In Vitro Comparison of Device-Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps.

IF 2.2 3区医学 Q3 ENGINEERING, BIOMEDICAL

Artificial organs Pub Date : 2025-04-24 DOI:10.1111/aor.15013

John Vandenberge, Dong Han, Wenji Sun, Shigang Wang, Douglas Tran, Nancy Kim, Kiersten Clark, Randy Perez, Bartley P Griffith, Zhongjun J Wu

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引用次数: 0

Abstract

Background: Left ventricular assist devices (LVADs) have been utilized to maintain the circulatory demands of patients with end-stage heart failure. Despite their positive impact, hemocompatibility-related adverse events remain a major challenge. The aim of this study is to compare in vitro hemocompatibility performance between the HeartMate 2 (HM2) and HeartMate 3 (HM3) pumps by assessing device-induced blood damage in an in vitro circulatory loop.

Methods: Fresh healthy human blood was circulated for 4 h in a circulatory loop assisted by an HM2 or HM3 pump at a flow rate of 4.5 L/min and a pressure head of 75 mmHg. Hourly blood samples were collected for analysis of hemolysis, platelet activation, platelet receptor shedding, and high molecular weight multimer (HMWM) degradation of von Willebrand factor (VWF).

Results: The data from the hourly blood samples showed that the HM3 pump caused significantly lower levels of hemolysis, platelet activation, platelet receptor shedding, and HMWM degradation of VWF compared to the HM2 pump.

Conclusion: The HM3 exhibited superior overall hemocompatibility to the HM2, underscoring the advantages of the fully magnetically levitated centrifugal pump design in the HM3 compared to the mechanical bearing-supported axial pump design of the HM2.

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心脏伴侣2和心脏伴侣3泵之间装置诱导的溶血、血小板缺陷和血管性血友病因子降解的体外比较

背景：左心室辅助装置（lvad）已被用于维持终末期心力衰竭患者的循环需求。尽管有积极的影响，但与血液相容性相关的不良事件仍然是一个主要的挑战。本研究的目的是通过评估体外循环回路中装置引起的血液损伤来比较心脏伴侣2 （HM2）和心脏伴侣3 （HM3）泵的体外血液相容性性能。方法：新鲜健康人体血液在HM2或HM3泵的辅助下，以4.5 L/min的流速和75 mmHg的压头在循环回路中循环4 h。每小时采集一次血样，分析溶血、血小板活化、血小板受体脱落和血管性血友病因子（VWF）的高分子量多聚体（HMWM）降解。结果：每小时血液样本数据显示，与HM2泵相比，HM3泵引起的VWF溶血、血小板活化、血小板受体脱落和HMWM降解水平明显降低。结论：HM3整体血液相容性优于HM2，说明HM3采用全磁悬浮离心泵设计优于HM2采用机械轴承支撑轴流泵设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artificial organs 工程技术-工程：生物医学

CiteScore

4.30

自引率

12.50%

发文量

303

审稿时长

4-8 weeks

期刊介绍： Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.