Asia Pacific journal of clinical nutrition最新文献

{"title":"Impact of fatty diets on blood pressure: A systematic review and meta-analysis.","authors":"Tingzhen Zang, Waseem Hassan, Faraza Javaid, Ramla Shabbir, Andleeb Shahzadi, Hammad Ahmed","doi":"10.6133/apjcn.202508_34(4).0005","DOIUrl":"10.6133/apjcn.202508_34(4).0005","url":null,"abstract":"<p><strong>Background and objectives: </strong>Hypertension is a major risk factor for cardiovascular diseases, with dietary fats playing a critical role in its regulation. While unsaturated fats are associated with blood pressure (BP) reduction, saturated and trans fats may exacerbate hypertension. This systematic review and meta-analysis aimed to evaluate the impact of various fatty diets on systolic (SBP) and diastolic blood pressure (DBP) and identify dietary patterns most effective for BP management.</p><p><strong>Methods and study design: </strong>A comprehensive search of MEDLINE and ClinicalTrials.gov (inception to February 2025) identified randomized clinical trials and observational studies assessing dietary fats' effects on BP. Twenty-five studies (n=14,522 participants) met inclusion criteria. Data were analyzed to estimate mean differences (MDs) with 95% confidence intervals (CIs). Funnel plots were generated to assess publication bias. Risk of bias was assessed using the RevMan Web tool, and sensitivity analyses were conducted.</p><p><strong>Results: </strong>Food-based oil diets significantly reduced SBP and DBP (MD: -18.43 and -12.90 mm Hg). Low-fat and unsaturated fat-enriched diets lowered SBP (-6.91 and -4.46 mm Hg) and DBP (-3.78 and -0.74 mm Hg). The DASH diet had moderate effects (SBP: -3.83, DBP: -2.18 mm Hg). Omega-3 and high-fat diets showed smaller reductions. Saturated fat restriction had minimal impact.</p><p><strong>Conclusions: </strong>Food-based fatty oil diets had the greatest BP reduction, while low-fat, unsatu-rated fat-enriched, and DASH diets (fat-based variation) showed moderate effects. High-fat and omega-3 diets had smaller impacts, emphasizing diet's role in BP management.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"542-550"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Life's Essential 8 and hyperuricemia in the Chinese elderly.","authors":"Yingying Jiao, Liusen Wang, Xi Hong, Weiyi Li, Hongru Jiang, Xiaofang Jia, Huijun Wang, Bing Zhang, Zhihong Wang, Gangqiang Ding","doi":"10.6133/apjcn.202508_34(4).0018","DOIUrl":"10.6133/apjcn.202508_34(4).0018","url":null,"abstract":"<p><strong>Background and objectives: </strong>Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.</p><p><strong>Methods and study design: </strong>The subjects were the elderly aged 60 and over who participated in the China Health and Nutrition Survey (CHNS) in 2018. The definition of American Heart Association (AHA) was used to measure the score of LE8. Multivariate Logistic regression and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between LE8 and HUA.</p><p><strong>Results: </strong>A total of 4229 subjects were included, and the prevalence of HUA was 13.2%. The LE8 score was 68.5 points, and physical activity (85.8) and blood pressure (37.6) were the highest and lowest scores, respectively. People with low, medium and high CVH accounted for 5.7%, 77.3% and 17.0%, respectively. Multivariate Logistic regression showed that high CVH in LE8 score reduced the risk of HUA (OR = 0.62, 95%CI = 0.39-0.99) significantly, and the risk decreased by 15% (OR = 0.85, 95%CI = 0.78-0.93) for every 10-point increase in LE8 score. RCS showed a linear dose-response relationship between LE8 and HUA, and the beneficial protective threshold was 68.6 points. The negative association between LE8 score and HUA was more significant in 60-69 years.</p><p><strong>Conclusions: </strong>This study suggested that the elderly in 15 provinces of China were at a moderate level of CVH, and a higher LE8 score was beneficial for reducing the risk of HUA.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"677-688"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of time-restricted eating and a six-meal diet: Effects on body composition and biochemical parameters.","authors":"Merve Yüzbaşıoğlu, Aclan Özder","doi":"10.6133/apjcn.202508_34(4).0010","DOIUrl":"10.6133/apjcn.202508_34(4).0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>Obesity and obesity-related diseases is increasing worldwide. The widely accepted approach in the dietary treatment of obesity is the calorie-restricted six meal diet; however, alternative approaches are needed. This study aimed to compare time-restricted eating (TRE), a method that can be easily conveyed and applied in overcoming obesity, to six meals diet.</p><p><strong>Methods and study design: </strong>A total of 174 participants aged 18-65, BMI>25 kg/m2 were included, with 88 participants in the time-restricted eating group and 86 participants in the six-meal group. Diet lists with similar calorie, macro counts suitable for their respective groups were prepared. Anthropometric measurements, blood pressure, blood tests were analyzed before the study and at the end of the 8-week.</p><p><strong>Results: </strong>More weight loss [MD: 1.17 kg, (95% CI: 0.23-2.06), Cohen's d=0.42], higher decrease in BMI [MD: 0.41 kg/m2 (95% CI: -0.77 to -0.06), Cohen's d=0.39] , decrease in waist-to-hip ratio [MD: 0.008 (95% CI: -0.016-0.000), Cohen's d=0.35], decrease in obesity degree [MD: 2.35 (95% CI: -3.99 to -0.70), Cohen's d=0.50] were observed in the time-restricted eating group (p<0.05). In the six meals group, decrease in LDL values was higher compared to the time-restricted eating group [p<0.05, MD:0.23 mmol/L (95% Cl:0.41-15.79), Cohen's d=0.36]. More participants preferred to continue TRE (p<0.001).</p><p><strong>Conclusions: </strong>TRE resulted in greater weight loss, body fat reduction, and improved metabolic parameters, proving more effective for weight management. The six-meal diet was superior for LDL reduction. Both approaches yielded positive outcomes, with TRE emerging as an alternative weight loss strategy.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"589-595"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors and nutritional support in menopausal women with chronic heart failure.","authors":"Li Ma, Zhen Yang","doi":"10.6133/apjcn.202508_34(4).0007","DOIUrl":"10.6133/apjcn.202508_34(4).0007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Menopausal women with chronic heart failure (CHF) exhibit unique physiolog-ical characteristics and prognostic features. The aim of this study is to analyze the significant predictive factors for the prognosis of chronic heart failure in menopausal women and the impact of different nutritional interventions on prognosis.</p><p><strong>Methods and study design: </strong>A total of 270 menopausal women with CHF were enrolled in the study and divided into two groups based on the nutritional intervention received. Analyze the significant predictive factors of all-cause mortality, readmission rate, deterioration of cardiac function, deterioration of nutritional status, and deterioration of quality of life, as well as the impact of nutritional interven-tion on these prognoses. Build a risk score model based on significant factors in the prognostic model. Evaluate the predictive ability of the model through the ROC curve.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that NYHA grading BNP, eGFR, The level of estradiol (E2) and nutritional intervention are signif-icant influencing factors in multiple prognostic indicators, among which the enhanced nutritional support and micronutrient supplementation program in nutritional intervention have a significant protective effect on poor prognosis. The constructed nutritional risk model has good discriminative ability and robustness in predicting prognosis.</p><p><strong>Conclusions: </strong>This study identified menopausal characteristics, NYHA classification, BNP, eGFR, and estradiol levels as important prognostic predictors in menopausal women with CHF. Enhanced nutritional support and micronutrient supplementation significantly improved patient prognosis. The risk model based on nutritional intervention provides scientific basis for the management strategy of chronic heart failure in menopausal women.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"557-565"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between riboflavin and hypertension with MTHFR C677T in older adults in northern China: a case-control study.","authors":"Liyang Zhang, Zehao Wang, Tongyang Wu, Xukun Chen, Huilian Duan, Di Wang, Zhongxia Li, Ruikun He, Guowei Huang, Wen Li","doi":"10.6133/apjcn.202508_34(4).0013","DOIUrl":"10.6133/apjcn.202508_34(4).0013","url":null,"abstract":"<p><strong>Background and objectives: </strong>The incidence of hypertension is higher in individuals with the methylenetetra-hydrofolate reductase (MTHFR) 677TT genotype. Riboflavin serves as a coenzyme of MTHFR, but its role in hypertension prevalence is poorly understood. This study aimed to explore the relationship between riboflavin levels and hypertension and the impact of genotype on this relationship.</p><p><strong>Methods and study design: </strong>The case-control study used data from the Tianjin Elderly Nutrition and Cognition study, with 200 hypertensive patients and 200 matched non-hypertensive controls. It collected questionnaires, clinical data, and measured blood riboflavin levels using the dried blood spot technique. Conditional logistic regression analyzed varia-bles related to hypertension prevalence, with effects assessed by odds ratios (ORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The hypertensive group had significantly lower riboflavin concentration than the non-hypertensive group (p<0.001). The regression analysis indicated that regardless of adjustment for sociodemographic characteristics, riboflavin concentration was negatively associated with the prevalence of hypertension. In the multivariable model, the OR was 0.607 [95%CI, 0.507-0.727], p<0.001. Additionally, we found an interaction between MTHFR genotype and riboflavin status. Compared with the combined TT genotype and below-median riboflavin levels as the reference category, the CC genotype and above-median riboflavin levels decreased the prevalence of hypertension (OR, 0.189 [95%CI, 0.071-0.501], p=0.001).</p><p><strong>Conclusions: </strong>In conclusion, riboflavin status impacts the development of hypertension. There is also interaction between the MTHFR genotype and riboflavin. Specifically, low riboflavin status increases the prevalence of hypertension when combined with the MTHFR 677TT genotype.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"619-626"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new method for developing an efficient, regional semi-quantitative food frequency questionnaire.","authors":"Desheng Liu, Xiaopei Guo, Hui Chen, Rui Zheng, Qingquan Liu","doi":"10.6133/apjcn.202508_34(4).0016","DOIUrl":"10.6133/apjcn.202508_34(4).0016","url":null,"abstract":"<p><strong>Background and objectives: </strong>To establish a new method for developing an efficient and region-specific semi-quantitative food frequency questionnaire (SQFFQ), and to make it a simple, effective and widely applicable measurement tool, this study takes Xi'an City, Shaanxi Province as a case study.</p><p><strong>Methods and study design: </strong>For 129 common food items, an initial food frequency questionnaire (FFQ) and a 24-hour dietary recall survey (24hDR) are constructed, and a variety of methods are combined to improve the convenience and credibility of the questionnaire itself in the inspection process, and the reliability and validity test are carried out.</p><p><strong>Results: </strong>A total of 367 questionnaires are collected in study, including FFQ and 24hDR at various correction stages, in a three-month interval, and finally a semi-quantitative food frequency questionnaire containing 104 food items is obtained. The Pearson correlation coefficient of SQFFQ1 and SQFFQ2 ranges from 0.60-0.75, and the Spearman and Kendall correlation coefficients range from 0.50-0.89, and the corre-lation coefficient increases slightly after logarithmic transformation by logarithmic transformation, and the CCC correlation coefficient increases to 0.5-0.95. On average, more than 80% of subjects are classified as identical or adjacent tertiles per SQFFQ result. The Pearson, Spearman, Kendall, CCC correlation coefficients between 24hDR and SQFFQ2 range from 0.50-0.90, and on average more than 75% of participants are in the same or adjacent energy and nutrient tertiles in SQFFQ2 versus 24hDR results.</p><p><strong>Conclusions: </strong>The semi-quantitative food frequency questionnaire for dietary pattern surveys in Xi'an, Shaanxi can effectively assess nutrient intake in dietary nutrient correlation studies.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"647-664"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between low vitamin B-12 status and latent tuberculosis infection among adults.","authors":"Liping Jiang, Taoli Yan, Xueqian Zhang, Chunchun Liu, Qiaoyi Yan, Yi Chai, Yan Li, Yuanyuan Tan, Xin Gao, Qiuzhen Wang","doi":"10.6133/apjcn.202508_34(4).0014","DOIUrl":"10.6133/apjcn.202508_34(4).0014","url":null,"abstract":"<p><strong>Background and objectives: </strong>Tuberculosis (TB) remains a major public health threat worldwide, but most of the presumed infected individuals remain asymptomatic and contain Mycobacterium tuberculosis (MTB) in a latent tuberculosis infection (LTBI), and some of them will progress to active tuberculosis. Vitamin B-12 is crucial to maintain immune function, and play a role in the metabolism of MTB, while few studies investigated the impact of vitamin B-12 deficiency on tuberculosis. Therefore, we carried out the study to explore the association between vitamin B-12 deficiency and LTBI using the National Health and Nutrition Examination Surveys (NHANES).</p><p><strong>Methods and study design: </strong>A cross-sectional study was conducted by using data from NHANES 2011-2012. Adults (aged ≥18 years) who had available data on serum Vitamin B-12, serum Methylmalonic Acid (MMA) and QuantiFERON-TB Gold In-Tube (QFT-GIT) results were included in the analysis. Multivariable logistic regression was used to assess the association between Vitamin B-12 deficiency and LTBI.</p><p><strong>Results: </strong>A total of 4773 subjects were included in the present study, of whom 479 were screened as LTBI. The LTBI group had a higher proportion of participants with low Vitamin B-12 status. After adjusting for the possible confounders, Vitamin B-12 deficiency was independently associated with a 37% increased odds ratio of LTBI in the participants (OR: 1.37; 95% CI: 1.01-1.85). Similar correlations remained in subjects aged ≥35 years and female subjects by further stratified analysis.</p><p><strong>Conclusions: </strong>Vitamin B-12 deficiency was significantly associated with higher prevalence of LTBI in US adults. Maintenance of optimal Vitamin B-12 status has potential benefits for LTBI prevention. Future studies are needed to assess the roles and clinical implications of Vitamin B-12 in MTB infection.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"627-635"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sleep and plant-based diet with cognitive function in older adults-Based on a national cohort study.","authors":"Luyao Bian, Xiaoqing Chen, Xianghai Li","doi":"10.6133/apjcn.202508_34(4).0019","DOIUrl":"https://doi.org/10.6133/apjcn.202508_34(4).0019","url":null,"abstract":"<p><strong>Background and objectives: </strong>To explore the relationship between sleep, plant-based diets, and cognitive function in the elderly, addressing the challenges of global aging.</p><p><strong>Methods and study design: </strong>Using data from the 2005 China Longitudinal Healthy Longevity Survey (CLHLS), cognitive function was assessed with the Mini-Mental State Examination (MMSE), dietary patterns through a short-form FFQ, and sleep duration and quality via self-report measures. A Cox regression model analyzed the associations between sleep, plant-based diet, and cognitive function, with mediating effect analysis to explore these relationships further.</p><p><strong>Results: </strong>A total of 5911 subjects were included in the study. In both univariate and multivariate Cox regression analysis, the sleep quality with average level (HR=1.26; 95%CI=1.06-1.48), sleep duration (HR=1.03; 95%CI=1.01-1.05), the unhealthful plant-based diet index (uPDI) (HR=1.02; 95%CI=1.01-1.03), the healthful plant-based diet index (hPDI) (HR=1.01; 95%CI=1.00-1.03), and the plant-based diet index (PDI) (HR=0.99; 95%CI=0.97-1.00) were always significantly correlated with cognitive function. The sleep quality with bad level (HR=1.28; 95% CI=1.03-1.58) was associated with cognitive function only in multivariate Cox regression analysis. In the mediating analysis, PDI and hPDI had a significant overall effect on cognitive function, and the proportion mediated by sleep duration were about 4.4% (95%CI=0.01-0.15) and 7.92% (95%CI=0.03-0.25).</p><p><strong>Conclusions: </strong>A significant correlation exists between sleep, plant-based diets, and cognitive function in older adults, with sleep duration mediating the relationship between diet and cognitive function. These findings emphasize the role of diet and sleep in preventing cognitive decline in the elderly.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"689-698"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride glucose index and atrial fibrillation: A systematic review and meta-analysis.","authors":"Qiang Chen, Jianqiang Zhao, Wei Wang","doi":"10.6133/apjcn.202508_34(4).0002","DOIUrl":"10.6133/apjcn.202508_34(4).0002","url":null,"abstract":"<p><strong>Background and objectives: </strong>Previous studies have demonstrated that insulin resistance (IR) is associated with atrial fibrillation (AF). As a reliable indicator of IR, the triglyceride glucose (TyG) index has been extensively studied in relation to AF. We aimed to investigate the relationship between the TyG index and AF through a systematic review and meta-analysis.</p><p><strong>Methods and study design: </strong>We systematically searched studies published up to August 2024 in online databases including PubMed, Embase, Web of Science, Wan-fang, and the China National Knowledge Internet database. Seventeen studies involving 57,213 patients were included in the analysis. A random-effects model and exposure-effect analysis were used to calculate the pooled effect estimate and compute the linear trend.</p><p><strong>Results: </strong>A significantly higher TyG index was observed in AF patients (standardized mean difference [SMD]: 0.78; 95% CI: 0.43- 1.13; p<0.001). The TyG index was associated with the risk of AF in both continuous analysis (odds ratio [OR]: 1.80; 95% CI: 1.50-2.17; p<0.001) and category analysis (odds ratio [OR]: 1.98; 95% CI: 1.35-2.91]; p<0.001). Exposure-effect analysis confirmed a linear positive relationship between the TyG index and the risk of AF (plinearity = 0.006).</p><p><strong>Conclusions: </strong>The TyG index is associated with an increased risk of AF, including pure AF, post-operative AF and AF recurrence after ablation. Further studies are needed to confirm the causal relationship between the TyG index and AF.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"502-515"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Dietary Index for Gut Microbiota (DI-GM) and non-alcoholic fatty liver disease (NAFLD): Evidence from NHANES 1999-2018.","authors":"Yan Xue, Jianxian Zhang","doi":"10.6133/apjcn.202508_34(4).0015","DOIUrl":"10.6133/apjcn.202508_34(4).0015","url":null,"abstract":"<p><strong>Background and objectives: </strong>Gut microbiota and liver are closely linked, and disruption of the gut-liver axis has been associated with various conditions, including non-alcoholic fatty liver disease (NAFLD). The Die-tary Index for Gut Microbiota (DI-GM), a recently developed measure of gut microbiota variety, has not been researched in connection with NAFLD.</p><p><strong>Methods and study design: </strong>We conducted a cross-sectional analysis of 12,910 eligible participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018 by adjusting for covariates. Dietary recall data were used to calculate the DI-GM (including components beneficial and unfavorable to gut microbiota). Multiple logistic regression and subgroup analyses were used.</p><p><strong>Results: </strong>A total of 12,910 patients were included in the study, of whom 4673 (36.2%) were identified as NAFLD. Each point increase in DI-GM was associated with an 8% decrease in the prevalence of NAFLD (OR = 0.92, 95% CI = 0.90, 0.94, p <0.001), the associations remained significant after adjusting for potential confounders (OR = 0.92, 95% CI = 0.89, 0.95, p <0.001). After grouping DI-GM, in the fully adjusted model, participants with DI-GM ≥ 6 were significantly negatively associated with the prevalence of NAFLD (OR = 0.71, 95% CI = 0.61, 0.82, p <0.001) compared to participants with DI-GM ≤3 group with adjustment for potential confounders. After subgroup analyses and sensitivity analyses, the relationship between DI-GM and NAFLD remained robust.</p><p><strong>Conclusions: </strong>Our findings indicate an inverse association between the newly proposed DI-GM and the presence of NAFLD in adult Americans, offering a novel perspective on NAFLD research.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"636-646"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}