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Annual review of nutrition最新文献

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Nutritional Regulation of Intestinal Stem Cells. 肠干细胞的营养调节。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 Epub Date: 2018-05-23 DOI: 10.1146/annurev-nutr-082117-051644
Salvador Alonso, Ömer H Yilmaz
{"title":"Nutritional Regulation of Intestinal Stem Cells.","authors":"Salvador Alonso, Ömer H Yilmaz","doi":"10.1146/annurev-nutr-082117-051644","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051644","url":null,"abstract":"Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases including cancer. Stem cells, the central mediators of tissue regeneration, integrate dietary and energy cues via nutrient-sensing pathways to maintain growth or respond to stress. We discuss emerging data on the effects of diet and nutrient-sensing pathways on intestinal stem cells, as well as their potential application in the development of regenerative and therapeutic interventions.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"273-301"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36130296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
A Life in Food: A Grain of Salt and Some Humble Pie. 食物中的生活:一粒盐和一些谦卑的派。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 Epub Date: 2018-03-26 DOI: 10.1146/annurev-nutr-082117-051816
Michael J Gibney
{"title":"A Life in Food: A Grain of Salt and Some Humble Pie.","authors":"Michael J Gibney","doi":"10.1146/annurev-nutr-082117-051816","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051816","url":null,"abstract":"<p><p>From my senior school days, I had wanted to pursue a career in food. In quite what capacity I was not too sure. So my starting points were within the fields of animal nutrition before moving for the major part of my career to medical schools to study human nutrition and health. My career scientific achievements lie within the Kuhnian spectrum of normal science, but within that normality, I was always one to challenge conventional wisdom. An academic career is about more than just research. It is about teaching and not just the minutiae of nutrition, but about life and living, about challenges and failures. Reflecting on the experience of that career, my advice to early stage researchers is this: Be patient, determined, and resilient in the very early stages. Hold no fear of change and be courageous in challenging conventional wisdom. Always favor openness and collaboration and always seek to help others. Citation indices are important to your career, but these other avenues that I advise you to follow are what you will eventually be most proud of.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"1-16"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35947036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity. 营养对单碳代谢的影响:对砷甲基化和毒性的影响。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 Epub Date: 2018-05-23 DOI: 10.1146/annurev-nutr-082117-051757
Anne K Bozack, Roheeni Saxena, Mary V Gamble
{"title":"Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity.","authors":"Anne K Bozack,&nbsp;Roheeni Saxena,&nbsp;Mary V Gamble","doi":"10.1146/annurev-nutr-082117-051757","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051757","url":null,"abstract":"<p><p>Exposure to inorganic arsenic (InAs) via drinking water and/or food is a considerable worldwide problem. Methylation of InAs generates monomethyl (MMAs<sup>III+V</sup>)- and dimethyl (DMAs<sup>III+V</sup>)-arsenical species in a process that facilitates urinary As elimination; however, MMAs is considerably more toxic than either InAs or DMAs. Emerging evidence suggests that incomplete methylation of As to DMAs, resulting in increased MMAs, is associated with increased risk for a host of As-related health outcomes. The biochemical pathway that provides methyl groups for As methylation, one-carbon metabolism (OCM), is influenced by folate and other micronutrients, including choline and betaine. Individuals and species differ widely in their ability to methylate As. A growing body of research, including cell-culture, animal-model, and epidemiological studies, has demonstrated the role of OCM-related micronutrients in As methylation. This review examines the evidence that nutritional status and nutritional interventions can influence the metabolism and toxicity of As, with a primary focus on folate.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"401-429"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36130758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Introduction. 介绍。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 DOI: 10.1146/annurev-nu-38-070218-100001
Rudi Balling, Patrick J Stover
{"title":"Introduction.","authors":"Rudi Balling,&nbsp;Patrick J Stover","doi":"10.1146/annurev-nu-38-070218-100001","DOIUrl":"https://doi.org/10.1146/annurev-nu-38-070218-100001","url":null,"abstract":"","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"v"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nu-38-070218-100001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36417378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apocarotenoids: Emerging Roles in Mammals. 类伪胡萝卜素:在哺乳动物中的新作用。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 Epub Date: 2018-05-11 DOI: 10.1146/annurev-nutr-082117-051841
Earl H Harrison, Loredana Quadro
{"title":"Apocarotenoids: Emerging Roles in Mammals.","authors":"Earl H Harrison,&nbsp;Loredana Quadro","doi":"10.1146/annurev-nutr-082117-051841","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051841","url":null,"abstract":"<p><p>Apocarotenoids are cleavage products of C40 isoprenoid pigments, named carotenoids, synthesized exclusively by plants and microorganisms. The colors of flowers and fruits and the photosynthetic process are examples of the biological properties conferred by carotenoids to these organisms. Mammals do not synthesize carotenoids but obtain them from foods of plant origin. Apocarotenoids are generated upon enzymatic and nonenzymatic cleavage of the parent compounds both in plants and in the tissues of mammals that have ingested carotenoid-containing foods. The best-characterized apocarotenoids are retinoids (vitamin A and its derivatives), generated upon central oxidative cleavage of provitamin A carotenoids, mainly β-carotene. In addition to the well-known biological actions of vitamin A, it is becoming apparent that nonretinoid apocarotenoids also have the potential to regulate a broad spectrum of critical cellular functions, thus influencing mammalian health. This review discusses the current knowledge about the generation and biological activities of nonretinoid apocarotenoids in mammals.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"153-172"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36089931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 74
Consumption of Sugars, Sugary Foods, and Sugary Beverages in Relation to Cancer Risk: A Systematic Review of Longitudinal Studies. 糖、含糖食品和含糖饮料与癌症风险的关系:一项纵向研究的系统综述。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 Epub Date: 2018-05-25 DOI: 10.1146/annurev-nutr-082117-051805
Nour Makarem, Elisa V Bandera, Joseph M Nicholson, Niyati Parekh
{"title":"Consumption of Sugars, Sugary Foods, and Sugary Beverages in Relation to Cancer Risk: A Systematic Review of Longitudinal Studies.","authors":"Nour Makarem,&nbsp;Elisa V Bandera,&nbsp;Joseph M Nicholson,&nbsp;Niyati Parekh","doi":"10.1146/annurev-nutr-082117-051805","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051805","url":null,"abstract":"<p><p>High sugar intake may increase cancer risk by promoting insulin-glucose dysregulation, oxidative stress, inflammation, and body adiposity, but epidemiologic evidence is unclear. Associations between dietary sugars and lifestyle-related cancer risk from longitudinal studies were evaluated. We systematically searched PubMed, Embase, and CINAHL and identified 37 prospective cohort studies (1990-2017) reporting multivariable adjusted risk estimates for dietary sugars in relation to cancer. Of 15 and 14 studies on total sugar and sucrose respectively, 11 reported a null association in relation to cancer. Of 14 studies on fructose, 8 reported null associations, and 2 reported protective and 4 reported detrimental associations. In two of five studies on added sugars, a 60-95% increased cancer risk was observed with higher intakes. In 8 of 15 studies on sugary foods and beverages, a 23-200% higher cancer risk was observed with higher sugary beverage consumption. In conclusion, most studies were indicative of a null association, but suggestive detrimental associations were reported for added sugars and sugary beverages.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"17-39"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051805","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36131450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 73
Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry. 穿越铁门:转铁蛋白受体为何及如何介导病毒进入。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 Epub Date: 2018-05-31 DOI: 10.1146/annurev-nutr-082117-051749
Marianne Wessling-Resnick
{"title":"Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry.","authors":"Marianne Wessling-Resnick","doi":"10.1146/annurev-nutr-082117-051749","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051749","url":null,"abstract":"Because both the host and pathogen require iron, the innate immune response carefully orchestrates control over iron metabolism to limit its availability during times of infection. Nutritional iron deficiency can impair host immunity, while iron overload can cause oxidative stress to propagate harmful viral mutations. An emerging enigma is that many viruses use the primary gatekeeper of iron metabolism, the transferrin receptor, as a means to enter cells. Why and how this iron gate is a viral target for infection are the focus of this review.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"431-458"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36180286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 118
Iron and Cancer. 铁和癌症。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 DOI: 10.1146/annurev-nutr-082117-051732
Suzy V Torti, David H Manz, Bibbin T Paul, Nicole Blanchette-Farra, Frank M Torti
{"title":"Iron and Cancer.","authors":"Suzy V Torti,&nbsp;David H Manz,&nbsp;Bibbin T Paul,&nbsp;Nicole Blanchette-Farra,&nbsp;Frank M Torti","doi":"10.1146/annurev-nutr-082117-051732","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051732","url":null,"abstract":"<p><p>This review explores the multifaceted role that iron has in cancer biology. Epidemiological studies have demonstrated an association between excess iron and increased cancer incidence and risk, while experimental studies have implicated iron in cancer initiation, tumor growth, and metastasis. The roles of iron in proliferation, metabolism, and metastasis underpin the association of iron with tumor growth and progression. Cancer cells exhibit an iron-seeking phenotype achieved through dysregulation of iron metabolic proteins. These changes are mediated, at least in part, by oncogenes and tumor suppressors. The dependence of cancer cells on iron has implications in a number of cell death pathways, including ferroptosis, an iron-dependent form of cell death. Uniquely, both iron excess and iron depletion can be utilized in anticancer therapies. Investigating the efficacy of these therapeutic approaches is an area of active research that promises substantial clinical impact.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"97-125"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36417331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 259
Bioavailability of Fat-Soluble Vitamins and Phytochemicals in Humans: Effects of Genetic Variation. 人体内脂溶性维生素和植物化学物质的生物利用度:遗传变异的影响。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 DOI: 10.1146/annurev-nutr-082117-051628
Patrick Borel, Charles Desmarchelier
{"title":"Bioavailability of Fat-Soluble Vitamins and Phytochemicals in Humans: Effects of Genetic Variation.","authors":"Patrick Borel,&nbsp;Charles Desmarchelier","doi":"10.1146/annurev-nutr-082117-051628","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082117-051628","url":null,"abstract":"Recent data have shown that interindividual variability in the bioavailability of vitamins A (β-carotene), D, and E, and carotenoids (lutein and lycopene), as well as that of phytosterols, is modulated by single nucleotide polymorphisms (SNPs). The identified SNPs are in or near genes involved in intestinal uptake or efflux of these compounds, as well as in genes involved in their metabolism and transport. The phenotypic effect of each SNP is usually low, but combinations of SNPs can explain a significant part of the variability. Nevertheless, results from these studies should be considered preliminary since they have not been validated in other cohorts. Guidelines for future studies are provided to ensure that sound associations are elucidated that can be used to build consolidated genetic scores that may allow recommended dietary allowances to be tailored to individuals or groups by taking into account the multiloci genotypic signature of people of different ethnic origin or even of individuals.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"69-96"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082117-051628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36417377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
Nuclear Folate Metabolism. 核叶酸代谢。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2018-08-21 DOI: 10.1146/annurev-nutr-071714-034441
Martha S Field, Elena Kamynina, James Chon, Patrick J Stover
{"title":"Nuclear Folate Metabolism.","authors":"Martha S Field,&nbsp;Elena Kamynina,&nbsp;James Chon,&nbsp;Patrick J Stover","doi":"10.1146/annurev-nutr-071714-034441","DOIUrl":"https://doi.org/10.1146/annurev-nutr-071714-034441","url":null,"abstract":"<p><p>Despite unequivocal evidence that folate deficiency increases risk for human pathologies, and that folic acid intake among women of childbearing age markedly decreases risk for birth defects, definitive evidence for a causal biochemical pathway linking folate to disease and birth defect etiology remains elusive. The de novo and salvage pathways for thymidylate synthesis translocate to the nucleus of mammalian cells during S- and G2/M-phases of the cell cycle and associate with the DNA replication and repair machinery, which limits uracil misincorporation into DNA and genome instability. There is increasing evidence that impairments in nuclear de novo thymidylate synthesis occur in many pathologies resulting from impairments in one-carbon metabolism. Understanding the roles and regulation of nuclear de novo thymidylate synthesis and its relationship to genome stability will increase our understanding of the fundamental mechanisms underlying folate- and vitamin B<sub>12</sub>-associated pathologies.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"38 ","pages":"219-243"},"PeriodicalIF":8.9,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-071714-034441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36417380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
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