Annual review of nutrition最新文献_第9页

Obesity Dysregulates the Immune Response to Influenza Infection and Vaccination Through Metabolic and Inflammatory Mechanisms. 肥胖症通过代谢和炎症机制调节对流感感染和疫苗接种的免疫反应

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062320-115937

Saame Raza Shaikh, Nancie J MacIver, Melinda A Beck

{"title":"Obesity Dysregulates the Immune Response to Influenza Infection and Vaccination Through Metabolic and Inflammatory Mechanisms.","authors":"Saame Raza Shaikh, Nancie J MacIver, Melinda A Beck","doi":"10.1146/annurev-nutr-062320-115937","DOIUrl":"10.1146/annurev-nutr-062320-115937","url":null,"abstract":"The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is a significant risk factor for severe outcomes from infection. This susceptibility mirrors a similar pattern with influenza infection; that is, obesity is a unique risk factor for increased morbidity and mortality. Therefore, it is critical to understand how obesity contributes to a reduced ability to respond to respiratory viral infections. Herein, we discuss human and animal studies with influenza infection and vaccination that show obesity impairs immunity. We cover several key mechanisms for the dysfunction. These mechanisms include systemic and cellular level changes that dysregulate immune cell metabolism and function in addition to how obesity promotes deficiencies in metabolites that control the resolution of inflammation and infection. Finally, we discuss major gaps in knowledge, particularly as they pertain to diet and mechanisms, which will drive future efforts to improve outcomes in response to respiratory viral infections in an increasingly obese population.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"67-89"},"PeriodicalIF":13.4,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9346641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models. 性别作为营养研究中的生物变量:从人体研究到动物模型。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062220-105852

Yilin Chen, Minhoo Kim, Sanjana Paye, Bérénice A Benayoun

引用次数: 7

The Origins, Evolution, and Future of Dietary Methionine Restriction. 膳食蛋氨酸限制的起源、演变和未来。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2022-08-22 Epub Date: 2022-05-19 DOI: 10.1146/annurev-nutr-062320-111849

Han Fang, Kirsten P Stone, Desiree Wanders, Laura A Forney, Thomas W Gettys

{"title":"The Origins, Evolution, and Future of Dietary Methionine Restriction.","authors":"Han Fang, Kirsten P Stone, Desiree Wanders, Laura A Forney, Thomas W Gettys","doi":"10.1146/annurev-nutr-062320-111849","DOIUrl":"10.1146/annurev-nutr-062320-111849","url":null,"abstract":"The original description of dietary methionine restriction (MR) used semipurified diets to limit methionine intake to 20% of normal levels, and this reduction in dietary methionine increased longevity by ∼30% in rats. The MR diet also produces paradoxical increases in energy intake and expenditure and limits fat deposition while reducing tissue and circulating lipids and enhancing overall insulin sensitivity. In the years following the original 1993 report, a comprehensive effort has been made to understand the nutrient sensing and signaling systems linking reduced dietary methionine to the behavioral, physiological, biochemical, and transcriptional components of the response. Recent work has shown that transcriptional activation of hepatic fibroblast growth factor 21 (FGF21) is a key event linking the MR diet to many but not all components of its metabolic phenotype. These findings raise the interesting possibility of developing therapeutic, MR-based diets that produce the beneficial effects of FGF21 by nutritionally modulating its transcription and release.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"201-226"},"PeriodicalIF":12.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936953/pdf/nihms-1854633.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis. 非酒精性脂肪性肝炎的肝脏代谢和微环境重编程。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062220-105200

Liangyou Rui, Jiandie D Lin

引用次数: 15

National Food Intake Assessment: Technologies to Advance Traditional Methods. 国家食物摄入评估:改进传统方法的技术。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062320-110636

Alanna J Moshfegh, Donna G Rhodes, Carrie L Martin

引用次数: 4

Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies. 叶酸与预防出生缺陷：30年的机遇与争议。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-043020-091647

Krista S Crider, Yan Ping Qi, Lorraine F Yeung, Cara T Mai, Lauren Head Zauche, Arick Wang, Kelicia Daniels, Jennifer L Williams

{"title":"Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies.","authors":"Krista S Crider, Yan Ping Qi, Lorraine F Yeung, Cara T Mai, Lauren Head Zauche, Arick Wang, Kelicia Daniels, Jennifer L Williams","doi":"10.1146/annurev-nutr-043020-091647","DOIUrl":"10.1146/annurev-nutr-043020-091647","url":null,"abstract":"For three decades, the US Public Health Service has recommended that all persons capable of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects (NTDs). The neural tube forms by 28 days after conception. Fortification can be an effective NTD prevention strategy in populations with limited access to folic acid foods and/or supplements. This review describes the status of mandatory FA fortification among countries that fortify (n = 71) and the research describing the impact of those programs on NTD rates (up to 78% reduction), blood folate concentrations [red blood cell folate concentrations increased ∼1.47-fold (95% CI, 1.27, 1.70) following fortification], and other health outcomes. Across settings, high-quality studies such as those with randomized exposures (e.g., randomized controlled trials, Mendelian randomization studies) are needed to elucidate interactions of FA with vitamin B12 as well as expanded biomarker testing.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"423-452"},"PeriodicalIF":12.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875360/pdf/nihms-1856824.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10398780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Fructose and Fructose-Induced Pathologies. 膳食果糖和果糖诱导的病理。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062220-025831

Sunhee Jung, Hosung Bae, Won-Suk Song, Cholsoon Jang

引用次数: 17

Advancing Health Equity Efforts to Reduce Obesity: Changing the Course. 促进健康公平，减少肥胖：改变路线。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2022-08-22 Epub Date: 2022-04-13 DOI: 10.1146/annurev-nutr-092021-050805

Shiriki K Kumanyika

引用次数: 0

A Female Career in Research. 研究中的女性职业生涯。

IF 13.4 2区医学

Annual review of nutrition Pub Date : 2022-08-22 Epub Date: 2022-04-01 DOI: 10.1146/annurev-nutr-062220-103411

Katherine M Flegal

{"title":"A Female Career in Research.","authors":"Katherine M Flegal","doi":"10.1146/annurev-nutr-062220-103411","DOIUrl":"10.1146/annurev-nutr-062220-103411","url":null,"abstract":"After a long career at the National Center for Health Statistics, I retired and joined the Stanford Prevention Research Center as an unpaid associate. I was once described by a former US Food and Drug Administration commissioner as \"one of the great epidemiologists.\" The chair of the Harvard nutrition department, speaking on National Public Radio, once described my research as \"rubbish.\" Both may be exaggerations. Here I address some of the events that led to these contrasting descriptions. I also address the extent to which the so-called Matilda effect may have influenced my career. Are women in science on an equal footing with men? The Matilda effect suggests not. Unlike the Matthew effect for scientists, whereby those of higher prestige accrue a disproportionate share of recognition and rewards, the Matilda effect proposes that women scientists are systematically undervalued and underrecognized. I could never get a faculty job and was often treated like an underling. Nonetheless I persevered to publish highly cited research on several high-profile and sometimes controversial topics. Though overt sexism in science and workplaces has diminished over the course of my career, progress toward eliminating unconscious bias has been slower. The Matthew and Matilda effects are still powerful forces that distort incentives and rewards in science.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"1 1","pages":"1-19"},"PeriodicalIF":13.4,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41599663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life. 婴儿、虫子和屏障：早期生活中肠道屏障功能的饮食调节。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-06-13 DOI: 10.1146/annurev-nutr-122221-103916

J. Wells, Yifan Gao, N. de Groot, M. Vonk, L. Ulfman, R. V. van Neerven

{"title":"Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life.","authors":"J. Wells, Yifan Gao, N. de Groot, M. Vonk, L. Ulfman, R. V. van Neerven","doi":"10.1146/annurev-nutr-122221-103916","DOIUrl":"https://doi.org/10.1146/annurev-nutr-122221-103916","url":null,"abstract":"The intestinal barrier is essential in early life to prevent infection, inflammation, and food allergies. It consists of microbiota, a mucus layer, an epithelial layer, and the immune system. Microbial metabolites, the mucus, antimicrobial peptides, and secretory immunoglobulin A (sIgA) protect the intestinal mucosa against infection. The complex interplay between these functionalities of the intestinal barrier is crucial in early life by supporting homeostasis, development of the intestinal immune system, and long-term gut health. Exclusive breastfeeding is highly recommended during the first 6 months. When breastfeeding is not possible, milk-based infant formulas are the only safe alternative. Breast milk contains many bioactive components that help to establish the intestinal microbiota and influence the development of the intestinal epithelium and the immune system. Importantly, breastfeeding lowers the risk for intestinal and respiratory tract infections. Here we review all aspects of intestinal barrier function and the nutritional components that impact its functionality in early life, such as micronutrients, bioactive milk proteins, milk lipids, and human milk oligosaccharides. These components are present in breast milk and can be added to milk-based infant formulas to support gut health and immunity. Expected final online publication date for the Annual Review of Nutrition, Volume 42 is August 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44096659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8