Annual review of nutrition最新文献

Mammalian 2-Oxo Acid Dehydrogenase Complexes in Metabolic Regulation and Signaling. 哺乳动物2-氧酸脱氢酶复合物的代谢调节和信号传导。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2026-05-06 DOI: 10.1146/annurev-nutr-061824-065013

Victoria I Bunik

{"title":"Mammalian 2-Oxo Acid Dehydrogenase Complexes in Metabolic Regulation and Signaling.","authors":"Victoria I Bunik","doi":"10.1146/annurev-nutr-061824-065013","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061824-065013","url":null,"abstract":"2-Oxo acid dehydrogenase complexes include four members to oxidatively decarboxylate pyruvate, 2-oxoglutarate, 2-oxoadipate, and branched-chain 2-oxo acids. The complexes produce CO2, acyl-coenzyme As (acyl-CoAs), and NADH through consecutive action of three enzymes with their coenzymes: 2-oxo acid dehydrogenase with thiamine diphosphate, dihydrolipoyllysine-residue acyltransferase with the lipoyllysine prosthetic group, and dihydrolipoyl dehydrogenase with FAD. Some of the complexes include additional regulatory proteins. Producing energy in the form of NADH and acyl-CoAs, which are feedback inhibitors, the complexes mediate the Ca2+ activation of mitochondrial function, couple metabolism of glucose and amino acids, are essential for biosynthesis of the signaling molecules acetylcholine and glutamate, regulate metabolism through posttranslational acylations including histones acylations, and sense the metabolic imbalance as nonoptimal ratios of their substrates and products. The complexes signal the imbalance by the generation of reactive species: O2*-, thiyl radicals, thiamine-dependent carbon radicals, and/or peracids, potentially involved in DNA damage and development of diseases.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":13.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Nutrition and Oral Vaccine Efficacy. 人类营养和口服疫苗功效。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2026-05-06 DOI: 10.1146/annurev-nutr-062024-123217

Gaurav Kwatra, Jamie I Klein, Sean R Moore

{"title":"Human Nutrition and Oral Vaccine Efficacy.","authors":"Gaurav Kwatra, Jamie I Klein, Sean R Moore","doi":"10.1146/annurev-nutr-062024-123217","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062024-123217","url":null,"abstract":"The advent of oral vaccines (OVs) in the mid-twentieth century led to dramatic reductions in the global burden of gut and gut-acquired infectious diseases such as polio, rotavirus, cholera, and typhoid. Paradoxically, OVs have been less effective in low- and middle-income countries (LMICs) where morbidity and mortality from these diseases are highest. This so-called tropical barrier does not reflect intrinsic defects of OV platforms but rather the influence of adverse host and environmental conditions more prevalent in LMIC settings. Among these, nutritional status stands out as a key modifiable determinant of OV performance. The collision of undernutrition and poor sanitation in LMIC contexts fosters repeated exposure to enteropathogens via contaminated food, water, and living environments; proinflammatory gut microbiota; disrupted intestinal mucosal architecture and barrier function; and profoundly altered immune development. Together, these factors hinder the replication and take of OVs. Micronutrient deficiencies-particularly in zinc, vitamin A, vitamin D, and iron-further compromise intestinal epithelial homeostasis, antigen presentation, and antibody responses to undermine OV efficacy. This review synthesizes recent advances in our understanding of how human nutrition shapes OV immunogenicity. By integrating epidemiologic evidence, field interventions, and mechanistic insights, we outline pathways linking diet, gut health, and vaccine response and strategies to close global gaps in OV performance.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":13.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full Plate: Integrating Ingestive Behavior into Nutritional Science. 全餐：将摄食行为纳入营养科学。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2026-02-24 DOI: 10.1146/annurev-nutr-073124-120815

Barbara J Rolls

引用次数: 0

Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention. 十字花科蔬菜、生物活性代谢物和微生物组预防乳腺癌。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 DOI: 10.1146/annurev-nutr-062222-024321

Emily Ho, Carmen P Wong, John A Bouranis, Jackilen Shannon, Zhenzhen Zhang

{"title":"Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention.","authors":"Emily Ho, Carmen P Wong, John A Bouranis, Jackilen Shannon, Zhenzhen Zhang","doi":"10.1146/annurev-nutr-062222-024321","DOIUrl":"10.1146/annurev-nutr-062222-024321","url":null,"abstract":"Breast cancer is a heterogeneous disease with varying subtypes, prognoses, and treatment responses. Cruciferous vegetables have shown promise in reducing breast cancer risk. This review discusses (a) the efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast cancer risk, prognosis, and treatment outcomes in recent human studies through 2024; (b) preclinical studies (2018-2024) that evaluate the efficacy and synergism of SFN, DIM, and other phytochemicals with conventional breast cancer treatments as promising combination therapy strategies for validation in future clinical trials; and (c) the role of the microbiome in breast cancer and the interaction between interindividual variations in gut microbiome and glucosinolate metabolism that could modify the benefits of cruciferous vegetable consumption and breast cancer treatment efficacy. Integrating cruciferous vegetables and their bioactive compounds in light of an individual's microbiome profile as a complementary approach alongside standard treatments is a promising strategy in breast cancer care.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"45 1","pages":"171-195"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral and Economic Interventions: A Path to Improved Dietary Behaviors. 行为和经济干预：改善饮食行为的途径。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI: 10.1146/annurev-nutr-111124-101104

Hanin Hosni, Marco A Palma, Michelle S Segovia

引用次数: 0

Obesity and Autoimmunity Epidemic: The Role of Immunometabolism. 肥胖与自身免疫流行：免疫代谢的作用。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-05 DOI: 10.1146/annurev-nutr-111324-122456

Alessandra Colamatteo, Clorinda Fusco, Alessandro Matarese, Giuseppe Matarese

{"title":"Obesity and Autoimmunity Epidemic: The Role of Immunometabolism.","authors":"Alessandra Colamatteo, Clorinda Fusco, Alessandro Matarese, Giuseppe Matarese","doi":"10.1146/annurev-nutr-111324-122456","DOIUrl":"10.1146/annurev-nutr-111324-122456","url":null,"abstract":"The relationship between obesity and autoimmune diseases has attracted significant attention in recent years, highlighting the multifaceted connection between metabolic dysregulation and loss of self-immune tolerance. Compelling epidemiological evidence has revealed an elevated prevalence of autoimmune diseases among overweight or obese individuals, suggesting a potential causal link. Mechanistically, adipose tissue is a key immunometabolic organ that secretes an array of adipocytokines that can facilitate proinflammatory immune responses against self-antigens. Indeed, adipose tissue dysfunction in obesity fosters a state of chronic low-grade inflammation, which may contribute to the so-called accelerator hypothesis, in which circulating self-autoreactive T cells can easily lose their regulatory mechanisms, resulting in self-tissue damage and autoinflammation. In this review, we elucidate the intricate immunometabolic pathomechanisms underlying the obesity and autoimmunity epidemic, and we explore innovative therapeutic avenues that could be pivotal for advancing public health initiatives in the context of this epidemic.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"115-140"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Nutrition in the Spotlight. 聚光灯下的人类营养。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 DOI: 10.1146/annurev-nutr-052725-110837

Patrick J Stover

引用次数: 0

Progress in Understanding the Regulation of Glucose and Fructose Metabolism. 葡萄糖和果糖代谢调控的研究进展。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-04-18 DOI: 10.1146/annurev-nutr-111824-012939

Meng Zhao, Jameel Lone, Saranya Reghupaty, Karen Y Linde-Garelli, Katrin J Svensson

{"title":"Progress in Understanding the Regulation of Glucose and Fructose Metabolism.","authors":"Meng Zhao, Jameel Lone, Saranya Reghupaty, Karen Y Linde-Garelli, Katrin J Svensson","doi":"10.1146/annurev-nutr-111824-012939","DOIUrl":"10.1146/annurev-nutr-111824-012939","url":null,"abstract":"Hexoses, including glucose, fructose, and galactose, are six-carbon monosaccharides that play fundamental roles in mammalian metabolism, with glucose serving as the primary energy source and fructose and galactose metabolized through pathways converging with glucose metabolism. While glucose metabolism has been extensively studied over the past hundred years, the mechanisms of fructose metabolism and uptake, the transporters involved, and its roles in physiology and disease are far less explored. Recent data also suggest that excessive fructose intake can have detrimental effects on metabolic organs, including the liver. Emerging studies have uncovered novel regulatory mechanisms in glucose and fructose metabolism, including the role of posttranslational modifications of transporters and enzymes, and the discovery of regulators of transporters. Here, we highlight new findings on the regulation of glucose and fructose transporters and integrate recent molecular and clinical insights into how glucose and fructose contribute to metabolic diseases.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"93-114"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unique Energy Profile Associated with Persistent Thin Phenotype. 与持久瘦表型相关的独特能量谱。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-05-06 DOI: 10.1146/annurev-nutr-111824-014837

Mélina Bailly, David Thivel, Laurie Isacco, Julien Verney

{"title":"Unique Energy Profile Associated with Persistent Thin Phenotype.","authors":"Mélina Bailly, David Thivel, Laurie Isacco, Julien Verney","doi":"10.1146/annurev-nutr-111824-014837","DOIUrl":"10.1146/annurev-nutr-111824-014837","url":null,"abstract":"The concept of constitutional thinness first emerged in the scientific literature at the beginning of the 20th century. Yet, this concept of a physiologically determined thinness, which clearly differentiated it from anorexia nervosa and challenged the basic notions of metabolism, intrigued the medical community. How could a young, healthy person with normal food intake present such an underweight state that resists body-weight gain? Due to either skepticism or disinterest, the fact remains that fewer than 50 clinical studies have focused on constitutional thinness in the last 90 years, contrasting with the hundreds of thousands conducted on the other end of the weight status spectrum (obesity). The aim of this review is to discuss current evidence of various aspects of this persistent thin phenotype, from its definition and diagnosis to its metabolic and physiological mechanisms. A deeper understanding of constitutional thinness would facilitate medical/societal recognition and clinical management of this condition. Greater insight into constitutional thinness could also help identify metabolic patterns that may be protective in the current context of the global obesity pandemic and its related critical health implications. Constitutional thinness stands out as a unique model questioning basic dogmatic knowledge about energy balance and metabolism.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"65-91"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate Change, Extreme Weather Events, Food Security, and Nutrition: Evolving Relationships and Critical Challenges. 气候变化、极端天气事件、粮食安全和营养：不断演变的关系和关键挑战。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2025-08-01 Epub Date: 2025-04-16 DOI: 10.1146/annurev-nutr-111324-111252

Jessica Fanzo, Bianca Carducci, Jochebed Louis-Jean, Mario Herrero, Kevin Karl, Cynthia Rosenzweig

{"title":"Climate Change, Extreme Weather Events, Food Security, and Nutrition: Evolving Relationships and Critical Challenges.","authors":"Jessica Fanzo, Bianca Carducci, Jochebed Louis-Jean, Mario Herrero, Kevin Karl, Cynthia Rosenzweig","doi":"10.1146/annurev-nutr-111324-111252","DOIUrl":"10.1146/annurev-nutr-111324-111252","url":null,"abstract":"Climate change, also known as global warming, poses significant challenges to the planet and humanity. With further warming, every region across the world is projected to increasingly experience concurrent and multiple changes in climate, compounding overall risk. Long-term climate change and near-term extreme weather events have multiple negative effects on food security, diets, and nutrition via complex, multidirectional pathways through food, health, water, and social protection systems. However, measuring climate-attributable malnutrition impacts, especially among the most vulnerable populations, remains challenging. Changes in climate across a range of geographies have been modeled, projected, and observed showing detrimental associations with dietary and nutrition outcomes, particularly undernutrition. Many undernourished populations are climate vulnerable due to a variety of determinants challenging their ability to adapt to impending risks. While nutrition integration within climate adaptation plans has lagged, there is momentum for robust collaboration between climate and nutrition communities to fill data gaps that are critical for joint decision-making.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"335-360"},"PeriodicalIF":13.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0