{"title":"Are vitamin B-12 measurements adequate for evaluating its deficiency in individuals?","authors":"Sedat Özdemir, Selda Demirtaş","doi":"10.6133/apjcn.202504_34(2).0010","DOIUrl":"10.6133/apjcn.202504_34(2).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Measurement of vitamin B-12 deficiency using different methods may cause diagnostic difficulties. In order to rapidly and safely diagnose vitamin B-12 deficiency, it is important to determine the reference ranges of serum B-12 and its related biomarkers such as homocysteine, holotranscobalamine (holo-TC) and methylmalonic acid (MMA). This study aimed to determine reference interval (RI)s for serum vitamin B-12 and related markers.</p><p><strong>Methods and study design: </strong>Samples were collected from 404 young-to-middle-aged healthy adults aged 18-65 years. Vitamin B-12, homocysteine, holotranscobalamin, folate were analyzed using the Arcitect i2000 device. Plasma MMA was analyzed by LC/MS. RIs were then evaluated accordingly.</p><p><strong>Results: </strong>Vitamin B-12, folate, homocysteine, holotranscobalamin and plasma MMA were 139-619 pg/mL, 3.0-14.7 ng/mL, 5.6-18.4 μmol/L, 10.7-101 pmol/L, and 0.01-0.8 μmol/L, respectively. Age group-specific RIs were also generated.</p><p><strong>Conclusions: </strong>This study revealed that the diagnosis of vitamin B-12 deficiency should not only be based on serum vitamin B-12 levels, but also of folate, homocysteine, holotranscobalamin and MMA levels; all which are related to vitamin B-12 metabolism.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 2","pages":"232-239"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qin Deng, Zhengxia Pan, Lin Kong, Min Gong, Zhongmin Gao, Yongfang Liu
{"title":"Nutrition-related risk factors for prolonged pleural effusion after congenital heart surgery in Chinese infants.","authors":"Qin Deng, Zhengxia Pan, Lin Kong, Min Gong, Zhongmin Gao, Yongfang Liu","doi":"10.6133/apjcn.202504_34(2).0007","DOIUrl":"10.6133/apjcn.202504_34(2).0007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Previous studies on the risk factors for prolonged pleural effusion (PPE) have primarily focused on surgical-related risk factors, with little research exploring the influence of nutritional factors on this delay. This study aimed to identify the nutritional risk factors for PPE in Chinese infants following congenital heart disease (CHD) surgery.</p><p><strong>Methods and study design: </strong>We retrospectively reviewed the medical records of patients under 3 years old with chylothorax following CHD surgery from 2016 to 2020. PPE was defined as pleural effusion lasting over 14 days. Logistical regression analysis was conducted to identify the risk factors.</p><p><strong>Results: </strong>Of 136 patients, 42 patients developed PPE (30.9%). The PPE group had lower Height-for-Age Z-scores (HAZ) compared to the non-PPE group, while other demographic factors were not significantly different. Univariate analysis revealed that patients in PPE group exhibited delayed onset of chylothorax, prolonged duration of mechanical ventilation, increased chest effusion volume on the first postoperative day, and a reduced proportion of energy intake from enteral nutrition (EN) during the stable phase. Variables with p-value of <0.1 in univariate logistic regression analysis were included in the multivariate logistic regression analysis. A delayed onset of chylothorax, extended periods of mechanical ventilation, a lower HAZ and a reduced proportion of energy intake from EN during the recovery phase.</p><p><strong>Conclusions: </strong>A delayed onset of chylothorax, extended periods of mechanical ventilation, a lower HAZ, and a reduced proportion of energy intake from EN during the recovery phase predict a higher risk of PPE.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 2","pages":"202-207"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between dietary niacin intake and dyslipidemia prevalence in the National Health and Nutrition Examination Surveys (NHANES).","authors":"Mengqi Gao, Youming He, Ying Xiao, Lili Yang","doi":"10.6133/apjcn.202504_34(2).0005","DOIUrl":"10.6133/apjcn.202504_34(2).0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>The association of niacin intake with dyslipidemia remains uncertain. The aim of this study was to explore the association between dietary niacin intake and the prevalence of dyslipidemia among adults in the United States (US).</p><p><strong>Methods and study design: </strong>Data were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2014. The exposure variable was dietary niacin intake, measured through 24-hour dietary recall interviews and treated as both a continuous and categorical variable. Dyslipidemia, defined by diagnostic criteria, was the outcome. Logistic regression and restricted cubic spline models were applied to examine the association between niacin intake and the prevalence of dyslipidemia.</p><p><strong>Results: </strong>Among the 19,275 individuals, the prevalence of dyslipidemia was 78.8%. Compared with individuals with lower niacin consumption Q1 (≤15.9 mg/day), the adjusted OR values for dietary niacin intake and dyslipidemia in Q3 (22.7-31.8 mg/day) and Q4 (≥31.8 mg/day) were 0.78 (95% CI: 0.64-0.94, p = 0.011) and 0.77 (95% CI: 0.61-0.98, p = 0.033), respectively. The association between niacin intake and the prevalence of dyslipidemia followed a L-shaped dose-response curve (non-linear, p = 0.009). Participants with a niacin intake of <22.3 mg/day exhibited an OR of 0.98 (95% CI: 0.96-0.99, p = 0.040) for dyslipidemia. In subgroup analyses, the inverse associations of niacin intake with the prevalence of dyslipidemia remained robust only in female.</p><p><strong>Conclusions: </strong>In the 2005-2014 NHANES popu-lation, higher levels of niacin intake were associated with decreased odds of dyslipidemia overall. Further studies are needed to examine the potential protective effects of niacin on dyslipidemia risk.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 2","pages":"183-192"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictive value of frailty and nutritional risk screening for in-hospital complications in elderly hip fracture patients.","authors":"Zhifang Chen, Lili Sun, Xiaohong Yu, Yuexia Zhang","doi":"10.6133/apjcn.202504_34(2).0009","DOIUrl":"10.6133/apjcn.202504_34(2).0009","url":null,"abstract":"<p><strong>Background and objectives: </strong>To investigate the underlying inflammatory markers of frailty and evaluate the predictive power of frailty and nutritional risk screening (NRS) for in-hospital complications in elderly patients with hip fractures.</p><p><strong>Methods and study design: </strong>A total of 233 elderly patients with hip fractures partic-ipated in the study. Frailty and nutritional risk screening was performed on all participants, who were then divided into frail ('frail only' and 'frail and malnourished') and non-frail ('robust' and 'malnourished only') cohorts. The clinical data were collected for all participants, and in-hospital complications were followed up.</p><p><strong>Results: </strong>Among the patients, 39.9% were frail, 26.2% were malnourished and 15.5% were both frail and malnourished. The frail group were older and had higher Charlson comorbidity index (CCI) scores, systemic immune-inflammation index (SII) levels and fibrinogen levels than patients in the other cohorts. After adjusting for age, CCI and nutritional status,the SII was an independent predictor of frailty, indicating its role as an inflammatory marker of frailty. Frail patients had significantly higher rates of total complications, lower limb deep vein thrombosis (DVT), infections and cardiac complications than the non-frail group. Patients who were both frail and malnourished had a 1.98 times higher risk of nosocomial infection than those who were only frail.</p><p><strong>Conclusions: </strong>The SII is a significant predictor of frailty, and it may be used as an inflammatory marker of frailty. The fatigue, resistance, ambulation, illnesses and loss of weight scale can effectively predict the in-hospital complications of elderly patients with hip fractures.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 2","pages":"225-231"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The association between noodle consumption and metabolic syndrome in Korean adults.","authors":"Da Eun Jeon, Youngyo Kim","doi":"10.6133/apjcn.202504_34(2).0006","DOIUrl":"10.6133/apjcn.202504_34(2).0006","url":null,"abstract":"<p><strong>Background and objectives: </strong>The proportion of noodles in the Korean diet is increasing, but the effect of noodle intake on metabolic syndrome has not been sufficiently investigated. Therefore, we investigated noodle consumption and its relation to metabolic syndrome in Korean adults.</p><p><strong>Methods and study design: </strong>This study was conducted on 10,505 adults using the combined data of the 2012-2016 Korea National Health and Nutrition Examination Survey (KNHANES). Noodle intake was evaluated with a food frequency question-naire (FFQ) based on 112 food items. To compute odds ratios (ORs) and their 95% confidence intervals (CIs) controlled for confounders, multivariable logistic regression models were used.</p><p><strong>Results: </strong>Compared to people in the lowest levels of noodle intake, the OR of the metabolic syndrome of those in the highest levels was 1.48 (95% CI, 1.16-1.90; p-trend = 0.002). This positive association was also found for hypertriglyceridemia and abdominal obesity, which were metabolic syndrome components. Specifically, the odds of having hypertriglyceridemia were 38% (OR, 1.38; 95% CI, 1.14-1.66; p-trend < 0.001) higher for people with high noodle consumption compared to those with low noodle consumption in the overall population. The tendency for people who consume a lot of noodles to have raised odds of metabolic syndrome was observed when analyzed by the type of noodles.</p><p><strong>Conclusions: </strong>This study suggested noodle intake was positively related to met-abolic syndrome and its components in Korean adults. Further clinical trials and prospective cohort studies are required to identify a causal relationship between noodle intake and metabolic syndrome in Koreans.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"193-201"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Du, Ying Duan, Ling Yang, Yan Cui, Huaqing Liu
{"title":"Garlic consumption and risk of diabetes mellitus in the Chinese elderly: A population-based cohort study.","authors":"Jing Du, Ying Duan, Ling Yang, Yan Cui, Huaqing Liu","doi":"10.6133/apjcn.202504_34(2).0003","DOIUrl":"10.6133/apjcn.202504_34(2).0003","url":null,"abstract":"<p><strong>Background and objectives: </strong>Diabetes mellitus (DM) is a major public health problem worldwide. Numerous traditional plants are used for preventing DM. However, limited evidence supports the association between garlic consumption and DM.</p><p><strong>Methods and study design: </strong>Data used in this study was from the 2008-2018 Chinese Longitudinal Healthy Longevity Survey. Data on garlic consumption was obtained by questionnaire, and DM by self-reported diagnosis. A multivariate adjusted Cox regression model was used to estimate haz-ard ratios (HR) and 95% confidence intervals (CI) to determine the incidence of DM.</p><p><strong>Results: </strong>A total of 1927 participants were included in this study, of which 24.08% consumed garlic daily and 20.08% developed DM. The HR for daily garlic consumption decreased by 42%, when compared to rare or no garlic con-sumption. Our subgroup analyses revealed that daily garlic consumption significantly reduced the risk of DM in older adults aged 65-79, rural, non-drinkers informal education, financial dependence, and working in agriculture (aged 65-79: HR = 0.54, 95% CI: 0.36-0.80; rural area: HR = 0.48, 95% CI: 0.29-0.77; non-drinkers: HR = 0.60, 95% CI: 0.41-0.86; informal education: HR = 0.46, 95% CI: 0.29-0.74; financial dependence: HR = 0.39, 95% CI: 0.23-0.65; agricultural work: HR = 0.49, 95% CI: 0.32-0.76).</p><p><strong>Conclusions: </strong>Garlic consumption can reduce the risk of DM in older Chinese adults. This benefit varies by age, current residence, drinking status, education level, occupation, and economic source. Future efforts should focus on developing dietary intervention strategies that consider demographic, educational, financial, and occupational disparities to effectively prevent diabetes in older populations.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 2","pages":"165-173"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systematic review on supplementation, fortification, and food-based interventions for preventing iron deficiency anemia in low- and middle-income countries.","authors":"Siti Helmyati, Lely Lusmilasari, Ayyu Sandhi, Marina Hardiyanti, Gifani Rosilia, Yuliana Novita Rachmawati, Mitha Aristyarini","doi":"10.6133/apjcn.202502_34(1).0002","DOIUrl":"10.6133/apjcn.202502_34(1).0002","url":null,"abstract":"<p><strong>Background and objectives: </strong>Prioritizing key preventive and therapeutic interventions is one of the actions to accelerate the reduction of anemia. This study aimed to examine interventions designed to prevent anemia.</p><p><strong>Methods and study design: </strong>A systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library. Analysis of publication bias was done using The Joanna-Briggs Institute critical appraisal tool. Data collected from articles included author, year of publication, setting and location of the study, study type, participant of the study, intervention and control given, main outcome, main findings, and risk of bias.</p><p><strong>Results: </strong>Three nutrition-specific interventions aimed at preventing iron deficiency anemia in low- and middle-income countries used various types and dosages of iron. While most studies showed success, some indicated a worsening trend in anemia, even with standard dosages and the same form of iron. Determining effective interventions requires consideration of factors such as other micronutrient composition, compliance rate, availability of educational intervention, and dietary backgrounds in those countries.</p><p><strong>Conclusions: </strong>Supplementation, fortification, and food-based interventions generally lead to higher hemoglobin levels and a lower prevalence of anemia. However, it is important to consider several factors before deciding on an approach.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"10-35"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between serum vitamin D and depression among non-alcoholic fatty liver disease.","authors":"Rong Jiang, Manman Lu, Yunfeng Hua, Zhen Hong","doi":"10.6133/apjcn.202502_34(1).0011","DOIUrl":"10.6133/apjcn.202502_34(1).0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>While previous population-based studies have suggested a link between serum vitamin D levels and depression in individuals with non-alcoholic fatty liver disease (NAFLD), the exact correlation between serum vitamin D and depression among NAFLD patients remains controversial and disputed. Thus, we conducted this study to evaluate the relationship between serum vitamin D and depression in NAFLD participants diagnosed via transient elastography.</p><p><strong>Methods and study design: </strong>This cross-sectional study was extracted from the latest NHANES 2017-2018 dataset. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9) score of ≥10. NAFLD phenotype was identified by vibration-controlled transient elastography (VCTE) examination based on diagnostic criteria. Binary logistic regression models were applied to estimate the impact of increased serum vitamin D on the reduced risk of depression based on sample weights.</p><p><strong>Results: </strong>A total of 1339 participants with NAFLD were included in this investigation, of which 127 (8.58%) were diagnosed with depression according to PHQ-9 scores. Binary logistic regression analysis presented that high serum vitamin D level was a protective factor for depression in NAFLD (OR=0.61, 95% CI: 0.37-0.99, p=0.048) after adjusting for all confounding factors. In subgroup analyses, these associations were more pronounced among men (OR=0.32, 95% CI: 0.13-0.81, p=0.024) and obese population (OR=0.53, 95% CI: 0.33-0.86, p=0.019).</p><p><strong>Conclusions: </strong>Increased serum vitamin D was negatively associated to the prevalence of depression in males and obese individuals with NAFLD diagnosed by VCTE.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"112-117"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huijuan Ruan, Qi Yang, Xuelin Zhao, Qingya Tang, Yi Feng
{"title":"Respiratory quotient as an early predictor of length of stay after cardiac surgery: A prospective observational study.","authors":"Huijuan Ruan, Qi Yang, Xuelin Zhao, Qingya Tang, Yi Feng","doi":"10.6133/apjcn.202502_34(1).0006","DOIUrl":"10.6133/apjcn.202502_34(1).0006","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to investigate the respiratory quotient (RQ) levels and its trend in the early postoperative period of patients with heart disease. Additionally, we explored factors influencing RQ and evaluated the predictive capabilities of RQ and lactic acid for various outcomes.</p><p><strong>Methods and study design: </strong>In this prospective observational study, participants included were heart disease patients aged 18-80 years who underwent elective open-heart surgery and were subsequently admitted to the cardiothoracic surgery ICU post-operation. Indirect calorimetry (IC) measurements were conducted on patients dur-ing the first three days after surgery to assess their RQ levels. Clinical data, including personal information, postoperative characteristics, and duration of surgery, were documented based on the patient's medical history.</p><p><strong>Results: </strong>In this study, 135 patients, of whom 57.04% were male, underwent a total of 247 IC measurements following cardiac surgery. On the first, second, and third days of admission to the ICU, the RQ values were 0.77±0.09, 0.80±0.07, and 0.78±0.05, respectively. The ROC curve analysis showed that on the first day of admission to the ICU, RQ was a better predictor of prolonged mechanical ventilation, LOS in ICU, and LOS in hospital compared to lactate level. However, on the second day of ICU admission, neither RQ nor lactate level could predict longer durations of mechanical ventilation, LOS in ICU, and LOS in hospital.</p><p><strong>Conclusions: </strong>RQ may serve as a potential predictor for LOS in patients after cardiac surgery.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"66-75"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global trends in the revision of nutrient reference values and formulations for infants and toddlers.","authors":"Hazuki Akazawa, Chika Okada","doi":"10.6133/apjcn.202502_34(1).0003","DOIUrl":"10.6133/apjcn.202502_34(1).0003","url":null,"abstract":"<p><strong>Background and objectives: </strong>Nutrient Reference Values (NRVs) play an important role in nutrition labeling and nutrition and health claims based on scientific data. This study, with a global perspective, reviewed recent trends in NRVs for adults and their establishment for infants and toddlers.</p><p><strong>Methods and study design: </strong>We searched for laws and regulations on official government websites for nutrition labeling in the United States, Canada, Australia, New Zealand, China, South Korea, Japan, the Codex Committee, and the European Union.</p><p><strong>Results: </strong>NRV revisions have been made in the United States, Canada, and South Korea. In the United States and Canada, NRVs for most nutrients, including macronutrients, vitamins, and minerals, were revised in 2016, reflecting updated Dietary Reference Intakes and new scientific findings. NRVs for infants and toddlers have already been formulated in the United States, Canada, Australia, New Zealand, and South Korea and are used for nutrition labeling. However, concerns have been raised regarding the labeling of all foods with NRVs for infants and toddlers, which may result in challenges in distinguishing foods formulated under different standards as appropriate for infants and toddlers.</p><p><strong>Conclusions: </strong>This study highlights recent general NRV revisions and formulation status for infants and toddlers. This provides useful information for determining the basis for future updates and the development of NRVs in various countries.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"36-45"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}