Vitamin D Deficiency and Driveline Infections in Patients With Left Ventricular Assist Devices.

IF 2.2 3区 医学 Q3 ENGINEERING, BIOMEDICAL
Wesley A Borman, Luke M Landrigan, Nicholas J Berg, Jeanette Pickrell, Maya E Guglin
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引用次数: 0

Abstract

Background: Despite major advancements in the field of durable left ventricular assist devices (LVADs), driveline infection is a major source of morbidity and mortality. Risk factors have been proposed, but few are modifiable. We evaluated vitamin D deficiency as a potential modifiable risk factor for driveline infection.

Methods and results: This single-center, retrospective study included 134 LVAD recipients between 2010 and 2022. Patients were divided into two groups based on their pre-implant vitamin D levels: the vitamin D sufficient group (≥ 30 ng/mL) and the vitamin D deficient group (< 30 ng/mL). The Kaplan-Meier method estimated 18-month freedom from driveline infection. The Cox proportional hazards model estimated the effect of vitamin D deficiency on driveline infections. Kaplan-Meier estimates for infection-free survival were significantly higher in the sufficient group (90.5% vs. 69.6%, p = 0.014). Vitamin D deficiency (HR: 3.644, 95% CI: 1.271-10.448, p = 0.016) and obesity (HR: 3.190, 95% CI: 1.464-7.400, p = 0.004) were found to be independent risk factors for driveline infection.

Conclusion: Our findings support vitamin D deficiency as a potential modifiable risk factor for driveline infection. Obesity was also noted as a significant risk factor for infection. Further research is warranted to establish causality and assess the impact of vitamin D repletion on infection rates.

使用左心室辅助装置患者的维生素D缺乏和动力系统感染。
背景:尽管耐用左心室辅助装置(lvad)领域取得了重大进展,但传动系统感染是发病率和死亡率的主要来源。已经提出了风险因素,但很少是可以改变的。我们评估了维生素D缺乏作为传动系统感染的一个潜在的可改变的危险因素。方法和结果:这项单中心回顾性研究纳入了2010年至2022年期间134名LVAD受者。根据植入前的维生素D水平将患者分为两组:维生素D充足组(≥30 ng/mL)和维生素D缺乏组(结论:我们的研究结果支持维生素D缺乏是驱动系统感染的潜在可改变危险因素。肥胖也被认为是感染的一个重要风险因素。进一步的研究是必要的,以确定因果关系,并评估维生素D补充对感染率的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Artificial organs
Artificial organs 工程技术-工程:生物医学
CiteScore
4.30
自引率
12.50%
发文量
303
审稿时长
4-8 weeks
期刊介绍: Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.
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