Asia Pacific journal of clinical nutrition最新文献

{"title":"Diet quality and biochemical parameters in individuals with type 2 diabetes across BMI categories: A cross-sectional study.","authors":"Cemaliye Süt Kurt, Nazife Hürer, Rojina Deniz Aygül Elma, Deniz Engin Gök, Seyit Mehmet Mercanligil","doi":"10.6133/apjcn.202608_35(4).0014","DOIUrl":"10.6133/apjcn.202608_35(4).0014","url":null,"abstract":"<p><strong>Background and objectives: </strong>Type 2 diabetes mellitus (T2DM) is closely associated with obesity and metabolic disturbances. Although diet quality has been linked to metabolic outcomes, its role relative to adiposity remains unclear. This study aimed to evaluate differences in biochemical parameters across body mass index (BMI) categories and examine relationships between diet quality and biochemical markers.</p><p><strong>Methods and study design: </strong>This cross-sectional study included 150 individuals with T2DM aged 46-60 years attending an endocrinology outpatient clinic between September 2023 and May 2024. Participants were classified as being of normal weight, overweight, or obese based on BMI. Diet quality was assessed using three-day food consumption records and calculated using the Healthy Eating Index-2015 (HEI-2015). Biochemical parameters were obtained from medical records. Between-group comparisons were performed using one-way ANOVA with Bonferroni post hoc tests and Pearson correlation analysis was used to assess associations. Benjamini-Hochberg false discovery rate (BH-FDR) correction was applied for multiple testing.</p><p><strong>Results: </strong>Several biochemical parameters differed significantly across BMI categories (p <0.05). Obese individuals had higher triglyceride, uric acid, C-reactive protein, liver function, and fasting insulin levels, whereas normal-weight individuals had higher high-density lipoprotein cholesterol and estimated glomerular filtration rate. No significant differences were observed in HEI-2015 scores across BMI groups (p >0.05). Weak correlations between diet quality and biochemical markers were not significant after BH-FDR correction.</p><p><strong>Conclusions: </strong>Biochemical parameters differed across BMI categories, highlighting the role of adiposity in metabolic risk. Associations between diet quality and biochemical markers were limited, suggesting that BMI-based stratification may be more informative than diet quality alone.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"703-713"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Association between dietary fat intake and fatty acid profiles and hyperuricemia among Chinese adults: Results from the China Health and Nutrition Survey.","authors":"Pengfeng Qu, Yingying Jiao, Liusen Wang, Weiyi Li, Hongru Jiang, Jiguo Zhang, Huijun Wang, Bing Zhang, Junhua Han, Aidong Liu, Zhihong Wang","doi":"10.6133/apjcn.202608_35(4).0018","DOIUrl":"10.6133/apjcn.202608_35(4).0018","url":null,"abstract":"<p><p>This erratum corrects the academic qualifications of the authors of the article DOI: 10.6133/apjcn.202604_35(2).0007 The correct academic qualifications of the authors are: Pengfeng Qu MSc, Yingying Jiao MSc, Liusen Wang MSc, Weiyi Li MPH, Hongru Jiang MPH, Jiguo Zhang PhD, Huijun Wang MSc, Bing Zhang PhD, Junhua Han PhD, Aidong Liu PhD, Zhihong Wang PhD The authors regret this error. This correction does not affect the scientific content, results, or conclusions of the article.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"749"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of oral nutritional supplements on chemotherapy tolerance and overall survival in postoperative colorectal cancer patients undergoing chemotherapy.","authors":"Zhige Zhang, Qiulei Xi, Qiulin Zhuang, Mingyue Yan, Qingyang Meng, Shanjun Tan, Guohao Wu","doi":"10.6133/apjcn.202608_35(4).0010","DOIUrl":"10.6133/apjcn.202608_35(4).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>The primary objective of this study was to evaluate the efficacy of oral nutritional supplements (ONS) on chemotherapy tolerance and long-term survival outcomes in postoperative colorectal cancer patients undergoing chemotherapy.</p><p><strong>Methods and study design: </strong>This study was a secondary analysis based on a randomized controlled trial, and patients undergoing chemotherapy after hospital discharge were included. Patients in the ONS group received dietary advice as well as ONS for three months, while the control group received only dietary advice. Clinical characteristics and nutritional indicators were collected at baseline and three months after hospital discharge to assess nutritional status. These included body weight, body mass index, skeletal muscle index, serum albumin, and hemoglobin levels. Chemotherapy modifications including dose reduction, delay, and discontinuation were recorded to represent chemotherapy tolerance. The survival information within 5 years was collected and analysed.</p><p><strong>Results: </strong>There were 157 patients included in this study, with 80 patients in the ONS group and 77 in the control group. At three months after hospital discharge, nutrition-related parameters showed no significant differences between the two groups. However, the ONS group demonstrated a significant improvement in chemotherapy tolerance comparing to the control group (17.5% vs. 35.1%, p = 0.01). Additionally, the ONS group exhibited a lower 5-year all-cause mortality rate and significantly improved survival outcomes compared to the control group (hazard ratio 0.58, 95%CI: 0.34-0.98, p = 0.04).</p><p><strong>Conclusions: </strong>The administration of ONS after hospital discharge can improve chemotherapy tolerance and long-term survival rates in colorectal cancer patients under-going chemotherapy, highlighting the importance of nutritional support during postoperative chemotherapy. Further studies are warranted to validate the underlying mechanisms and other long-term effects.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"666-673"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of disease related malnutrition assessed by NRS2002, STAMP, MNA-SF, one-step and two-step GLIM at admission and discharge: A systematic review and meta-analysis.","authors":"Dongyu Mu, Yi Cheng, Qi Zhang, Jie Gong, Yana Qi, Jiajie Yu, Linan Zeng, Lingli Zhang, Wen Hu, Yuan Liu, Lei Shi","doi":"10.6133/apjcn.202608_35(4).0005","DOIUrl":"10.6133/apjcn.202608_35(4).0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Disease-related malnutrition (DRM) mandates routine screening in many nations to ensure quality care as nutritional status often deteriorates during hospitalization. This study aimed to establish tool-specific prevalence benchmarks at admission and discharge, investigate sources of heterogeneity and evaluate diagnostic yields of one-step versus two-step GLIM approaches.</p><p><strong>Methods and study design: </strong>A systematic search of Embase, PubMed, Web of Science, Cochrane Library, and CINAHL was conducted for cross-sectional studies on nutritional status published between 1 January 2018 and 30 Nov 2025 (PROS-PERO ID: CRD42023480467). Eligible studies were pooled in a meta-analysis of proportions using a random-effects model.</p><p><strong>Results: </strong>Of 9,693 records retrieved, 179 studies involving 755,092 patients from 30 countries were included. At admission, the pooled prevalence was 0.41 (95% CI 0.35-0.49, I2 = 99.9%) by NRS2002 (≥3, adults), 0.62 (95% CI 0.57-0.67, I2 = 99.3%) by MNA-SF (≤11, older adults), 0.55 (95% CI 0.44-0.68, I2 = 98.5%) by STAMP (≥2, pediatric patients), and 0.39 (95% CI 0.35-0.44, I2 = 99.6%) by GLIM (adults). At discharge, three studies reported a pooled prevalence of 0.19 (95% CI 0.09-0.40, I2 = 94.6%) by NRS2002 for adults, significantly lower than admission (p = 0.044). Comparing GLIM strategies, no statistically significant difference was observed between one-step and two-step GLIM approaches (p = 0.062).</p><p><strong>Conclusions: </strong>DRM prevalence remains high at both admission and discharge, varying widely across countries and by tools. Discharge data are critically limited, reflecting gaps in routine screening practices. Regarding diagnosis, findings support a risk-adapted strategy. Pooled estimates may overestimate the true prevalence and should be interpreted with caution.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"603-622"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measured resting energy expenditure via indirect calorimetry of critically ill patients: A comparison with predictive equations.","authors":"Zezhong Tian, Zicong Zheng, Xiaoling Wang, Yanling Yao","doi":"10.6133/apjcn.202606_35(4).0013","DOIUrl":"10.6133/apjcn.202606_35(4).0013","url":null,"abstract":"<p><strong>Background and objectives: </strong>Assessing the resting energy expenditure (REE) of critically ill patients is essential for individual nutritional programs. We hypothesized that different evaluated ways for REE can be compared, and REE may be associated with disease severity and clinical prognosis. This study aimed to compare the differences between measured resting energy expenditure (m-REE) by indirect calorimetry and values estimated by predictive equations in critically ill patients, and to explore the correlations between REE and inflammatory status or clinical prognosis.</p><p><strong>Methods: </strong>The patients in intensive care unit (ICU) were categorized based on APACHE II scores. REE was assessed using indirect calorimetry (m-REE) and compared with estimates from multiple equations including Harris-Benedict (H-B), adjusted H-B, Mifflin-St Jeor, WHO/FAO/UNU, Owen, Henry, and Weight-kilogram. Serum procalcitonin (PCT) and high-sensitivity C-reactive protein (hsCRP) were measured, and ICU staying days were recorded for correlation analysis.</p><p><strong>Results: </strong>Results showed that m-REE was significantly higher than most equation-predicted values (p <0.01) when APACHE II ≥15, while no significant differences were found with adjusted H-B, Owen, and Weight-kilogram equation. Additionally, m-REE was positively correlated with hsCRP, PCT, ICU staying days and hospital length (all p <0.05). When APACHE II <15, m-REE was generally lower than predicted values.</p><p><strong>Conclusion: </strong>The findings suggest that in the absence of indirect calorimetry, the adjusted H-B, Owen, and Weight-kilogram equations may be applicable for patients with APACHE II ≥15. Furthermore, m-REE may serve as a potential predictor of inflammatory status and clinical prognosis in critically ill patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 3","pages":"696-702"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal fat thickness predicts the risk of pregnancy-associated hypertension: A prospective cohort study.","authors":"Xueteng Ding, Caiping Xiang, Chao Wei, Xiaofei Chen, Hongge Fa, Zhanhui Du, Guoju Li","doi":"10.6133/apjcn.202608_35(4).0016","DOIUrl":"10.6133/apjcn.202608_35(4).0016","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pregnancy-associated hypertension (PAH) is a prevalent complication during pregnancy. Maternal obesity is a known risk factor for PAH. As nutrition is a key modifiable driver of obesity and metabolic health, this study aimed to evaluate whether early-pregnancy abdominal fat thickness and nutrient intake are associated with the development of PAH.</p><p><strong>Methods and study design: </strong>A prospective cohort study was conducted including pregnant women during 9 to 13+6 weeks of gestation. The abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured by ultrasound. Daily intake of key nutrients was assessed using a validated food frequency questionnaire. The primary outcome was development of PAH, encompassing gestational hypertension and pre-eclampsia.</p><p><strong>Results: </strong>A total of 1912 pregnant women were recruited in this study. The overall incidence of PAH was 7.1% (136/1912). High VAT was associated with a higher PAH incidence than normal VAT (11.2% vs. 4.5%). Independent of BMI, high SAT (≥17.05 mm; adjusted odds ratios (aOR): 2.74, 95% confidence interval (CI): 1.89-3.96) and high VAT (≥28.85 mm; aOR: 2.42, 95% CI: 1.67-3.50) significantly increased risk of PAH. Comparatively, obesity (BMI ≥30 kg/m²) was associated with an aOR of 7.04 (95% CI: 3.94-12.6) for PAH, while the aOR for overweight was 3.16 (95% CI: 2.11-4.71). A predictive model incorporating these adiposity indicators demonstrated an area under the ROC curve of 0.745 (95%CI: 0.703-0.788). In contrast, no significant associations were observed between daily nutrient intake and PAH risk.</p><p><strong>Conclusions: </strong>In this prospective cohort study, both early-pregnancy SAT and VAT are significant predictors of PAH independent of BMI. The developed predictive model facilitates the early identification of high-risk women, enabling timely interventions to reduce adverse perinatal outcomes.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"723-734"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.","authors":"Suhad Abumweis, Sarah Alqadi, Ala'a Al Tarteer, Waed Alrefai, Foad Alzoughool, Stephanie Jew, Taima Qudah","doi":"10.6133/apjcn.202608_35(4).0007","DOIUrl":"10.6133/apjcn.202608_35(4).0007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Vitamin D has been proposed to influence several cardiometabolic risk factors; however, evidence from randomized controlled trials (RCTs) and recent meta-analyses remains inconsistent regarding the magnitude of these effects. This meta-analysis evaluated the effects of vitamin D supplementation on lipid profile, blood pressure, and glycaemic parameters, and explored whether age and baseline serum vitamin D concentrations modified these associations.</p><p><strong>Methods and study design: </strong>A systematic review and meta-analysis of RCTs was conducted to compare oral vitamin D supplementation with placebo in adults. PubMed, the Cochrane Library, and ClinicalTrials.gov were searched systematically. Risk of bias was as-sessed using the Cochrane risk-of-bias tool. Pooled effect sizes with 95% confidence intervals (CIs) were estimated using random-effects models.</p><p><strong>Results: </strong>A total of 14,051 abstracts were identified, and 45 RCTs were included in the final analysis. Vitamin D supplementation significantly reduced low-density lipoprotein cho-lesterol (LDL-C) by 0.136 mmol/L (95% CI: -0.215, -0.056), systolic blood pressure (SBP) by 2.79 mm Hg (95% CI: -4.65, -0.94), fasting blood glucose (FBG) by 0.11 mmol/L (95% CI: -0.19, -0.04), and hemoglobin A1c (HbA1c) by 0.164% (95% CI: -0.32, -0.01) compared with placebo. Subgroup analyses showed reductions in SBP and LDL-C among participants aged ≥55 years, whereas FBG was reduced in those aged <55 years. While favorable effects on FBG and HbA1c were observed with a baseline blood level of vitamin D of less than 50 nmol/L.</p><p><strong>Conclusions: </strong>Vitamin D supplementation may modestly improve selected cardiomet-abolic risk factors. Age and baseline vitamin D status may influence these effects, although their clinical sig-nificance remains uncertain. Further well-designed RCTs are needed.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"631-643"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between factor analysis-derived dietary patterns at 24 months of age and allergic diseases in toddlers.","authors":"Hyoyeon Son, Weiqi Hong, Won Jang, Hyesook Kim","doi":"10.6133/apjcn.202608_35(4).0017","DOIUrl":"10.6133/apjcn.202608_35(4).0017","url":null,"abstract":"<p><strong>Background and objectives: </strong>Early-life diet may influence immune development and the risk of allergic diseases. This study investigated associations between dietary patterns at 24 months of age and allergic diseases in Korean toddlers.</p><p><strong>Methods and study design: </strong>In this cross-sectional study, 433 toddlers from the Korean Mothers and Children's Environmental Health (MOCEH) cohort were included. Dietary intake was assessed using two non-consecutive 24-hour recalls. Factor analysis of 26 food groups identified dietary patterns, and individual pattern scores were categorized into tertiles based on ascending distribution. Allergic diseases were determined by caregiver questionnaires. Multivariable logistic regression was used to assess associations, adjusting for confounders.</p><p><strong>Results: </strong>Three dietary patterns were identified: Pattern 1 (white rice, kimchi, and non-salt-preserved vegetables), Pattern 2 (seasoning, butter, and meat), and Pattern 3 (milk and dairy products). Compared with the lowest tertile, the highest tertile of Pattern 2 was associated with higher odds of other allergic diseases (OR: 7.55; 95% CI: 1.62-35.23), and any allergic disease (OR: 2.03; 95% CI: 1.10-3.73). Pattern 3 was inversely associated with atopic dermatitis (OR: 0.51; 95% CI: 0.27-0.98), while Pattern 1 showed no significant association.</p><p><strong>Conclusions: </strong>Early childhood dietary patterns may influence the development of allergic disease. A pattern characterized by seasoning, butter, and meat was associated with an increased risk of allergic disease, whereas a dairy-based pattern was inversely associated with atopic dermatitis in Korean toddlers.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"735-748"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and iron deficiency anemia: Mechanisms, microbial signatures, and dietary interactions (A narrative review).","authors":"Adhila Fayasari, Ratnayani, Anis Febri Nilansari, Brevi Istu Pambudi","doi":"10.6133/apjcn.202608_35(4).0004","DOIUrl":"10.6133/apjcn.202608_35(4).0004","url":null,"abstract":"<p><strong>Background and objectives: </strong>Iron deficiency anemia (IDA) is one of the most prevalent micronutrient disorders worldwide. Recent work suggests that dysbiosis may not simply be a consequence of low iron status but may actively contribute to impaired absorption. This narrative review synthesizes the evidence on gut microbiota patterns in IDA across age groups, examines the mechanistic links between dysbiosis and iron metabolism, and identifies the potential roles of microbiota-related dietary and therapeutic strategies.</p><p><strong>Methods and study design: </strong>This narrative review used a selective, theory-driven approach, based on targeted searches of PubMed, Scopus, and Web of Science (2005-2026), to synthesize heterogeneous human, experimental, and mechanistic evidence on gut microbiota-iron interactions in iron deficiency anemia (IDA).</p><p><strong>Results: </strong>Evidence suggests a bidirectional, context-dependent relationship between IDA and gut microbiota involving host iron regulation, microbial competition, metabolites, and diet. Individuals with IDA often show reduced microbial diversity, depletion of SCFA-producing taxa, and enrichment of iron-scavenging bacteria, although direct causal evidence in humans remains limited.</p><p><strong>Conclusions: </strong>IDA is commonly associated with recurring dysbiosis patterns characterized by reduced short-chain fatty acid-producing commensals and relative enrichment of inflammatory, iron-competitive taxa. While iron supplementation remains the cornerstone of evidence-based IDA management, the ecological effects of unabsorbed luminal iron on gut microbial communities support the concept of a potential \"iron paradox,\" particularly in inflammatory or high-infection settings. Therefore, microbiota-targeted strategies should currently be regarded as hypothesis-generating concepts rather than established clinical interventions and require further mechanism and clinical validation.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"589-602"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary oxidative balance score, dietary inflammatory potential and fractures among adults aged ≥ 40 years in the United States in 1999-2018.","authors":"Hegang Niu, Tong Li, Haoyu Gao, Jianting Ye, Dejin Chen, Zhao Guo, Xiong Zhang, Yanan Niu, Gaoqi Ye, Shaman Wen, Jilong An, Wenshan Gao","doi":"10.6133/apjcn.202608_35(4).0011","DOIUrl":"10.6133/apjcn.202608_35(4).0011","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Dietary Oxidative Balance Score (DOBS) and Dietary Inflammatory Index (DII) reflect dietary oxidative and inflammatory status. This study investigated their associations with the prevalence of wrist, hip, and spine fractures.</p><p><strong>Methods and study design: </strong>DOBS and DII were scored based on 16 and 28 dietary factors, respectively. Multivariate logistic regression models and restricted cubic spline (RCS) models were used to assess the associations of DOBS and DII with the prevalence of wrist, hip, and spine fractures. Temporal trends of DOBS and DII and their associations with fracture trends were also analyzed, with subgroup analyses for robustness.</p><p><strong>Results: </strong>Compared with the lowest DOBS tertile, the highest DOBS tertile was associated with lower prevalence of hip and spine fractures [OR = 0.57 (0.32, 0.72); OR = 0.79 (0.48, 1.00)]. In contrast, the highest DII tertile was associated with an increased prevalence of hip and spine fractures compared with the lowest DII tertile [OR = 1.85 (1.49, 2.72); OR = 1.75 (1.18, 2.58)]. Anti-inflammatory and antioxidant diets were associated with lower prevalence of hip and spine fractures compared with pro-inflammatory and pro-oxidative diets [OR = 0.45 (0.24, 0.85); OR = 0.66 (0.44, 0.84)]. No significant associations were observed for wrist fractures. The overall DOBS trended upward among U.S. adults, while the DII showed opposite trend during the same period, with consistent results observed in subgroup analyses.</p><p><strong>Conclusion: </strong>Higher DOBS and/or lower DII were significantly associated with lower hip and spine fracture prevalence, but not with wrist fracture prevalence.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"35 4","pages":"674-687"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}