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Annual review of nutrition最新文献

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Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer. 设计相关的临床前啮齿动物模型，以研究营养、肥胖、新陈代谢和癌症之间的联系。
IF 12.6 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-08-06 DOI: 10.1146/annurev-nutr-120420-032437
Elaine M Glenny, Michael F Coleman, Erin D Giles, Elizabeth A Wellberg, Stephen D Hursting
{"title":"Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer.","authors":"Elaine M Glenny, Michael F Coleman, Erin D Giles, Elizabeth A Wellberg, Stephen D Hursting","doi":"10.1146/annurev-nutr-120420-032437","DOIUrl":"10.1146/annurev-nutr-120420-032437","url":null,"abstract":"<p><p>Diet and nutrition are intricately related to cancer prevention, growth, and treatment response. Preclinical rodent models are a cornerstone to biomedical research and remain instrumental in our understanding of the relationship between cancer and diet and in the development of effective therapeutics. However, the success rate of translating promising findings from the bench to the bedside is suboptimal. Well-designed rodent models will be crucial to improving the impact basic science has on clinical treatment options. This review discusses essential experimental factors to consider when designing a preclinical cancer model with an emphasis on incorporatingthese models into studies interrogating diet, nutrition, and metabolism. The aims of this review are to (<i>a</i>) provide insight into relevant considerations when designing cancer models for obesity, nutrition, and metabolism research; (<i>b</i>) identify common pitfalls when selecting a rodent model; and (<i>c</i>) discuss strengths and limitations of available preclinical models.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"41 ","pages":"253-282"},"PeriodicalIF":12.6,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900211/pdf/nihms-1785130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Interventions and the Gut Microbiome in Children. 营养干预和儿童肠道微生物组。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-07-20 DOI: 10.1146/annurev-nutr-021020-025755
Saurabh Mehta, Samantha L Huey, Daniel McDonald, Rob Knight, Julia L Finkelstein
{"title":"Nutritional Interventions and the Gut Microbiome in Children.","authors":"Saurabh Mehta,&nbsp;Samantha L Huey,&nbsp;Daniel McDonald,&nbsp;Rob Knight,&nbsp;Julia L Finkelstein","doi":"10.1146/annurev-nutr-021020-025755","DOIUrl":"https://doi.org/10.1146/annurev-nutr-021020-025755","url":null,"abstract":"<p><p>The gut microbiome plays an integral role in health and disease, and diet is a major driver of its composition, diversity, and functional capacity. Given the dynamic development of the gut microbiome in infants and children, it is critical to address two major questions: (<i>a</i>) Can diet modify the composition, diversity, or function of the gut microbiome, and (<i>b</i>) will such modification affect functional/clinical outcomes including immune function, cognitive development, and overall health? We synthesize the evidence on the effect of nutritional interventions on the gut microbiome in infants and children across 26 studies. Findings indicate the need to study older children, assess the whole intestinal tract, and harmonize methods and interpretation of findings, which are critical for informing meaningful clinical and public health practice. These findings are relevant for precision health, may help identify windows of opportunity for intervention, and may inform the design and delivery of such interventions.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"479-510"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39201532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The Influence of Timing in Critical Care Nutrition. 危重护理营养时机的影响。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-06-18 DOI: 10.1146/annurev-nutr-111120-114108
Liam McKeever, Sarah J Peterson, Omar Lateef, Carol Braunschweig
{"title":"The Influence of Timing in Critical Care Nutrition.","authors":"Liam McKeever,&nbsp;Sarah J Peterson,&nbsp;Omar Lateef,&nbsp;Carol Braunschweig","doi":"10.1146/annurev-nutr-111120-114108","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111120-114108","url":null,"abstract":"<p><p>Proper timing of critical care nutrition has long been a matter of controversy. Critical illness waxes and wanes in stages, creating a dynamic flux in energy needs that we have only begun to examine. Furthermore, response to nutrition support likely differs greatly at the level of the individual patient in regard to genetic status, disease stage, comorbidities, and more. We review the observational and randomized literature concerning timing in nutrition support, discuss mechanisms of harm in feeding critically ill patients, and highlight the role of precision nutrition for moving the literature beyond the realm of blunt population averages into one that accounts for the patient-specific complexities of critical illness and host genetics.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"203-222"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39244874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Roles of Endocannabinoids and Endocannabinoid-Like Molecules in Energy Homeostasis and Metabolic Regulation: A Nutritional Perspective. 内源性大麻素和内源性大麻素样分子在能量稳态和代谢调节中的作用:营养学的观点。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-06-11 DOI: 10.1146/annurev-nutr-043020-090216
S M Khaledur Rahman, Toru Uyama, Zahir Hussain, Natsuo Ueda
{"title":"Roles of Endocannabinoids and Endocannabinoid-Like Molecules in Energy Homeostasis and Metabolic Regulation: A Nutritional Perspective.","authors":"S M Khaledur Rahman,&nbsp;Toru Uyama,&nbsp;Zahir Hussain,&nbsp;Natsuo Ueda","doi":"10.1146/annurev-nutr-043020-090216","DOIUrl":"https://doi.org/10.1146/annurev-nutr-043020-090216","url":null,"abstract":"<p><p>The endocannabinoid system is involved in signal transduction in mammals. It comprises principally G protein-coupled cannabinoid receptors and their endogenous agonists, called endocannabinoids, as well as the enzymes and transporters responsible for the metabolism of endocannabinoids. Two arachidonic acid-containing lipid molecules, arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol, function as endocannabinoids. <i>N</i>-acylethanolamines and monoacylglycerols, in which the arachidonic acid chain is replaced with a saturated or monounsaturated fatty acid, are not directly involved in the endocannabinoid system but exhibit agonistic activities for other receptors. These endocannabinoid-like moleculesinclude palmitoylethanolamide, oleoylethanolamide (OEA), and 2-oleoylglycerol. Endocannabinoids stimulate feeding behavior and the anabolism of lipids and glucose, while OEA suppresses appetite. Both central and peripheral systems are included in these nutritional and metabolic contexts. Therefore, they have potential in the treatment and prevention of obesity. We outline the structure, metabolism, and biological activities of endocannabinoids and related molecules, and focus on their involvement in energy homeostasis and metabolic regulation.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"177-202"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39085180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Dietary and Physiological Effects of Zinc on the Immune System. 锌对免疫系统的饮食和生理影响。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-07-13 DOI: 10.1146/annurev-nutr-122019-120635
Inga Wessels, Henrike Josephine Fischer, Lothar Rink
{"title":"Dietary and Physiological Effects of Zinc on the Immune System.","authors":"Inga Wessels,&nbsp;Henrike Josephine Fischer,&nbsp;Lothar Rink","doi":"10.1146/annurev-nutr-122019-120635","DOIUrl":"https://doi.org/10.1146/annurev-nutr-122019-120635","url":null,"abstract":"<p><p>Evidence for the importance of zinc for all immune cells and for mounting an efficient and balanced immune response to various environmental stressors has been accumulating in recent years. This article describes the role of zinc in fundamental biological processes and summarizes our current knowledge of zinc's effect on hematopoiesis, including differentiation into immune cell subtypes. In addition, the important role of zinc during activation and function of immune cells is detailed and associated with the specific immune responses to bacteria, parasites, and viruses. The association of zinc with autoimmune reactions and cancers as diseases with increased or decreased immune responses is also discussed. This article provides a broad overview of the manifold roles that zinc, or its deficiency, plays in physiology and during various diseases. Consequently, we discuss why zinc supplementation should be considered, especially for people at risk of deficiency.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"133-175"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 43
Ins and Outs of the TCA Cycle: The Central Role of Anaplerosis. TCA循环的来龙去脉:骨质疏松的中心作用。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-07-16 DOI: 10.1146/annurev-nutr-120420-025558
Melissa Inigo, Stanisław Deja, Shawn C Burgess
{"title":"Ins and Outs of the TCA Cycle: The Central Role of Anaplerosis.","authors":"Melissa Inigo,&nbsp;Stanisław Deja,&nbsp;Shawn C Burgess","doi":"10.1146/annurev-nutr-120420-025558","DOIUrl":"https://doi.org/10.1146/annurev-nutr-120420-025558","url":null,"abstract":"<p><p>The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can facilitate the oxidation of an infinite number of nutrient molecules. However, TCA cycle intermediates can be lost to cataplerotic pathways that provide precursors for biosynthesis, and they must be replaced by anaplerotic pathways that regenerate these intermediates. Together, anaplerosis and cataplerosis help regulate rates of biosynthesis by dictating precursor supply, and they play underappreciated roles in catabolism and cellular energy status. They facilitate recycling pathways and nitrogen trafficking necessary for catabolism, and they influence redox state and oxidative capacity by altering TCA cycle intermediate concentrations. These functions vary widely by tissue and play emerging roles in disease. This article reviews the roles of anaplerosis and cataplerosis in various tissues and discusses how they alter carbon transitions, and highlights their contribution to mechanisms of disease.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"19-47"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up? 维生素A和维生素E：真正的抗氧化剂会站起来吗？
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-06-11 DOI: 10.1146/annurev-nutr-082018-124228
William S Blaner, Igor O Shmarakov, Maret G Traber
{"title":"Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?","authors":"William S Blaner, Igor O Shmarakov, Maret G Traber","doi":"10.1146/annurev-nutr-082018-124228","DOIUrl":"10.1146/annurev-nutr-082018-124228","url":null,"abstract":"<p><p>Vitamin A, acting through its metabolite, all-<i>trans</i>-retinoic acid, is a potent transcriptional regulator affecting expression levels of hundreds of genes through retinoic acid response elements present within these genes. However, the literature is replete with claims that consider vitamin A to be an antioxidant vitamin, like vitamins C and E. This apparent contradiction in the understanding of how vitamin A acts mechanistically within the body is a major focus of this review. Vitamin E, which is generally understood to act as a lipophilic antioxidant protecting polyunsaturated fatty acids present in membranes, is often proposed to be a transcriptional regulator. The evaluation of this claim is another focus of the review. We conclude that vitamin A is an indirect antioxidant, whose indirect function is to transcriptionally regulate a number of genes involved in mediating the body's canonical antioxidant responses. Vitamin E, in addition to being a direct antioxidant, prevents the increase of peroxidized lipids that alter both metabolic pathways and gene expression profiles within tissues and cells. However, there is little compelling evidence that vitamin E has a direct transcriptional mechanism like that of vitamin A. Thus, we propose that the term antioxidant not be applied to vitamin A, and we discourage the use of the term transcriptional mediator when discussing vitamin E.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"41 ","pages":"105-131"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9704486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Front-of-Package Nutrition Labeling on Consumer Behavior and Product Reformulation. 包装正面营养标签对消费者行为及产品改型的影响。
IF 12.6 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-08-02 DOI: 10.1146/annurev-nutr-111120-094932
Christina A Roberto, Shu Wen Ng, Montserrat Ganderats-Fuentes, David Hammond, Simon Barquera, Alejandra Jauregui, Lindsey Smith Taillie
{"title":"The Influence of Front-of-Package Nutrition Labeling on Consumer Behavior and Product Reformulation.","authors":"Christina A Roberto, Shu Wen Ng, Montserrat Ganderats-Fuentes, David Hammond, Simon Barquera, Alejandra Jauregui, Lindsey Smith Taillie","doi":"10.1146/annurev-nutr-111120-094932","DOIUrl":"10.1146/annurev-nutr-111120-094932","url":null,"abstract":"<p><p>Countries worldwide have implemented mandatory or voluntary front-of-package nutrition labeling systems. We provide a narrative review of (<i>a</i>) real-world evaluations of front-of-package nutrition labels that analyze objective sales data and (<i>b</i>) studies that objectively assess product reformulation in response to a front-of-package nutrition label implementation. We argue that there is sufficient scientific evidence to recommend that governments implement mandatory front-of-package nutrition labeling systems to improvepopulation health. We also present a conceptual framework to describe front-of-package label influence and provide recommendations for the optimal label design, emphasizing that labeling systems should be highly visible and salient, be simple and easy to understand, leverage automatic associations, and integrate informational and emotional messaging. The existing research suggests that Guideline Daily Amount labels should be avoided and that the Health Star Rating and Nutri-Score systems are promising but that systems with warning labels like the one in Chile are likely to produce the largest public health benefits.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"529-550"},"PeriodicalIF":12.6,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39268319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic and Signaling Roles of Ketone Bodies in Health and Disease. 酮体在健康和疾病中的代谢和信号作用。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 DOI: 10.1146/annurev-nutr-111120-111518
Patrycja Puchalska, Peter A Crawford
{"title":"Metabolic and Signaling Roles of Ketone Bodies in Health and Disease.","authors":"Patrycja Puchalska,&nbsp;Peter A Crawford","doi":"10.1146/annurev-nutr-111120-111518","DOIUrl":"https://doi.org/10.1146/annurev-nutr-111120-111518","url":null,"abstract":"<p><p>Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and ameliorate disease via nutritional, chronobiological, and pharmacological interventions have markedly intensified interest in ketone body metabolism. The two ketone body redox partners, acetoacetate and D-β-hydroxybutyrate, serve distinct metabolic and signaling roles in biological systems. We discuss the pleiotropic roles played by both of these ketones in health and disease. While enthusiasm is warranted, prudent procession through therapeutic applications of ketogenic and ketone therapies is also advised, as a range of metabolic and signaling consequences continue to emerge. Organ-specific and cell-type-specific effects of ketone bodies are important to consider as prospective therapeutic and wellness applications increase.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"49-77"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922216/pdf/nihms-1785211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39507966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
A Dissenter's Journey. 异议者的旅程。
IF 8.9 2区 医学
Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-06-11 DOI: 10.1146/annurev-nutr-101220-114101
W Philip T James
{"title":"A Dissenter's Journey.","authors":"W Philip T James","doi":"10.1146/annurev-nutr-101220-114101","DOIUrl":"https://doi.org/10.1146/annurev-nutr-101220-114101","url":null,"abstract":"<p><p>After I studied medicine, my career took an early and unusual course when I was offered a clinical research post in Jamaica dealing with childhood malnutrition, of which I knew nothing. My subsequent nutritional explorations allowed gastrointestinal and metabolic analyses to have an impact on several public health policies. The biggest challenges came from unexpected political demands: coping with poor school performers in the Caribbean; addressing UK public health initiatives in health education; breaking the siege of Sarajevo; developing a Food Standards Agency as a sudden need for Tony Blair as incoming prime minister; dealing with widespread bovine spongiform encephalopathy in Europe; and responding to a United Nations request to assess global malnutrition. This last task revealed the need for a lifelong approach to nutrition, which also encompassed pregnancy. But perhaps the biggest challenge was establishing the criteria for obesity assessment, management, and prevention for policy makers across the globe.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":" ","pages":"1-18"},"PeriodicalIF":8.9,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39085178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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