Vitamin D and CRP are associated in hospitalized inflammatory bowel disease (IBD) patients in Shanghai.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Fangfang Song, Juntao Lu, Zhiqi Chen, Yiquan Zhou, Zhijun Cao, Renying Xu
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Abstract

Background and objectives: Patients with inflammatory bowel disease (IBD) are more likely to be confirmed with vitamin D deficiency. However, the association between inflammation and vitamin D remains unclear. The purpose of this study was to evaluate the association between inflammation and vitamin D in hospitalized patients with IBD.

Methods and study design: All the participants were recruited from one teaching hospital from June 2018 to October 2022. Inflammation was evaluated by serum concentration of C-reactive protein (CRP), using an immunoturbidimetric method at admission. We further divided the participants into five groups based on serum CRP levels: <5, 5-9.9, 10-19.9, 20-39.9, and >40mg/L. Serum 25-hydroxy-vitamin D (25-(OH)-D) was assessed by liquid chromatography tandem mass spectrometry. Addi-tional information, including age, sex, body mass index (BMI), IBD (ulcerative colitis vs. Crohn's disease) subtype, was abstracted from medical records.

Results: This study included 1,989 patients with IBD (average age was 39.4 years, 33.8% of them were women, 1,365 CD and 624 UC patients). The median CRP was 5.49 mg/L (range of quartiles: 1.64~19.5 mg/L) and the prevalence of 25-(OH)-D deficiency was 69.8%. CRP was significantly associated with serum level of 25-(OH)-D. The difference in 25-(OH)-D was -4.28 ng/ml (-5.27 ng/ml, -3.31 ng/ml) between two extremist CRP groups after adjustment of potential covariates (age, sex, BMI, type of IBD, dietary type, season, and lymphocyte count). Subgroup analysis in sex, type of IBD, and age, were similar to the main analysis results.

Conclusions: There was a negative association between CRP levels and vitamin D in hospitalized patients with IBD.

上海住院炎症性肠病(IBD)患者的维生素 D 与 CRP 相关。
背景和目的:炎症性肠病(IBD)患者更有可能被证实缺乏维生素 D。然而,炎症与维生素 D 之间的关系仍不清楚。本研究旨在评估住院 IBD 患者的炎症与维生素 D 之间的关系:所有参与者均于2018年6月至2022年10月期间从一家教学医院招募。入院时使用免疫比浊法,通过血清中C反应蛋白(CRP)的浓度来评估炎症。我们根据血清CRP水平进一步将参与者分为五组:40mg/L。血清 25- 羟基维生素 D(25-(OH)-D)采用液相色谱串联质谱法进行评估。其他信息包括年龄、性别、体重指数(BMI)、IBD(溃疡性结肠炎与克罗恩病)亚型,均从病历中提取:研究共纳入了 1,989 名 IBD 患者(平均年龄 39.4 岁,33.8% 为女性,其中 1,365 名为 CD 患者,624 名为 UC 患者)。CRP 中位数为 5.49 mg/L(四分位数范围:1.64~19.5 mg/L),25-(OH)-D 缺乏率为 69.8%。CRP 与血清中 25-(OH)-D 的水平明显相关。在调整了潜在的协变量(年龄、性别、体重指数、IBD类型、饮食类型、季节和淋巴细胞计数)后,CRP极端化的两组之间的25-(OH)-D差异为-4.28纳克/毫升(-5.27纳克/毫升,-3.31纳克/毫升)。对性别、IBD类型和年龄的分组分析结果与主分析结果相似:结论:住院的 IBD 患者的 CRP 水平与维生素 D 呈负相关。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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