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Annual review of nutrition最新文献

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Introduction. 介绍。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 DOI: 10.1146/annurev-nutr-042826-022759
Patrick J Stover
{"title":"Introduction.","authors":"Patrick J Stover","doi":"10.1146/annurev-nutr-042826-022759","DOIUrl":"https://doi.org/10.1146/annurev-nutr-042826-022759","url":null,"abstract":"","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"46 1","pages":"i-ii"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Paradox and Future of GLP-1/GIP Combination Therapies: Efficacy and Mechanisms. GLP-1/GIP联合治疗的悖论和未来：疗效和机制。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-21 DOI: 10.1146/annurev-nutr-061824-043740
Iona Davies, Jens J Holst, Mette M Rosenkilde, Tricia M M Tan
{"title":"The Paradox and Future of GLP-1/GIP Combination Therapies: Efficacy and Mechanisms.","authors":"Iona Davies, Jens J Holst, Mette M Rosenkilde, Tricia M M Tan","doi":"10.1146/annurev-nutr-061824-043740","DOIUrl":"10.1146/annurev-nutr-061824-043740","url":null,"abstract":"<p><p>Glucagon-like peptide-1 (GLP-1)-based obesity pharmacotherapies have revolutionized obesity treatment. In this review, we discuss the discovery of GLP-1 and evaluate the efficacy of marketed and investigational GLP-1 receptor (GLP-1R) agonists (GLP-1RAs), most notably semaglutide, as well as their potential central mechanism of action. We highlight the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide and the GLP-1RA/GIPR antagonist maridebart cafraglutide, discussing how both methods of GIPR targeting can produce beneficial metabolic effects. The lack of evidence for the anorectic effects of GIPR agonism or antagonism alone in humans is noted, and the review concludes with an evaluation of other reasons for the greater efficacy of GIPR/GLP-1R dual targeting compounds over semaglutide.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"387-414"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolite Damage and Repair in Health and Disease. 健康与疾病中的代谢物损伤与修复。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-28 DOI: 10.1146/annurev-nutr-062024-123639
Carole L Linster, Maria Veiga-da-Cunha, Thomas D Niehaus, Guido T Bommer, Emile Van Schaftingen
{"title":"Metabolite Damage and Repair in Health and Disease.","authors":"Carole L Linster, Maria Veiga-da-Cunha, Thomas D Niehaus, Guido T Bommer, Emile Van Schaftingen","doi":"10.1146/annurev-nutr-062024-123639","DOIUrl":"10.1146/annurev-nutr-062024-123639","url":null,"abstract":"<p><p>Metabolite repair, or metabolite damage control, has emerged as a fundamental pillar of intermediary metabolism alongside catalysis and regulation. Enzyme promiscuity and spontaneous chemical reactions inevitably generate abnormal metabolites that can interfere with classical metabolic processes. Dedicated metabolite repair enzymes prevent or reverse such damage, thereby preserving metabolic integrity. Defects in these systems define a growing class of inborn errors of metabolism, several of which are now clinically recognized and, in some cases, treatable. We summarize recent advances in the discovery and characterization of metabolite damage and repair systems in the tricarboxylic acid cycle, glycolysis, and other pathways, highlighting examples with established or potential links to human disease. We outline strategies for identifying additional metabolite repair defects and discuss diagnostic challenges, therapeutic perspectives, and connections between metabolite repair and aging. Understanding metabolite repair exposes the mechanisms that safeguard metabolism and opens new paths toward molecular diagnosis and targeted therapy.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"19-48"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraprocessed Foods and the Aging Brain: State of the Science. 超加工食品和大脑老化：科学现状。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-15 DOI: 10.1146/annurev-nutr-061824-053453
Owen T Carmichael, Puja Agarwal, Benedict C Albensi, Vyshnavy Balendra, Nathan M D'Cunha, Diandra N Denier-Fields, Naomi Vidal Ferreira, Natalia Gomes Gonçalves, Rashi Kumar, Corinne Labyak, Susanna Lopez, Mychael V Lourenco, Ilianna Lourida, Rishav Nag, Zuzana Nedelska, Juliet Nnenda Olayinka, Jung Hyun Park, Kayalvizhi Rajendran, Ashley Shaw, Hom Lal Shrestha, Aaron N Smith, Natalia Soldevila-Domenech, Débora G Souza, Claudia Kimie Suemoto, Jodi R Titiner, Rafael de la Torre, Debora Melo van Lent
{"title":"Ultraprocessed Foods and the Aging Brain: State of the Science.","authors":"Owen T Carmichael, Puja Agarwal, Benedict C Albensi, Vyshnavy Balendra, Nathan M D'Cunha, Diandra N Denier-Fields, Naomi Vidal Ferreira, Natalia Gomes Gonçalves, Rashi Kumar, Corinne Labyak, Susanna Lopez, Mychael V Lourenco, Ilianna Lourida, Rishav Nag, Zuzana Nedelska, Juliet Nnenda Olayinka, Jung Hyun Park, Kayalvizhi Rajendran, Ashley Shaw, Hom Lal Shrestha, Aaron N Smith, Natalia Soldevila-Domenech, Débora G Souza, Claudia Kimie Suemoto, Jodi R Titiner, Rafael de la Torre, Debora Melo van Lent","doi":"10.1146/annurev-nutr-061824-053453","DOIUrl":"10.1146/annurev-nutr-061824-053453","url":null,"abstract":"<p><p>Ultraprocessed foods (UPFs), which feature reductions in naturally occurring food components (fiber, phytochemicals) as well as the addition of fat, sugar, salt, and artificial food components (colorings, preservatives) are consumed in large quantities globally. Although a growing body of research has suggested that higher levels of UPF consumption are associated with poorer cardiometabolic outcomes, literature synthesizing the evidence that UPF consumption has negative effects on the aging brain has been scarce. This review provides a comprehensive view of the evidence connecting UPF consumption to downstream consequences for the brain in aging, including proposed mechanisms of action, evidence supporting those mechanisms from basic science studies, and clinical evidence. We then survey current challenges and opportunities in the study of brain aging effects of UPF consumption and provide recommendations for researchers and policymakers.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"533-561"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Intake of Plant Bioactives. 植物生物活性物质的膳食摄入量。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-13 DOI: 10.1146/annurev-nutr-070225-031119
Costanza Michelini, Alice Rosi, Nicola Bragazzi, Daniele Del Rio, Pedro Mena
{"title":"Dietary Intake of Plant Bioactives.","authors":"Costanza Michelini, Alice Rosi, Nicola Bragazzi, Daniele Del Rio, Pedro Mena","doi":"10.1146/annurev-nutr-070225-031119","DOIUrl":"10.1146/annurev-nutr-070225-031119","url":null,"abstract":"<p><p>This review provides a comprehensive overview of dietary plant bioactive intake among populations. Plant-based diets are rich in bioactive phytochemicals such as (poly)phenols, carotenoids, alkaloids, glucosinolates, and many other molecules scarcely assessed. Despite the recognized health benefits attributed to most phytochemicals, there is a considerable lack of information on the intake of these food bioactives across different populations. When available, data indicate that the intake of plant bioactives may be influenced by factors such as dietary habits, age, sex/gender, ethnicity, and cultural practices. Most information available regards (poly)phenols and carotenoids, as well as some specific compounds of interest because of commercial or safety aspects. This work represents a pioneering effort to compile comprehensive data on the intake of dietary plant bioactives, thereby contributing to the body of scientific knowledge and informing future research on these dietary components of nutritional interest.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"229-261"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Diet on Cancer Progression and Treatment. 饮食对癌症进展及治疗的影响。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-26 DOI: 10.1146/annurev-nutr-062122-021518
Anna M Barbeau, John W R Kincaid, Alissandra L Hillis, Edrees H Rashan, Yichi Zhang, Gillian E Oaks, Matthew G Vander Heiden
{"title":"The Influence of Diet on Cancer Progression and Treatment.","authors":"Anna M Barbeau, John W R Kincaid, Alissandra L Hillis, Edrees H Rashan, Yichi Zhang, Gillian E Oaks, Matthew G Vander Heiden","doi":"10.1146/annurev-nutr-062122-021518","DOIUrl":"10.1146/annurev-nutr-062122-021518","url":null,"abstract":"<p><p>Growing evidence suggests that dietary interventions can influence cancer progression and patient outcomes. Here, we discuss mechanistic links between diet and cancer biology including those related to systemic hormone signaling, modulation of nutrient availability within the tumor microenvironment, and interactions with the immune system and microbiome, while highlighting their interconnectedness. Further, we review preclinical and clinical data evaluating specific diets, including their use with cancer therapies. Given the interest in diet as an adjunct to cancer care, it is essential to establish evidence-based dietary strategies for optimizing patient outcomes and quality of life.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"357-386"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Bariatric Surgery and Obesity Medicines on Human Eating Behavior. 减肥手术和肥胖药物对人类饮食行为的影响。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-15 DOI: 10.1146/annurev-nutr-070225-105258
Francisca Contreras Hernández, Itxaso Villelabeitia, Isabelle Levine, Carel W le Roux, Alexander D Miras, Ruth K Price
{"title":"Effects of Bariatric Surgery and Obesity Medicines on Human Eating Behavior.","authors":"Francisca Contreras Hernández, Itxaso Villelabeitia, Isabelle Levine, Carel W le Roux, Alexander D Miras, Ruth K Price","doi":"10.1146/annurev-nutr-070225-105258","DOIUrl":"10.1146/annurev-nutr-070225-105258","url":null,"abstract":"<p><p>Obesity is a chronic disease driven by complex neurohormonal and behavioral mechanisms that regulate adipocyte mass by impacting appetite, food reward, and ingestive patterns. This review synthesizes evidence from objective, rather than verbal report-based, methodologies examining how bariatric surgery and obesity medicines modify human eating behavior. Roux-en-Y gastric bypass and sleeve gastrectomy consistently reduce total energy intake through sustained reductions in meal size and eating rate, without systematic changes in meal initiation or macronutrient selection. In small cohorts where food choices did shift, alterations were associated with greater weight loss, highlighting interindividual variability. GLP-1-based therapy similarly reduces energy intake and improves appetitive behavior through strengthened gut-brain signaling, whereas naltrexone/bupropion primarily targets central reward circuits. Overall, bariatric surgery leads to reduced intake without altering food choices, suggesting a benefit from eating \"less of the same,\" whereas equivalent conclusions for obesity medicines remain premature due to limited direct evidence.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"339-356"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lac-Phe: An Exercise Hormone for Metabolic Regulation. lacc - phe：代谢调节的运动激素。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 DOI: 10.1146/annurev-nutr-061824-054717
Qingzhuo Liu, Yong Xu
{"title":"Lac-Phe: An Exercise Hormone for Metabolic Regulation.","authors":"Qingzhuo Liu, Yong Xu","doi":"10.1146/annurev-nutr-061824-054717","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061824-054717","url":null,"abstract":"<p><p><i>N</i>-Lactoyl-phenylalanine (Lac-Phe), a conserved exercise-induced metabolite that rises rapidly in circulation, has emerged as a key molecular mediator linking fundamental metabolism to translational medicine. In this review, we elaborate recent findings that define a two-step framework for Lac-Phe biosynthesis and excretion. Functional studies show that Lac-Phe exerts broad metabolic benefits and should be regarded as a bioactive molecule rather than a passive by-product of intermediary metabolism. Furthermore, we review the neural mechanisms through which Lac-Phe conveys peripheral metabolic cues to central circuits regulating appetite and energy balance. Beyond the role of Lac-Phe in energy balance, alterations in Lac-Phe concentrations are associated with disease pathogenesis and progression, underscoring its potential as both a biomarker and a therapeutic agent. Collectively, these advances position Lac-Phe at the intersection of exercise physiology, metabolism, and disease and thus highlight its potential to integrate metabolic and physiological health.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"46 1","pages":"153-175"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in What Americans Eat. 美国人饮食的趋势
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 DOI: 10.1146/annurev-nutr-062024-124301
Heather A Eicher-Miller
{"title":"Trends in What Americans Eat.","authors":"Heather A Eicher-Miller","doi":"10.1146/annurev-nutr-062024-124301","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062024-124301","url":null,"abstract":"<p><p>Determining trends in what Americans eat is important for determining shortfalls, assessing overconsumption, developing dietary guidance, creating dietary interventions, informing nutrition education and food product design, and understanding dietary risks to health, among other reasons. This review uses a historical lens to consider the early estimation of diet, specifically the intake of certain nutrients in small samples of US males, as well as the nationally representative estimation and tracking of usual dietary patterns, including dietary quality and beverage and food group intake among population groups. The trends in what Americans eat currently and over time are synthesized with evidence of how the factors of age, sex, race/ethnicity, and income may or may not differentiate food and beverage intake and which are most influential to meeting dietary recommendations. The results provide a rich context to inform future trends, dietary needs, and improvement.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"46 1","pages":"483-504"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mammalian 2-Oxo Acid Dehydrogenase Complexes in Metabolic Regulation and Signaling. 哺乳动物2-氧酸脱氢酶复合物的代谢调节和信号传导。
IF 13.3 2区 医学
Annual review of nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-06 DOI: 10.1146/annurev-nutr-061824-065013
Victoria I Bunik
{"title":"Mammalian 2-Oxo Acid Dehydrogenase Complexes in Metabolic Regulation and Signaling.","authors":"Victoria I Bunik","doi":"10.1146/annurev-nutr-061824-065013","DOIUrl":"10.1146/annurev-nutr-061824-065013","url":null,"abstract":"<p><p>2-Oxo acid dehydrogenase complexes include four members that oxidatively decarboxylate pyruvate, 2-oxoglutarate, 2-oxoadipate, and branched-chain 2-oxo acids. The complexes produce CO<sub>2</sub>, acylated coenzyme A, and NADH through consecutive action of three enzymes with their coenzymes: 2-oxo acid dehydrogenase with thiamine diphosphate, dihydrolipoyllysine-residue acyltransferase with the lipoyllysine prosthetic group, and dihydrolipoyl dehydrogenase with FAD. Some of the complexes include additional regulatory proteins. Producing energy in the form of NADH and acyl-CoAs, which are feedback inhibitors, the complexes mediate the Ca2+ activation of mitochondrial function, couple metabolism of glucose and amino acids, are essential for biosynthesis of the signaling molecules acetylcholine and glutamate, regulate metabolism through posttranslational acylations, including histone acylations, and sense the metabolic imbalance as nonoptimal ratios of their substrates and products. The complexes signal the imbalance by the generation of reactive species: O<sub>2</sub>•-, thiyl radicals, thiamine-dependent carbon radicals, and/or peracids, potentially involved in DNA damage and development of diseases.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"263-287"},"PeriodicalIF":13.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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