Annual review of nutritionPub Date : 2020-09-23Epub Date: 2020-07-06DOI: 10.1146/annurev-nutr-121619-045319
Catherine E Woteki, Brandon L Kramer, Samantha Cohen, Vicki A Lancaster
{"title":"Impacts and Echoes: The Lasting Influence of the White House Conference on Food, Nutrition, and Health.","authors":"Catherine E Woteki, Brandon L Kramer, Samantha Cohen, Vicki A Lancaster","doi":"10.1146/annurev-nutr-121619-045319","DOIUrl":"https://doi.org/10.1146/annurev-nutr-121619-045319","url":null,"abstract":"<p><p>The 1969 White House Conference on Food, Nutrition, and Health had a significant influence on the direction of food and nutrition policy in the United States. The conference produced recommendations leading to federal legislation and programs to alleviate hunger and malnutrition, improve consumers' nutrition knowledge through education and labeling, and monitor the nutritional status of the population. Fifty years later, its legacy was revisited at a conference convened by Harvard University and Tufts University. This article reviews the literature contributing to the first author's keynote speech at the conference, its influencers, and its influences. We focus on the highlights of five domains that set the stage for the conference: the social environment, the food environment, nutrition science, public health data, and policy events. We briefly describe the conference, its proposed directions, and its lasting legacy in these five domains.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"40 ","pages":"437-461"},"PeriodicalIF":8.9,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-121619-045319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38126364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Policy Progress in Reducing Sodium in the American Diet, 2010-2019.","authors":"Aviva A Musicus, Vivica I Kraak, Sara N Bleich","doi":"10.1146/annurev-nutr-122319-040249","DOIUrl":"https://doi.org/10.1146/annurev-nutr-122319-040249","url":null,"abstract":"<p><p>Most Americans consume dietary sodium exceeding age-specific government-recommended targets of 1,500-2,300 mg/day per person. The majority (71%) of US dietary sodium comes from restaurant and packaged foods. Excess sodium intake contributes to hypertension and cardiovascular disease, which is the leading cause of death in the United States. This review summarizes evidence for policy progress to reduce sodium in the US food supply and the American diet. We provide a historical overview of US sodium-reduction policy (1969-2010), then examine progress toward implementing the 2010 National Academy of Medicine (NAM) sodium report's recommendations (2010-2019). Results suggest that the US Food and Drug Administration made no progress in setting mandatory sodium-reduction standards, industry made some progress in meeting voluntary targets, and other stakeholders made some progress on sodium-reduction actions. Insights from countries that have significantly reduced population sodium intake offer strategies to accelerate US progress toward implementing the NAM sodium-reduction recommendations in the future.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"40 ","pages":"407-435"},"PeriodicalIF":8.9,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-122319-040249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38507532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta U Wołoszynowska-Fraser, Azita Kouchmeshky, Peter McCaffery
{"title":"Vitamin A and Retinoic Acid in Cognition and Cognitive Disease.","authors":"Marta U Wołoszynowska-Fraser, Azita Kouchmeshky, Peter McCaffery","doi":"10.1146/annurev-nutr-122319-034227","DOIUrl":"https://doi.org/10.1146/annurev-nutr-122319-034227","url":null,"abstract":"<p><p>The history of vitamin A goes back over one hundred years, but our realization of its importance for the brain and cognition is much more recent. The brain is more efficient than other target tissues at converting vitamin A to retinoic acid (RA), which activates retinoic acid receptors (RARs). RARs regulate transcription, but their function in the cytoplasm to control nongenomic actions is also crucial. Controlled synthesis of RA is essential for regulating synaptic plasticity in regions of the brain involved in learning and memory, such as the hippocampus. Vitamin A deficiency results in a deterioration of these functions, and failure of RA signaling is perhaps associated with normal cognitive decline with age as well as with Alzheimer's disease. Further, several psychiatric and developmental disorders that disrupt cognition are also linked with vitamin A and point to their possible treatment with vitamin A or RA.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"40 ","pages":"247-272"},"PeriodicalIF":8.9,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-122319-034227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38507535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2019-08-21Epub Date: 2019-04-24DOI: 10.1146/annurev-nutr-082018-124344
John Y L Chiang, Jessica M Ferrell
{"title":"Bile Acids as Metabolic Regulators and Nutrient Sensors.","authors":"John Y L Chiang, Jessica M Ferrell","doi":"10.1146/annurev-nutr-082018-124344","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082018-124344","url":null,"abstract":"<p><p>Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile acid, and immune homeostasis. Fasting and feeding transitions alter nutrient content in the gut, which influences bile acid composition and pool size. In turn, bile acid signaling controls lipid and glucose use and protection against inflammation. Altered bile acid metabolism resulting from gene mutations, high-fat diets, alcohol, or circadian disruption can contribute to cholestatic and inflammatory diseases, diabetes, and obesity. Bile acids and their derivatives are valuable therapeutic agents for treating these inflammatory metabolic diseases.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 ","pages":"175-200"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082018-124344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2019-08-21Epub Date: 2019-05-15DOI: 10.1146/annurev-nutr-082018-124555
Lydia Sauer, Binxing Li, Paul S Bernstein
{"title":"Ocular Carotenoid Status in Health and Disease.","authors":"Lydia Sauer, Binxing Li, Paul S Bernstein","doi":"10.1146/annurev-nutr-082018-124555","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082018-124555","url":null,"abstract":"<p><p>Retinal carotenoids are dietary nutrients that uniquely protect the eye from light damage and various retinal pathologies. Their antioxidative properties protect the eye from many retinal diseases, such as age-related macular degeneration. As many retinal diseases are accompanied by low carotenoid levels, accurate noninvasive assessment of carotenoid status can help ophthalmologists identify the patients most likely to benefit from carotenoid supplementation. This review focuses on the different methods available to assess carotenoid status and highlights disease-related changes and potential nutritional interventions.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 ","pages":"95-120"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082018-124555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37243278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing the Increased Expectations of Nutrition.","authors":"R. Balling, P. Stover","doi":"10.1146/annurev-nu-39-190619-100001","DOIUrl":"https://doi.org/10.1146/annurev-nu-39-190619-100001","url":null,"abstract":"","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 1","pages":"v-vi"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nu-39-190619-100001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47274396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2019-08-21Epub Date: 2019-05-15DOI: 10.1146/annurev-nutr-082018-124213
Michael K Georgieff, Nancy F Krebs, Sarah E Cusick
{"title":"The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood.","authors":"Michael K Georgieff, Nancy F Krebs, Sarah E Cusick","doi":"10.1146/annurev-nutr-082018-124213","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082018-124213","url":null,"abstract":"<p><p>Iron deficiency is the most common micronutrient deficiency in the world and disproportionately affects pregnant women and young children. Iron deficiency has negative effects on pregnancy outcomes in women and on immune function and neurodevelopment in children. Iron supplementation programs have been successful in reducing this health burden. However, iron supplementation of iron-sufficient individuals is likely not necessary and may carry health risks for iron-sufficient and potentially some iron-deficient populations. This review considers the physiology of iron as a nutrient and how this physiology informs decision-making about weighing the benefits and risks of iron supplementation in iron-deficient, iron-sufficient, and iron-overloaded pregnant women and children.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 ","pages":"121-146"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082018-124213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37245781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Adolph, Lisa Mayr, F. Grabherr, J. Schwärzler, H. Tilg
{"title":"Pancreas-Microbiota Cross Talk in Health and Disease.","authors":"T. Adolph, Lisa Mayr, F. Grabherr, J. Schwärzler, H. Tilg","doi":"10.1146/annurev-nutr-082018-124306","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082018-124306","url":null,"abstract":"The pancreas controls metabolism through endocrine and exocrine functions. Pancreatic diseases comprise a spectrum of mild to life-threatening conditions, including acute and chronic pancreatitis, diabetes, and pancreatic cancer, which affect endocrine and exocrine pancreatic function and impose a substantial disease burden on individuals. Increasing experimental evidence demonstrates that the intestinal microbiota has an important impact on pancreatic function and diseases. This influence may be conferred by bacterial metabolites, such as short-chain fatty acids, or the modulation of immune responses. In turn, pancreatic factors, such as the excretion of antimicrobials, might have a substantial impact on the composition and functional properties of the gut microbiota. Here, we summarize experimental and clinical approaches used to untie the intricate pancreas-microbiota cross talk. Future advances will allow clinicians to manipulate the intestinal microbiota and guide patient management in pancreatic diseases.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 1","pages":"249-266"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082018-124306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41805701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence Collection and Evaluation for the Development of Dietary Guidelines and Public Policy on Nutrition.","authors":"D. Zeraatkar, B. Johnston, G. Guyatt","doi":"10.1146/annurev-nutr-082018-124610","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082018-124610","url":null,"abstract":"Dietary guidelines and recommendations, usually developed by government bodies or large authoritative organizations, have major downstream effects on public policy. A growing body of evidence supports the notion that there are serious deficiencies in the methods used to develop dietary guidelines. Such deficiencies include the failure to access or conduct comprehensive systematic reviews, a lack of systematic or rigorous evaluation of the quality of the evidence, a failure to acknowledge the limitations of the evidence base underlying recommendations, and insufficiently stringent management of conflicts of interest. These issues may be addressed by adhering to international standards for guideline development, including adopting systematic review methodology and using rigorous systems to evaluate the certainty of the evidence and to move from evidence to recommendations, of which the GRADE approach (Grading of Recommendations Assessment,Development and Evaluation) is the most rigorous and fully developed. Improving the methods by which dietary guidelines are produced has considerable potential to substantially improve public policy decision-making.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 1","pages":"227-247"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082018-124610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48749937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2019-08-21Epub Date: 2019-05-31DOI: 10.1146/annurev-nutr-082018-124235
Kendra A Tiani, Patrick J Stover, Martha S Field
{"title":"The Role of Brain Barriers in Maintaining Brain Vitamin Levels.","authors":"Kendra A Tiani, Patrick J Stover, Martha S Field","doi":"10.1146/annurev-nutr-082018-124235","DOIUrl":"https://doi.org/10.1146/annurev-nutr-082018-124235","url":null,"abstract":"<p><p>It is increasingly recognized that tissue-specific nutrient deficiencies can exist in the absence of whole-body deficiency and that these deficiencies may result from disease or disease-related physiological processes. Brain and central nervous system tissues require adequate nutrient levels to function. Many nutrients are concentrated in the cerebrospinal fluid relative to the serum in healthy individuals, and other nutrients resist depletion in the presence of whole-body nutrient depletion. The endothelial, epithelial, and arachnoid brain barriers work in concert to selectively transport, concentrate, and maintain levels of the specific nutrients required by the brain while also blocking the passage of blood-borne toxins and pathogens to brain and central nervous system tissues. These barriers preserve nutrient levels within the brain and actively concentrate nutrients within the cerebrospinal fluid and brain. The roles of physical and energetic barriers, including the blood-brain and blood-nerve barriers, in maintaining brain nutrient levels in health and disease are discussed.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"39 ","pages":"147-173"},"PeriodicalIF":8.9,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-nutr-082018-124235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37295548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}