Artificial organs最新文献

{"title":"Impact of Vitamin E-Coated Membrane Hemodiafilter on Serum Albumin Redox State in the Acute Kidney Injury Pig Hemodialysis Model.","authors":"Shouichi Fujimoto, Masahide Koremoto, Shushi Yamamoto, Hiroshi Umeno, Yusuke Sano, Toshihiro Tsuruda","doi":"10.1111/aor.14982","DOIUrl":"https://doi.org/10.1111/aor.14982","url":null,"abstract":"<p><strong>Background: </strong>Several studies have evaluated the biocompatibility of dialysis membranes. The use of vitamin E-coated membranes has been reported multilaterally in in vitro and clinical studies. Nevertheless, the effect of vitamin E-coated membranes on the redox state of serum albumin, which forms the largest fraction of reactive sulfhydryl groups, has not been reported.</p><p><strong>Methods: </strong>Hemodiafiltration (HDF) with and without a vitamin E-coated hemodiafilter (V-RA^TM group and ABH^TM groups, respectively) was performed in an acute kidney injury pig model to determine whether changes in the serum albumin, the oxidized albumin (OxiALB), and the reduced albumin (RedALB) levels differ between the two groups.</p><p><strong>Results: </strong>Analyses were conducted 22-24 times in the V-RA^TM group and 16-18 times in the ABH^TM group, excluding missing data. The serum albumin levels decreased in both groups after nephrectomy; however, the decrease observed in the V-RA^TM group was significantly lesser than that in the ABH^TM group. RedALB levels were significantly higher in the V-RA^TM group; in contrast, OxiALB levels did not differ between the two groups. A significant positive correlation was observed between the serum albumin and RedALB levels.</p><p><strong>Conclusions: </strong>The present study demonstrated that HDF performed using a vitamin E-coated hemodiafilter effectively minimized the reduction in serum albumin and RedALB levels compared to the vitamin E-non-coated hemodiafilter in an acute kidney injury pig model.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readmission and Temporal Trends of Post-LVAD Placement Complications in Patients With End-Stage Heart Failure.","authors":"Sherif Eltawansy, Faizan Ahmed, Grishma Sharma, Areehah Zafar Masood, Naazmin Chandrani, Mohammad Hossein, Swapnil Patel, Ravitej Khunkhun, Hritvik Jain, Mushood Ahmed, Raheel Ahmed, Adnan Bhat, Nisar Asmi, Kainat Aman, Joseph Heaton, Jesus Almendral","doi":"10.1111/aor.14989","DOIUrl":"https://doi.org/10.1111/aor.14989","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 5%-10% of heart failure (HF) patients progress to advanced stages. Left ventricular assist devices (LVADs) have emerged as a favored therapy for end-stage HF as destination therapy or as a bridge to heart transplantation. However, complications and provider expertise hinder their widespread use. To address this, the third-generation LVAD was introduced in late 2018 to enhance usability and reduce complications. We aimed to investigate the temporal trends in post-LVAD complications with the newest generation LVAD versus the previous version.</p><p><strong>Methods: </strong>We utilized the 2016-2020 Nationwide Readmission Database to identify patients ≥ 18 years of age with advanced HF implanted with an LVAD. Variables were determined using the International Classification of Diseases, Tenth revision codes. We compared patients through all years individually. In addition, we created two groups based on the implant year (2016-2018 and 2019-2020). The primary outcome was 30-day readmission, while secondary outcomes were complications and mortality rates. Multivariate analyses and descriptive bivariate analyses were performed. A value of p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>We identified 7975 patients (21.3% females), of which 17.1% (n = 1214) were readmitted within 30 days. Readmission rates were 18% (n = 778) for 2016-2018 and 16% (n = 435) for 2019-2020 (adjusted Wald test, p = 0.26). The 2019-2020 group exhibited a reduction in cardiac device complications (p = 0.024), cardiac tamponade (p = 0.009), and periprocedural circulatory complications (p = 0.014) in subgroup comparison (2016-2018 vs. 2019-2020). Despite these improvements, the mortality rate and hospital stay did not differ significantly between the two periods. No significant differences in mortality or LOS were observed between the two groups (adjusted Wald test, p > 0.05 in both).</p><p><strong>Conclusions: </strong>Complications following LVAD placement continue to impede its broader adoption for advanced HF. Advancements in newer LVAD technology and improved provider expertise hold promise for increased utilization. Our study indicated a decline in some complications, including cardiac tamponade and cardiac device complications, including periprocedural circulatory ones, which may be attributed to newer device innovations. Further research is necessary to explore this correlation in greater depth.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic Suitability for Axillary Intra-Aortic Balloon Pump Circulatory Support.","authors":"Carlos Alberto Valdes, Kristin Drew, Omar M Sharaf, Mustafa M Ahmed, Alex M Parker, Juan R Vilaro, Juan M Aranda, Michael R Massoomi, R David Anderson, Yomary Jimenez, Mohammad A Z Al-Ani","doi":"10.1111/aor.14994","DOIUrl":"https://doi.org/10.1111/aor.14994","url":null,"abstract":"<p><strong>Background: </strong>Intra-aortic balloon pumps (IABP) are commonly used as a bridge to heart transplant (Htx). Although IABPs were designed for transfemoral arterial placement, axillary IABPs (axIABP) allow for continued ambulation and rehabilitation. However, increased rates of device complications with axillary compared to femoral insertion suggest anatomic variations that predispose patients to device failure.</p><p><strong>Methods: </strong>We conducted a single-center retrospective study of patients who received axIABP as a bridge to HTx between February 2018 and July 2022. Pre-axIABP computed tomography (CT) images were reviewed for all patients, and anatomic features of the axillary and central arteries were measured and correlated with mechanical axIABP complications.</p><p><strong>Results: </strong>A total of 48 patients underwent successful axIABP placement with available pre-insertion CT images, of whom 35 (72.9%) were male. Out of 48 patients, 26 (54.2%) experienced 34 complications, including axIABP rupture (n = 10, 29%), infection (n = 8, 23%), and thrombosis (n = 6, 18%). CTs showed an average axillary artery diameter and depth of 6.79 and 55.6 mm, respectively. The average subclavian artery takeoff angle from the aortic arch was 95.4°.</p><p><strong>Conclusion: </strong>Of the 10 vascular anatomic features measured, there was no association between any single measurement and axIABP complications. However, there may be other structural features not measured by routine CT, technical issues with insertion, and device factors not accounted for in this study that drive axIABP complications. Nonetheless, our findings suggest that normal variations in the measured vascular anatomy should not preclude axIABP use.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Disturbance in Bodily Experience After Ventricular Assist Device Implantation: A Multicenter Randomized Controlled Trial of Curricular Psychological Support.","authors":"Wolfgang Albert, Hannah Spielmann, Sandra Semmig-Koenze, Christoph Knosalla, Johanna Mulzer, Katharina Tigges-Limmer, Christiane Kugler, Fabian Richter","doi":"10.1111/aor.14996","DOIUrl":"https://doi.org/10.1111/aor.14996","url":null,"abstract":"<p><strong>Background: </strong>Disturbance in bodily experience (BE) after ventricular assist device (VAD) implantation is common. This study aims to investigate the effect of focused psychological support to improve BE in VAD patients.</p><p><strong>Methods: </strong>This national, multicenter, longitudinal study enrolled 140 VAD patients from four centers across Germany in a prospective, randomized controlled trial. Patients were randomized (1:1) to receive curricular and focused psychological intervention in the post-implantation step-down units after implantation (n = 70) or treatment as usual (n = 70). BE was assessed using the Bodily Experience Scale in VAD Patients (BE-S) after implantation (baseline) and followed up 12 months later. Data were analyzed using mixed-effects models.</p><p><strong>Results: </strong>VAD patients with disturbance in BE (BE-S ≥ 2) after implantation (n = 43, 63.24%) benefit from the targeted intervention. Compared to the subsample of the control group (CG) patients with initial BE disturbance (n = 46, 69.7%), the intervention group (IG) displays a significantly stronger decrease from baseline to the 1-year follow-up (p = 0.01). Generally, women (p = 0.4) and emergently implanted patients (p = 0.24) show a smaller, albeit not significant, decrease in BE disturbance. All patients have high overall gratitude scores, which increase slightly but not significantly over time.</p><p><strong>Conclusion: </strong>The efficacy of targeted psychological support in reducing disturbance in BE among VAD patients is highlighted. Given the strong correlation between BE and other mental health domains, such as anxiety and depression, it is essential to address disturbances in BE to improve the overall mental health of VAD patients.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Deficiency and Driveline Infections in Patients With Left Ventricular Assist Devices.","authors":"Wesley A Borman, Luke M Landrigan, Nicholas J Berg, Jeanette Pickrell, Maya E Guglin","doi":"10.1111/aor.14988","DOIUrl":"https://doi.org/10.1111/aor.14988","url":null,"abstract":"<p><strong>Background: </strong>Despite major advancements in the field of durable left ventricular assist devices (LVADs), driveline infection is a major source of morbidity and mortality. Risk factors have been proposed, but few are modifiable. We evaluated vitamin D deficiency as a potential modifiable risk factor for driveline infection.</p><p><strong>Methods and results: </strong>This single-center, retrospective study included 134 LVAD recipients between 2010 and 2022. Patients were divided into two groups based on their pre-implant vitamin D levels: the vitamin D sufficient group (≥ 30 ng/mL) and the vitamin D deficient group (< 30 ng/mL). The Kaplan-Meier method estimated 18-month freedom from driveline infection. The Cox proportional hazards model estimated the effect of vitamin D deficiency on driveline infections. Kaplan-Meier estimates for infection-free survival were significantly higher in the sufficient group (90.5% vs. 69.6%, p = 0.014). Vitamin D deficiency (HR: 3.644, 95% CI: 1.271-10.448, p = 0.016) and obesity (HR: 3.190, 95% CI: 1.464-7.400, p = 0.004) were found to be independent risk factors for driveline infection.</p><p><strong>Conclusion: </strong>Our findings support vitamin D deficiency as a potential modifiable risk factor for driveline infection. Obesity was also noted as a significant risk factor for infection. Further research is warranted to establish causality and assess the impact of vitamin D repletion on infection rates.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in the Field of Artificial Organs.","authors":"Aakash M Shah, John A Treffalls, Ander Dorken-Gallastegi, Donald D Chang","doi":"10.1111/aor.14990","DOIUrl":"https://doi.org/10.1111/aor.14990","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Frailty in Patients With Continuous-Flow Left Ventricular Assist Device Therapy in End-Stage Heart Failure: A Systematic Review and Meta-Analysis.","authors":"Christos Costa, Arian Arjomandi Rad, Yi Ting Yu, Nithiananthan Mayooran, Andrew Xanthopoulos, Marinos Koulouroudias, Robert Vardanyan, Gustavo Antonio Guida, Lydia Wilkinson, Jan Schmitto, Arjang Ruhparwar, Alina Zubarevich, Alexander Weymann, Peyman Sardari Nia, Antonios Kourliouros, Thanos Athanasiou","doi":"10.1111/aor.14998","DOIUrl":"https://doi.org/10.1111/aor.14998","url":null,"abstract":"<p><strong>Background: </strong>Frailty, marked by increased vulnerability and reduced physiological reserve, is common in end-stage heart failure patients. Continuous flow left ventricular assist devices (LVADs) have improved outcomes, but the impact of frailty on these outcomes is unclear. This systematic review and meta-analysis investigate the effect of frailty on clinical outcomes in patients undergoing LVAD therapy.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we searched PubMed, Cochrane, EMBASE, MEDLINE, and Google Scholar up to September 2023 for studies comparing frail and non-frail patients undergoing LVAD implantation. Data on mortality, hospital length of stay, intubation duration, bleeding, infection, and readmission rates were extracted and analyzed using the Mantel-Haenszel random-effects model, with heterogeneity assessed by the I2 statistic.</p><p><strong>Results: </strong>Fifteen studies involving 3458 patients were included. Frailty was significantly associated with higher long-term mortality (OR: 2.12; 95% CI: 1.17-3.83; p = 0.01), but not with short-term mortality (OR: 1.61; 95% CI: 0.71-3.65; p = 0.26), hospital length of stay (MD: 1.93; 95% CI: -9.83 to 13.68; p = 0.75), or intubation duration (MD: 34.28; 95% CI: -1.15-69.71; p = 0.06). No significant differences were found in bleeding (OR: 1.76; 95% CI: 0.76-4.10; p = 0.19), infection (OR: 0.44; 95% CI: 0.11-1.84; p = 0.26), or readmission rates (OR: 1.07; 95% CI: 0.78-1.46; p = 0.68).</p><p><strong>Conclusion: </strong>Frail patients with LVADs have higher long-term mortality but similar short-term outcomes, hospital stays, intubation times, bleeding, infection, and readmission rates compared to non-frail patients. These findings highlight the need for tailored strategies to improve outcomes in frail LVAD patients and suggest further research on frailty interventions.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magenta Elevate: The Beginning of a New Era in Protected PCI?","authors":"Jacopo D'Andria Ursoleo, Aakash Manish Shah","doi":"10.1111/aor.14991","DOIUrl":"https://doi.org/10.1111/aor.14991","url":null,"abstract":"<p><p>The Magenta Elevate (Magenta Medical Ltd.) pump-a novel transvalvular percutaneous ventricular assist device-was tested in the first-in-human study at the Israeli-Georgian Medical Research Clinic 'Helsicore' in Tbilisi, Georgia. Results on 14 patients undergoing high-risk percutaneous coronary intervention suggested a promising safety and efficacy profile. Characterized by a low profile, percutaneous insertion, and a self-expandable pump, the Magenta Elevate pump holds promising venues for the implementation of mechanical circulatory support in a wide range of patients.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eligibility for eCPR Warming in Hypothermic Cardiac Arrest: Lack of Guidelines and the Current Constraints of Artificial Intelligence in Clinical Decision-Making.","authors":"Michał P Pluta, Tomasz Darocha, Michał Pasternak, Mathieu Pasquier, Konrad Mendrala, Radosław Gocoł, Sylweriusz Kosiński","doi":"10.1111/aor.14993","DOIUrl":"https://doi.org/10.1111/aor.14993","url":null,"abstract":"<p><strong>Aim of the study: </strong>Artificial intelligence (AI) such as large language models (LLMs) tools are potential sources of information on hypothermic cardiac arrest (HCA). The aim of our study was to determine whether, for patients with HCA, LLMs provide information consistent with expert consensus on criteria that would usually contraindicate extracorporeal cardiopulmonary resuscitation (eCRP) in patients with normothermic cardiac arrest (NCA), but not HCA.</p><p><strong>Methods: </strong>Based on Extracorporeal Life Support Organization guidelines, selected factors were identified that may be contraindications to eCPR in NCA but not in HCA. Four questions were created and entered into AI software (GPT-3.5 turbo, GPT-4o, GPT-4o-mini, Claude 3.5 Sonnet, Claude 3 Haiku, Mistral Large, Mistral Small, Gemini Pro and Gemini Flash). The responses obtained and citations returned were assessed by an international panel of experts for consistency with current knowledge.</p><p><strong>Results: </strong>Complete agreement of responses with expert consensus was obtained for 5/10 AI tools. In total, all AI tools presented 101 items in the literature. No reference was rated as \"correct\"; 45 citations (45%) \"existed but did not answer the question\"; and 56 citations (55%) were considered \"hallucinatory\".</p><p><strong>Conclusion: </strong>Use of artificial intelligence in decision-making for extracorporeal cardiopulmonary resuscitation in patients with hypothermic cardiac arrest risks unjustifiably withdrawing treatment from patients who have a chance of survival with a good neurological outcome. Large language models should not be used as the only tool for decision-making.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Medium Cut-Off Dialyzers on Fat Tissue and Muscle Mass Indices.","authors":"Yelda Deligoz Bildaci, Mert Esme, Berfu Korucu, Ege Erbay, Barkin Yigitbasi, Banu Dilek, Zekiye Selin Senturk, Caner Cavdar, Serpil Muge Deger","doi":"10.1111/aor.14997","DOIUrl":"https://doi.org/10.1111/aor.14997","url":null,"abstract":"<p><strong>Background: </strong>Medium cut-off (MCO) dialyzers are designed to provide clearance of large-middle molecular weight uremic toxins and cytokines that are also responsible for the pathogenesis of sarcopenia.</p><p><strong>Aim: </strong>To investigate the short- and long-term effects of MCO dialyzers on fat and muscle mass.</p><p><strong>Methods: </strong>This single-center prospective, cross-over study includes 20 maintenance hemodialysis (MHD) patients treated with low-flux (LF) dialyzers. Baseline parameters were measured under LF dialyzers and repeated at 2nd week and 6th month after switching to MCO dialyzers. Fat tissues were measured with a skinfold caliper and mid-upper arm circumference. Muscle thickness and strength parameters were measured with ultrasound and handgrip tests.</p><p><strong>Results: </strong>Median skinfold thickness showed a statistically significant increase in the second week of HD with MCO dialyzers [15 mm (10, 17) to 16 mm (13.3, 19.8), p = 0.04] and remained similar in the 6th month (p = 0.08). There was a gradual increase in median mid-upper arm circumference with a significant increase in the 6th month [28 (27, 29.5), 28.5 cm (27, 30), and 30.6 cm (26.7, 32), respectively, p = 0.03]. Significant increases were detected in the measurements of all four abdominal muscle groups (p = 0.03 for rectus abdominis and external oblique; p = 0.002 for internal oblique and transversus abdominis) in the 2nd week of MCO dialyzers and remained similar in the 6th month. Median RF and GCM thicknesses also significantly increased in the 2nd week (p = 0.001 and p < 0.001, respectively). The thicknesses of the external oblique, internal oblique, transversus abdominis, and rectus femoris muscles showed no significant differences in the 6th month. We also observed significant increases in the median GCM fibril length and GCM fibril pennation (p = 0.01 and p = 0.008, respectively) in the 2nd week, which also remained similar in the 6th month. The handgrip strength test showed a gradual increase at each time point without statistical significance.</p><p><strong>Conclusion: </strong>MCO dialyzers provide increased fat and muscle mass, which might be due to their better clearance of uremic toxins compared to low-flux dialyzers. This study serves as a hypothesis-generating investigation; larger randomized controlled trials are required to validate the hypothesis.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}