Artificial organs最新文献

{"title":"Current and Future State of Advanced Heart and Lung Failure Therapies: Highlights From the International Society for Heart and Lung Transplantation 45th Annual Meeting and Scientific Sessions.","authors":"Nayeem Nasher, Brandon E Ferrell, Stephen J Forest, Daniel J Goldstein","doi":"10.1111/aor.15035","DOIUrl":"https://doi.org/10.1111/aor.15035","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-Infrared Spectroscopy for Preventing Limb Ischemia in Extracorporeal Membrane Oxygenation.","authors":"Bongyeon Sohn, Heemoon Lee","doi":"10.1111/aor.15045","DOIUrl":"10.1111/aor.15045","url":null,"abstract":"<p><strong>Background: </strong>Limb ischemia is a serious complication of venoarterial (VA) extracorporeal membrane oxygenation (ECMO), potentially resulting in amputation, rhabdomyolysis, or death. This study aimed to evaluate the effectiveness of near-infrared spectroscopy (NIRS) monitoring in the early detection and prevention of limb ischemia in peripheral VA ECMO.</p><p><strong>Methods: </strong>We retrospectively reviewed 166 patients who underwent peripheral VA ECMO between January 2018 and December 2022. Patients were categorized into two groups based on the implementation of NIRS monitoring (Before-NIRS [n = 83] vs. After-NIRS [n = 83]). An inverse probability of treatment weighting (IPTW)-adjusted analysis was conducted.</p><p><strong>Results: </strong>Baseline characteristics were not significantly different between the groups. The ECMO weaning success rate was significantly higher in the After-NIRS group (45.9% vs. 63.4%, p = 0.026). However, survival to discharge did not differ significantly (31.8% vs. 42.7%, p = 0.174). The incidences of rhabdomyolysis and acute limb ischemia were significantly lower in the After-NIRS group (10.6% vs. 1.2% and 11.8% vs. 0%, respectively). In the After-NIRS group, a decrease in NIRS values was observed in three patients, prompting timely placement of distal perfusion catheters. None of these patients developed limb ischemia.</p><p><strong>Conclusions: </strong>After the implementation of NIRS monitoring, no cases of limb ischemia were observed. NIRS enables early identification of limb malperfusion, facilitates timely intervention, and reduces unnecessary distal perfusion catheter placement. As a non-invasive, real-time monitoring modality, NIRS offers continuous assessment of limb perfusion and plays a valuable role in the early prevention of limb ischemia in patients undergoing peripheral VA ECMO.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Machine Perfusion Organ Preservation: Highlights From the American Transplant Congress 2024\".","authors":"Haizam Oubari, Yanis Berkane, Alexandre Lellouch","doi":"10.1111/aor.15046","DOIUrl":"https://doi.org/10.1111/aor.15046","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ghost Cells as a Two-Phase Blood Analog Fluid-Optical Thrombus Growth Detection Using Particle Image Velocimetry.","authors":"Benjamin J Schürmann, Pia Creutz, Thomas Schmitz-Rode, Ulrich Steinseifer, Johanna C Clauser","doi":"10.1111/aor.15042","DOIUrl":"https://doi.org/10.1111/aor.15042","url":null,"abstract":"<p><strong>Background: </strong>In vitro thrombosis tests for mechanical circulatory support systems lack standardized ISO guidelines. A major limitation of current approaches is the absence of continuous thrombus monitoring, as terminated experiments at a single time point fail to capture the dynamic nature of thrombus formation. However, spatially resolved thrombus formation and its underlying dynamics are crucial for the optimization of mechanical circulatory support systems.</p><p><strong>Methods: </strong>In this study, we present a high-resolution thrombus monitoring approach using particle image velocimetry with a thrombogenic, two-phase blood analog fluid, designated as \"ghost blood\". Ghost blood consists of plasma and ghost cells, which are hemoglobin-depleted erythrocytes. We validate and quantify the particle image velocimetry with ghost blood and use this combination to monitor thrombus growth.</p><p><strong>Results: </strong>The validation demonstrated velocity fields in the FDA-pump are consistent with existing literature, confirming the usability of ghost blood in particle image velocimetry. The use range of ghost blood is quantified as a formula to determine the maximum possible optical penetration depth. Finally, thrombus growth was successfully monitored in the FDA-pump.</p><p><strong>Conclusion: </strong>In this proof of principle study, we grew a thrombus in the FDA-pump and were able to monitor its growth from a first thrombus thread to a complete obstruction of the flow. This approach enables both the localization and the temporal growth of the thrombus to be visualized and thereby provides a foundation for future advancements in thrombosis assessment and the optimization of mechanical circulatory support systems.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic Organ Transplantation and Device Therapies for Advanced Heart and Lung Failure: Highlights From the 105th Annual Meeting of the American Association for Thoracic Surgery.","authors":"Nayeem Nasher, Vakhtang Tchantchaleishvili, Keshava Rajagopal","doi":"10.1111/aor.15044","DOIUrl":"https://doi.org/10.1111/aor.15044","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Control of Realheart Total Artificial Heart.","authors":"Emanuele Perra, Daniel Jonasson, Shaikh Faisal Zaman, Nils Brynedal Ignell, Michael Broomé, Thomas Finocchiaro, Ina Laura Perkins, Seraina Anne Dual","doi":"10.1111/aor.15036","DOIUrl":"https://doi.org/10.1111/aor.15036","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) affects approximately 64 million patients worldwide, where the heart's impaired ability to pump blood leads to reduced quality of life and a high 5-year mortality rate. Total artificial hearts (TAHs) offer a promising solution, but to ensure a good quality of life and prolong life expectancy for end-stage HF patients, TAHs must adapt to the body's varying metabolic demands.</p><p><strong>Methods: </strong>This study evaluates the physiological control performance of the Realheart TAH using a hybrid mock circulation loop that simulates dynamic physiological states, such as sleep, rest, and exercise. The Realheart TAH features a preload-based control mechanism that adjusts heart rate (HR) and stroke volume (SV) in response to changes in atrial pressure, closely mimicking the native heart's ability to meet varying blood flow demands. The controller's adaptability and robustness were further tested under different levels of pulmonary vascular resistance (PVR), simulating conditions that challenge flow balance.</p><p><strong>Results: </strong>The results demonstrate that the Realheart TAH maintains flow balance between the right and left ventricles and stabilizes atrial pressures across all tested conditions. During simulated exercise, the controller increased cardiac output (CO) by up to 2.1 times from rest while maintaining stable atrial pressures, compared to a maximum increase of 1.2 times without the controller. During sleep, CO decreased by 25%, whereas a decrease of only 5% was observed without the controller. Under increased PVR, the controller adjusted SV and HR to preserve consistent CO and prevent blood volume build-up in the atria, which could otherwise lead to dangerously high atrial pressures.</p><p><strong>Conclusion: </strong>The physiological control system demonstrated its ability to adapt to rapid transitions between physiological states, although occasional undershoots in pressure were observed during transitions from exercise to rest conditions. This study highlights the Realheart TAH's ability to autonomously adjust to varying physiological conditions and patient needs, showing promise for treating patients with advanced HF. Future work will focus on optimizing the control system to further enhance the device's responsiveness and stability during rapid physiological transitions.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Human Bladder Transplant.","authors":"Aakash M Shah","doi":"10.1111/aor.15041","DOIUrl":"https://doi.org/10.1111/aor.15041","url":null,"abstract":"<p><p>First human bladder transplant performed in southern California. The procedure is a testament to surgical advances and offers hope to patients in need of a neobladder. Trial Registration: ClinicalTrials.gov identifier: NCT06337942.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in Artificial Organs.","authors":"","doi":"10.1111/aor.15039","DOIUrl":"https://doi.org/10.1111/aor.15039","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Decellularization and Crosslinking Efficacy of Perfusion Bioreactors in Small-Diameter Porcine Carotid Artery Grafts.","authors":"Nho Thuan Nguyen, Binh Duc Vu, Thao Duy Huynh, Thang Quoc Bui, Ha Le Bao Tran","doi":"10.1111/aor.15037","DOIUrl":"https://doi.org/10.1111/aor.15037","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease patients may find new hope in tissue engineering vascular grafts (TEVGs), which show promise as a substitute for small-diameter grafts in bypass surgery. Decellularized and crosslinked arteries are good TEVGs because they have native tissue structure, mechanical stability, reduced immunogenicity, and biocompatibility. Currently, procedures for decellularization and crosslinking related to bioreactors are emergent due to creating a stable flow, reducing both time and chemical concentration-factors affecting vascular structural degradation.</p><p><strong>Methods: </strong>In the bioreactor system, the arteries were decellularized with low-concentration (0.3% or 0.5%) sodium dodecyl sulfate (SDS) before being crosslinked using N-hydroxysuccinimide (NHS) and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC). The samples were tested for mechanical properties, in vitro cytotoxicity, histological analysis, degradation, and subcutaneous embedding for about 3 months to see how well the crosslinking and decellularization process worked.</p><p><strong>Results: </strong>A perfusion bioreactor along with 0.5% SDS shows the efficiency in removing cells from the arteries compared to 0.3% SDS. Using crosslinking with EDC and NHS by bioreactor also improved their mechanical properties, lowered inflammatory reactions, and sped up the time it took for them to break down.</p><p><strong>Conclusion: </strong>The combination of SDS, EDC/NHS, and a bioreactor may serve as an appropriate method for arterial decellularization and crosslinking. This research indicates that crosslinked decellularized grafts by bioreactor systems are a promising scaffold materials for bypass surgery or vascular repair.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulating the Use of Discontinuous Patterned Hydrogel to Improve Inter-Electrode Resistance on Electrode Arrays.","authors":"Mark L Reeves, T Jamie Healey, Avril D McCarthy","doi":"10.1111/aor.15030","DOIUrl":"https://doi.org/10.1111/aor.15030","url":null,"abstract":"<p><strong>Background: </strong>A novel form of sensory stimulation aiming to treat spasticity has been developed, and a clinical trial is currently underway. This uses an electrode array controlled by a programmable 64-channel stimulator to spatially vary the electrical stimulation over time. However, when a continuous layer of hydrogel interfaces between the array and skin, stimulation spreads, causing lower current densities applied over larger areas of tissue. A new approach was developed, modeled, and tested, utilizing discontinuous patterned hydrogel to improve inter-electrode resistance on electrode arrays.</p><p><strong>Methods: </strong>Finite-difference modeling was used to estimate stimulation distribution within the hydrogel and subcutaneous tissue under the electrode array. Repeated simulations modeled changes due to variations in hydrogel, skin, and subcutaneous tissue resistivity. Properties of both continuous sheets and patterned hydrogel were used for the simulation. Physical prototypes of the continuous and patterned hydrogel were manufactured and tested for comparison with the simulation.</p><p><strong>Results: </strong>Simulation results showed a reduced spread of stimulation between electrodes when using the discontinuous patterned hydrogel compared to the continuous hydrogel. This was demonstrated consistently for all variations in hydrogel, skin, and subcutaneous tissue resistivity. Laboratory testing supported the simulation results and suggested the improved performance of the patterned hydrogel, compared with the continuous hydrogel, may become more substantial over time.</p><p><strong>Conclusions: </strong>While the simulation only approximates the stimulation distribution on electrode arrays, the results do show potential benefits of utilizing discontinuous patterned hydrogel to increase inter-electrode resistance. Laboratory testing and initial feedback from the clinical trial support the results indicated in the simulations.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}