Asia Pacific journal of clinical nutrition最新文献

{"title":"Associations between diet quality scores and cardiometabolic status in young Japanese women: A cross-sectional study.","authors":"Fumi Oono, Kentaro Murakami, Kazuhiro Uenishi, Aya Fujiwara, Nana Shinozaki, Satoshi Sasaki","doi":"10.6133/apjcn.202502_34(1).0009","DOIUrl":"10.6133/apjcn.202502_34(1).0009","url":null,"abstract":"<p><strong>Background and objectives: </strong>This cross-sectional study aimed to examine associations between diet quality scores and adverse cardiometabolic status in young Japanese women.</p><p><strong>Methods and study design: </strong>In total, 1084 female dietetics students aged 18-22 years completed a validated self-administered diet history questionnaire. Diet quality was assessed using the Diet Quality Score for Japanese (DQSJ), Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet score (AMED), Dietary Approaches to Stop Hypertension score (DASH), and Japanese Food Guide Spinning Top score (JFGST). Adverse cardiometabolic status was defined as the highest quartile of the sum of z scores for waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol (multiplied by -1), triacylglycerol, glucose, and insulin.</p><p><strong>Results: </strong>After adjustment for potential confounding factors, adverse cardiometabolic status was significantly associated with all the diet quality scores except for AMED, with adjusted odds ratios (95% confidence interval) in the highest quartile compared with the lowest of 0.39 (0.25-0.61) for DQSJ, 0.40 (0.26-0.61) for DASH, 0.44 (0.30-0.66) for AHEI-2010, 0.59 (0.39-0.88) for HEI-2015, 0.67 (0.45-0.99) for JFGST, and 0.80 (0.54-1.18) for AMED. Associations with each of the cardiometabolic risk factors were most prominent for AHEI-2010 (significant associations with all factors except triacylglycerol), followed by DQSJ (significant associations with all factors except triacylglycerol and glucose).</p><p><strong>Conclusions: </strong>This cross-sectional study of young Japanese women showed associations between several diet quality scores and cardiometabolic status. These associations should be confirmed in other populations, prospectively where possible.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"91-103"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum food and nutrition: Subatomic approaches to nourishment for health and well-being.","authors":"Mark L Wahlqvist, Naiyana Wattanapenpaiboon, Menglei Shuai, Hsiao-Yu Liu, Liezhou Zhong, Ju-Sheng Zheng","doi":"10.6133/apjcn.202502_34(1).0001","DOIUrl":"10.6133/apjcn.202502_34(1).0001","url":null,"abstract":"<p><p>Nutrition science has been represented as biomedical, environmental, societal and economic field, but quantum biology is sidestepped, thereby obscuring cognate problems and solutions. We are generally nourished for health, optimal well-being, longevity and personal security through sustainable livelihoods. Our nourish-ments include not only food and energy but also light from the sun, the firmament and the earth itself, along with information transmitted in subatomic particles and electromagnetic wave forms. We propose 'quantum nutrition' as an approach to reconcile quantum phenomena with nutritional biology. Appreciating quantum nutrition and recognizing its potential applications will provide opportunities for future health and well-being and for planetary habitability.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.","authors":"Hongli Dong, Nan Lu, Jie Wang, Ping Hu","doi":"10.6133/apjcn.202502_34(1).0010","DOIUrl":"10.6133/apjcn.202502_34(1).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Mechanism studies have indicated that magnesium (Mg) and calcium (Ca) have important biological functions in glucose regulation, but epidemiological data on their associations with glycosylated hemoglobin (HbA1c) are sparse. We aimed to explore the associations of Mg and Ca with abnormal HbA1c, and examine the mediating effects of inflammation in coronary artery disease (CAD) Chinese adults.</p><p><strong>Methods and study design: </strong>A hospital-based cross-sectional study of 11934 patients with CAD was conducted. Serum Mg and Ca concentrations were measured.</p><p><strong>Results: </strong>In multivariable analyses, Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c (Q4 vs Q1: ORMg: 0.61, 95% CIMg: 0.53, 0.71; ORMg/Ca ratio: 0.67, 95% CIMg/Ca ratio: 0.54, 0.84). However, null association of Ca with abnormal HbA1c was shown (Q4 vs Q1: OR: 1.15, 95% CI: 0.92, 1.44). Serum Mg and Mg/Ca ratio were inversely associated with abnormal fasting blood glucose (FBG). In contrast, serum Ca was positively associated with abnormal FBG. Path analysis indicated that there were no mediating effects of hypersensitivity C reactive protein (hsCRP) on Mg and Mg/Ca-abnormal HbA1c associations.</p><p><strong>Conclusions: </strong>Our study suggested that serum Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c in Chinese adults with CAD. The Mg-abnormal HbA1c relationship might not be mediated by hsCRP.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"104-111"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary, metabolic and gut microbiota influences on primary ovarian failure: a two-sample Mendelian randomization study.","authors":"Xueying Liu, Zhongliang Lin, Kejing Zhu, Renke He, Zhaoying Jiang, Haiyan Wu, Jiaen Yu, Qinyu Luo, Jianzhong Sheng, Jiaxue Pan, Hefeng Huang","doi":"10.6133/apjcn.202502_34(1).0005","DOIUrl":"10.6133/apjcn.202502_34(1).0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Previous studies have reported there were associations between ovarian function and dietary factors, metabolic factors and gut microbiota. However, it is unclear whether causal associations exist. We aimed to explore the causal relationship of these factors with risk of primary ovarian failure (POF).</p><p><strong>Methods and study design: </strong>Two-sample Mendelian randomization (MR) analysis was performed to genetically predict the causal effects of dietary and metabolic factors and gut microbiota on POF. The inverse variance weighted (IVW) method was used as the primary statistical method. A series of sensitivity analyses, including weighted median, MR-Egger, simple mode, weighted mode methods, and leave-one-out analysis, were conducted to assess the robustness of the MR analysis results.</p><p><strong>Results: </strong>IVW analysis revealed that cigarettes smoked per day, coffee intake and cooked vegetable intake were not causally correlated with POF at the genetic level. However, POF were associated with fresh fruit intake, BMI, Eubacterium (hallii group), Eubacterium (ventriosum group), Adlercreutzia, Intestinibacter, Lachnospiraceae (UCG008), and Terrisporobacter. These findings were robust according to extensive sensitivity analyses.</p><p><strong>Conclusions: </strong>This study identified several dietary factors, metabolic factors and gut microbiota taxa that may be causally implicated in POF, potentially offering new therapeutic targets.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"57-65"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically mimicked effects of evinacumab on psoriasis: a drug target Mendelian randomization study.","authors":"Zhihui Yang, Wendi Xiao, Zhenhuang Zhuang, Siyan Zhan, Mingyue Wang, Yan Wu, Tao Huang, Ruoyu Li","doi":"10.6133/apjcn.202502_34(1).0004","DOIUrl":"10.6133/apjcn.202502_34(1).0004","url":null,"abstract":"<p><strong>Background and objectives: </strong>Dyslipidemia has been reported to contribute to the psoriasis pathogenesis. Thus, evinacumab, a novel lipid-lowering drug targeting angiopoietin-like 3, may have therapeutic potential to treat and/or manage psoriasis.</p><p><strong>Methods and study design: </strong>Summary statistics were obtained from genome-wide association studies addressing psoriasis (FinnGen Consortium; n=216,752) and serum lipid concentrations (United Kingdom Biobank; n=403,943-440,546). Two-sample Mendelian randomization analyses were conducted to evaluate the associations of serum lipid concentrations and genetically mimicked effects of evinacumab, respectively, with the risks of psoriasis and its subtypes.</p><p><strong>Results: </strong>Genetically determined per standard deviation increase in triglyceride concentrations was associated with increased risk of psoriasis (OR: 1.17, 95% CI: 1.03-1.32, p=0.018), whereas that in low-density lipoprotein-cholesterol (LDL-C) was associated with both psoriasis (OR: 1.22, 95% CI: 1.05-1.43, p=0.011) and its subtypes, including arthropathic psoriasis (OR: 1.30, 95% CI: 1.02-1.65, p=0.032), psoriasis vulgaris (OR: 1.87, 95% CI: 1.16-2.99, p=0.0095), and guttate psoriasis (OR: 2.19, 95% CI: 1.17-4.07, p=0.014). Moreover, genetically mimicked effects of evinacumab, via angiopoietin-like 3 inhibition, significantly reduced the risk of psoriasis (OR: 0.752 per standard deviation reduction in triglycerides, 95% CI: 0.577-0.982, p=0.036) and arthropathic psoriasis (OR: 0.266 per standard deviation reduction in LDL-C, 95% CI: 0.0886-0.799, p=0.018).</p><p><strong>Conclusions: </strong>The genetically mimicked effect of evinacumab has the potential to reduce the risk of psoriasis and arthropathic psoriasis by lowering circulating triglyceride and LDL-C concentrations, respectively. These findings suggest that evinacumab may help prevent psoriasis and psoriatic arthritis progression in clinical practice.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 1","pages":"46-56"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men: a nested case-control study.","authors":"Ting Li, Jing Zeng, Xinyu Miao, Zimo Pan, Fan Hu, Xiaoyan Cai, Xinjiang Wang, Guanzhong Liu, Xinghe Hu, Xinli Deng, Meiliang Gong, Xue Yang, Yanping Gong, Nan Li, Chunlin Li","doi":"10.6133/apjcn.202412_33(4).0012","DOIUrl":"10.6133/apjcn.202412_33(4).0012","url":null,"abstract":"<p><strong>Background and objectives: </strong>Malnutrition is associated with a higher risk of osteoporosis. We aim to assess the relationship between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men.</p><p><strong>Methods and study design: </strong>This is a nested case-control study from a prospective cohort enrolled 1109 individuals who were followed for seven years. Demographic data, medical history, signs and symptoms, and laboratory parameters were collected and analysed. Nutritional status and Geriatric Nutritional Risk Index (GNRI) were assessed. The nutrition-related indexes predictive value for osteopenia development was analyzed through multivariate Cox regression analysis and by creating a receiver operating characteristic curve (ROC), calculating the area under the curve (AUC). Kaplan-Meier (K-M) method was further used to find the nutritional status level in the elderly men.</p><p><strong>Results: </strong>The ALB and GNRI correlated with the risk of osteopenia in Chinese elderly men. After adjusting for all covariates, people with higher ALB level (HR: 0.821; 95% CI: 0.790-0.852) and higher GNRI score (HR: 0.889; 95% CI: 0.869-0.908) had a smaller risk of osteopenia. ROC analysis showed that the AUC for ALB was 0.729 (p<0.05) and for the GNRI score was 0.731 (p<0.05). K-M curve indicated a significant difference in ALB level (p<0.001) and GNRI score (p<0.001) in the respective subgroups.</p><p><strong>Conclusions: </strong>This study found that lower ALB level and lower GNRI score are associated with a higher prevalence of osteopenia among elderly men in China.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"33 4","pages":"569-580"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal dysfunction in Parkinson's Disease: absence of anti-gliadin antibodies.","authors":"Gulhan Sahbaz, Serap Demir Tekol, Banu Ozen Barut","doi":"10.6133/apjcn.202412_33(4).0003","DOIUrl":"10.6133/apjcn.202412_33(4).0003","url":null,"abstract":"<p><strong>Background and objectives: </strong>Parkinson disease (PD), which is a neurodegenerative disorder, includes several gastrointestinal symptoms that are similar to those of Celiac disease (CD). However, the presence of celiac antibodies in PD patients has not yet been studied. Our aim in this study is to compare anti-transglutaminase (ATA) and antigliadin antibodies (AGA) as well as gastrointestinal symptoms and nutrition habits between patients with Parkinson's disease (PD) and healthy controls.</p><p><strong>Methods and study design: </strong>Serum AGA IgG and IgA and the ATA antibodies IgA and IgG were studied in 102 PD patients and 91 healthy controls. Gastrointestinal symptoms, specifically constipation, were investigated using the gastrointestinal system rating scale (GSRS) and the constipation rating scale (CRS). Dietary habits were also investigated and compared between the groups.</p><p><strong>Results: </strong>No significant differences were found between the two groups in terms of celiac antibodies. As expected, the hypokinetic GSRS and CRS scores were significantly higher in the PD group (p<0.001). Dietary habits, especially carbohydrate-rich diets, had a negative impact on gastrointestinal symptoms in the PD patients.</p><p><strong>Conclusions: </strong>Studies have suggested a connection between PD and CD, which infers a probable non-celiac gluten intolerance and the need to offer PD patients an elimination diet. However, the results of our study did not support any link between celiac antibodies and PD. Notwithstanding, the negative impact of a carbohydrate-rich diet in PD patients still leaves a question regarding gluten sensitivity in these patients.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"33 4","pages":"490-495"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional therapy among adult patients with severe burns: A retrospective observational study.","authors":"Juan Fu, Wei Cui, Bi Sheng","doi":"10.6133/apjcn.202412_33(4).0004","DOIUrl":"10.6133/apjcn.202412_33(4).0004","url":null,"abstract":"<p><strong>Background and objectives: </strong>The objective of this study was to examine the effects of nutritional therapy in adult patients with severe burns.</p><p><strong>Methods and study design: </strong>Sixty adult patients with severe burns were enrolled. Data on nutritional intake through enteral nutrition (EN) or parenteral nutrition (PN) on days 7, 14, 21, and 28 post-injury were collected. Patients were divided into target and non-target groups according to whether their energy or protein intake reached the target. Age, length of ventilation, and total bilirubin (TBIL), albumin (ALB), prealbumin (pALB), and C-reactive protein (CRP) concentrations of patients were recorded.</p><p><strong>Results: </strong>The percentage of protein targets with protein delivery was lower than that of energy target with energy delivery. The ratio of PN protein to total protein was lower than that of PN energy to total energy on days 7, 14, 21, and 28 (p<0.001, p<0.001, p=0.001, and p=0.003, respectively). Compared to the non-target group on day 21, the target group was younger, had lower TBIL on day 7, higher ALB and pALB on day 21, and lower CRP on day 14 (p=0.025, p=0.021, p=0.028, p=0.029, and p=0.049, respectively). Multivariate logistic regression analysis showed that older age and longer ventilation were independent risk factors in patients who did not meet the nutritional target on day 21 (p=0.026 and p=0.043, respectively).</p><p><strong>Conclusions: </strong>The protein intake of adult patients with severe burns was low. Compared to the non-target group, the target group had better laboratory test results. Older age and longer ventilation were independent risk factors for patients not meeting the nutritional target.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"33 4","pages":"496-502"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk or associated factors of wasting among under-five children in Bangladesh: A systematic review.","authors":"Md Iqbal Hossain, Sayeeda Huq, M Munirul Islam, Mustafa Mahfuz, Mayang Sari, Golam Muhiuddin Khan, Farhana Sharmin, Md M Islam Bulbul, Sm Mustafizur Rahman, Piyali Mustaphi, Nurun Nahar Naila, Tahmeed Ahmed","doi":"10.6133/apjcn.202412_33(4).0001","DOIUrl":"10.6133/apjcn.202412_33(4).0001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Wasting among under-five years old (U-5) children is a significant global public-health-nutrition burden. To effectively address this problem in Bangladesh, knowing its prevalence, caus-es and associated-factors are essential. This review aimed to identify evidences available in the existing-accessible literature/documents that describe the individual, socioeconomic, demographic, and contextual risk-factors associated with wasting among U-5 children in Bangladesh.</p><p><strong>Methods and study design: </strong>Electronic-databases included were MEDLINE, EMBASE, CINAHL, WoS, and Cochrane-Library written in English and published until 29 February 2024.</p><p><strong>Results: </strong>The search from the five databases yielded 167 publications. Of these, 50 papers/articles were duplicates and 108 were irrelevant, and nine have met the inclusion criteria. Additionally, 22 articles/documents were identified from other sources. Finally, a total of 31 articles/documents have been included in this review. The odds of childhood wasting observed were high for smaller birth-size, higher birth-order, male child, 12-24 months age-group, improper breastfeeding- and complementary-feeding practices, not-receiving DPT1 and/or measles vaccine, ≥1 sibling(s), maternal-undernutrition, less food-consumption during pregnancy, lack of maternal-education, lack of hand-washing practices by the mother/caregiver, paternal tobacco use, lower socioeconomic-status, food-insecurity, lack of access to hygienic-latrine and/or improved-water, Monsoon season (May-August), flood exposure, living es-pecially in Barishal, Rajshahi Chittagong and Rangpur-division and/or Eastern part of Bangladesh, and urban-slum.</p><p><strong>Conclusions: </strong>The risk/associated factors of wasting among U-5 children in Bangladesh were found at various multilevel. Rarely caused by any one factor alone, wasting in U-5 children results from an interplay between pregnant-mother's health and nutrition, child-caring practices, diets, poverty, and disease, which vary by context.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"33 4","pages":"457-480"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of tea consumption on the risk of depression: A Mendelian randomization and Bayesian weighting algorithm study.","authors":"Guifeng Zhuo, Wei Chen, Jinzhi Zhang, Mingyang Su, Xiaomin Zhu, Shanshan Pu, Naibing Liao, Deqing Huang, Xiangyi Chen, Lin Wu","doi":"10.6133/apjcn.202412_33(4).0010","DOIUrl":"10.6133/apjcn.202412_33(4).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>The precise impact of tea consumption on the risk of depression remains unclear. This study aimed to explore the relationship between the consumption patterns of tea and the likelihood of depression onset, utilizing a two-sample Mendelian randomization (MR) methodology.</p><p><strong>Methods and study design: </strong>We utilized available genome-wide association study (GWAS) datasets on tea intake and depressive disorders. To investigate the causal relationship between tea consumption and depression, we employed a set of two-sample Mendelian Randomization (MR) methods. These included the inverse-variance weighted (IVW) analysis, weighted median approach, and MR-Egger regression. Additionally, we utilized MR-PRESSO and the MR-Egger intercept test for the detection of pleiotropic effects. To ensure the robustness and consistency of our findings, a sensitivity analysis was carried out, applying the 'leave-one-out' strategy. The Bayesian weighted Mendelian randomization (BWMR) was employed to conduct additional testing on the obtained results.</p><p><strong>Results: </strong>The study's outcomes revealed a causal association between increased tea intake and an increased risk of depression (Inverse-Variance Weighted Analysis: Odds Ratio [OR] = 1.029, 95% Confidence Interval [CI]: 1.003-1.055, p = 0.027). This was observed despite variations in instrumental variables and the nonexistence of horizontal pleiotropy. Furthermore, the robustness of our Mendelian Randomization investigation was affirmed through the implementation of the 'leave-one-out' method in our sensitivity analysis. The findings from BWMR were in line with those obtained from IVW (BWMR: OR=1.030, 95% CI: 1.003-1.057, p = 0.029).</p><p><strong>Conclusions: </strong>The results from this study indicate a substantial and positive causal link between the regularity of tea drinking and the risk of depression onset.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"33 4","pages":"554-561"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}