science, and Scopus) were searched from March 31, 2022, to March 31, 2023. The search results included only original research articles that used nanoparticles smaller than 1 µm in the treatment context. Additionally, a search was conducted in the references of the identified articles to retrieve works that could not be found solely using the original search formula. As a result, 65 articles that met the established criteria were identified. Inorganic and polymeric nanoparticles were the most prevalent nanosystems used. Gold was the primary material used to produce inorganic nanoparticles, while poly(lactic-co-glycolic acid) and chitosan were commonly used to produce polymeric nanoparticles. None of these identified works presented results in the clinical phase. Finally, based on our findings, the outlook appears favorable, as there is a significant diversity of new substances with schistosomicidal potential. However, financial efforts are required to advance these nanoformulations.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"15 ","pages":"13-25"},"PeriodicalIF":3.1,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10777326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139429424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes. 在氮化硅膜上用 TEM 制备光刻图案化 permalloy 纳米结构的样品。

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2024-01-02 eCollection Date: 2024-01-01 DOI: 10.3762/bjnano.15.1

Joshua Williams, Michael I Faley, Joseph Vimal Vas, Peng-Han Lu, Rafal E Dunin-Borkowski

{"title":"TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes.","authors":"Joshua Williams, Michael I Faley, Joseph Vimal Vas, Peng-Han Lu, Rafal E Dunin-Borkowski","doi":"10.3762/bjnano.15.1","DOIUrl":"10.3762/bjnano.15.1","url":null,"abstract":"We have prepared ferromagnetic nanostructures intended for the investigation of high-frequency magnetization dynamics in permalloy (Py) nanodisks using Lorentz transmission electron microscopy (LTEM) and electron holography. Py nanodisks were fabricated on thin silicon nitride (SiN) membranes using three different fabrication methods: lift-off, ion beam etching (IBE), and stencil lithography. They were further analyzed using different instruments, including scanning electron microscopy, LTEM, and electron holography. A bilayer of positive PMMA resist was utilized in the first fabrication method to form an undercut structure that guarantees a clean lift-off procedure. The second approach used dry etching with an Ar beam to etch a thin Py film, while an electron-beam-patterned negative resist mask kept the desired structure. In the third process, nanostencils (shadow masks) with submicrometer apertures were milled on SiN membranes using a focused ion beam. Furthermore, we have developed a new TEM sample preparation method, where we fabricated Py nanostructures on a bulk substrate with a SiN buffer layer and etched the substrate to create a thin SiN membrane under the Py nanostructure. Finally, we observed the vortex dynamics of the Py nanodisk under magnetic fields using LTEM and off-axis electron holography. A correlation between preparation methods and the properties of the Py nanostructures was made.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"15 ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10777327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139429427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

unDrift: A versatile software for fast offline SPM image drift correction. unDrift：用于快速离线校正 SPM 图像漂移的多功能软件。

IF 2.6 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.3762/bjnano.14.101

Tobias Dickbreder, Franziska Sabath, Lukas Höltkemeier, Ralf Bechstein, Angelika Kühnle

{"title":"unDrift: A versatile software for fast offline SPM image drift correction.","authors":"Tobias Dickbreder, Franziska Sabath, Lukas Höltkemeier, Ralf Bechstein, Angelika Kühnle","doi":"10.3762/bjnano.14.101","DOIUrl":"10.3762/bjnano.14.101","url":null,"abstract":"Scanning probe microscopy (SPM) techniques are widely used to study the structure and properties of surfaces and interfaces across a variety of disciplines in chemistry and physics. One of the major artifacts in SPM is (thermal) drift, an unintended movement between sample and probe, which causes a distortion of the recorded SPM data. Literature holds a multitude of strategies to compensate for drift during the measurement (online drift correction) or afterwards (offline drift correction). With the currently available software tools, however, offline drift correction of SPM data is often a tedious and time-consuming task. This is particularly disadvantageous when analyzing long image series. Here, we present unDrift, an easy-to-use scientific software for fast and reliable drift correction of SPM images. unDrift provides three different algorithms to determine the drift velocity based on two consecutive SPM images. All algorithms can drift-correct the input data without any additional reference. The first semi-automatic drift correction algorithm analyzes the different distortion of periodic structures in two consecutive up and down (down and up) images, which enables unDrift to correct SPM images without stationary features or overlapping scan areas. The other two algorithms determine the drift velocity from the apparent movement of stationary features either by automatic evaluation of the cross-correlation image or based on positions identified manually by the user. We demonstrate the performance and reliability of unDrift using three challenging examples, namely images distorted by a very high drift velocity, only partly usable images, and images exhibiting an overall weak contrast. Moreover, we show that the semi-automatic analysis of periodic images can be applied to a long series containing hundreds of images measured at the calcite-water interface.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"14 ","pages":"1225-1237"},"PeriodicalIF":2.6,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10760460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells 荧光生物启发白蛋白/多巴胺纳米粒子及其与大肠杆菌细胞的相互作用

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2023-12-22 DOI: 10.3762/bjnano.14.100

Eloïse Equy, Jordana Hirtzel, Sophie Hellé, Béatrice Heurtault, Eric Mathieu, Morgane Rabineau, Vincent Ball, L. Ploux

{"title":"Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells","authors":"Eloïse Equy, Jordana Hirtzel, Sophie Hellé, Béatrice Heurtault, Eric Mathieu, Morgane Rabineau, Vincent Ball, L. Ploux","doi":"10.3762/bjnano.14.100","DOIUrl":"https://doi.org/10.3762/bjnano.14.100","url":null,"abstract":"Inspired by the eumelanin aggregates in human skin, polydopamine nanoparticles (PDA NPs) are promising nanovectors for biomedical applications, especially because of their biocompatibility. We synthesized and characterized fluorescent PDA NPs of 10–25 nm diameter based on a protein containing a lysine–glutamate diad (bovine serum albumin, BSA) and determined whether they can penetrate and accumulate in bacterial cells to serve as a marker or drug nanocarrier. Three fluorescent PDA NPs were designed to allow for tracking in three different wavelength ranges by oxidizing BSA/PDA NPs (Ox-BSA/PDA NPs) or labelling with fluorescein 5-isothiocyanate (FITC-BSA/PDA NPs) or rhodamine B isothiocyanate (RhBITC-BSA/PDA NPs). FITC-BSA/PDA NPs and RhBITC-BSA/PDA NPs penetrated and accumulated in both cell wall and inner compartments of Escherichia coli (E. coli) cells. The fluorescence signals were diffuse or displayed aggregate-like patterns with both labelled NPs and free dyes. RhBITC-BSA/PDA NPs led to the most intense fluorescence in cells. Penetration and accumulation of NPs was not accompanied by a bactericidal or inhibitory effect of growth as demonstrated with the Gram-negative E. coli species and confirmed with a Gram-positive bacterial species (Staphylococcus aureus). Altogether, these results allow us to envisage the use of labelled BSA/PDA NPs to track bacteria and carry drugs in the core of bacterial cells.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"36 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138946743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of the radii of coated and uncoated silicon AFM sharp tips using a height calibration standard grating and a nonlinear regression function. 使用高度校准标准光栅和非线性回归函数确定有涂层和无涂层硅原子力显微镜尖头的半径。

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2023-12-15 eCollection Date: 2023-01-01 DOI: 10.3762/bjnano.14.99

Perawat Boonpuek, Jonathan Robert Felts

{"title":"Determination of the radii of coated and uncoated silicon AFM sharp tips using a height calibration standard grating and a nonlinear regression function.","authors":"Perawat Boonpuek, Jonathan Robert Felts","doi":"10.3762/bjnano.14.99","DOIUrl":"10.3762/bjnano.14.99","url":null,"abstract":"AFM sharp tips are used to characterize nanostructures and quantify the mechanical properties of the materials in several areas of research. The analytical results can show unpredicted errors if we do not know the exact values of the AFM tip radius. There are many techniques of in situ measurements for determining the actual AFM tip radius, but they are limited to uncoated tips. This paper presents an alternative and simple method to determine the radii of coated tips and an uncoated tip. Pt-coated, Cr/Au-coated, and uncoated Si tips were used to scan a calibration standard grating in AFM contact mode with sub-nanonewton load to obtain the curved scan profile of the edge corner of the grating structure. The data points of the curved profile of each tip were fitted with a nonlinear regression function to estimate the curvature radius of the tip. The results show that the estimated radius of the coated tips is in the range of nominal values provided by the tip manufacturer, while the estimated radius of the uncoated Si tip is bigger than the nominal radius because of tip blunting during the scan. However, this method yields an accurate estimate of the tip radius with a low root mean squared error of the curve fitting results.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"14 ","pages":"1200-1207"},"PeriodicalIF":3.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH3)2Cl]2 对潜在的 FEBID 前体 [Au(CH3)2Cl]2进行气相离解电离、离解电子附着和沉积综合研究

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2023-12-06 DOI: 10.3762/bjnano.14.98

Elif Bilgilisoy, Ali Kamali, T. X. Gentner, G. Ballmann, Sjoerd Harder, Hans-Peter Steinrück, H. Marbach, O. Ingólfsson

{"title":"A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH3)2Cl]2","authors":"Elif Bilgilisoy, Ali Kamali, T. X. Gentner, G. Ballmann, Sjoerd Harder, Hans-Peter Steinrück, H. Marbach, O. Ingólfsson","doi":"10.3762/bjnano.14.98","DOIUrl":"https://doi.org/10.3762/bjnano.14.98","url":null,"abstract":"Motivated by the potential of focused-electron-beam-induced deposition (FEBID) in the fabrication of functional gold nanostructures for application in plasmonic and detector technology, we conducted a comprehensive study on [Au(CH3)2Cl]2 as a potential precursor for such depositions. Fundamental electron-induced dissociation processes were studied under single collision conditions, and the composition and morphology of FEBID deposits fabricated in an ultrahigh-vacuum (UHV) chamber were explored on different surfaces and at varied beam currents. In the gas phase, dissociative ionization was found to lead to significant carbon loss from this precursor, and about 50% of the chlorine was on average removed per dissociative ionization incident. On the other hand, in dissociative electron attachment, no chlorine was removed from the parent molecule. Contrary to these observations, FEBID in the UHV setup was found to yield a quantitative loss and desorption of the chlorine from the deposits, an effect that we attribute to electron-induced secondary and tertiary reactions in the deposition process. We find this precursor to be stable at ambient conditions and to have sufficient vapor pressure to be suitable for use in HV instruments. More importantly, in the UHV setup, FEBID with [Au(CH3)2Cl]2 yielded deposits with high gold content, ranging from 45 to 61 atom % depending on the beam current and on the cleanliness of the substrates surface.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"30 11","pages":"1178 - 1199"},"PeriodicalIF":3.1,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial variations of conductivity of self-assembled monolayers of dodecanethiol on Au/mica and Au/Si substrates 金/云母和金/硅基底上十二硫醇自组装单层电导率的空间变化

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2023-12-05 DOI: 10.3762/bjnano.14.97

Julian Skolaut, Jędrzej Tepper, Federica Galli, W. Wulfhekel, J. V. van Ruitenbeek

引用次数: 0

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment. 具有纳米柱或纳米孔的分层图案聚氨酯微槽，用于神经元的伸长和排列。

IF 3.1 4区材料科学

Beilstein Journal of Nanotechnology Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.3762/bjnano.14.96

Lester Uy Vinzons, Guo-Chung Dong, Shu-Ping Lin

{"title":"Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment.","authors":"Lester Uy Vinzons, Guo-Chung Dong, Shu-Ping Lin","doi":"10.3762/bjnano.14.96","DOIUrl":"https://doi.org/10.3762/bjnano.14.96","url":null,"abstract":"Surface micro- and nanostructures profoundly affect the functional performance of nerve regeneration implants by modulating neurite responses. However, few studies have investigated the impact of discrete nanostructures, such as nanopillars and nanoholes, and their combination with microgrooves on neurite outgrowth and alignment. Furthermore, numerous techniques have been developed for surface micro-/nanopatterning, but simple and low-cost approaches are quite limited. In this work, we show that nanopillars and nanoholes, and their combination with microgrooves, can be patterned on polyurethane (PU) films using a low-cost, reusable photoresist master mold prepared via nanosphere lens lithography and UV-LED photolithography, with specific \"reinforcement\" methods for overcoming the inherent drawbacks of using photoresist masters. We show that the PU nanopillars and nanoholes increase the neurite length of pheochromocytoma 12 (PC12) cells through unique growth cone interactions. Moreover, we demonstrate, for the first time, that hierarchically patterned nano-/microstructured PU films enhance both PC12 neurite elongation and alignment, showing the potential use of our proposed method for the micro-/nanopatterning of polymers for nerve tissue engineering.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"14 ","pages":"1157-1168"},"PeriodicalIF":3.1,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0