Artificial organs最新文献

{"title":"Advancements in Bone Tissue Engineering: A Comprehensive Review of Biomaterial Scaffolds and Freeze-Drying Techniques From Perspective Global and Future Research.","authors":"Nurvadillah Angraini, Syarifuddin Syarifuddin, Nurlaela Rauf, Dahlang Tahir","doi":"10.1111/aor.14976","DOIUrl":"https://doi.org/10.1111/aor.14976","url":null,"abstract":"<p><strong>Background: </strong>Tissue engineering is an interdisciplinary field that integrates therapeutic agents, cells, biomaterials, and methodologies to regenerate damaged tissues. In bone tissue engineering, selecting and modifying materials to enhance mechanical strength, porosity, and pore size is critical for developing scaffolds that effectively support tissue regeneration.</p><p><strong>Methods: </strong>A systematic review was conducted using Scopus, employing keywords such as \"biomaterials for scaffold,\" \"polymer for scaffold,\" and \"freeze-drying synthesis method.\" After a rigorous screening and review process, 26 studies published between 2014 and 2024 were included in the analysis.</p><p><strong>Results: </strong>The analysis revealed that lower freeze-drying temperatures lead to denser and more compact scaffold structures due to slower ice crystal formation. These scaffolds exhibit interconnected porous architectures critical for nutrient diffusion and cell infiltration. Key improvements in compressive strength and porosity were observed, making these scaffolds suitable for bone tissue engineering applications.</p><p><strong>Conclusions: </strong>Freeze-drying is a sustainable and effective method for scaffold fabrication, enabling the use of eco-friendly biomaterials. The resulting scaffolds demonstrate superior compressive strength and high porosity, facilitating effective cell attachment and proliferation. This study underscores the potential of freeze-drying methodologies in advancing scaffold design for bone tissue regeneration.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Hemolysis Evaluation of the Second Heart Assist Whisper Percutaneous Mechanical Circulatory Support Device.","authors":"Chris H H Chan, Asma Farooqui, Preston Peak, Yaxin Wang, Sai Kode, Hadeel Al-Sahli, Zvonimir Krajcer, Sejal Chaudhari, Alex Richardson, Leslie Miller","doi":"10.1111/aor.14979","DOIUrl":"https://doi.org/10.1111/aor.14979","url":null,"abstract":"<p><strong>Background: </strong>High rotational pump speeds in percutaneous mechanical circulatory support (pMCS) devices frequently result in hemolysis. Consequently, in vitro hemolysis testing for newly developed devices is essential to mitigate this significant risk. This study compared the degree of hemolysis induced by the Second Heart Assist Whisper pMCS at its maximum pump speed, representing the worst-case scenario, with that of the Impella CP, following American society for testing and materials standards.</p><p><strong>Methods: </strong>Five Whisper devices were tested at 10000 RPM, while a comparator Impella CP was operated at 44 133 ± 606 RPM to match the Whisper's flow rate. Both devices were evaluated in two identical in vitro blood circulatory loops using citrated bovine blood. Hemolysis was analyzed by the tetramethylbenzidine method.</p><p><strong>Results: </strong>The change in plasma free hemoglobin (ΔpfHb) was significantly greater with the Impella CP than with the Whisper (p < 0.01). Both devices caused a steady increase in pfHb, with significant differences after 60 min of in vitro testing (p < 0.01). The Whisper and Impella CP differed significantly in normalized index of hemolysis (0.088 ± 0.022 vs. 0.194 ± 0.029 g/100, p < 0.01) and modified index of hemolysis (9.72 ± 2.4 vs. 20.83 ± 3.5, p < 0.01).</p><p><strong>Conclusion: </strong>The Whisper exhibited superior hemolytic performance to that of the Impella CP under identical hemodynamic conditions. Our newly designed blood circulatory loop and these benchmark values will aid future in vitro hemolysis testing for pMCS devices.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Mechanical Circulatory Support for Cardiac Assistance in Thoracic Surgery: A Scoping Review.","authors":"Viviana Teresa Agosta, Jacopo D'Andria Ursoleo, Alice Bottussi, Samuele Bugo, Fabrizio Monaco","doi":"10.1111/aor.14973","DOIUrl":"https://doi.org/10.1111/aor.14973","url":null,"abstract":"<p><strong>Background: </strong>Patients with pre-existing severe cardiovascular comorbidities are often deemed ineligible for potentially life-saving thoracic surgeries and are referred to other conservative therapies. However, this patient population may theoretically benefit from the timely perioperative implantation of temporary mechanical circulation support (tMCS) to both mitigate the surgical stress and stabilize hemodynamics. We performed a scoping review to summarize the evidence regarding the use of tMCS in thoracic surgery.</p><p><strong>Methods: </strong>We conducted a systematic search across PubMed/MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and Google Scholar from their inception, aided by a search string encompassing a combination of terms for the key research concepts: i) tMCS devices; ii) thoracic surgery procedures (except lung transplantation); and iii) the adult population.</p><p><strong>Results: </strong>Fifteen studies pertinent to the research question, which summarized data from 28 patients, were retrieved for inclusion. In 14 patients, tMCS implantation occurred as a \"pre-emptive\" strategy, while the remaining patients had tMCS implanted either intra and/or postoperatively as a \"bail-out\" strategy. Specifically, 14 patients required an intra-aortic balloon pump, 10 veno-arterial extracorporeal membrane oxygenation, two required a multidevice strategy, and one cardiopulmonary bypass. The relative risk analysis revealed that the mortality rate in the pre-emptive group was half that of the bail-out group. Additionally, the risk of both infectious and vascular complications was lower in the pre-emptive group compared to the bail-out tMCS strategy.</p><p><strong>Conclusion: </strong>We found that the timely implantation of tMCS in thoracic surgery-either to mitigate patients' heightened cardiovascular risk or as a rescue strategy in the event of life-threatening surgical complications-may lead to better patient outcomes, as well as allowing them to undergo curative surgery with an acceptable safety profile, characterized by overall good survival rates and a low incidence of device-related complications.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential Hypothermic and Normothermic Machine Perfusion of Extended Criteria Donors in Liver Transplantation: A Single-Center Preliminary Experience","authors":"Paolo Magistri,&nbsp;Silvia Zamboni,&nbsp;Barbara Catellani,&nbsp;Cristiano Guidetti,&nbsp;Giuseppe Esposito,&nbsp;Daniela Caracciolo,&nbsp;Roberta Odorizzi,&nbsp;Giacomo Assirati,&nbsp;Tiziana Olivieri,&nbsp;Samuele Frassoni,&nbsp;Vincenzo Bagnardi,&nbsp;Gian Piero Guerrini,&nbsp;Stefano Di Sandro,&nbsp;Fabrizio Di Benedetto","doi":"10.1111/aor.14936","DOIUrl":"10.1111/aor.14936","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Liver transplantation (LT) is the sole curative option for liver failure and other primary liver conditions. However, the limited number of suitable donors compared with the growing number of patients requiring LT remains a leading cause of mortality among those on the waiting list. This has resulted in the expansion of criteria for donor eligibility. The sequential combination of ex situ reperfusion, dHOPE, and NMP helps reduce the occurrence of ischemia–reperfusion injury and assess organ viability prior to transplantation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a retrospective, single-arm, single-center study including all cases of liver grafts that underwent sequential perfusion between October 2021 and July 2024. Eligibility criteria for sequential perfusion were extended criteria DBD with macrosteatosis &gt; 35%, use of high-dose vasopressors during donor ICU stay or episodes of cardiac arrest, hemodynamic instability during procurement, prolonged ischemia time for logistic reasons, as well as DCD showing prolonged fWIT, flow alteration during normothermic regional perfusion (NRP), and DCDs in Maastricht 2 class. Viability was assessed following the Groeningen group criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-three cases were included and 16 met the viability criteria at the end of the sequential perfusion and were transplanted. One patient developed an early allograft failure (EAF) and another a primary nonfunction (PNF). All the other patients had a regular postoperative course, with no retransplantation, 56% of the cohort showing no postoperative complication and all currently in good standing, median follow-up 19 months (range 4–39).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Sequential dHOPE and NMP is a strategy that can help assessing both viability and functionality of liver grafts from high-risk donors, expanding the donor pool and increasing the opportunities for patients on the waiting list to get a transplant.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"705-715"},"PeriodicalIF":2.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Heart and Lung Failure Highlights From the 61st Annual Meeting of the Society of Thoracic Surgeons.","authors":"Nayeem Nasher, John W Entwistle","doi":"10.1111/aor.14972","DOIUrl":"https://doi.org/10.1111/aor.14972","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Over Three Years Commercial Use of Ex Vivo Normothermic Machine Perfusion for Liver Transplantation in the USA: A UNOS/OPTN Database Analysis.","authors":"Takayuki Yamamoto, Naoru Koizumi, James F Markmann","doi":"10.1111/aor.14975","DOIUrl":"https://doi.org/10.1111/aor.14975","url":null,"abstract":"<p><strong>Background: </strong>Data to date using normothermic machine perfusion (NMP) devices to resuscitate and assess marginal livers such as donation after circulatory death (DCD) livers has shown impressive prevention of ischemic reperfusion injury and ischemic cholangiopathy (IC). We examined the impact of these NMP devices over 3 years after their release for commercial use on deceased donor liver transplantation (LT).</p><p><strong>Methods: </strong>We conducted a retrospective analysis of UNOS-SRTR data of livers recovered from DCD donors or older (≥ 60 years old) donation after brain death (DBD) donors for LT as well as the outcome of LT from DBD or DCD donors performed from 1/1/2016 to 6/30/2024 to compare differences with ischemic cold storage (ICS) versus NMP.</p><p><strong>Results: </strong>Among 10 778 donors of DCD livers, 1987 donors used NMP, and 8791 donors used ICS. In NMP group, the proportion of discarded livers was significantly less (7.25% vs. 30.52%), donors were older, donor BMI higher and more expanded criteria donor than those in ICS group (all, p < 0.001). For older donors, 416 cases used NMP and in 10 708 cases the liver was recovered via ICS. The discard rate of livers in NMP group was significantly less (4.33% vs. 12.18%, p < 0.001) and donors were older and donor BMI higher than that in ICS group. In DCD LT, the incidence of primary nonfunction (PNF), acute rejection within 1 year after LT as well as graft failure due to IC and hepatic artery thrombosis (HAT) in NMP group were significantly less than those in ICS group.</p><p><strong>Conclusion: </strong>In conclusion, commercial use of NMP has expanded the donor pool by accelerated usage of marginal livers such as DCD and older donors by permitting longer preservation and functional assessment of the liver. In addition, the usage of NMP for DCD LTs was associate with a reduced incidence of rejection, PNF, graft failure due to IC and HAT.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pump-Induced Hemolysis of Speed Modulated Axial-Flow Left Ventricular Assist Devices.","authors":"Patrick Borchers, Ailín Österlein Kück, Steffen Leonhardt, Marian Walter","doi":"10.1111/aor.14966","DOIUrl":"https://doi.org/10.1111/aor.14966","url":null,"abstract":"<p><strong>Background: </strong>Reduced arterial pulsatility during continuous-flow left ventricular assist device (LVAD) support is associated with certain adverse events. An approach to increase arterial pulsatility is pump speed modulation. Therefore, this in vitro study compares the pump-induced hemolysis of constant speed and modulated speed modes for two different axial-flow LVADs. Furthermore, the hemolytic performance of both LVADs is compared.</p><p><strong>Methods: </strong>Two Sputnik1 and two HeartMate2 (HM2) axial-flow LVADs were operated simultaneously for 6 h in automated hemolysis test benches (n = 7 for each mode). Rectangular speed patterns with modulation rates of 70 and 140 bpm were investigated. Speed modulation amplitudes provided head pressures between 80 and 120 mmHg. To quantify hemolysis, plasma-free hemoglobin was determined every hour and the modified index of hemolysis (MIH) was calculated.</p><p><strong>Results: </strong>Speed modulation increased all MIH values of the Sputnik1 LVADs, but decreased most MIH values of the HM2 LVADs compared to the constant speed mode. However, significant differences were only observed for one Sputnik1. Furthermore, the Sputnik1 pumps induced lower MIH levels compared to the HM2 pumps using constant speed mode.</p><p><strong>Conclusions: </strong>It seems that the HM2 can be operated in speed modulation mode without an increased risk of hemolysis. However, for the Sputnik1, the potential benefits of speed modulation must be balanced against the risk of increased hemolysis. The underlying causes need to be investigated in future studies using computational fluid dynamics. Furthermore, using the clinically established constant speed mode, it appears that the Sputnik1 will cause fewer hemolytic issues than the HM2.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex Vivo Preservation of Porcine Vascularized Composite Soft Tissue Allografts.","authors":"Abigail Meyers, Varun Lingaiah Kopparthy, Jacob Lammers, Mazen Al-Malak, Brian Figueroa, Ying Ku, Lianne Mulvihill, Ryan Khalaf, Jose Reyes, Diane Jo, R'ay Fodor, Payam Sadeghi, Antonio Rampazzo, Bahar Bassiri Gharb","doi":"10.1111/aor.14969","DOIUrl":"https://doi.org/10.1111/aor.14969","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate ex vivo perfusion (EVP) for vascularized composite tissue preservation. We hypothesized that EVP could maintain allografts in near-physiologic conditions for ≥ 24 h.</p><p><strong>Methods: </strong>Twenty superior epigastric artery perforator-based abdominal flaps were procured from 10 Yorkshire pigs. Flaps were preserved for 12 h (n = 5) or 24 h (n = 5) using EVP with an oxygenated colloid solution containing HBOC-201 oxygen carrier (HbO₂ Therapeutics, Souderton, PA). Contralateral flaps were cold storage controls (4°C) (n = 10). Hemodynamics, temperature, gases, metabolites, electrolytes, indocyanine green (ICG) angiography, and weight were analyzed. Biopsies were taken every 6 h for histology.</p><p><strong>Results: </strong>Ischemia time was 16 ± 6 min. There were no significant differences between the 12 h EVP and 24 h EVP groups at perfusion end for the following parameters: MAP (p = 0.63), pH (p = 0.77), pO2 (p = 0.20), venous pCO₂ (p = 0.22), lactate (p = 0.28), creatine kinase (p = 0.89), or myoglobin (p = 0.95). Electrolytes were also comparable at perfusion termination: sodium (p = 0.31), potassium (p = 0.61), and calcium (p = 0.29). After 12 h, flaps in the 24 h EVP group demonstrated a significant weight decrease (-4.5% [-4.6%, -4.1%] weight change), compared to the 12 h EVP group (1.2% [-1.1%, 1.6%] weight change) (p = 0.03). At perfusion end, weight did not differ from baseline between the 24 h EVP (2.3% [0%, 3%]) and 12 h EVP groups (p = 0.37). SCS flap weight was unchanged from baseline at 12 h (p = 0.954) and 24 h (p = 0.616). ICG revealed well-perfused flaps. H&E staining revealed preserved skin architecture without histopathological changes.</p><p><strong>Conclusion: </strong>EVP preserved flaps for 24 h within physiologic parameters and without development of edema. EVP may extend preservation time for VCAs.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Extracorporeal Membrane Oxygenation Initiation in Cardiogenic Shock During Work-Hours Versus After-Hours.","authors":"Chenglong Li, Xiaomeng Wang, Zhongtao Du, Andong Lu, Liwen Lyv, Sheng Zhang, Jianling Liu, Yan Liu, Liuer Zuo, Yue Huang, Binfei Li, Ping Chang, Yi Yang, Jianhua Liu, Man Huang, Haixiu Xie, Liangshan Wang, Feng Yang, Hong Wang, Xiaotong Hou","doi":"10.1111/aor.14952","DOIUrl":"https://doi.org/10.1111/aor.14952","url":null,"abstract":"<p><strong>Background: </strong>Extracorporeal membrane oxygenation (ECMO) as rescue therapy for cardiogenic shock (CS) is highly dependent on timeliness and medical resources.</p><p><strong>Objectives: </strong>Aimed to assess ECMO management and outcomes in adult patients with CS in terms of on- and after-hour ECMO initiation from a national ECMO registry.</p><p><strong>Methods: </strong>Adult patients diagnosed with CS and those who received ECMO were enrolled in the study. The population was divided into the work-hours and the after-hours group based on the time of ECMO initiation. In-hospital mortality and ECMO management were compared between them. Electronic data in this research were provided by Chinese Society of Extracorporeal Life Support.</p><p><strong>Results: </strong>In a cohort of 1862 patients, 552 (29.6%) received ECMO during work-hours, whereas 1310 (70.4%) received ECMO during after-hours. After-hour ECMO had more patients with elective cardiac procedures (35.1% vs. 26.3%, p < 0.001) and higher severity (p < 0.001), with more patients with Society for Cardiovascular Angiography and Interventions shock stage D (29.6% vs. 24.5), E (60.0% vs. 51.8%), and fewer B (3.6% vs. 13.2%) and C (6.8% vs. 10.5%). A high proportion underwent intra-aortic balloon pump (IABP) implantation before ECMO (28.4% vs. 23.0%, p = 0.016) and mechanical ventilation (92.1% vs. 87.0%, p < 0.001) during after-hours. The in-hospital mortality in patients with after-hour ECMO initiation was higher than that in patients with work-hour ECMO initiation (51.8% vs. 45.3%, p = 0.011).</p><p><strong>Conclusion: </strong>In this cohort, 70% were initiated during after-hours and showed higher in-hospital mortality than patients with work-hour ECMO initiation. After-hour ECMO initiation should be a concern for ECMO programs.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmable Self-Assembling Organizer Cells for High-Fidelity In Vitro Organogenesis","authors":"Ander Dorken-Gallastegi","doi":"10.1111/aor.14967","DOIUrl":"10.1111/aor.14967","url":null,"abstract":"<div>\u0000 \u0000 <p>A recent advancement in the field of organogensis involves self-assembly of embryoids using strategically positioned organizer cells. This offers a reliable and self-programmable model for organoid development.</p>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"49 4","pages":"539-540"},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}