Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention.

IF 13.4 2区 医学 Q1 NUTRITION & DIETETICS
Emily Ho, Carmen P Wong, John A Bouranis, Jackilen Shannon, Zhenzhen Zhang
{"title":"Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention.","authors":"Emily Ho, Carmen P Wong, John A Bouranis, Jackilen Shannon, Zhenzhen Zhang","doi":"10.1146/annurev-nutr-062222-024321","DOIUrl":null,"url":null,"abstract":"<p><p>Breast cancer is a heterogeneous disease with varying subtypes, prognoses, and treatment responses. Cruciferous vegetables have shown promise in reducing breast cancer risk. This review discusses (<i>a</i>) the efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast cancer risk, prognosis, and treatment outcomes in recent human studies through 2024; (<i>b</i>) preclinical studies (2018-2024) that evaluate the efficacy and synergism of SFN, DIM, and other phytochemicals with conventional breast cancer treatments as promising combination therapy strategies for validation in future clinical trials; and (<i>c</i>) the role of the microbiome in breast cancer and the interaction between interindividual variations in gut microbiome and glucosinolate metabolism that could modify the benefits of cruciferous vegetable consumption and breast cancer treatment efficacy. Integrating cruciferous vegetables and their bioactive compounds in light of an individual's microbiome profile as a complementary approach alongside standard treatments is a promising strategy in breast cancer care.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"45 1","pages":"171-195"},"PeriodicalIF":13.4000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479016/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-nutr-062222-024321","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Breast cancer is a heterogeneous disease with varying subtypes, prognoses, and treatment responses. Cruciferous vegetables have shown promise in reducing breast cancer risk. This review discusses (a) the efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast cancer risk, prognosis, and treatment outcomes in recent human studies through 2024; (b) preclinical studies (2018-2024) that evaluate the efficacy and synergism of SFN, DIM, and other phytochemicals with conventional breast cancer treatments as promising combination therapy strategies for validation in future clinical trials; and (c) the role of the microbiome in breast cancer and the interaction between interindividual variations in gut microbiome and glucosinolate metabolism that could modify the benefits of cruciferous vegetable consumption and breast cancer treatment efficacy. Integrating cruciferous vegetables and their bioactive compounds in light of an individual's microbiome profile as a complementary approach alongside standard treatments is a promising strategy in breast cancer care.

十字花科蔬菜、生物活性代谢物和微生物组预防乳腺癌。
乳腺癌是一种异质性疾病,具有不同的亚型、预后和治疗反应。十字花科蔬菜已显示出降低乳腺癌风险的希望。本综述讨论(a)到2024年,萝卜硫素(SFN)和吲哚-3-甲醇(I3C)/3,3'-二吲哚基甲烷(DIM)对乳腺癌风险、预后和治疗结果的影响;(b)临床前研究(2018-2024),评估SFN、DIM和其他植物化学物质与传统乳腺癌治疗的疗效和协同作用,作为有希望的联合治疗策略,在未来的临床试验中进行验证;(c)微生物组在乳腺癌中的作用,以及肠道微生物组和硫代葡萄糖苷代谢的个体间差异之间的相互作用,这种相互作用可能会改变十字花科蔬菜消费的益处和乳腺癌治疗效果。结合十字花科蔬菜及其生物活性化合物,根据个体的微生物组特征,作为标准治疗的补充方法,是乳腺癌治疗的一种很有前途的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信