The Role of Scalp EEG Recordings During Cortical Visual Prosthesis Testing.

IF 2.2 3区医学 Q3 ENGINEERING, BIOMEDICAL

Artificial organs Pub Date : 2025-05-27 DOI:10.1111/aor.15023

Katarina Stephan, Philip R Troyk, Gislin Dagnelie, Stuart Cogan, Michael P Barry, Patricia Grant, Frank Lane, Janet P Szlyk, Maggie McNulty, Wim van Drongelen, Tuan H Pham, Kelsey L Stipp, Meesa Royster, Vernon L Towle

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引用次数: 0

Abstract

Introduction: This article highlights the value of recording scalp electroencephalogram (EEG) from two individuals with blindness who received intracortical visual stimulators to create artificial vision. Given the known risk of cortical stimulation inducing seizures, we recorded occipital scalp EEG as a safety precaution. Over a 3-year period, over 330 h of EEG data were collected.

Methods: Twenty-five wireless floating microelectrode arrays (WFMAs), each containing 16 stimulating electrodes, were implanted in the right dorsolateral occipital cortex of the first participant, totaling 400 independently controlled stimulating electrodes. Similarly, 32 WFMAs were implanted in the second participant's cortex, totaling 512 electrodes. Phosphenes were characterized and mapped to align their locations in the visual field to create camera-driven imagery of the visual environment.

Results: Scalp EEG recordings during intracortical stimulation provided early warning of impending epileptic activity, reducing the risk of stimulation-induced seizures. In two instances, seizures occurred during direct cortical stimulation and were visible in the scalp EEG recordings. Normal electrically evoked potentials (eEPs) were also evident in the EEG records.

Conclusion: Scalp EEG can be valuable to alert researchers to impending seizures. However, it is not required for conditions in which low levels of stimulation are employed.

Trial registration: Clinical Trial Number NCT04634383.

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头皮脑电图记录在皮质视觉假体测试中的作用。

简介：本文重点介绍了对两名接受皮质内视觉刺激以创造人工视觉的失明患者的头皮脑电图（EEG）记录的价值。考虑到皮质刺激诱发癫痫发作的已知风险，我们记录枕部头皮脑电图作为安全预防措施。在3年的时间里，收集了超过330小时的脑电图数据。方法：将25个无线浮动微电极阵列（wfma），每个包含16个刺激电极，植入第一名参与者的右侧枕侧背外侧皮层，共400个独立控制的刺激电极。同样，在第二个参与者的皮层植入32个wfma，总共512个电极。对光幻视进行表征和映射，使其在视野中的位置对齐，从而创建由相机驱动的视觉环境图像。结果：皮层内刺激期间的头皮脑电图记录提供了即将发生的癫痫活动的早期预警，降低了刺激诱发癫痫发作的风险。在两例中，癫痫发作发生在直接皮层刺激期间，并在头皮脑电图记录中可见。正常电诱发电位（eEPs）在脑电图记录中也很明显。结论：头皮脑电图对研究人员预警癫痫发作具有重要价值。然而，在采用低水平刺激的条件下，则不需要。试验注册：临床试验号NCT04634383。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artificial organs 工程技术-工程：生物医学

CiteScore

4.30

自引率

12.50%

发文量

303

审稿时长

4-8 weeks

期刊介绍： Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.