Annual review of nutrition最新文献

Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention. 十字花科蔬菜、生物活性代谢物和微生物组预防乳腺癌。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 DOI: 10.1146/annurev-nutr-062222-024321

Emily Ho, Carmen P Wong, John A Bouranis, Jackilen Shannon, Zhenzhen Zhang

{"title":"Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention.","authors":"Emily Ho, Carmen P Wong, John A Bouranis, Jackilen Shannon, Zhenzhen Zhang","doi":"10.1146/annurev-nutr-062222-024321","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062222-024321","url":null,"abstract":"Breast cancer is a heterogeneous disease with varying subtypes, prognoses, and treatment responses. Cruciferous vegetables have shown promise in reducing breast cancer risk. This review discusses (a) the efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast cancer risk, prognosis, and treatment outcomes in recent human studies through 2024; (b) preclinical studies (2018-2024) that evaluate the efficacy and synergism of SFN, DIM, and other phytochemicals with conventional breast cancer treatments as promising combination therapy strategies for validation in future clinical trials; and (c) the role of the microbiome in breast cancer and the interaction between interindividual variations in gut microbiome and glucosinolate metabolism that could modify the benefits of cruciferous vegetable consumption and breast cancer treatment efficacy. Integrating cruciferous vegetables and their bioactive compounds in light of an individual's microbiome profile as a complementary approach alongside standard treatments is a promising strategy in breast cancer care.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"45 1","pages":"171-195"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Autoimmunity Epidemic: The Role of Immunometabolism. 肥胖与自身免疫流行：免疫代谢的作用。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-05 DOI: 10.1146/annurev-nutr-111324-122456

Alessandra Colamatteo, Clorinda Fusco, Alessandro Matarese, Giuseppe Matarese

{"title":"Obesity and Autoimmunity Epidemic: The Role of Immunometabolism.","authors":"Alessandra Colamatteo, Clorinda Fusco, Alessandro Matarese, Giuseppe Matarese","doi":"10.1146/annurev-nutr-111324-122456","DOIUrl":"10.1146/annurev-nutr-111324-122456","url":null,"abstract":"The relationship between obesity and autoimmune diseases has attracted significant attention in recent years, highlighting the multifaceted connection between metabolic dysregulation and loss of self-immune tolerance. Compelling epidemiological evidence has revealed an elevated prevalence of autoimmune diseases among overweight or obese individuals, suggesting a potential causal link. Mechanistically, adipose tissue is a key immunometabolic organ that secretes an array of adipocytokines that can facilitate proinflammatory immune responses against self-antigens. Indeed, adipose tissue dysfunction in obesity fosters a state of chronic low-grade inflammation, which may contribute to the so-called accelerator hypothesis, in which circulating self-autoreactive T cells can easily lose their regulatory mechanisms, resulting in self-tissue damage and autoinflammation. In this review, we elucidate the intricate immunometabolic pathomechanisms underlying the obesity and autoimmunity epidemic, and we explore innovative therapeutic avenues that could be pivotal for advancing public health initiatives in the context of this epidemic.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"115-140"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral and Economic Interventions: A Path to Improved Dietary Behaviors. 行为和经济干预：改善饮食行为的途径。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI: 10.1146/annurev-nutr-111124-101104

Hanin Hosni, Marco A Palma, Michelle S Segovia

引用次数: 0

Human Nutrition in the Spotlight. 聚光灯下的人类营养。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 DOI: 10.1146/annurev-nutr-052725-110837

Patrick J Stover

引用次数: 0

Unique Energy Profile Associated with Persistent Thin Phenotype. 与持久瘦表型相关的独特能量谱。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-06 DOI: 10.1146/annurev-nutr-111824-014837

Mélina Bailly, David Thivel, Laurie Isacco, Julien Verney

{"title":"Unique Energy Profile Associated with Persistent Thin Phenotype.","authors":"Mélina Bailly, David Thivel, Laurie Isacco, Julien Verney","doi":"10.1146/annurev-nutr-111824-014837","DOIUrl":"10.1146/annurev-nutr-111824-014837","url":null,"abstract":"The concept of constitutional thinness first emerged in the scientific literature at the beginning of the 20th century. Yet, this concept of a physiologically determined thinness, which clearly differentiated it from anorexia nervosa and challenged the basic notions of metabolism, intrigued the medical community. How could a young, healthy person with normal food intake present such an underweight state that resists body-weight gain? Due to either skepticism or disinterest, the fact remains that fewer than 50 clinical studies have focused on constitutional thinness in the last 90 years, contrasting with the hundreds of thousands conducted on the other end of the weight status spectrum (obesity). The aim of this review is to discuss current evidence of various aspects of this persistent thin phenotype, from its definition and diagnosis to its metabolic and physiological mechanisms. A deeper understanding of constitutional thinness would facilitate medical/societal recognition and clinical management of this condition. Greater insight into constitutional thinness could also help identify metabolic patterns that may be protective in the current context of the global obesity pandemic and its related critical health implications. Constitutional thinness stands out as a unique model questioning basic dogmatic knowledge about energy balance and metabolism.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"65-91"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Outcomes of Produce Prescription Programs Associated with Gus Schumacher Nutrition Incentive Program Funding. 与格斯·舒马赫营养激励计划资金相关的农产品处方项目的健康结果。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-12 DOI: 10.1146/annurev-nutr-111124-092627

Carmen Byker Shanks, Michelle S Park, Amy L Yaroch, Eliza Short, Hilary K Seligman

{"title":"Health Outcomes of Produce Prescription Programs Associated with Gus Schumacher Nutrition Incentive Program Funding.","authors":"Carmen Byker Shanks, Michelle S Park, Amy L Yaroch, Eliza Short, Hilary K Seligman","doi":"10.1146/annurev-nutr-111124-092627","DOIUrl":"10.1146/annurev-nutr-111124-092627","url":null,"abstract":"The US Department of Agriculture's Gus Schumacher Nutrition Incentive Program (GusNIP) funds produce prescription (PPR) programs that allow healthcare to support patients in accessing fruits and vegetables. This hybrid systematic narrative review identified 16 studies of PPR programs associated with GusNIP funding in some way that examined health outcomes, including clinical measures and healthcare utilization. Program designs were heterogeneous, sample sizes were generally small, and methodological rigor was often low, with most studies using a prepost design and none using a randomized control group. Fewer than half of the studies examining clinical values showed an association between PPR participation and improved health outcomes (for example, three of eight studies measuring weight or body mass index showed a statistically significant reduction, as well as two of the six studies measuring glycosylated hemoglobin). Only three studies examined healthcare utilization, two of which showed improvements in hospitalization and/or emergency department utilization. Overall, evidence for the health impact of PPRs is nascent but growing. PPRs with capacity should engage in rigorous study designs and examine a variety of downstream health and utilization outcomes.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"319-333"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate Change, Extreme Weather Events, Food Security, and Nutrition: Evolving Relationships and Critical Challenges. 气候变化、极端天气事件、粮食安全和营养：不断演变的关系和关键挑战。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-04-16 DOI: 10.1146/annurev-nutr-111324-111252

Jessica Fanzo, Bianca Carducci, Jochebed Louis-Jean, Mario Herrero, Kevin Karl, Cynthia Rosenzweig

{"title":"Climate Change, Extreme Weather Events, Food Security, and Nutrition: Evolving Relationships and Critical Challenges.","authors":"Jessica Fanzo, Bianca Carducci, Jochebed Louis-Jean, Mario Herrero, Kevin Karl, Cynthia Rosenzweig","doi":"10.1146/annurev-nutr-111324-111252","DOIUrl":"10.1146/annurev-nutr-111324-111252","url":null,"abstract":"Climate change, also known as global warming, poses significant challenges to the planet and humanity. With further warming, every region across the world is projected to increasingly experience concurrent and multiple changes in climate, compounding overall risk. Long-term climate change and near-term extreme weather events have multiple negative effects on food security, diets, and nutrition via complex, multidirectional pathways through food, health, water, and social protection systems. However, measuring climate-attributable malnutrition impacts, especially among the most vulnerable populations, remains challenging. Changes in climate across a range of geographies have been modeled, projected, and observed showing detrimental associations with dietary and nutrition outcomes, particularly undernutrition. Many undernourished populations are climate vulnerable due to a variety of determinants challenging their ability to adapt to impending risks. While nutrition integration within climate adaptation plans has lagged, there is momentum for robust collaboration between climate and nutrition communities to fill data gaps that are critical for joint decision-making.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"335-360"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-Restricted Diets and Their Impact on Metabolic Health and Aging. 蛋白质限制饮食及其对代谢健康和衰老的影响。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-13 DOI: 10.1146/annurev-nutr-121624-114918

Sora Q Kim, Redin A Spann, Cristal M Hill, Claire E Berryman, Hans-Rudolf Berthoud, David H McDougal, Yanlin He, Heike Münzberg, Sangho Yu, Christopher D Morrison

{"title":"Protein-Restricted Diets and Their Impact on Metabolic Health and Aging.","authors":"Sora Q Kim, Redin A Spann, Cristal M Hill, Claire E Berryman, Hans-Rudolf Berthoud, David H McDougal, Yanlin He, Heike Münzberg, Sangho Yu, Christopher D Morrison","doi":"10.1146/annurev-nutr-121624-114918","DOIUrl":"10.1146/annurev-nutr-121624-114918","url":null,"abstract":"Recent improvements in human longevity have highlighted the challenge of maintaining health throughout extended lifespans. This review examines how organisms regulate nutrient intake and metabolism, focusing on dietary protein's unique role in health and longevity. While caloric restriction enhances longevity, adherence to a low-calorie diet is challenging. Protein restriction represents an alternate nutritional intervention that improves longevity and health in model organisms and may be easier to translate to humans. However, its impacts are complex, and its mechanisms are poorly understood. The beneficial effects of protein restriction on metabolism and longevity may come at a cost to lean mass and physical resilience. Conversely, while public health recommendations often emphasize high protein intake, human epidemiological data and work on model organisms suggest that excessive protein consumption correlates with increased mortality. Understanding this paradox is crucial for developing evidence-based protein intake recommendations that balance longevity with physical performance.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"269-297"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural Considerations in Assessing Dietary Intake in Racially, Ethnically, or Socioeconomically Diverse Populations. 评估不同种族、民族或社会经济背景人群饮食摄入的文化因素。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1146/annurev-nutr-111424-112604

Katherine L Tucker, Sabrina E Noel

引用次数: 0

Dietary Patterns and Brain Aging: Enthusiasm Before Evidence? 饮食模式与大脑衰老：证据面前的热情？

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 DOI: 10.1146/annurev-nutr-013125-030429

Sarah L Booth, Laural K English, Nicole A Reigh, Paul F Jacques, Brent P Forester, M Kyla Shea

引用次数: 0