Annual review of nutrition最新文献_第2页

Human Nutrition and Oral Vaccine Efficacy. 人类营养和口服疫苗功效。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-06 DOI: 10.1146/annurev-nutr-062024-123217

Gaurav Kwatra, Jamie I Klein, Sean R Moore

{"title":"Human Nutrition and Oral Vaccine Efficacy.","authors":"Gaurav Kwatra, Jamie I Klein, Sean R Moore","doi":"10.1146/annurev-nutr-062024-123217","DOIUrl":"10.1146/annurev-nutr-062024-123217","url":null,"abstract":"The advent of oral vaccines (OVs) in the mid-twentieth century led to dramatic reductions in the global burden of gut and gut-acquired infectious diseases such as polio, rotavirus, cholera, and typhoid. Paradoxically, OVs have been less effective in low- and middle-income countries (LMICs) where morbidity and mortality from these diseases are highest. This so-called tropical barrier does not reflect intrinsic defects of OV platforms but rather the influence of adverse host and environmental conditions more prevalent in LMIC settings. Among these, nutritional status stands out as a key modifiable determinant of OV performance. The collision of undernutrition and poor sanitation in LMIC contexts fosters repeated exposure to enteropathogens via contaminated food, water, and living environments; proinflammatory gut microbiota; disrupted intestinal mucosal architecture and barrier function; and profoundly altered immune development. Together, these factors hinder the replication and take of OVs. Micronutrient deficiencies-particularly in zinc, vitamin A, vitamin D, and iron-further compromise intestinal epithelial homeostasis, antigen presentation, and antibody responses to undermine OV efficacy. This review synthesizes recent advances in our understanding of how human nutrition shapes OV immunogenicity. By integrating epidemiologic evidence, field interventions, and mechanistic insights, we outline pathways linking diet, gut health, and vaccine response and strategies to close global gaps in OV performance.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"415-434"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shaping Human Health and Nutrition Through Innovations in Spatial Metabolism. 通过空间代谢创新塑造人类健康和营养。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-19 DOI: 10.1146/annurev-nutr-062024-111053

Craig W Vander Kooi, Matthew S Gentry, Ramon C Sun

引用次数: 0

The Role of Emotional Well-Being in Diabetes Prevention and Management. 情绪健康在糖尿病预防和管理中的作用。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-15 DOI: 10.1146/annurev-nutr-061824-063618

Weidi Qin, Julie Ober Allen, Kara M Mannor, Alejandro Rodríguez-Putnam, Viktoryia A Kalesnikava, Briana Mezuk

{"title":"The Role of Emotional Well-Being in Diabetes Prevention and Management.","authors":"Weidi Qin, Julie Ober Allen, Kara M Mannor, Alejandro Rodríguez-Putnam, Viktoryia A Kalesnikava, Briana Mezuk","doi":"10.1146/annurev-nutr-061824-063618","DOIUrl":"10.1146/annurev-nutr-061824-063618","url":null,"abstract":"This article presents a nuanced analysis of current evidence regarding the role of emotions as understudied mediators of the effectiveness of type 2 diabetes (T2D) prevention and management programs. It reviews empirical literature on how indicators of poor mental health, as well as positive affective functioning, are relevant to health behaviors that contribute to T2D risk, such as compliance with recommended diets and improved nutrition. Addressing these emotional aspects of diabetes may be an effective means of improving uptake, and ultimately efficacy, of efforts to reduce the burden of T2D. This article also discusses examples of diabetes self-management efforts that aim to simultaneously address diabetes care and emotional health needs across clinical and community settings, including the collaborative care model, peer-led programs, and community health educators. Finally, this article considers what centering the emotional side of diabetes means for innovative health promotion efforts for people with T2D.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"463-481"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full Plate: Integrating Ingestive Behavior into Nutritional Science. 全餐：将摄食行为纳入营养科学。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-02-24 DOI: 10.1146/annurev-nutr-073124-120815

Barbara J Rolls

引用次数: 0

The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans. 早期营养可能影响人类2型糖尿病病理生理的潜在生理机制

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-21 DOI: 10.1146/annurev-nutr-101024-091914

Elaine A Yu, Melissa A Chapnick, Aryeh D Stein

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Nutritional Strategies for Targeting Biological Age. 针对生物年龄的营养策略。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 DOI: 10.1146/annurev-nutr-062322-025848

Stephen M Albright, Jesse R Poganik, Vadim N Gladyshev

{"title":"Nutritional Strategies for Targeting Biological Age.","authors":"Stephen M Albright, Jesse R Poganik, Vadim N Gladyshev","doi":"10.1146/annurev-nutr-062322-025848","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062322-025848","url":null,"abstract":"Biological age represents a quantifiable measure of physiological health that can be assessed using molecular biomarkers and potentially modulated through interventions. This review examines nutritional strategies affecting biological age in model organisms and humans, emphasizing recent clinical trials employing composite omics-based aging biomarkers. Accumulating evidence demonstrates that caloric restriction, Mediterranean diet, intermittent fasting (IF), and micronutrient supplementation are associated with reduced biological age, while obesity, inflammatory dietary patterns, and malnutrition are associated with accelerated aging across certain populations and measurement platforms. Substantial challenges remain in clinical translation, including difficulties extrapolating from animal models and heterogeneity in intervention responses. Proteomic analyses further reveal that organ systems may age at heterogeneous rates, with dietary patterns differentially affecting organ-specific aging trajectories. This complexity underscores both the promise of precision nutrition approaches tailored to individual characteristics and the need for improved adherence to evidence-based dietary recommendations that measurably influence biological age and age-related disease risk.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"46 1","pages":"315-337"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Food to Function: Cross-Kingdom Transfer and Regulatory Potential of Dietary microRNAs Highlighted by Breast Milk. 从食物到功能：以母乳为重点的饮食microrna的跨界转移和调控潜力。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-26 DOI: 10.1146/annurev-nutr-100225-084130

Federica Ceccarelli, Barbara Pascucci, Cecilia Bartolucci, Annamaria Altomare, Michele Pier Luca Guarino, Giuseppina Rea

{"title":"From Food to Function: Cross-Kingdom Transfer and Regulatory Potential of Dietary microRNAs Highlighted by Breast Milk.","authors":"Federica Ceccarelli, Barbara Pascucci, Cecilia Bartolucci, Annamaria Altomare, Michele Pier Luca Guarino, Giuseppina Rea","doi":"10.1146/annurev-nutr-100225-084130","DOIUrl":"10.1146/annurev-nutr-100225-084130","url":null,"abstract":"Dietary microRNAs (miRNAs) constitute a novel nexus among nutrition, gene regulation, and human health. Accumulating evidence indicates that miRNAs ingested with food can traverse the gastrointestinal barrier, enter systemic circulation, and modulate gene expression through gene-silencing mechanisms in critical metabolic pathways of mammals. These observations have driven growing interest in elucidating their bioavailability, molecular stability, and physiological relevance. In this review, we provide a systematic analysis of dietary miRNAs, with particular emphasis on plant-derived species and those present in breast milk, evaluating controversies and their potential implications for human health and disease. Breast milk is highlighted as a key vehicle for miRNA-mediated communication in early life, integrating maternal, environmental, and infant signals. Drawing on these insights, we identify major challenges in dietary miRNA research and propose strategies to address them, establishing a structured framework to guide future studies. Finally, we highlight the biotechnological potential of dietary miRNAs in promoting nutritional approaches to advance human health.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"203-227"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of NAD+ Homeostasis in Aging and Disease. NAD+在衰老和疾病中的稳态机制。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-06-02 DOI: 10.1146/annurev-nutr-112525-013335

Melanie R McReynolds

引用次数: 0

Circadian Alignment Through Time-Restricted Feeding: Implications for Health and Longevity. 通过限时进食的昼夜节律调整：对健康和寿命的影响。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-11 DOI: 10.1146/annurev-nutr-112525-011241

Samantha E Iiams, Nathan J Skinner, Carla B Green, Joseph S Takahashi

{"title":"Circadian Alignment Through Time-Restricted Feeding: Implications for Health and Longevity.","authors":"Samantha E Iiams, Nathan J Skinner, Carla B Green, Joseph S Takahashi","doi":"10.1146/annurev-nutr-112525-011241","DOIUrl":"10.1146/annurev-nutr-112525-011241","url":null,"abstract":"Time-restricted feeding (TRF), which confines food intake to a defined daily window, has emerged as a promising nonpharmacological strategy to improve health by aligning behavior and physiology with the endogenous circadian clock. Preclinical research has expanded substantially, now spanning both nocturnal and diurnal species, diverse dietary regimens, varying intervention durations, and examinations of sex-specific responses. These consistently show that synchronizing feeding-fasting cycles with the natural active phase of an organism's circadian rhythm enhances rhythmic gene expression across tissues. Concomitantly, this mitigates metabolic dysfunction, reduces inflammation, and lowers disease risk, often without reducing caloric intake. While findings in animal models are robust, human outcomes have been more modest and variable, influenced by the timing and duration of feeding window, metabolic state, and sex. This review synthesizes current insights into the relationship between TRF and circadian rhythms, highlighting recent discoveries and the challenges that remain for translation to humans.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"435-462"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile Acids as Integrators of Nutrient Sensing and Postprandial Metabolism. 胆汁酸作为营养感知和餐后代谢的整合者。

IF 13.3 2区医学

Annual review of nutrition Pub Date : 2026-08-01 DOI: 10.1146/annurev-nutr-092724-025135

Larissa Rodrigues, Carlos M Donado-Pestana, Guilherme Noronha Hernandez, Vinicius Leonardo Sousa Diniz, Marina Robles de Paola, Jarlei Fiamoncini

{"title":"Bile Acids as Integrators of Nutrient Sensing and Postprandial Metabolism.","authors":"Larissa Rodrigues, Carlos M Donado-Pestana, Guilherme Noronha Hernandez, Vinicius Leonardo Sousa Diniz, Marina Robles de Paola, Jarlei Fiamoncini","doi":"10.1146/annurev-nutr-092724-025135","DOIUrl":"https://doi.org/10.1146/annurev-nutr-092724-025135","url":null,"abstract":"Bile acids (BAs) are increasingly recognized as signaling molecules, with functions that extend far beyond their classical role in lipid digestion. Acting through receptors such as the farnesoid X receptor and the Takeda G protein-coupled receptor, BAs integrate nutrient-derived signals to coordinate energy expenditure, glucose and lipid metabolism, and immune responses. In the postprandial state, circulating BAs are among the most dynamically modulated metabolites. BA profiles are shaped by diet composition, sex, age, and metabolic status, while the gut microbiota diversifies BA pool composition by generating secondary BA species with distinct receptor affinities and influencing host physiology. Dysregulation of BA kinetics or pool composition is closely linked to metabolic diseases including obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis. This review highlights how changes in BA levels in the postprandial period coordinate enterohepatic flux, hormonal feedback, and microbiota interactions to regulate postprandial metabolic homeostasis.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"46 1","pages":"99-126"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0