Annual review of nutrition最新文献

Behavioral and Economic Interventions: A Path to Improved Dietary Behaviors. 行为和经济干预：改善饮食行为的途径。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-14 DOI: 10.1146/annurev-nutr-111124-101104

Hanin Hosni, Marco A Palma, Michelle S Segovia

引用次数: 0

Interplay Between Dietary Bioactive Compounds and Gut Microbiota in Modulating Obesity-Associated Inflammation and Metabolic Dysfunction. 膳食生物活性化合物和肠道微生物群在调节肥胖相关炎症和代谢功能障碍中的相互作用。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-14 DOI: 10.1146/annurev-nutr-111224-024937

Maryam Seifishahpar, Nishan Sudheera Kalupahana, Jung Han Kim, Naima Moustaid-Moussa

{"title":"Interplay Between Dietary Bioactive Compounds and Gut Microbiota in Modulating Obesity-Associated Inflammation and Metabolic Dysfunction.","authors":"Maryam Seifishahpar, Nishan Sudheera Kalupahana, Jung Han Kim, Naima Moustaid-Moussa","doi":"10.1146/annurev-nutr-111224-024937","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111224-024937","url":null,"abstract":"Dietary bioactive compounds such as omega-3 polyunsaturated fatty acids and phytochemicals have numerous health benefits, which include alleviating obesity-associated inflammation and metabolic dysfunction. While mechanistic studies have focused thus far on how these compounds or their metabolites affect whole-animal physiology or exert tissue-specific effects, detailed reports are lacking about how these bioactives specifically affect gut microbiota and mitochondrial function, two important processes impacted by metabolic diseases. Gut microbiota, through their composition and metabolites, play a significant role in overall health and mediating the effects of diet. Therefore, understanding how dietary bioactive compounds modulate gut microbiota is crucial for elucidating their contributions to metabolic health. Conversely, gut microbiota may also alter the metabolism of bioactives, especially phytochemicals, and impact their bioavailability and function. Mitochondria, particularly in adipose tissue, play a central role in energy metabolism and are implicated in the development of obesity-associated metabolic dysfunction. Thus, investigating the effects of dietary bioactive compounds on mitochondrial function provides valuable insight into their potential roles in addressing obesity-related diseases. Accordingly, the goal of this review is to discuss key published work on the interplay between dietary bioactives, gut microbiota and their metabolites, and mitochondria function in the context of improving obesity-associated inflammation and metabolic dysfunction.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Make America Healthy, Again? The Past, Present and Future of Dietary Guidelines. 让美国再次健康？膳食指南的过去、现在和未来。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-14 DOI: 10.1146/annurev-nutr-020725-113350

Kevin C Klatt

引用次数: 0

Protein-Restricted Diets and Their Impact on Metabolic Health and Aging. 蛋白质限制饮食及其对代谢健康和衰老的影响。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-13 DOI: 10.1146/annurev-nutr-121624-114918

Sora Q Kim, Redin A Spann, Cristal M Hill, Claire E Berryman, Hans-Rudolf Berthoud, David H McDougal, Yanlin He, Heike Münzberg, Sangho Yu, Christopher D Morrison

{"title":"Protein-Restricted Diets and Their Impact on Metabolic Health and Aging.","authors":"Sora Q Kim, Redin A Spann, Cristal M Hill, Claire E Berryman, Hans-Rudolf Berthoud, David H McDougal, Yanlin He, Heike Münzberg, Sangho Yu, Christopher D Morrison","doi":"10.1146/annurev-nutr-121624-114918","DOIUrl":"https://doi.org/10.1146/annurev-nutr-121624-114918","url":null,"abstract":"Recent improvements in human longevity have highlighted the challenge of maintaining health throughout extended lifespans. This review examines how organisms regulate nutrient intake and metabolism, focusing on dietary protein's unique role in health and longevity. While caloric restriction enhances longevity, adherence to a low-calorie diet is challenging. Protein restriction represents an alternate nutritional intervention that improves longevity and health in model organisms and may be easier to translate to humans. However, its impacts are complex, and its mechanisms are poorly understood. The beneficial effects of protein restriction on metabolism and longevity may come at a cost to lean mass and physical resilience. Conversely, while public health recommendations often emphasize high protein intake, human epidemiological data and work on model organisms suggest that excessive protein consumption correlates with increased mortality. Understanding this paradox is crucial for developing evidence-based protein intake recommendations that balance longevity with physical performance.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Outcomes of Produce Prescription Programs Associated with Gus Schumacher Nutrition Incentive Program Funding. 与格斯·舒马赫营养激励计划资金相关的农产品处方项目的健康结果。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-12 DOI: 10.1146/annurev-nutr-111124-092627

Carmen Byker Shanks, Michelle S Park, Amy L Yaroch, Eliza Short, Hilary K Seligman

{"title":"Health Outcomes of Produce Prescription Programs Associated with Gus Schumacher Nutrition Incentive Program Funding.","authors":"Carmen Byker Shanks, Michelle S Park, Amy L Yaroch, Eliza Short, Hilary K Seligman","doi":"10.1146/annurev-nutr-111124-092627","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111124-092627","url":null,"abstract":"The US Department of Agriculture's Gus Schumacher Nutrition Incentive Program (GusNIP) funds produce prescription (PPR) programs that allow healthcare to support patients in accessing fruits and vegetables. This hybrid systematic narrative review identified 16 studies of PPR programs associated with GusNIP funding in some way that examined health outcomes, including clinical measures and healthcare utilization. Program designs were heterogeneous, sample sizes were generally small, and methodological rigor was often low, with most studies using a prepost design and none using a randomized control group. Fewer than half of the studies examining clinical values showed an association between PPR participation and improved health outcomes (for example, three of eight studies measuring weight or body mass index showed a statistically significant reduction, as well as two of the six studies measuring glycosylated hemoglobin). Only three studies examined healthcare utilization, two of which showed improvements in hospitalization and/or emergency department utilization. Overall, evidence for the health impact of PPRs is nascent but growing. PPRs with capacity should engage in rigorous study designs and examine a variety of downstream health and utilization outcomes.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unique Energy Profile Associated with Persistent Thin Phenotype. 与持久瘦表型相关的独特能量谱。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-06 DOI: 10.1146/annurev-nutr-111824-014837

Mélina Bailly, David Thivel, Laurie Isacco, Julien Verney

{"title":"Unique Energy Profile Associated with Persistent Thin Phenotype.","authors":"Mélina Bailly, David Thivel, Laurie Isacco, Julien Verney","doi":"10.1146/annurev-nutr-111824-014837","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111824-014837","url":null,"abstract":"The concept of constitutional thinness first emerged in the scientific literature at the beginning of the 20th century. Yet, this concept of a physiologically determined thinness, which clearly differentiated it from anorexia nervosa and challenged the basic notions of metabolism, intrigued the medical community. How could a young, healthy person with normal food intake present such an underweight state that resists body-weight gain? Due to either skepticism or disinterest, the fact remains that fewer than 50 clinical studies have focused on constitutional thinness the last 90 years, contrasting with the hundreds of thousands conducted on the other end of the weight status spectrum (obesity). The aim of this review is to discuss current evidence of various aspects of this persistent thin phenotype, from its definition and diagnosis to its metabolic and physiological mechanisms. A deeper understanding of constitutional thinness would facilitate medical/societal recognition and clinical management of this condition. Greater insight into constitutional thinness could also help identify metabolic patterns that may be protective in the current context of the global obesity pandemic and its related critical health implications. Constitutional thinness stands out as a unique model questioning basic dogmatic knowledge about energy balance and metabolism.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Adipose Tissue Metabolism During Fasting. 禁食期间脂肪组织代谢的调节。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-06 DOI: 10.1146/annurev-nutr-120524-013857

Philip M M Ruppert, Sander Kersten

引用次数: 0

Obesity and Autoimmunity Epidemic: The Role of Immunometabolism. 肥胖与自身免疫流行：免疫代谢的作用。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-05 DOI: 10.1146/annurev-nutr-111324-122456

Alessandra Colamatteo, Clorinda Fusco, Alessandro Matarese, Giuseppe Matarese

{"title":"Obesity and Autoimmunity Epidemic: The Role of Immunometabolism.","authors":"Alessandra Colamatteo, Clorinda Fusco, Alessandro Matarese, Giuseppe Matarese","doi":"10.1146/annurev-nutr-111324-122456","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111324-122456","url":null,"abstract":"The relationship between obesity and autoimmune diseases has attracted significant attention in recent years, highlighting the multifaceted connection between metabolic dysregulation and loss of self-immune tolerance. Compelling epidemiological evidence has revealed an elevated prevalence of autoimmune diseases among overweight or obese individuals, suggesting a potential causal link. Mechanistically, adipose tissue is a key immunometabolic organ that secretes an array of adipocytokines that can facilitate proinflammatory immune responses against self-antigens. Indeed, adipose tissue dysfunction in obesity fosters a state of chronic low-grade inflammation, which may contribute to the so-called accelerator hypothesis, in which circulating self-autoreactive T cells can easily lose their regulatory mechanisms, resulting in self-tissue damage and autoinflammation. In this review, we elucidate the intricate immunometabolic pathomechanisms underlying the obesity and autoimmunity epidemic, and we explore innovative therapeutic avenues that could be pivotal for advancing public health initiatives in the context of this epidemic.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural Considerations in Assessing Dietary Intake in Racially, Ethnically, or Socioeconomically Diverse Populations. 评估不同种族、民族或社会经济背景人群饮食摄入的文化因素。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-02 DOI: 10.1146/annurev-nutr-111424-112604

Katherine L Tucker, Sabrina E Noel

{"title":"Cultural Considerations in Assessing Dietary Intake in Racially, Ethnically, or Socioeconomically Diverse Populations.","authors":"Katherine L Tucker, Sabrina E Noel","doi":"10.1146/annurev-nutr-111424-112604","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111424-112604","url":null,"abstract":"The United States is experiencing rapid growth of racial and ethnic minority aging populations, with implications for health disparities research, as many of these groups experience excess prevalence of chronic diseases. The reasons for health disparities are multifactorial, including social determinants of health, with nutrition playing a critical role. The current inadequacy of dietary assessment methods limits this research. Evidence from food frequency questionnaires with multiethnic studies consistently shows lower validity among minority adults, even with some adaptation, relative to non-Hispanic White adults. This is likely to introduce not only error but also bias in estimates. In addition to adding foods, culturally specific recipes and portion sizes must be considered. Among those with low education, careful data collection with trained interviewers is essential. Important barriers to change include limited access to healthy foods, cultural preferences that influence dietary choices, and limited nutrition knowledge. Rediscovering traditional foodways may be an effective tool.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Insights into Folate-Vitamin B₁₂ Interactions. 叶酸-维生素B12相互作用的新见解。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2025-05-02 DOI: 10.1146/annurev-nutr-120524-043056

Luisa F Castillo, Caitlyn M Pelletier, Katarina E Heyden, Martha S Field

{"title":"New Insights into Folate-Vitamin B12 Interactions.","authors":"Luisa F Castillo, Caitlyn M Pelletier, Katarina E Heyden, Martha S Field","doi":"10.1146/annurev-nutr-120524-043056","DOIUrl":"https://doi.org/10.1146/annurev-nutr-120524-043056","url":null,"abstract":"Folate and vitamin B12 (B12) are essential cofactors in folate-mediated one-carbon metabolism (FOCM). FOCM includes a series of methyl transfer reactions for methionine regeneration and de novo synthesis of nucleotides, including thymidylate. Deficiency in either folate or B12 can result in negative health outcomes including megaloblastic anemia, with additional neurocognitive impairments observed as a result of B12 deficiency. While folate deficiency is not common in the United States due to mandatory folic acid fortification, B12 deficiency is observed more frequently, particularly in certain subpopulations such as vegetarians/vegans and older adults. Fortification of the food supply with folic acid has been effective to increase folate status and reduce the incidence of birth defects. However, consumption of fortified foods and use of dietary supplements containing folic acid have led to an increase in the proportion of individuals exceeding the tolerable upper intake level of folic acid. Although the interaction between folate and B12 has been appreciated for decades in relation to megaloblastic anemia, it has been recently proposed that elevated serum folate may worsen neurocognitive effects and other metabolic impairments (altered glucose homeostasis, type 2 diabetes in offspring) associated with B12 deficiency. This review highlights molecular mechanisms that may explain the biology underlying these associations with a focus on findings from studies in model systems.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0