Mendelian randomization study to assess causality between diet and phenotype of aging.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Yingye Tu, Yuting Liu, Xuan Zhang, Xinyu Wang, Guoping Yin
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引用次数: 0

Abstract

Background and objectives: Observational research findings have demonstrated correlations between diet and the process of aging. Nevertheless, there remains uncertainty regarding possible disruption caused by confounding variables. To elucidate the connections between diet and aging, we employed the Mendelian randomization analysis.

Methods and study design: The exposure factor was the daily diet, whereas accelerated aging was measured through telomere length, facial aging (FA), frailty index (FI), and senescence-associated secretory phenotypes (SASPs), representing the outcome factors. The primary analysis employed IVW analysis, with additional MR-Egger and Weighted Median analyses conducted to assess the reliability of the findings. Furthermore, we analyzed the heterogeneity and pleiotropy of the results.

Results: The results revealed that the consumption of salad/raw vegetables and oily fish exhibited a negative correlation with FA, whereas coffee intake showed a positive correlation with FA. On the other hand, the intake of cheese, oily fish, dried fruit, and cereal showed negative associations with FI. Additionally, coffee, alcohol, and pork intake were positively associated with FI. Lastly, the intake of bread exhibited a positively correlated with SASPs, while the intake of cheese and coffee showed a negative correlation with SASPs.

Conclusions: Our study revealed that the consumption of cheese, vegetables, oily fish, dried fruit, bread, coffee, and alcohol was associated with the aging process. Interestingly, our findings suggest that coffee intake may accelerate aging, whereas intake of oily fish may delay the aging process. However, it is important to note that further well-designed prospective studies are required to validate our findings in the future.

孟德尔随机研究,评估饮食与衰老表型之间的因果关系。
背景和目的:观察研究结果表明,饮食与衰老过程之间存在相关性。然而,混杂变量可能造成的干扰仍存在不确定性。为了阐明饮食与衰老之间的联系,我们采用了孟德尔随机分析法:暴露因素为日常饮食,而加速衰老则通过端粒长度、面部衰老(FA)、虚弱指数(FI)和衰老相关分泌表型(SASPs)等结果因素来衡量。主要分析采用了 IVW 分析,并进行了 MR-Egger 和加权中位数分析,以评估研究结果的可靠性。此外,我们还分析了结果的异质性和多义性:结果显示,沙拉/生蔬菜和油性鱼类的摄入量与脂肪酸呈负相关,而咖啡的摄入量与脂肪酸呈正相关。另一方面,奶酪、油性鱼类、干果和谷物的摄入量与脂肪指数呈负相关。此外,咖啡、酒精和猪肉的摄入量与 FI 呈正相关。最后,面包的摄入量与 SASPs 呈正相关,而奶酪和咖啡的摄入量与 SASPs 呈负相关:我们的研究表明,奶酪、蔬菜、油鱼、干果、面包、咖啡和酒精的摄入量与衰老过程有关。有趣的是,我们的研究结果表明,咖啡的摄入可能会加速衰老,而油性鱼类的摄入可能会延缓衰老。不过,值得注意的是,今后需要进一步开展设计良好的前瞻性研究,以验证我们的发现。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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