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Annual review of nutrition最新文献

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Guild-Level Response of the Gut Microbiome to Nutritional Signals: Advancing Precision Nutrition for Metabolic Health. 肠道微生物组对营养信号的行会级反应：促进代谢健康的精确营养。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-29 DOI: 10.1146/annurev-nutr-122424-022254
Liping Zhao
{"title":"Guild-Level Response of the Gut Microbiome to Nutritional Signals: Advancing Precision Nutrition for Metabolic Health.","authors":"Liping Zhao","doi":"10.1146/annurev-nutr-122424-022254","DOIUrl":"10.1146/annurev-nutr-122424-022254","url":null,"abstract":"<p><p>The gut microbiome functions as a hidden organ, providing essential ecosystem services to sustain human health. By identifying stably connected bacteria, we reveal two competing guilds (TCG) as the resilient core of the microbiome: the health-promoting foundation guild (FG) and the proinflammatory pathobiont guild (PG). FG members produce short-chain fatty acids (SCFAs), enhancing gut barrier integrity and systemic resilience, while PG members disrupt metabolism through endotoxins, indoles, and hydrogen sulfide. Together, the FG and PG mediate ∼85% of ecological interactions in a dynamic, seesaw-like relationship. As evolved nutrient sensors for coping with feast-famine cycles, these guilds align host metabolism with dietary patterns. Fiber-rich diets bolster FG activity, maintaining microbial balance and metabolic health, whereas fiber-deficient diets in modern-day society favor chronic PG dominance, driving inflammation and disease. Synthesizing clinical and experimental evidence, this review positions the TCG model as a transformative framework for precision nutrition, guiding strategies to restore microbial balance and address metabolic disorders.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"197-221"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How I Became the "Goddess of Vitamin E". 我是如何成为“维生素E女神”的。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-03-28 DOI: 10.1146/annurev-nutr-111324-115034
Maret G Traber
{"title":"How I Became the \"Goddess of Vitamin E\".","authors":"Maret G Traber","doi":"10.1146/annurev-nutr-111324-115034","DOIUrl":"10.1146/annurev-nutr-111324-115034","url":null,"abstract":"<p><p>My scientific journey is not traditional; it begins with the career opportunities available for and expectations of young women during the outset of the women's liberation era and how life changed along the way. I've started my story when I was a child in the 1950s, daughter of a milkman and an immigrant fleeing the communists in her home country. My story reaches an apex when I became an internationally recognized vitamin E expert. Overall, I made transformative contributions to our understanding of α-tocopherol function in humans, and, using model systems, I have reported how its absence has a major impact on cellular metabolism. This is the story of my transformation. I have had some excellent mentors. I have a passion about learning why the body needs α-tocopherol. Certainly, when I started out, I had no expectations that I would become a world-renowned scientist, a term I now use to describe myself.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"1-21"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Adipose Tissue Metabolism During Fasting. 禁食期间脂肪组织代谢的调节。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-06 DOI: 10.1146/annurev-nutr-120524-013857
Philip M M Ruppert, Sander Kersten
{"title":"Regulation of Adipose Tissue Metabolism During Fasting.","authors":"Philip M M Ruppert, Sander Kersten","doi":"10.1146/annurev-nutr-120524-013857","DOIUrl":"10.1146/annurev-nutr-120524-013857","url":null,"abstract":"<p><p>There is widespread interest in fasting as a therapeutic or preventive regimen for improving health. This review provides an overview of the impact of fasting on adipose tissue metabolism, with special attention to sexually dimorphic regulation. During fasting, the storage of triacylglycerols in adipose tissue is inhibited via suppression of the extracellular lipolytic enzyme lipoprotein lipase. By contrast, the breakdown of stored triacylglycerols and subsequent release of fatty acids and glycerol in the blood are enhanced via stimulation of the intracellular lipolytic enzymes adipose triglyceride lipase and hormone-sensitive lipase. These metabolic alterations are driven by changes in humoral factors such as insulin, glucagon, corticosteroids, growth hormone, and catecholamines, as well as by neuronal pathways, and are mediated by transcriptional and posttranscriptional regulation of critical enzymes. Overall, fasting profoundly influences adipose tissue metabolism and leads to mobilization of stored triacylglycerols and the repartitioning of circulating triacylglycerols to nonadipose tissues.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"41-64"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Insights into Folate-Vitamin B12 Interactions. 叶酸-维生素B12相互作用的新见解。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1146/annurev-nutr-120524-043056
Luisa F Castillo, Caitlyn M Pelletier, Katarina E Heyden, Martha S Field
{"title":"New Insights into Folate-Vitamin B<sub>12</sub> Interactions.","authors":"Luisa F Castillo, Caitlyn M Pelletier, Katarina E Heyden, Martha S Field","doi":"10.1146/annurev-nutr-120524-043056","DOIUrl":"10.1146/annurev-nutr-120524-043056","url":null,"abstract":"<p><p>Folate and vitamin B<sub>12</sub> (B12) are essential cofactors in folate-mediated one-carbon metabolism (FOCM). FOCM includes a series of methyl transfer reactions for methionine regeneration and de novo synthesis of nucleotides, including thymidylate. Deficiency in either folate or B12 can result in negative health outcomes including megaloblastic anemia, with additional neurocognitive impairments observed as a result of B12 deficiency. While folate deficiency is not common in the United States due to mandatory folic acid fortification, B12 deficiency is observed more frequently, particularly in certain subpopulations such as vegetarians/vegans and older adults. Fortification of the food supply with folic acid has been effective to increase folate status and reduce the incidence of birth defects. However, consumption of fortified foods and use of dietary supplements containing folic acid have led to an increase in the proportion of individuals exceeding the tolerable upper intake level of folic acid. Although the interaction between folate and B12 has been appreciated for decades in relation to megaloblastic anemia, it has been recently proposed that elevated serum folate may worsen neurocognitive effects and other metabolic impairments (altered glucose homeostasis, type 2 diabetes in offspring) associated with B12 deficiency. This review highlights molecular mechanisms that may explain the biology underlying these associations with a focus on findings from studies in model systems.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"23-39"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay Between Dietary Bioactive Compounds and Gut Microbiota in Modulating Obesity-Associated Inflammation and Metabolic Dysfunction. 膳食生物活性化合物和肠道微生物群在调节肥胖相关炎症和代谢功能障碍中的相互作用。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI: 10.1146/annurev-nutr-111224-024937
Maryam Seifishahpar, Nishan Sudheera Kalupahana, Jung Han Kim, Naima Moustaid-Moussa
{"title":"Interplay Between Dietary Bioactive Compounds and Gut Microbiota in Modulating Obesity-Associated Inflammation and Metabolic Dysfunction.","authors":"Maryam Seifishahpar, Nishan Sudheera Kalupahana, Jung Han Kim, Naima Moustaid-Moussa","doi":"10.1146/annurev-nutr-111224-024937","DOIUrl":"10.1146/annurev-nutr-111224-024937","url":null,"abstract":"<p><p>Dietary bioactive compounds such as omega-3 polyunsaturated fatty acids and phytochemicals have numerous health benefits, which include alleviating obesity-associated inflammation and metabolic dysfunction. While mechanistic studies have focused thus far on how these compounds or their metabolites affect whole-animal physiology or exert tissue-specific effects, detailed reports are lacking about how these bioactives specifically affect gut microbiota and mitochondrial function, two important processes impacted by metabolic diseases. Gut microbiota, through their composition and metabolites, play a significant role in overall health and mediating the effects of diet. Therefore, understanding how dietary bioactive compounds modulate gut microbiota is crucial for elucidating their contributions to metabolic health. Conversely, gut microbiota may also alter the metabolism of bioactives, especially phytochemicals, and impact their bioavailability and function. Mitochondria, particularly in adipose tissue, play a central role in energy metabolism and are implicated in the development of obesity-associated metabolic dysfunction. Thus, investigating the effects of dietary bioactive compounds on mitochondrial function provides valuable insight into their potential roles in addressing obesity-related diseases. Accordingly, the goal of this review is to discuss key published work on the interplay between dietary bioactives, gut microbiota and their metabolites, and mitochondria function in the context of improving obesity-associated inflammation and metabolic dysfunction.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"141-169"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Make America Healthy, Again? The Past, Present and Future of Dietary Guidelines. 让美国再次健康？膳食指南的过去、现在和未来。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI: 10.1146/annurev-nutr-020725-113350
Kevin C Klatt
{"title":"Make America Healthy, Again? The Past, Present and Future of Dietary Guidelines.","authors":"Kevin C Klatt","doi":"10.1146/annurev-nutr-020725-113350","DOIUrl":"10.1146/annurev-nutr-020725-113350","url":null,"abstract":"<p><p>Dietary guidelines have been placed under unprecedented scrutiny in the past decade, as the \"obesity epidemic\" enters its fifth decade with limited evidence of public health progress. In the era of successful obesity pharmacotherapy, there is a heightened sense of urgency to make progress on dietary prevention of obesity and related chronic diseases, contributing to both diverse criticism of guidelines and low degrees of trust in nutritional sciences. In this review, I view nutritional guidance through a historical lens, tracking its development from its genesis through the modern focus on obesity and chronic diseases and consider criticisms of past and existing dietary guidance. I reflect on themes that emerge from this history and consider potential paths forward to improve the quality of nutritional guidance and actualize its goals of improving population health.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"223-249"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in Understanding the Regulation of Glucose and Fructose Metabolism. 葡萄糖和果糖代谢调控的研究进展。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2025-04-18 DOI: 10.1146/annurev-nutr-111824-012939
Meng Zhao, Jameel Lone, Saranya Reghupaty, Karen Yasmin Linde-Garelli, Katrin J Svensson
{"title":"Progress in Understanding the Regulation of Glucose and Fructose Metabolism.","authors":"Meng Zhao, Jameel Lone, Saranya Reghupaty, Karen Yasmin Linde-Garelli, Katrin J Svensson","doi":"10.1146/annurev-nutr-111824-012939","DOIUrl":"10.1146/annurev-nutr-111824-012939","url":null,"abstract":"<p><p>Hexoses, including glucose, fructose, and galactose, are six-carbon monosaccharides that play fundamental roles in mammalian metabolism, with glucose serving as the primary energy source and fructose and galactose metabolized through pathways converging with glucose metabolism. While glucose metabolism has been extensively studied over the past hundred years, the mechanisms of fructose metabolism and uptake, the transporters involved, and its roles in physiology and disease are far less explored. Recent data also suggest that excessive fructose intake can have detrimental effects on metabolic organs, including the liver. Emerging studies have uncovered novel regulatory mechanisms in glucose and fructose metabolism, including the role of posttranslational modifications of transporters and enzymes, and the discovery of regulators of transporters. Here, we highlight new findings on the regulation of glucose and fructose transporters and integrate recent molecular and clinical insights into how glucose and fructose contribute to metabolic diseases.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":13.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eating Around the Clock: Circadian Rhythms of Eating and Metabolism. 昼夜饮食：饮食和新陈代谢的昼夜节律。
IF 13.4 2区 医学
Annual review of nutrition Pub Date : 2024-08-01 Epub Date: 2024-08-12 DOI: 10.1146/annurev-nutr-062122-014528
Andrew W McHill, Matthew P Butler
{"title":"Eating Around the Clock: Circadian Rhythms of Eating and Metabolism.","authors":"Andrew W McHill, Matthew P Butler","doi":"10.1146/annurev-nutr-062122-014528","DOIUrl":"10.1146/annurev-nutr-062122-014528","url":null,"abstract":"<p><p>The time of day that we eat is increasingly recognized as contributing as importantly to overall health as the amount or quality of the food we eat. The endogenous circadian clock has evolved to promote intake at optimal times when an organism is intended to be awake and active, but electric lights and abundant food allow eating around the clock with deleterious health outcomes. In this review, we highlight literature pertaining to the effects of food timing on health, beginning with animal models and then translation into human experiments. We emphasize the pitfalls and opportunities that technological advances bring in bettering understanding of eating behaviors and their association with health and disease. There is great promise for restricting the timing of food intake both in clinical interventions and in public health campaigns for improving health via nonpharmacological therapies.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"25-50"},"PeriodicalIF":13.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Maternal Diet Influence Future Infant Taste and Odor Preferences? A Critical Analysis. 母亲的饮食会影响婴儿未来对味道和气味的偏好吗？批判性分析。
IF 12.6 2区 医学
Annual review of nutrition Pub Date : 2024-08-01 Epub Date: 2024-08-12 DOI: 10.1146/annurev-nutr-121222-101404
Catherine A Forestell
{"title":"Does Maternal Diet Influence Future Infant Taste and Odor Preferences? A Critical Analysis.","authors":"Catherine A Forestell","doi":"10.1146/annurev-nutr-121222-101404","DOIUrl":"10.1146/annurev-nutr-121222-101404","url":null,"abstract":"<p><p>The dietary choices a mother makes during pregnancy offer her developing fetus its earliest exposure to the family's culinary preferences. This comprehensive literature review synthesizes five decades of research, which has provided valuable insights into fetal flavor learning. Converging evidence across various species supports the functionality of fetal chemoreceptive systems by the end of gestation, enabling the detection of an extensive array of chemosensory cues derived from the maternal diet and transmitted to the amniotic fluid. The fetus effectively encodes these flavors, resulting in their enhanced acceptance after birth. While existing studies predominantly concentrate on fetal learning about odor volatiles, limited evidence suggests a capacity for learning about gustatory (i.e., taste) properties. Examining whether these prenatal odor, taste, and flavor experiences translate into enduring shifts in dietary behaviors beyond weaning remains a crucial avenue for further investigation.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"313-337"},"PeriodicalIF":12.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helminth Infections and Diabetes: Mechanisms Accounting for Risk Amelioration. 螺旋体感染与糖尿病：风险改善的机制。
IF 12.6 2区 医学
Annual review of nutrition Pub Date : 2024-08-01 Epub Date: 2024-08-12 DOI: 10.1146/annurev-nutr-061121-100742
Anuradha Rajamanickam, Subash Babu
{"title":"Helminth Infections and Diabetes: Mechanisms Accounting for Risk Amelioration.","authors":"Anuradha Rajamanickam, Subash Babu","doi":"10.1146/annurev-nutr-061121-100742","DOIUrl":"10.1146/annurev-nutr-061121-100742","url":null,"abstract":"<p><p>The global prevalence of type 2 diabetes mellitus (T2D) is increasing rapidly, with an anticipated 600 million cases by 2035. While infectious diseases such as helminth infections have decreased due to improved sanitation and health care, recent research suggests a link between helminth infections and T2D, with helminths such as <i>Schistosoma</i>, <i>Nippostrongylus</i>, <i>Strongyloides</i>, and <i>Heligmosomoides</i> potentially mitigating or slowing down T2D progression in human and animal models. Helminth infections enhance host immunity by promoting interactions between innate and adaptive immune systems. In T2D, type 1 immune responses are suppressed and type 2 responses are augmented, expanding regulatory T cells and innate immune cells, particularly type 2 immune cells and macrophages. This article reviews recent research shedding light on the favorable effects of helminth infections on T2D. The potential defense mechanisms identified include heightened insulin sensitivity and reduced inflammation. The synthesis of findings from studies investigating parasitic helminths and their derivatives underscores promising avenues for defense against T2D.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"339-355"},"PeriodicalIF":12.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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