Artificial organs最新文献

{"title":"Recent Progress in Artificial Organs","authors":"","doi":"10.1111/aor.15039","DOIUrl":"10.1111/aor.15039","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 8","pages":"1225-1226"},"PeriodicalIF":2.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Decellularization and Crosslinking Efficacy of Perfusion Bioreactors in Small-Diameter Porcine Carotid Artery Grafts.","authors":"Nho Thuan Nguyen, Binh Duc Vu, Thao Duy Huynh, Thang Quoc Bui, Ha Le Bao Tran","doi":"10.1111/aor.15037","DOIUrl":"https://doi.org/10.1111/aor.15037","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease patients may find new hope in tissue engineering vascular grafts (TEVGs), which show promise as a substitute for small-diameter grafts in bypass surgery. Decellularized and crosslinked arteries are good TEVGs because they have native tissue structure, mechanical stability, reduced immunogenicity, and biocompatibility. Currently, procedures for decellularization and crosslinking related to bioreactors are emergent due to creating a stable flow, reducing both time and chemical concentration-factors affecting vascular structural degradation.</p><p><strong>Methods: </strong>In the bioreactor system, the arteries were decellularized with low-concentration (0.3% or 0.5%) sodium dodecyl sulfate (SDS) before being crosslinked using N-hydroxysuccinimide (NHS) and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC). The samples were tested for mechanical properties, in vitro cytotoxicity, histological analysis, degradation, and subcutaneous embedding for about 3 months to see how well the crosslinking and decellularization process worked.</p><p><strong>Results: </strong>A perfusion bioreactor along with 0.5% SDS shows the efficiency in removing cells from the arteries compared to 0.3% SDS. Using crosslinking with EDC and NHS by bioreactor also improved their mechanical properties, lowered inflammatory reactions, and sped up the time it took for them to break down.</p><p><strong>Conclusion: </strong>The combination of SDS, EDC/NHS, and a bioreactor may serve as an appropriate method for arterial decellularization and crosslinking. This research indicates that crosslinked decellularized grafts by bioreactor systems are a promising scaffold materials for bypass surgery or vascular repair.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulating the Use of Discontinuous Patterned Hydrogel to Improve Inter-Electrode Resistance on Electrode Arrays.","authors":"Mark L Reeves, T Jamie Healey, Avril D McCarthy","doi":"10.1111/aor.15030","DOIUrl":"https://doi.org/10.1111/aor.15030","url":null,"abstract":"<p><strong>Background: </strong>A novel form of sensory stimulation aiming to treat spasticity has been developed, and a clinical trial is currently underway. This uses an electrode array controlled by a programmable 64-channel stimulator to spatially vary the electrical stimulation over time. However, when a continuous layer of hydrogel interfaces between the array and skin, stimulation spreads, causing lower current densities applied over larger areas of tissue. A new approach was developed, modeled, and tested, utilizing discontinuous patterned hydrogel to improve inter-electrode resistance on electrode arrays.</p><p><strong>Methods: </strong>Finite-difference modeling was used to estimate stimulation distribution within the hydrogel and subcutaneous tissue under the electrode array. Repeated simulations modeled changes due to variations in hydrogel, skin, and subcutaneous tissue resistivity. Properties of both continuous sheets and patterned hydrogel were used for the simulation. Physical prototypes of the continuous and patterned hydrogel were manufactured and tested for comparison with the simulation.</p><p><strong>Results: </strong>Simulation results showed a reduced spread of stimulation between electrodes when using the discontinuous patterned hydrogel compared to the continuous hydrogel. This was demonstrated consistently for all variations in hydrogel, skin, and subcutaneous tissue resistivity. Laboratory testing supported the simulation results and suggested the improved performance of the patterned hydrogel, compared with the continuous hydrogel, may become more substantial over time.</p><p><strong>Conclusions: </strong>While the simulation only approximates the stimulation distribution on electrode arrays, the results do show potential benefits of utilizing discontinuous patterned hydrogel to increase inter-electrode resistance. Laboratory testing and initial feedback from the clinical trial support the results indicated in the simulations.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Influence of Microstructured Surface Characterization Parameters on Blood Damage.","authors":"Chengyang Liu, Longhui Cheng, Wangwang Su, Zhenling Wei, Zhuo Li, Haidong He, Liudi Zhang","doi":"10.1111/aor.15034","DOIUrl":"https://doi.org/10.1111/aor.15034","url":null,"abstract":"<p><strong>Background: </strong>Mechanical circulatory support devices (MCSDs) are among the most effective treatments of end-stage heart failure. Despite their efficacy, patients often experience hemocompatibility issues such as hemolysis and gastrointestinal bleeding caused by blood damage. The surface characteristics of blood-contacting materials significantly affect hemocompatibility, and designing specific surface microstructures may help mitigate blood damage.</p><p><strong>Methods: </strong>In this study, microstructures with various morphologies were designed and fabricated on silicon wafer surfaces, and an in vitro blood circulation platform was involved to conduct blood-shearing experiments on these modified surfaces. The sheared blood samples were analyzed for free hemoglobin concentration and high molecular weight von Willebrand Factor (HMW-VWF) degradation.</p><p><strong>Results: </strong>The results demonstrated that microcylindrical structures with higher aspect ratios could simultaneously reduce both hemolysis and HMW-VWF degradation. While microcylindrical structures outperformed micrograting structures in reducing hemolysis, both of them performed similarly regarding VWF damage. The results highlight that variations in the morphological parameters of the microstructure significantly influence hemolysis and HMW-VWF degradation. Specifically, different aspect ratios and structural designs affect how blood interacts with the surface, altering the extent of blood component damage.</p><p><strong>Conclusions: </strong>These findings suggest that tailoring surface microstructures could enhance the hemocompatibility of blood-contacting materials in MCSDs, offering valuable insights for their design and optimization.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Bypass Grafting on Microaxial Flow Pump Support in Patients With Severely Reduced Left Ventricular Ejection Fraction","authors":"Gaik Nersesian,&nbsp;Daniel Lewin,&nbsp;Yuriy Hrytsyna,&nbsp;Pia Lanmueller,&nbsp;Sascha Ott,&nbsp;Nicolas Merke,&nbsp;Volkmar Falk,&nbsp;Felix Schoenrath,&nbsp;Evgenij Potapov,&nbsp;Alaa Abd El Al","doi":"10.1111/aor.15038","DOIUrl":"10.1111/aor.15038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patients with coronary artery disease (CAD) and severely reduced left ventricular ejection fraction (LVEF) face high perioperative risks during surgical revascularization. This case series examines outcomes in CAD patients with LVEF ≤ 25% undergoing surgical revascularization on microaxial flow pump (mAFP) support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 12 patients at Deutsches Herzzentrum der Charité who underwent scheduled protected coronary artery bypass grafting (CABG) with full-flow mAFP support. Patients with acute myocardial infarction or no myocardial viability were excluded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cohort had a median age of 60 years [59; 66], 92% male, BMI 26 ± 6.2 kg/m², median LVEF 18% [15; 24], and LVEDD 69 mm [59; 78]. Seven patients had diabetes mellitus and chronic renal failure, and five had prior myocardial infarctions. The mean EUROSCORE II was 2.5 ± 0.6.</p>\u0000 \u0000 <p>Surgical revascularization was performed with ongoing mAFP support, with a median of 3 distal anastomoses. Complete revascularization was achieved in 11 cases and surgical time was 254 min [187; 266]. Myocardial recovery occurred in seven patients, while four required durable left ventricular assist device implantation, and one died on mAFP support. Two (16.6%) patients died during a follow-up period of 93 days. Median Impella support lasted 6 days [3; 9], invasive ventilation 13 h [11; 20], and ICU stays 4.5 days [4; 17].</p>\u0000 \u0000 <p>Complications included one bleeding requiring revision, two mAFP exchanges due to thrombosis/dislodgement, and four thromboembolic strokes in three patients during mAFP explantation/exchange.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Revascularization with mAFP support is a feasible approach for high-risk CAD patients but is associated with support-related complications, including thromboembolic strokes during mAFP manipulations (e.g., explantation or exchange). Prospective randomized trials are essential to evaluate the potential benefits of intraoperative mAFP support during surgical revascularization compared to alternative mechanical support strategies and/or pharmacological measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 8","pages":"1346-1355"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.15038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis After Seven Days of Veno-Venous Extracorporeal Membrane Oxygenation Support.","authors":"Felix A Rottmann, Rebecca Book, Alexander Supady, Viviane Zotzmann, Markus Jäckel, Alexander Maier, Frederic Arnold, Dirk Westermann, Tobias Wengenmayer, Jonathan Rilinger, Dawid L Staudacher","doi":"10.1111/aor.15032","DOIUrl":"https://doi.org/10.1111/aor.15032","url":null,"abstract":"<p><strong>Background: </strong>Prognostication in patients receiving veno-venous extracorporeal membrane oxygenation (V-V ECMO) remains challenging, particularly during prolonged support. Accurate prognostic indicators are essential for patients, caregivers, and clinicians. This study evaluates outcomes in patients supported with V-V ECMO for at least seven days.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study of patients cannulated for V-V ECMO due to respiratory failure. The primary endpoint was hospital survival. The subgroup of patients still on V-V ECMO on day 7, stratified by respirator and ECMO parameters, was analyzed with respect to predictors of the primary outcome. A survival favorability margin was defined as the bound of the hospital survivors' 95% confidence interval closest to the non-survivor median.</p><p><strong>Results: </strong>Among 299 patients treated with V-V ECMO (median age 55 years, 66.9% male), hospital survival was 44.8%. Pneumonia was the primary cause of respiratory failure in 216 patients (72.2%). By day 7, 182/299 patients (60.9%) remained on V-V ECMO, with a hospital survival rate of 45.1%. Three respiratory parameters (ventilator FiO₂, tidal volume, compliance) and three V-V ECMO parameters (blood flow, sweep gas flow, O₂ fraction) significantly predicted hospital survival (all p ≤ 0.015). All six predictors separated survivors and non-survivors through day 1 to 10 (all p < 0.001). Moreover, the clustering of several parameters above the favorability margin showed a clear discrimination of the overall survival (≥ 5 vs. zero parameters, survival 67.5% vs. 13.8%, OR 13.0, 95% CI 3.5-38.6, p < 0.001).</p><p><strong>Conclusion: </strong>Among patients still on V-V ECMO on day seven, respiratory and ECMO parameters above the favorability margin correlated strongly with hospital survival. Survival was rare in patients with all predictors below the favorability margin. Day seven could provide a useful, though not definitive, time point for prognostication based on respiratory and ECMO parameters.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neurophysiological Effects of Cervical Transcutaneous Spinal Cord Stimulation With and Without a High Frequency Carrier in Able-Bodied Adults.","authors":"Frances Gawne, Sarah Massey, Lynsey Duffell","doi":"10.1111/aor.15031","DOIUrl":"https://doi.org/10.1111/aor.15031","url":null,"abstract":"<p><strong>Background: </strong>Transcutaneous spinal cord stimulation (tSCS) is a promising avenue in spinal cord injury (SCI) rehabilitation; however, high currents are required to excite afferents in the spinal cord roots, which patients may not tolerate. Modulating tSCS pulses with a kHz carrier frequency (kHz-tSCS) may be used to reduce discomfort; however, the way that kHz-tSCS interacts with neural networks, compared to unmodulated pulses (conv-tSCS), is largely unknown.</p><p><strong>Method: </strong>Ten able-bodied participants received conv-tSCS, kHz-tSCS, and sham interventions for 20 min over the C7/T1 vertebrae. Charge delivery of both waveforms was measured. Posterior root reflexes (PRRs) and motor-evoked potentials (MEPs) were recorded from the Flexor Carpi Radialis (FCR), Extensor Carpi Radialis Longus (ECRL), Flexor Carpi Ulnaris (FCU), and Brachioradialis (BR). PRR and MEP peak-peak amplitudes were measured at baseline, 0-, 15-, and 30-min post-intervention.</p><p><strong>Results: </strong>The charge required to activate posterior roots with kHz-tSCS was 3.8 times higher than with conv-tSCS (p < 0.001). Differences in PRR amplitude were found in the FCR between conv-tSCS and kHz-tSCS at 0- and 15-min post-intervention (p < 0.028). PRR inhibition was found in the FCR between baseline and 30-min post-intervention with conv-tSCS and the sham intervention (p < 0.037). No change in PRR amplitudes was found for kHz-tSCS. No other muscle showed any differences in PRR responses between intervention groups. Neither intervention caused any effect in MEP responses across time or between intervention groups.</p><p><strong>Conclusions: </strong>kHz-tSCS was a less efficient waveform for stimulation. Differences in effects on spinal excitability were found to be inconclusive, and conv-tSCS and kHz-tSCS had no effect on corticospinal excitability. Significant PRR inhibition in the FCR was found with this experimental setup even when no stimulation was applied, suggesting a natural reduction in spinal excitability caused by participants laying supine for an extended period. Future research should consider how participant positioning could affect neural excitability.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Artificial Intelligence and Machine Learning in Left Ventricular Assist Device Implantation: A Systematic Review.","authors":"Usama Hussein, Wing Kiu Chou, Abhinav Balasubramanian, Jamolbi Rahmatova, Lydia Wilkinson, Arian Arjomandi Rad, Ioannis Dimarakis, Antonios Kourliouros","doi":"10.1111/aor.15025","DOIUrl":"https://doi.org/10.1111/aor.15025","url":null,"abstract":"<p><strong>Background: </strong>This systematic review evaluates the current evidence pertaining to the application of artificial intelligence (AI) and machine learning (ML) in left ventricular assist device (LVAD) implantation. Specifically, the potential of AI/ML in risk stratification, predicting complications, and improving patient outcomes is explored, whereas also identifying key challenges and elucidating avenues of future research.</p><p><strong>Methods: </strong>A comprehensive search was conducted across EMBASE, MEDLINE, Cochrane, PubMed, and Google Scholar databases to identify studies on AI/ML in LVAD implantation up to March 2024. Articles were selected if they utilized AI/ML techniques in LVAD settings and met predefined criteria. A total of 17 studies were included after a rigorous screening and appraisal process.</p><p><strong>Results: </strong>The included studies highlighted the use of ML in five main areas: (1) mortality prediction, where ML models demonstrated higher accuracy compared to traditional models; (2) adverse event prediction, including aortic regurgitation and suction events; (3) myocardial recovery, with ML models outperforming traditional stratification methods; (4) deciphering thrombosis risk, with ML identifying key predictors such as younger age and higher BMI; and (5) right ventricular failure prognostication, within which ML models leveraged hemodynamic and imaging data for superior prediction accuracy. Despite such prevalent advances, challenges including data heterogeneity, lack of causality, and limited generalizability persist.</p><p><strong>Conclusion: </strong>AI and ML possess transformative potential in optimizing LVAD management, offering both advanced prediction of commonly encountered risk occurrence and personalized care respectively. However, identified issues in AI/ML application, including data interpretability, dataset diversity, and integration into clinical workflows, must be addressed in order to enhance their broader adoption and impact.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recumbent FES-Cycling Exercise Improves Muscle Performance and Ambulation Capacity in Hospitalized Patients: A Randomized Controlled Trial.","authors":"Murillo Frazão, Fábio de Lima Martins, Gerson Cipriano","doi":"10.1111/aor.15029","DOIUrl":"https://doi.org/10.1111/aor.15029","url":null,"abstract":"<p><strong>Background: </strong>Acquired muscle weakness is a prevalent complication during hospitalization. Supportive technologies, such as functional electrical stimulation cycling (FES-cycling), are increasingly recognized as a tool with the potential to improve physical exercise in patients constrained to bed rest.</p><p><strong>Methods: </strong>In this randomized clinical trial, patients admitted to a high-complexity ward exhibiting clinical signs of muscle weakness (e.g., report of loss of strength, gait, or balance deficit due to weakness or restriction to bed) were enrolled. Participants were randomly allocated to a recumbent high-intensity, low-volume FES-cycling exercise or a control group. The primary outcomes measured were torque, power output, stimulation cost (neuromuscular efficiency), and ambulation capacity.</p><p><strong>Results: </strong>The analysis included 16 patients (eight in each group). Postintervention, the FES-cycling group presented a greater increase in both absolute (4.25 ± 3.15 vs. 0.04 ± 3.49 Nm, p = 0.02) and percentage torque (117 ± 88 vs. 8% ± 53%, p < 0.01) compared to the control. Similarly, the FES-cycling group presented higher absolute (3.91 ± 2.25 vs. 0.57 ± 1.82 watts, p < 0.01) and percentage power (61 ± 36 vs. 10% ± 23%, p < 0.01), along with a higher absolute (-2903 ± 2598 vs. -523 ± 1319 μC/watt, p = 0.03) and percentage stimulation cost (-33 ± 18 vs. -6% ± 1 8%, p = 0.01). Additionally, enhanced ambulation capacity was observed in the FES-cycling group, with 6 patients showing improvement versus 2 in the control group (p = 0.03).</p><p><strong>Conclusions: </strong>Recumbent high-intensity, low-volume FES-cycling exercise increased muscle strength, power, and neuromuscular efficiency in hospitalized patients with muscle weakness. Improvements in ambulation capacity were also noted, supporting the intervention potential.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Extracorporeal Cardiopulmonary Resuscitation for Refractory In-Hospital Cardiac Arrest.","authors":"Thays Sokolov, Thomas Varin, Maxime Zimmermann, Xavier Armoiry, Bertrand Scheppler, Matthias Jacquet-Lagrèze, Philippe Portran, Anais Schwab, Jean Luc Fellahi, Martin Ruste, Matteo Pozzi","doi":"10.1111/aor.15028","DOIUrl":"https://doi.org/10.1111/aor.15028","url":null,"abstract":"<p><strong>Background: </strong>Extracorporeal cardiopulmonary resuscitation (ECPR) is a potential intervention for refractory in-hospital cardiac arrest (IHCA). This study aimed to evaluate the outcomes of ECPR in patients with refractory IHCA at a university-affiliated tertiary care center.</p><p><strong>Methods: </strong>We performed a retrospective, observational analysis of an institutional database of adult patients who received ECPR for refractory IHCA from January 2007 to December 2023. The primary endpoint was survival to hospital discharge with a favorable neurological outcome, defined as a Cerebral Performance Category (CPC) score of 1 or 2. Patients with a CPC score of 1-2 were compared to those with a CPC score ≥ 3.</p><p><strong>Results: </strong>During the study period, 147 patients received ECPR for refractory IHCA (mean age 51.0 years, 64.6% male). Baseline characteristics were comparable between both groups. Mean no-flow time and low-flow time and the rate of shockable rhythms were comparable between both groups. Eighty-nine (60.5%) patients died during temporary mechanical circulatory support. Among the 56 (38.1%) patients who were weaned from mechanical circulatory support, 24 (16.3%) died before hospital discharge. The overall survival to discharge was 22.4%, with 20.4% achieving a CPC score of 1-2.</p><p><strong>Conclusions: </strong>Owing to the invariably fatal nature of refractory IHCA, ECPR offered a reasonable survival with a favorable neurological outcome in this critically ill patients' population.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}