Asia Pacific journal of clinical nutrition最新文献

{"title":"Multivitamin-mineral supplementation prevents acute upper respiratory tract infections.","authors":"Fang Wang, Junren Kang, Wei Wei, Yuanyuan Bao, Allan Chen, Feifei Deng, Kang Yu","doi":"10.6133/apjcn.202508_34(4).0011","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>Large-scale studies on the role of multivitamin-mineral (MVM) supplementation in preventing and managing acute respiratory infections (AURIs) are limited in Chinese populations. This study evaluated the impact of routine MVM use on AURI prevalence and symptom severity in a community-based Chinese cohort.</p><p><strong>Methods and study design: </strong>This retrospective study was conducted among community-based populations across China (n=3,415). Using a structured questionnaire, participants self-reported epi-sodes of AURIs over three months. Based on regular use of MVM for at least 3 months, eligible participants were categorized into the MVM group and the control group. The impact of MVM on the frequency and severity of AURIs was assessed. Rigorous methodological approaches were applied to minimize potential biases.</p><p><strong>Results: </strong>The period prevalence of AURIs was significantly lower in the MVM group (29.9%) compared to controls (45.6%), odds ratio (OR) =0.508 (p<0.001). After propensity score matching, demographic and lifestyle factors were comparable between groups. The period prevalence of AURIs was 31.7% and 44.8% in the MVM and control groups (OR=0.572, p<0.001). Subgroup analysis indicated the protective effect of MVM supplementation was particularly significant among participants aged ≥45 years (OR=0.407, p<0.001). The MVM group reported lower prevalence of nasal congestion (OR=0.624, p<0.001), sore throat (OR=0.575, p<0.001), headache (OR=0.642, p<0.001), diarrhea (OR=0.718, 0.026), sneezing (OR=0.651, p=0.002), and fatigue (OR=0.694, p=0.004) relative to the control group.</p><p><strong>Conclusions: </strong>Daily MVM supplementation for at least 3 months reduced the period prevalence of the common cold and influenza and may contribute to enhanced immune resilience in the Chinese population.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"596-609"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of early versus late enteral nutrition on the nutritional status of surgical intensive care unit patients: A retrospective observational study.","authors":"Pei-Chun Chao, Frank Cheau-Feng Lin, Hsien-Hua Liao, Lu-Huan R Chou, Chun-Fen R Lee","doi":"10.6133/apjcn.202508_34(4).0012","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0012","url":null,"abstract":"<p><strong>Background and objectives: </strong>We retrospectively evaluated the efficacy and safety of early enteral nutrition (within 48 h) and late enteral nutrition (after 48 h; control) in improving the nutritional status of surgical intensive care unit patients.</p><p><strong>Methods and study design: </strong>This single-center, retrospective, observational study was conducted using data from 82 patients (age > 18 years) who were admitted to surgical intensive care units between June and November 2019. Patients who received enteral nutrition for >7 days were included in this study, and those who received total parenteral nutrition or palliative care were excluded.</p><p><strong>Results: </strong>The early and late enteral nutrition groups comprised 41 patients each. Early enteral nutrition significantly increased the actual intake of calories and protein (p < 0.0001) as well as the length of stay in the surgical in-tensive care unit (p = 0.047) and hospital (p = 0.028). Late enteral nutrition significantly reduced albumin concentration (p < 0.05), hemoglobin concentration (p < 0.05), and lymphocyte count (p < 0.05) but significantly increased weight loss (p < 0.05). However, no significant between-group difference was observed in mortality rate.</p><p><strong>Conclusions: </strong>Early enteral nutrition improves the nutritional status of surgical intensive care unit patients. It shortens overall hospitalization duration and increases actual calorie and protein intake at dis-charge. Thus, early enteral nutrition is recommended for critically ill patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"610-618"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of FSMP on nutrition status and sarcopenia among nutritional risk cancer patients: A randomized, double-blind, placebo-controlled study.","authors":"Jin Fu, Kang Yu, Yu Zhang, Yuanyuan Bao, Shanshan Li","doi":"10.6133/apjcn.202508_34(4).0008","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0008","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cancer patients at nutritional risk have a worse prognosis, but this can be improved by nutritional support. Food for special medical purposes (FSMP), as a new form of nutritional support, needs to be further evaluated for its safety and efficacy in these patients. Our study elucidate the impact of FSMP on nutritional status and sarcopenia among nutritional risk cancer outpatients by assessing the NRS2002 score, exercise performance, muscle mass, and inflammatory factors pre- and postintervention.</p><p><strong>Methods and study design: </strong>We conducted a single-centre, double-blind, randomized controlled interventional study. Patients from the oncology clinic with nutritional risk were randomly allocated to the control group or the FSMP group and received oral intervention for 8 weeks. The primary outcome was improvement in nutritional risk, while the secondary outcomes were improvements in sarcopenia prevalence and physical performance indicators. Other outcomes included alterations in calf circumference, hsCRP, 25(OH)VD3, Alb. etc. A linear mixed-effects model was used to compare the prepost-intervention changes in these results.</p><p><strong>Results: </strong>Thirty-six cancer patients were included, 25 completed the study. The percentage of patients at nutritional risk after intervention in the FSMP group was significantly lower than the control group (Χ2=4.186, p=0.041). The FSMP group demonstrated significant improvements in the TUG test, gait speed, grip strength, and upper-limb muscle mass. However, there was no significant improvement in the rate of sarcopenia. Moreover, calf circumference, hsCRP, 25(OH)VD3, Alb exhibited no significant changes.</p><p><strong>Conclusions: </strong>FSMP can effectively improve the nutritional status, physical performance and upper-limb muscle mass of cancer patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"566-576"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and predictors of refeeding syndrome in adult patients receiving parenteral nutrition at a Malaysian teaching hospital: A retrospective study.","authors":"Tze Wei Ng, Nur Aina Abu Hassan Shaari, Birinder Kaur Sadu Singh, Chandini Menon Premakumar","doi":"10.6133/apjcn.202508_34(4).0006","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0006","url":null,"abstract":"<p><strong>Background and objectives: </strong>Refeeding syndrome (RS) is a potentially life-threatening condition character-ised by significant electrolyte and fluid imbalances, posing a considerable risk in patients undergoing parenteral nutrition (PN) therapy. This study aimed to determine the occurrence, risk factors, severity, and complications of RS in a teaching hospital in Malaysia.</p><p><strong>Methods and study design: </strong>A retrospective observational study was conducted using universal sampling from October to December 2023. Data were collected for adult patients receiving PN for more than 48 hours between July 2022 and July 2023 at Hospital Canselor Tuanku Muhriz.</p><p><strong>Results: </strong>Among 90 patients included, 30 (33.3%) developed RS. Upon consideration of interaction terms due to collinerity of variables, a statistically significant correlation was observed between pre-existing electrolyte derangements and RS occurrence (p = 0.001). Phosphate levels showed the most significant decline post-PN initiation (43%), followed by potassium (19%) and magnesium (17%), primarily within the first 24 hours. No significant associations were found between BMI, fasting duration, unintentional weight loss, or medication history and RS. However, fasting for more than five days (AOR 2.8, 95% CI 0.4-17.7) and ≥10% unintentional weight loss (AOR 1.8, 95% CI 0.4-7.7) increased the likelihood of RS.</p><p><strong>Conclusions: </strong>RS is prevalent among adult PN patients, predominantly with mild severity. Pre-existing electrolyte abnormalities, especially in phosphate levels, were robust predictors. Larger studies are needed to better elucidate the associations between risk factors and RS in the local population.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"551-556"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications.","authors":"Zhen Zhang, Shuai Li, Jianjun Sun","doi":"10.6133/apjcn.202508_34(4).0003","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0003","url":null,"abstract":"<p><strong>Background and objectives: </strong>To compare the effectiveness of silymarin or its combination with lifestyle modifications, Mediterranean hypocaloric diets, and medications for improving nonalcoholic fatty liver disease (NAFLD).</p><p><strong>Methods and study design: </strong>PubMed, Embase, Cochrane Library, Web of Science, and Clin-icalTrails.gov were used to identify relevant studies. The treatment arm was silymarin or its combination with Mediterranean hypocaloric diets, medications, or lifestyle modifications. The comparators were placebo, Mediterranean hypocaloric diets, medications, and lifestyle modifications.</p><p><strong>Results: </strong>This meta-analysis included 25 studies with 2283 patients. Total cholesterol levels were reduced by silymarin+Mediterranean hypocaloric diets (SMD: -0.39 (-0.81, 0.03), p=0.072) or medications [SMD: -1.12 (-1.67, -0.58), p<0.001]. Triglyceride levels were decreased by silymarin combined with the medication [SMD: -0.92 (-1.98, 0.14), p=0.080]. Low-density lipoprotein cholesterol levels were reduced by silymarin alone [SMD: -0.25 (-0.48, -0.03), p=0.027]. The combination of silymarin with Mediterranean hypocaloric diets [SMD: -0.47 (-0.90, -0.04), p=0.031] or lifestyle modifications [SMD: -0.88 (-1.09, -0.66), p<0.0001] decreased alanine aminotransferase levels. Aspartate aminotransferase levels were reduced by a combination of silymarin and life-style modifications [SMD: -0.72 (-1.49, 0.05), p=0.061] or medications [SMD: -1.41 (-2.24, -0.59), p=0.005]. Silymarin (2.5 times) or silymarin plus lifestyle modifications (39%) reduced the hepatic steatosis rate in patients with NAFLD. The silymarin use increased the rate of patients with adverse effects [RR:1.98 (1.11, 3.54)]; gastrointestinal problems were the most common adverse effects.</p><p><strong>Conclusions: </strong>Despite the overall advantages of therapies, different interventions showed different effects on markers in patients with NAFLD. These results highlight the need for more research to fully comprehend the features of the intervention.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"516-530"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrient status of patients with diabetic foot: A systematic review.","authors":"Sholpan Batarbekova, Dinara Zhunussova, Gulmira Derbissalina, Zhanagul Bekbergenova, Nadezhda Maksimova, Ayagoz Umbetzhanova, Elmira Kelimberdiyeva, Raushan Kassymova, Gaukhar Kuanyshbayeva, Altynay Imangaliyeva","doi":"10.6133/apjcn.202508_34(4).0001","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Micronutrient status encompasses a range of indicators that reflect the levels and balance of macro- and microelements, as well as vitamins within the body. These essential substances, required in minimal amounts, are crucial for supporting normal physiological processes, immune system functioning, and tissue repair. The aim of this systematic review is to summarize data on the deficiency or excess of microelements, macroelements, and vitamins in patients with diabetic foot ulcers.</p><p><strong>Methods and study design: </strong>Databases were searched for studies on vitamin, macronutrient, micronutrient levels and their impact on the course, treatment and healing of diabetic foot ulcers. The Cochrane Risk of Bias tool was employed for assessing randomized trials, while the Newcastle-Ottawa Scale was utilized for evaluating observa-tional studies in terms of quality and bias risk.</p><p><strong>Results: </strong>The findings revealed a notable correlation between deficiencies in vitamins D, C, A and the severity of clinical symptoms. Low vitamin D levels were linked to elevated proinflammatory cytokines. Higher concentrations of folate and vitamin B-12 were associated with improved ulcer healing, supplementation with zinc and magnesium contributed to a reduction in ulcer size. Inadequate intake of zinc, vitamins E, C was found to compromise antioxidant defences. Elevated ferritin levels may serve as an indicator of inflammation.</p><p><strong>Conclusions: </strong>The most important task is to adjust the in-take of micronutrients to maintain balance and prevent deficiency and excess, which is important in the complex therapy of patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"487-501"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic evaluation of risk prediction models for feeding intolerance in ICU patients during enteral nutrition.","authors":"Xianqiao Huang, Liming Zhong, Chao Li, Yu Tang","doi":"10.6133/apjcn.202508_34(4).0009","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0009","url":null,"abstract":"<p><strong>Background and objectives: </strong>It has been found that ICU patients may encounter various complications during enteral nutrition (EN). Of these, feeding intolerance (FI) is a common issue that often necessitates the reduction or cessation of EN. This study aims to evaluate risk prediction models for feeding intolerance (FI) in critically ill patients receiving EN by searching major public databases.</p><p><strong>Methods and study design: </strong>We searched for relevant studies in Embase, PubMed, Web of Science, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data, and cqvip.com up until January 2024. Two researchers independently conducted the screening and data extraction processes, and the quality of the literature was assessed using bias risk assessment tools.</p><p><strong>Results: </strong>A total of 13 references were included, and the subjects included patients with sepsis, pancreatitis or cerebral apoplexy; the incidence of FI was 35.2%-49.3%. The studies discussed the predictive performance of various models, with 11 studies reporting on their accuracy and calibration. The models demonstrated the area under the curve (AUC) of the receiver operating characteristic (ROC) curve or the concordance index (C-index) between 0.70 and 0.91, sensitivity from 0.81 to 0.93, and specificity from 0.68 to 0.83.</p><p><strong>Conclusions: </strong>There is a critical need for risk prediction models for FI in critically ill patients on EN that are both internally and externally validated and exhibit high performance.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"577-588"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fatty diets on blood pressure: A systematic review and meta-analysis.","authors":"Tingzhen Zang, Waseem Hassan, Faraza Javaid, Ramla Shabbir, Andleeb Shahzadi, Hammad Ahmed","doi":"10.6133/apjcn.202508_34(4).0005","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Hypertension is a major risk factor for cardiovascular diseases, with dietary fats playing a critical role in its regulation. While unsaturated fats are associated with blood pressure (BP) reduction, saturated and trans fats may exacerbate hypertension. This systematic review and meta-analysis aimed to evaluate the impact of various fatty diets on systolic (SBP) and diastolic blood pressure (DBP) and identify dietary patterns most effective for BP management.</p><p><strong>Methods and study design: </strong>A comprehensive search of MEDLINE and ClinicalTrials.gov (inception to February 2025) identified randomized clinical trials and observational studies assessing dietary fats' effects on BP. Twenty-five studies (n=14,522 participants) met inclusion criteria. Data were analyzed to estimate mean differences (MDs) with 95% confidence intervals (CIs). Funnel plots were generated to assess publication bias. Risk of bias was assessed using the RevMan Web tool, and sensitivity analyses were conducted.</p><p><strong>Results: </strong>Food-based oil diets significantly reduced SBP and DBP (MD: -18.43 and -12.90 mm Hg). Low-fat and unsaturated fat-enriched diets lowered SBP (-6.91 and -4.46 mm Hg) and DBP (-3.78 and -0.74 mm Hg). The DASH diet had moderate effects (SBP: -3.83, DBP: -2.18 mm Hg). Omega-3 and high-fat diets showed smaller reductions. Saturated fat restriction had minimal impact.</p><p><strong>Conclusions: </strong>Food-based fatty oil diets had the greatest BP reduction, while low-fat, unsatu-rated fat-enriched, and DASH diets (fat-based variation) showed moderate effects. High-fat and omega-3 diets had smaller impacts, emphasizing diet's role in BP management.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"542-550"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Life's Essential 8 and hyperuricemia in the Chinese elderly.","authors":"Yingying Jiao, Liusen Wang, Xi Hong, Weiyi Li, Hongru Jiang, Xiaofang Jia, Huijun Wang, Bing Zhang, Zhihong Wang, Gangqiang Ding","doi":"10.6133/apjcn.202508_34(4).0018","DOIUrl":"10.6133/apjcn.202508_34(4).0018","url":null,"abstract":"<p><strong>Background and objectives: </strong>Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.</p><p><strong>Methods and study design: </strong>The subjects were the elderly aged 60 and over who participated in the China Health and Nutrition Survey (CHNS) in 2018. The definition of American Heart Association (AHA) was used to measure the score of LE8. Multivariate Logistic regression and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between LE8 and HUA.</p><p><strong>Results: </strong>A total of 4229 subjects were included, and the prevalence of HUA was 13.2%. The LE8 score was 68.5 points, and physical activity (85.8) and blood pressure (37.6) were the highest and lowest scores, respectively. People with low, medium and high CVH accounted for 5.7%, 77.3% and 17.0%, respectively. Multivariate Logistic regression showed that high CVH in LE8 score reduced the risk of HUA (OR = 0.62, 95%CI = 0.39-0.99) significantly, and the risk decreased by 15% (OR = 0.85, 95%CI = 0.78-0.93) for every 10-point increase in LE8 score. RCS showed a linear dose-response relationship between LE8 and HUA, and the beneficial protective threshold was 68.6 points. The negative association between LE8 score and HUA was more significant in 60-69 years.</p><p><strong>Conclusions: </strong>This study suggested that the elderly in 15 provinces of China were at a moderate level of CVH, and a higher LE8 score was beneficial for reducing the risk of HUA.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"677-688"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of time-restricted eating and a six-meal diet: Effects on body composition and biochemical parameters.","authors":"Merve Yüzbaşıoğlu, Aclan Özder","doi":"10.6133/apjcn.202508_34(4).0010","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Obesity and obesity-related diseases is increasing worldwide. The widely accepted approach in the dietary treatment of obesity is the calorie-restricted six meal diet; however, alternative approaches are needed. This study aimed to compare time-restricted eating (TRE), a method that can be easily conveyed and applied in overcoming obesity, to six meals diet.</p><p><strong>Methods and study design: </strong>A total of 174 participants aged 18-65, BMI>25 kg/m2 were included, with 88 participants in the time-restricted eating group and 86 participants in the six-meal group. Diet lists with similar calorie, macro counts suitable for their respective groups were prepared. Anthropometric measurements, blood pressure, blood tests were analyzed before the study and at the end of the 8-week.</p><p><strong>Results: </strong>More weight loss [MD: 1.17 kg, (95% CI: 0.23-2.06), Cohen's d=0.42], higher decrease in BMI [MD: 0.41 kg/m2 (95% CI: -0.77 to -0.06), Cohen's d=0.39] , decrease in waist-to-hip ratio [MD: 0.008 (95% CI: -0.016-0.000), Cohen's d=0.35], decrease in obesity degree [MD: 2.35 (95% CI: -3.99 to -0.70), Cohen's d=0.50] were observed in the time-restricted eating group (p<0.05). In the six meals group, decrease in LDL values was higher compared to the time-restricted eating group [p<0.05, MD:0.23 mmol/L (95% Cl:0.41-15.79), Cohen's d=0.36]. More participants preferred to continue TRE (p<0.001).</p><p><strong>Conclusions: </strong>TRE resulted in greater weight loss, body fat reduction, and improved metabolic parameters, proving more effective for weight management. The six-meal diet was superior for LDL reduction. Both approaches yielded positive outcomes, with TRE emerging as an alternative weight loss strategy.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"589-595"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}