Associations of dietary and plasma lutein + zeaxanthin with depression in US adults: findings from NHANES.

IF 1.3 4区医学 Q4 NUTRITION & DIETETICS

Asia Pacific journal of clinical nutrition Pub Date : 2025-04-01 DOI:10.6133/apjcn.202504_34(2).0002

Jin-Hong Lu, Wen-Wen Zhong, Yu-Lei Tan, Li Zhuo, Gui-Zhi Luo

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引用次数: 0

Abstract

Background and objectives: Evidence regarding the relationship between dietary and plasma lutein + zeaxanthin (L + Z) levels and the risk of depression is scarce. This study aimed to investigate the associations of dietary consumption of L + Z and plasma L + Z level with risk of depression in adult of United States by using data from National Health and Nutrition Examination Survey (NHANES).

Methods and study design: A total of 7,829 and 7,324 individuals aged ≥ 20 years were included from the NHANES to analyze the relationship between dietary L + Z and depression, as well as plasma L+ Z levels with the risk of depression, separately. Multivariable logistic regression analyses were used. Subsequently, the dose-response relationships were conducted using restricted cubic splines.

Results: In the multivariable model, the highest quartile of dietary L + Z intake was associated with a significantly lower risk of depression compared to the lowest quartile (OR = 0.68, 95%CI: 0.52, 0.89, p < 0.01). Similarly, the highest quartile of plasma L + Z levels was linked to a reduced risk of depression compared to the lowest quartile (OR = 0.58, 95%CI: 0.44, 0.76, p < 0.001).

Conclusions: This study suggests that an appropriate increase in dietary L + Z intake and higher plasma L + Z levels are associated with a lower risk of depression. These results should be confirmed by randomized controlled trial (RCTs) to explore the effects of supplementing L + Z on depression.

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美国成年人饮食和血浆叶黄素+玉米黄质与抑郁症的关系：来自NHANES的研究结果

背景和目的：关于膳食和血浆叶黄素+玉米黄质（L + Z）水平与抑郁症风险之间关系的证据很少。本研究旨在利用美国国家健康与营养调查（NHANES）的数据，探讨美国成年人饮食中L + Z的摄入量和血浆L + Z水平与抑郁症风险的关系。方法和研究设计：从NHANES中共纳入7829和7324名年龄≥20岁的个体，分别分析饮食L+ Z与抑郁症的关系，以及血浆L+ Z水平与抑郁症风险的关系。采用多变量logistic回归分析。随后，使用受限三次样条进行了剂量-反应关系的研究。结果：在多变量模型中，与最低四分位数相比，饮食中L + Z摄入量最高的四分位数与抑郁风险显著降低相关（OR = 0.68, 95%CI: 0.52, 0.89, p < 0.01）。同样，与最低四分位数相比，血浆L + Z水平最高的四分位数与抑郁症风险降低有关（OR = 0.58, 95%CI: 0.44, 0.76, p < 0.001）。结论：本研究表明，适当增加饮食中L + Z摄入量和较高的血浆L + Z水平与降低抑郁症风险相关。这些结果需要通过随机对照试验（rct）来证实，以探索补充L + Z对抑郁症的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific journal of clinical nutrition 医学-营养学

CiteScore

2.50

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board