Artificial organs最新文献

{"title":"Functional Electrical Stimulation Cycling for Balance Rehabilitation in Stroke Survivors: A Systematic Review and Meta-Analysis.","authors":"Anas R Alashram","doi":"10.1111/aor.70116","DOIUrl":"https://doi.org/10.1111/aor.70116","url":null,"abstract":"<p><strong>Objectives: </strong>This review aims to examine the impacts of functional electrical stimulation (FES) cycling on balance post-stroke, identify the optimal treatment protocol, if possible, and provide future suggestions for research and clinical practice.</p><p><strong>Methods: </strong>\"PubMed, Scopus, EMBASE, CINAHL, MEDLINE, and Web of Science\" databases were screened until August 2025. Randomized controlled trials that included stroke survivors who underwent FES cycling, compared with active or passive treatments, and assessed balance impairments were included in this review. Meta-analysis was carried out using \"Comprehensive Meta-Analysis Version 4.\" The quality of the eligible studies was estimated using the PEDro scale.</p><p><strong>Results: </strong>Nine studies met our criteria. In total, 285 stroke patients (mean age 62.46 years; 59% male) were included in this review. The studies ranged from 6 to 9 on the PEDro scale, with a median of 8. The meta-analysis showed that FES cycling was inferior to control interventions for improving balance poststroke. For the Trunk control test, a non-significant improvement was observed (SMD = 0.250, 95% CI: -0.260 to 0.761, p = 0.336, I² = 41%). For the Berg Balance Scale, meta-analysis revealed a statistically significant pooled effect favoring control interventions over FES cycling (SMD = -0.52, 95% CI -0.97 to -0.08). Non-meta-analysis outcomes indicated some improvements in balance parameters, but overall findings remain inconclusive.</p><p><strong>Conclusions: </strong>Current evidence does not support a beneficial effect of FES cycling on balance poststroke. While commonly used stimulation parameters are physiologically justified, evidence is insufficient to determine optimal FES cycling parameters for improving balance outcomes post-stroke. FES cycling should be tailored to patient characteristics and baseline impairments. Further studies of larger sample sizes are needed.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Swine Whole Eye Transplant Ex Vivo Perfusion Protocol.","authors":"Haïzam Oubari, Lucile Cabanel, Yanis Berkane, Ali Mojallal, Mark A Randolph, Basak Uygun, Korkut Uygun, Curtis L Cetrulo, Alexandre G Lellouch","doi":"10.1111/aor.70118","DOIUrl":"https://doi.org/10.1111/aor.70118","url":null,"abstract":"<p><strong>Background: </strong>The first human Whole Eye Transplant (WET) has sparked new hope for patients who have lost vision due to major ophthalmic injury, but significant challenges remain to be addressed to achieve vision restoration. The eyeball, especially its neural components, undergoes nearly immediate degeneration unless adequately preserved. Oxygenated subnormothermic machine perfusion (SNMP) has emerged as a promising alternative to static cold storage (SCS), offering potential benefits for graft preservation and reconditioning.</p><p><strong>Methods: </strong>WETs were procured from adult swine following a mean 164.7 ± 6.1 min of warm ischemia and perfused ex vivo using a Steen+ solution administered at room temperature for 18 h. Perfusion parameters, weight gain, and metabolic markers were recorded throughout the perfusion. Histological analysis and an atropine mydriasis test were performed to assess WET integrity and function.</p><p><strong>Results: </strong>Following an initial phase of metabolic clearance and weight loss, perfusion parameters stabilized, and final weight gain (t = 18 h) remained below 10%. Histological evaluation confirmed tissue preservation, and iris function was restored upon atropine administration.</p><p><strong>Conclusions: </strong>This study represents the first application of SNMP to a whole eye composite transplant model, demonstrating promising outcomes in this large animal model and supporting SNMP as a potential alternative to SCS for WET.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Assessment of Kidney Quality During 24-h of Normothermic Machine Perfusion.","authors":"Marlene Pühringer, Magdalena Kött, Andras T Meszaros, Michael J Blumer, Bettina Zelger, Stefan Redl, Martin Hermann, Thomas Resch, Simon Mathis, Gabriel Putzer, Judith Martini, Christina Bogensperger, Franka Messner, Julia Hofmann, Margot Fodor, Andrea Griesmacher, Annemarie Weissenbacher, Theresa Hautz, Gert Mayer, Hannes Neuwirt, Gerald Brandacher, Silvia Oberparleiter, Stefan Schneeberger","doi":"10.1111/aor.70112","DOIUrl":"10.1111/aor.70112","url":null,"abstract":"<p><p>Normothermic machine perfusion (NMP) has emerged as a promising tool for assessing kidney quality prior to transplantation; however, reliable biomarkers remain to be established. In this study, thirteen porcine kidneys were perfused for 24 h using an autologous leukocyte-filtered whole blood-based perfusate applying urine recirculation. Functional, biochemical, and morphological parameters were assessed to comprehensively evaluate kidney quality. Stable hemodynamics, sustained urine output, and oxygen consumption rates indicated preserved kidney viability. Within two hours of perfusion, microperfusion in renal cortex and ureter improved significantly, as confirmed by near-infrared, tissue hemoglobin, and oxygen saturation metrics. Morphological assessment revealed progressive injury localized in proximal tubular cells, marked by increased vacuolization, reduced microvilli density, and swollen mitochondria with protruding membranes. In contrast, the architecture of distal tubules and glomeruli remained intact. Biomarker analysis corroborated these findings, with KIM-1 and IGFBP-7 levels, two biomarkers predominantly expressed in proximal tubular cells, rising. Notably, overall OXPHOS capacity declined with perfusion duration, while ATP production efficiency remained stable. Histological grading, in concordance with real-time confocal assessment, showed no significant alteration over time. This study provides a detailed phenotypical and bioenergetic profiling of kidney grafts over 24 h of NMP, demonstrating preserved kidney viability and function. The observed subcellular and molecular alterations, especially affecting the proximal tubules, were not reflected in frequently gathered metrics like hemodynamic flow, urine output, oxygen consumption, or lactate levels. Further studies are needed to confirm these findings and evaluate their clinical impact after transplantation.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital Costs Associated With Mechanical Left Ventricular Unloading Devices During VA ECMO for Adult Cardiogenic Shock.","authors":"Maxwell A Hockstein, Joshua J Horns, Thomas Hanff, Iosif Taleb, Craig Selzman, Stavros Drakos, Richard Nelson, Joseph E Tonna","doi":"10.1111/aor.70117","DOIUrl":"10.1111/aor.70117","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;To date, no studies have described the financial burden and behaviors of left ventricular mechanical unloading (LVMU) for patients on veno-arterial extracorporeal membrane oxygenation (VA ECMO). Given the uptrending use of VA ECMO, describing its associated costs is essential for its continued uptake.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;We describe the inpatient costs of patients who were managed with ECMO for cardiogenic shock (CS) with and without LVMU.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;We conducted a retrospective cohort study of adult (age ≥ 18 years) patients who received ECMO at some point during their hospital stay and were nonpostoperative patients (e.g., medical CS) using the IBM MarketScan database. Data were extracted from 1/1/2008-12/31/2021.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposures: &lt;/strong&gt;The exposure of interest was the additional use of LVMU (intra-aortic balloon pump, peripherally inserted left ventricular assist device [pVAD], or \"other\") added to ECMO. Costs were calculated daily and modeled according to the daily status of ECMO, LVMU, ECMO + LVMU, or no device.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;Patient characteristics, including age, sex, and comorbidities quantified using the Charlson Comorbidity Index (CCI), etiology of heart failure (acute myocardial infarction [AMI] vs. chronic heart failure [CHF]), hospital and intensive care unit (ICU) length of stay (LOS), and total inpatient costs, were described using descriptive statistics between groups. The outcomes of interest were total inpatient costs. Secondary outcomes included in-hospital mortality and hospital and intensive care unit (ICU) length of stay (LOS). We stratified patients by receipt of LVMU and used propensity score matching from patient-level characteristics to balance the use of LVMU between groups. Cost outcomes were modeled using mixed effects linear regression clustered on matched groups and reporting incident rate ratios (IRR). LOS and mortality outcomes were modeled using Poisson (IRR) and logistic (adjusted odds ratio [aOR]) regression, respectively, conditional on matched groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Enrolled patients (n = 1596) were 56 years old (interquartile range [IQR] 47 to 62), had an ICU LOS of 9 (3 to 19) days, and a hospital length of stay of 18 (7 to 35) days, which were not different between groups. Patients who received LVMU had a higher CCI (p &lt; 0.001), and were more likely to have a primary CS etiology of AMI (54% vs. 39%; p &lt; 0.001) but not CHF (66% vs. 62%; p &lt; 0.08). The median total inpatient cost of ECMO alone was $320 269 vs. $390 508 (ECMO + LVMU [p &lt; 0.001]). In adjusted analysis, compared to patients without ECMO or LVMU, the daily incurred costs for patients on ECMO alone were three times higher (cost ratio = 3.0, p &lt; 0.001), 2.6 times higher for patients on LVMU alone (cost ratio = 2.6, p &lt; 0.001), and 4.2 times higher for people on both ECMO and LVMU (cost ratio ","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Study of NT-proBNP in Heart Failure Patients With Left Ventricular Assist Device Implantation.","authors":"Yuxin Zhang, Entao Lian, Xinyi Wang, Ze Hou, Rui Jing, Kegang Jia, Zhigang Liu","doi":"10.1111/aor.70113","DOIUrl":"https://doi.org/10.1111/aor.70113","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the dynamic changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac Troponin I (cTnI) after left ventricular assist device (LVAD) implantation in patients with end-stage heart failure (ESHF), and to evaluate their prognostic value in predicting major adverse cardiac events (MACE), as well as to analyze the correlation between NT-proBNP and pump speed.</p><p><strong>Methods: </strong>A total of 78 ESHF patients implanted with the HeartCon LVAD between September 2020 and March 2025 were enrolled. Levels of NT-proBNP and cTnI were measured preoperatively and on postoperative days (POD) 1, 7, 30, 60, and 90. Patients were followed for MACE (death or rehospitalization for right heart failure) within 6 months. Receiver operating characteristic (ROC) analysis, Cox regression, and Kaplan-Meier (KM) survival curves were used to evaluate prognostic indicators. Spearman analysis was applied to assess the correlation between NT-proBNP and pump speed.</p><p><strong>Results: </strong>NT-proBNP showed a significant reduction from a preoperative level of 4336.51 pg/mL to 2916.03 pg/mL on postoperative Day 1 (p = 0.01) and continued to decline, reaching 869.50 pg/mL by Day 90, although it remained above the upper reference limit. Total bilirubin (TBIL) increased markedly on Day 1 (from 16.60 to 32.70 μmol/L, p < 0.001) but returned to normal by Day 30 (11.30 μmol/L). cTnI peaked on Day 1 (from 0.58 to 18.93 ng/mL, p < 0.001), decreased significantly by Day 7 (to 2.24 ng/mL, p < 0.001), and normalized by Day 30 (0.15 ng/mL). ROC analysis showed that NT-proBNP on POD7 predicted MACE with an AUC of 0.749 (p = 0.004). Cox regression indicated that patients with NT-proBNP ≥ 2983 pg/mL on POD7 had a 6.2-fold higher risk of MACE (HR = 6.163, p = 0.001). Spearman analysis revealed a positive correlation between NT-proBNP and pump speed in the MACE(+) group (r = 0.314, p = 0.011).</p><p><strong>Conclusion: </strong>LVAD effectively unloaded the left ventricle, leading to a significant reduction in NT-proBNP. NT-proBNP on POD7 served as an independent predictor of MACE. Moreover, pump speed positively correlated with NT-proBNP levels. Our findings provided a clinical evidence base supporting the application of precision medicine in the management of ESHF patients with LVAD implantation.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microaxial Support as a Bridge to Repair in Post-Myocardial Infarction Ventricular Septal Rupture: A Systematic Review and Patient-Level Analysis","authors":"Nayeem Nasher,&nbsp;Daler Rahimov,&nbsp;Keerti Mallur,&nbsp;T. Reese Macmillan,&nbsp;Konstadinos A. Plestis,&nbsp;Keshava Rajagopal,&nbsp;Charles W. Hoopes,&nbsp;John W. Entwistle,&nbsp;Joseph E. Bavaria,&nbsp;Vakhtang Tchantchaleishvili","doi":"10.1111/aor.70000","DOIUrl":"10.1111/aor.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Current guidelines recommend immediate surgical repair for post-infarct ventricular septal rupture (VSR); however, mortality remains exceedingly high. We sought to report outcomes following delayed surgical management bridged with microaxial support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search yielded 42 case reports/series comprising 78 patients who were initiated on microaxial support following the diagnosis of post-infarct VSR. Patient-level data were extracted and analyzed according to survival status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 78% (54/69) of patients were male, and the median age was 69 [IQR: 60–74] years, with no difference in age between survivors and non-survivors. Those who survived were significantly less likely to have a history of prior cardiac surgery than non-survivors [3% (1/30) vs. 43% (3/7), <i>p</i> = 0.016], and less likely to have undergone percutaneous coronary intervention at the time of presentation [41% (22/54) vs. 69% (11/16), <i>p</i> = 0.049]. There were no significant differences in culprit vessel (<i>p</i> = 0.875), VSR size (<i>p</i> = 1), or VSR location (<i>p</i> = 0.253). Those who survived had a significantly higher median Qp/Qs ratio than non-survivors [3.0 [2.3–3.8] vs. 2.1 [1.9–2.3], <i>p</i> = 0.038]. Patients were successfully bridged to definitive surgical management in 76% (59/78) of cases at a median time of 8 [5–14] days following microaxial support placement. The 30-day/in-hospital mortality rate was 22% (17/78), and the overall mortality rate was 27% (21/78).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Microaxial devices can safely and feasibly provide the necessary support to allow for a successful delayed repair in hemodynamically unstable patients following post-infarct VSR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 2","pages":"180-188"},"PeriodicalIF":2.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in the Field of Artificial Organs","authors":"","doi":"10.1111/aor.70095","DOIUrl":"https://doi.org/10.1111/aor.70095","url":null,"abstract":"","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 2","pages":"167-168"},"PeriodicalIF":2.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Donor Kidneys During Normothermic Machine Perfusion With Sevoflurane: Design of a Research Model","authors":"Philip N. Günkel,&nbsp;Shuqi Yang,&nbsp;Rozemarijn S. Tuinhout,&nbsp;Sebastiaan J. Luttik,&nbsp;Roland F. Hoffmann,&nbsp;Petra J. Ottens,&nbsp;Damien Richard,&nbsp;Matthieu Jabaudon,&nbsp;Michel M. R. F. Struys,&nbsp;Henri G. D. Leuvenink,&nbsp;Gertrude J. Nieuwenhuijs-Moeke","doi":"10.1111/aor.70035","DOIUrl":"10.1111/aor.70035","url":null,"abstract":"<p>Normothermic machine perfusion (NMP) of donor kidneys provides an opportunity not only for organ preservation but also for therapeutic intervention to reduce ischemia–reperfusion injury (IRI) and support tissue repair. Sevoflurane, a volatile anesthetic known to protect against IRI in other organ systems, has not previously been explored in the context of kidney NMP. This study aimed to establish a stable and reproducible porcine kidney NMP model incorporating sevoflurane delivery. Different administration techniques and oxygenator setups were evaluated to identify the most effective method of sevoflurane application. Administering sevoflurane directly as a liquid into the perfusate resulted in excessive gas formation and unstable drug concentrations. In contrast, using a vaporizer connected to an Inspire 8F M oxygenator allowed for stable and reproducible sevoflurane levels over a 90-min perfusion period, while maintaining sufficient oxygenation. This method proved to be a reliable approach for sevoflurane delivery in kidney NMP. However, oxygenators exposed to sevoflurane should not be reused due to the risk of membrane damage. These findings support the feasibility of using sevoflurane in kidney NMP and provide a platform for further investigation into its potential to improve renal graft outcomes.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 2","pages":"189-199"},"PeriodicalIF":2.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Hemolytic Performance of a Centrifugal Artificial Blood Pump","authors":"Xuemin Liu,&nbsp;Qing Han,&nbsp;Shikui Zhao,&nbsp;Jiejie Shao,&nbsp;Peng Wang,&nbsp;Honghua Zhao","doi":"10.1111/aor.70030","DOIUrl":"10.1111/aor.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Significant advances have been made in the design and manufacture of artificial blood pumps. However, blood compatibility issues such as hemolysis, thrombosis, and inflammation during the clinical use of artificial blood pumps have reduced their reliability. Among these issues, hemolysis problems can lead to acute kidney injury, hyperkalemia, and in severe cases, even serious threats to life. To address hemolysis problems, blood transfusion, reduction of blood pump speed, and medication to promote erythropoiesis are generally used. This study explores the hemolysis problem from the perspective of the essence of problem solving, that is, the design of the blood pump structure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A new centrifugal pump UJN-1 was designed based on empirical design theory and the velocity coefficient method of traditional centrifugal pumps. We used the commercial software Fluent to compare the data obtained from our simulation of FDA benchmark blood pumps with the results of other researchers to validate the accuracy of our simulation method. Based on the CFD numerical simulation method, we evaluated the hemolytic performance of three centrifugal pumps: Revolution, PuraLev 200SU, and UJN-1. The hydraulic performance of the designed UJN-1 blood pump was experimentally verified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The UJN-1 could provide a blood flow rate of 4–6 L/min and a blood pressure of 120 mmHg at 2500 rpm. The CFD numerical simulation and experimental results of the designed artificial blood pump UJN-1 were compared and verified, and the results showed that the error was small. The hemolysis results of the Revolution pump, 200SU pump, and UJN-1 pump were 3.35 × 10⁻⁴%, 2.20 × 10⁻⁴%, and 1.49 × 10⁻⁴%, respectively. In a comparison of hemolysis among the three pumps, the UJN-1 pump had the lowest level of hemolysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This low hemolysis artificial blood pump design is important for long-term clinical use and high reliability of medical devices.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 2","pages":"291-299"},"PeriodicalIF":2.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Impact of Polymyxin B Hemadsorption on Long-Term Mortality in Septic Shock: A Retrospective Analysis of Intra-Abdominal Versus Extra-Abdominal Infections","authors":"Tomoki Tanaka,&nbsp;Kazunori Fujino,&nbsp;Yasuyuki Tsujita,&nbsp;Yugo Matsumoto,&nbsp;Mitsuhiro Fujino,&nbsp;Hidemitsu Miyatake,&nbsp;Naoto Mizumura,&nbsp;Junji Shimizu,&nbsp;Takuma Kishimoto,&nbsp;Naoto Shiomi","doi":"10.1111/aor.70023","DOIUrl":"10.1111/aor.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The long-term benefit of polymyxin B hemadsorption (PMX-HA) in septic shock patients remains unclear and may depend on the site of infection. We evaluated the association between PMX-HA use and 1-year mortality in patients with intra-abdominal infection (IAI) and extra-abdominal infection (EAI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed adult patients with septic shock (Sepsis-3) admitted to an ICU between January 2017 and July 2023. Patients were categorized as IAI or EAI and further stratified by PMX-HA use. One-year mortality was assessed using Kaplan–Meier analysis, multivariable Cox regression (adjusted for age, sex, and SOFA score), and inverse probability of treatment weighting (IPTW), balancing age, sex, SOFA, CRRT use, and with or without surgical and/or radiological interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 182 patients (98 IAI, 84 EAI), PMX-HA was administered to 71 IAI and 32 EAI patients. In the IAI group, PMX-HA was associated with significantly lower 1-year mortality (32.3% vs. 59.2%, <i>p</i> = 0.005), supported by Cox regression (adjusted HR: 0.485; 95% CI: 0.252–0.935; <i>p</i> = 0.031) and IPTW (weighted HR: 0.415; 95% CI: 0.215–0.787; <i>p</i> = 0.007). In contrast, in the EAI group, 1-year mortality was similar between the non-PMX and PMX groups (44.4% vs. 56.6%, <i>p</i> = 0.516), with no significant association in Cox analysis (adjusted HR: 0.790; 95% CI: 0.404–1.543; <i>p</i> = 0.49) or IPTW (weighted HR: 0.85; 95% CI: 0.446–1.617; <i>p</i> = 0.62).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PMX-HA was significantly associated with a lower risk of 1-year mortality in patients with IAI, but not in those with EAI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 2","pages":"271-280"},"PeriodicalIF":2.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}