Asia Pacific journal of clinical nutrition最新文献

{"title":"Evaluation of micronutrients in stable COPD patients.","authors":"Turan Onur, Sarıoglu Nurhan, Turan Pakize Ayse, Özdemir Özer, Fazlıoglu Nevin, Köseoglu Mehmet, Özkanay Hayat, Mirici Arzu","doi":"10.6133/apjcn.202510_34(5).0002","DOIUrl":"10.6133/apjcn.202510_34(5).0002","url":null,"abstract":"<p><strong>Background and objectives: </strong>Chronic obstructive pulmonary disease (COPD) is a disease characterized by malnutrition, a catabolic process, and chronic inflammation; thus, vitamin deficiency may occur frequently. We aimed to evaluate the levels of micronutrients in stable COPD patients.</p><p><strong>Methods and study design: </strong>There were 168 COPD patients from six pulmonology departments, with 36 healthy controls. The patients also performed pulmonary function tests and filled out the St. George's Respiratory Questionnaire (SGRQ). Serum vitamin B-12 and folate levels were measured using the chemiluminescence immunoassay (CLIA) method. Plasma 25-OH D3 levels were measured by high-performance liquid chromatography (HPLC).</p><p><strong>Results: </strong>Our results revealed vitamin D deficiency in 68.9% (mild: 59.6%, intermediate: 25.7%, severe: 14.7%), vitamin B-12 deficiency in 21.7%, and folic acid deficiency in 50% of COPD patients. There was a significant difference between the COPD and healthy control groups regarding vitamin D deficiency (68.9% vs. 16.6%; p <0.001). Mean plasma 25-OH-D level was significantly lower in COPD patients (p <0.01). There was a positive correlation of plasma 25-OH-D level with the SGRQ impact score (r = 0.174, p = 0.028) and a negative correlation with age and number of exacerbations (respectively; r = -0.248, p = 0.002, and r = -0.160, p = 0.044).</p><p><strong>Conclusions: </strong>Vitamin D, B-12, and folate deficiencies frequently occur in COPD patients. Low plasma levels of 25-OH-D may be associated with advanced age and a higher number of exacerbations in patients with COPD. COPD patients with low vitamin D and folate may experience a decrease in quality of life.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 5","pages":"724-729"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quasi-experimental study on fortified tempeh: A nutritional intervention for fetal growth in Indonesia.","authors":"Risna Nurlia, Aminuddin Syam, Andi Zulkifli, Andi Dirpan, Sri Sumarmi, Hamka Naping, Balqis Balqis, Abdul Salam","doi":"10.6133/apjcn.202510_34(5).0011","DOIUrl":"10.6133/apjcn.202510_34(5).0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>Stunting is a global health challenge, especially in developing countries like Indonesia, where its prevalence reached 21.6% in 2022. This condition stems from malnutrition, recurrent infections, and inadequate care during the first 1,000 days of life. Maternal nutrition is critical for fetal growth, as deficiencies can lead to low birth weight and short birth length, increasing the risk of stunting. This study evaluates the potential of fortified tempeh as a nutritional intervention to improve birth outcomes.</p><p><strong>Methods and study design: </strong>A quasi-experimental study with a quantitative approach was conducted to compare the effects of regular and fortified tempeh on BW and BL among pregnant women in Kuningan Regency. Participants were divided into two groups: one receiving fortified tempeh and the other regular tempeh. BW and BL were measured at birth and statistically analyzed for differences.</p><p><strong>Results: </strong>The results showed no statistically significant differences in BW and BL between the two groups. However, the fortified tempeh group exhibited a positive trend, with an average BW of 2.92 kg and an average BL of 49.1 cm, compared to the regular tempeh group.</p><p><strong>Conclusions: </strong>Fortified tempeh demonstrates potential as a cost-effective, locally sourced intervention to support fetal growth and reduce stunting risks. Its integration into public health programs could enhance maternal nutrition and improve birth outcomes in Indonesia.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 5","pages":"829-838"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal iron and zinc and preterm labor risk: A nested case-control study based on the Lanzhou Birth Cohort Study (BBCS) in China.","authors":"Shuyu Ding, Yuqing Li, Jingyan Wang, Lei Cao, Zifu Wang, Liping Yang, Baohong Mao","doi":"10.6133/apjcn.202510_34(5).0012","DOIUrl":"10.6133/apjcn.202510_34(5).0012","url":null,"abstract":"<p><strong>Background and objectives: </strong>The aim of this study was to investigate the effect of dietary iron and zinc in-take on the risk of preterm labor before and during different trimesters, and to assess whether there is an interaction between iron and zinc intake and the risk of preterm labor.</p><p><strong>Methods and study design: </strong>The study was a nested case-control study of 880 cases and 8017 controls in Lanzhou City, northwest China. Unconditional logistic regression was used to determine the association between dietary iron/zinc intake and the risk of preterm labor and its clinical subtypes. Multivariable-adjusted restricted cubic spline (RCS) modeling was used to explore the non-linear relationship between dietary iron/zinc intake levels and the risk of preterm birth. Lower iron/zinc intake before and during pregnancy was associated with a higher risk of preterm labor and some of its subtypes, and there was a non-linear trend between iron/zinc intake and risk of preterm labor (p non-linear <0.05). A synergistic effect of low iron and zinc intake on the risk of preterm labor was also observed.</p><p><strong>Results: </strong>We observed a significant increase in the risk of preterm labor in women with low dietary zinc intake before and during pregnancy, with a dose-response relationship. Similarly, there was a significant negative association between lower dietary iron intake during pregnancy and preterm labor. In addition, there was a multiplicative interaction between low dietary iron and zinc intake and preterm delivery before pregnancy and during three different periods of pregnancy.</p><p><strong>Conclusions: </strong>Higher dietary intake of iron and zinc before and during pregnancy may reduce the risk of preterm labor. Low intakes of iron and zinc during pregnancy appear to have a synergistic effect on the risk of preterm labor.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 5","pages":"839-851"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivitamin-mineral supplementation prevents acute upper respiratory tract infections.","authors":"Fang Wang, Junren Kang, Wei Wei, Yuanyuan Bao, Allan Chen, Feifei Deng, Kang Yu","doi":"10.6133/apjcn.202508_34(4).0011","DOIUrl":"10.6133/apjcn.202508_34(4).0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>Large-scale studies on the role of multivitamin-mineral (MVM) supplementation in preventing and managing acute respiratory infections (AURIs) are limited in Chinese populations. This study evaluated the impact of routine MVM use on AURI prevalence and symptom severity in a community-based Chinese cohort.</p><p><strong>Methods and study design: </strong>This retrospective study was conducted among community-based populations across China (n=3,415). Using a structured questionnaire, participants self-reported epi-sodes of AURIs over three months. Based on regular use of MVM for at least 3 months, eligible participants were categorized into the MVM group and the control group. The impact of MVM on the frequency and severity of AURIs was assessed. Rigorous methodological approaches were applied to minimize potential biases.</p><p><strong>Results: </strong>The period prevalence of AURIs was significantly lower in the MVM group (29.9%) compared to controls (45.6%), odds ratio (OR) =0.508 (p<0.001). After propensity score matching, demographic and lifestyle factors were comparable between groups. The period prevalence of AURIs was 31.7% and 44.8% in the MVM and control groups (OR=0.572, p<0.001). Subgroup analysis indicated the protective effect of MVM supplementation was particularly significant among participants aged ≥45 years (OR=0.407, p<0.001). The MVM group reported lower prevalence of nasal congestion (OR=0.624, p<0.001), sore throat (OR=0.575, p<0.001), headache (OR=0.642, p<0.001), diarrhea (OR=0.718, 0.026), sneezing (OR=0.651, p=0.002), and fatigue (OR=0.694, p=0.004) relative to the control group.</p><p><strong>Conclusions: </strong>Daily MVM supplementation for at least 3 months reduced the period prevalence of the common cold and influenza and may contribute to enhanced immune resilience in the Chinese population.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"596-609"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of early versus late enteral nutrition on the nutritional status of surgical intensive care unit patients: A retrospective observational study.","authors":"Pei-Chun Chao, Frank Cheau-Feng Lin, Hsien-Hua Liao, Lu-Huan R Chou, Chun-Fen R Lee","doi":"10.6133/apjcn.202508_34(4).0012","DOIUrl":"10.6133/apjcn.202508_34(4).0012","url":null,"abstract":"<p><strong>Background and objectives: </strong>We retrospectively evaluated the efficacy and safety of early enteral nutrition (within 48 h) and late enteral nutrition (after 48 h; control) in improving the nutritional status of surgical intensive care unit patients.</p><p><strong>Methods and study design: </strong>This single-center, retrospective, observational study was conducted using data from 82 patients (age > 18 years) who were admitted to surgical intensive care units between June and November 2019. Patients who received enteral nutrition for >7 days were included in this study, and those who received total parenteral nutrition or palliative care were excluded.</p><p><strong>Results: </strong>The early and late enteral nutrition groups comprised 41 patients each. Early enteral nutrition significantly increased the actual intake of calories and protein (p < 0.0001) as well as the length of stay in the surgical in-tensive care unit (p = 0.047) and hospital (p = 0.028). Late enteral nutrition significantly reduced albumin concentration (p < 0.05), hemoglobin concentration (p < 0.05), and lymphocyte count (p < 0.05) but significantly increased weight loss (p < 0.05). However, no significant between-group difference was observed in mortality rate.</p><p><strong>Conclusions: </strong>Early enteral nutrition improves the nutritional status of surgical intensive care unit patients. It shortens overall hospitalization duration and increases actual calorie and protein intake at dis-charge. Thus, early enteral nutrition is recommended for critically ill patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"610-618"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of FSMP on nutrition status and sarcopenia among nutritional risk cancer patients: A randomized, double-blind, placebo-controlled study.","authors":"Jin Fu, Kang Yu, Yu Zhang, Yuanyuan Bao, Shanshan Li","doi":"10.6133/apjcn.202508_34(4).0008","DOIUrl":"10.6133/apjcn.202508_34(4).0008","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cancer patients at nutritional risk have a worse prognosis, but this can be improved by nutritional support. Food for special medical purposes (FSMP), as a new form of nutritional support, needs to be further evaluated for its safety and efficacy in these patients. Our study elucidate the impact of FSMP on nutritional status and sarcopenia among nutritional risk cancer outpatients by assessing the NRS2002 score, exercise performance, muscle mass, and inflammatory factors pre- and postintervention.</p><p><strong>Methods and study design: </strong>We conducted a single-centre, double-blind, randomized controlled interventional study. Patients from the oncology clinic with nutritional risk were randomly allocated to the control group or the FSMP group and received oral intervention for 8 weeks. The primary outcome was improvement in nutritional risk, while the secondary outcomes were improvements in sarcopenia prevalence and physical performance indicators. Other outcomes included alterations in calf circumference, hsCRP, 25(OH)VD3, Alb. etc. A linear mixed-effects model was used to compare the prepost-intervention changes in these results.</p><p><strong>Results: </strong>Thirty-six cancer patients were included, 25 completed the study. The percentage of patients at nutritional risk after intervention in the FSMP group was significantly lower than the control group (Χ2=4.186, p=0.041). The FSMP group demonstrated significant improvements in the TUG test, gait speed, grip strength, and upper-limb muscle mass. However, there was no significant improvement in the rate of sarcopenia. Moreover, calf circumference, hsCRP, 25(OH)VD3, Alb exhibited no significant changes.</p><p><strong>Conclusions: </strong>FSMP can effectively improve the nutritional status, physical performance and upper-limb muscle mass of cancer patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"566-576"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and predictors of refeeding syndrome in adult patients receiving parenteral nutrition at a Malaysian teaching hospital: A retrospective study.","authors":"Tze Wei Ng, Nur Aina Abu Hassan Shaari, Birinder Kaur Sadu Singh, Chandini Menon Premakumar","doi":"10.6133/apjcn.202508_34(4).0006","DOIUrl":"10.6133/apjcn.202508_34(4).0006","url":null,"abstract":"<p><strong>Background and objectives: </strong>Refeeding syndrome (RS) is a potentially life-threatening condition character-ised by significant electrolyte and fluid imbalances, posing a considerable risk in patients undergoing parenteral nutrition (PN) therapy. This study aimed to determine the occurrence, risk factors, severity, and complications of RS in a teaching hospital in Malaysia.</p><p><strong>Methods and study design: </strong>A retrospective observational study was conducted using universal sampling from October to December 2023. Data were collected for adult patients receiving PN for more than 48 hours between July 2022 and July 2023 at Hospital Canselor Tuanku Muhriz.</p><p><strong>Results: </strong>Among 90 patients included, 30 (33.3%) developed RS. Upon consideration of interaction terms due to collinerity of variables, a statistically significant correlation was observed between pre-existing electrolyte derangements and RS occurrence (p = 0.001). Phosphate levels showed the most significant decline post-PN initiation (43%), followed by potassium (19%) and magnesium (17%), primarily within the first 24 hours. No significant associations were found between BMI, fasting duration, unintentional weight loss, or medication history and RS. However, fasting for more than five days (AOR 2.8, 95% CI 0.4-17.7) and ≥10% unintentional weight loss (AOR 1.8, 95% CI 0.4-7.7) increased the likelihood of RS.</p><p><strong>Conclusions: </strong>RS is prevalent among adult PN patients, predominantly with mild severity. Pre-existing electrolyte abnormalities, especially in phosphate levels, were robust predictors. Larger studies are needed to better elucidate the associations between risk factors and RS in the local population.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"551-556"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications.","authors":"Zhen Zhang, Shuai Li, Jianjun Sun","doi":"10.6133/apjcn.202508_34(4).0003","DOIUrl":"10.6133/apjcn.202508_34(4).0003","url":null,"abstract":"<p><strong>Background and objectives: </strong>To compare the effectiveness of silymarin or its combination with lifestyle modifications, Mediterranean hypocaloric diets, and medications for improving nonalcoholic fatty liver disease (NAFLD).</p><p><strong>Methods and study design: </strong>PubMed, Embase, Cochrane Library, Web of Science, and Clin-icalTrails.gov were used to identify relevant studies. The treatment arm was silymarin or its combination with Mediterranean hypocaloric diets, medications, or lifestyle modifications. The comparators were placebo, Mediterranean hypocaloric diets, medications, and lifestyle modifications.</p><p><strong>Results: </strong>This meta-analysis included 25 studies with 2283 patients. Total cholesterol levels were reduced by silymarin+Mediterranean hypocaloric diets (SMD: -0.39 (-0.81, 0.03), p=0.072) or medications [SMD: -1.12 (-1.67, -0.58), p<0.001]. Triglyceride levels were decreased by silymarin combined with the medication [SMD: -0.92 (-1.98, 0.14), p=0.080]. Low-density lipoprotein cholesterol levels were reduced by silymarin alone [SMD: -0.25 (-0.48, -0.03), p=0.027]. The combination of silymarin with Mediterranean hypocaloric diets [SMD: -0.47 (-0.90, -0.04), p=0.031] or lifestyle modifications [SMD: -0.88 (-1.09, -0.66), p<0.0001] decreased alanine aminotransferase levels. Aspartate aminotransferase levels were reduced by a combination of silymarin and life-style modifications [SMD: -0.72 (-1.49, 0.05), p=0.061] or medications [SMD: -1.41 (-2.24, -0.59), p=0.005]. Silymarin (2.5 times) or silymarin plus lifestyle modifications (39%) reduced the hepatic steatosis rate in patients with NAFLD. The silymarin use increased the rate of patients with adverse effects [RR:1.98 (1.11, 3.54)]; gastrointestinal problems were the most common adverse effects.</p><p><strong>Conclusions: </strong>Despite the overall advantages of therapies, different interventions showed different effects on markers in patients with NAFLD. These results highlight the need for more research to fully comprehend the features of the intervention.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"516-530"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrient status of patients with diabetic foot: A systematic review.","authors":"Sholpan Batarbekova, Dinara Zhunussova, Gulmira Derbissalina, Zhanagul Bekbergenova, Nadezhda Maksimova, Ayagoz Umbetzhanova, Elmira Kelimberdiyeva, Raushan Kassymova, Gaukhar Kuanyshbayeva, Altynay Imangaliyeva","doi":"10.6133/apjcn.202508_34(4).0001","DOIUrl":"10.6133/apjcn.202508_34(4).0001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Micronutrient status encompasses a range of indicators that reflect the levels and balance of macro- and microelements, as well as vitamins within the body. These essential substances, required in minimal amounts, are crucial for supporting normal physiological processes, immune system functioning, and tissue repair. The aim of this systematic review is to summarize data on the deficiency or excess of microelements, macroelements, and vitamins in patients with diabetic foot ulcers.</p><p><strong>Methods and study design: </strong>Databases were searched for studies on vitamin, macronutrient, micronutrient levels and their impact on the course, treatment and healing of diabetic foot ulcers. The Cochrane Risk of Bias tool was employed for assessing randomized trials, while the Newcastle-Ottawa Scale was utilized for evaluating observa-tional studies in terms of quality and bias risk.</p><p><strong>Results: </strong>The findings revealed a notable correlation between deficiencies in vitamins D, C, A and the severity of clinical symptoms. Low vitamin D levels were linked to elevated proinflammatory cytokines. Higher concentrations of folate and vitamin B-12 were associated with improved ulcer healing, supplementation with zinc and magnesium contributed to a reduction in ulcer size. Inadequate intake of zinc, vitamins E, C was found to compromise antioxidant defences. Elevated ferritin levels may serve as an indicator of inflammation.</p><p><strong>Conclusions: </strong>The most important task is to adjust the in-take of micronutrients to maintain balance and prevent deficiency and excess, which is important in the complex therapy of patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"487-501"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic evaluation of risk prediction models for feeding intolerance in ICU patients during enteral nutrition.","authors":"Xianqiao Huang, Liming Zhong, Chao Li, Yu Tang","doi":"10.6133/apjcn.202508_34(4).0009","DOIUrl":"10.6133/apjcn.202508_34(4).0009","url":null,"abstract":"<p><strong>Background and objectives: </strong>It has been found that ICU patients may encounter various complications during enteral nutrition (EN). Of these, feeding intolerance (FI) is a common issue that often necessitates the reduction or cessation of EN. This study aims to evaluate risk prediction models for feeding intolerance (FI) in critically ill patients receiving EN by searching major public databases.</p><p><strong>Methods and study design: </strong>We searched for relevant studies in Embase, PubMed, Web of Science, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data, and cqvip.com up until January 2024. Two researchers independently conducted the screening and data extraction processes, and the quality of the literature was assessed using bias risk assessment tools.</p><p><strong>Results: </strong>A total of 13 references were included, and the subjects included patients with sepsis, pancreatitis or cerebral apoplexy; the incidence of FI was 35.2%-49.3%. The studies discussed the predictive performance of various models, with 11 studies reporting on their accuracy and calibration. The models demonstrated the area under the curve (AUC) of the receiver operating characteristic (ROC) curve or the concordance index (C-index) between 0.70 and 0.91, sensitivity from 0.81 to 0.93, and specificity from 0.68 to 0.83.</p><p><strong>Conclusions: </strong>There is a critical need for risk prediction models for FI in critically ill patients on EN that are both internally and externally validated and exhibit high performance.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"577-588"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}