Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning.

IF 12.6 2区医学 Q1 NUTRITION & DIETETICS

Annual review of nutrition Pub Date : 2020-09-23 Epub Date: 2020-06-16 DOI:10.1146/annurev-nutr-122319-034142

Nishan Sudheera Kalupahana, Bimba Lakmini Goonapienuwala, Naima Moustaid-Moussa

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引用次数: 24

Abstract

White adipose tissue (WAT) and brown adipose tissue (BAT) are involved in whole-body energy homeostasis and metabolic regulation. Changes to mass and function of these tissues impact glucose homeostasis and whole-body energy balance during development of obesity, weight loss, and subsequent weight regain. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which have known hypotriglyceridemic and cardioprotective effects, can also impact WAT and BAT function. In rodent models, these fatty acids alleviate obesity-associated WAT inflammation, improve energy metabolism, and increase thermogenic markers in BAT. Emerging evidence suggests that ω-3 PUFAs can also modulate gut microbiota impacting WAT function and adiposity. This review discusses molecular mechanisms, implications of these findings, translation to humans, and future work, especially with reference to the potential of these fatty acids in weight loss maintenance. Please see http://www.annualreviews.org/page/journal/pubdates for expected final online publication date for the Annual Review of Nutrition, Volume 40. 2020.

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Omega-3脂肪酸和脂肪组织:炎症和褐变。

白色脂肪组织(WAT)和棕色脂肪组织(BAT)参与全身能量稳态和代谢调节。在肥胖、体重减轻和随后的体重恢复过程中，这些组织的质量和功能的变化会影响葡萄糖稳态和全身能量平衡。ω-3多不饱和脂肪酸(ω-3 PUFAs)，已知具有降低甘油三酯和心脏保护作用，也可以影响WAT和BAT功能。在啮齿动物模型中，这些脂肪酸减轻肥胖相关的WAT炎症，改善能量代谢，增加BAT中的产热标志物。新出现的证据表明ω-3 PUFAs也可以调节影响WAT功能和肥胖的肠道微生物群。这篇综述讨论了分子机制，这些发现的意义，对人类的转化，以及未来的工作，特别是这些脂肪酸在维持体重方面的潜力。

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来源期刊

Annual review of nutrition 医学-营养学

CiteScore

15.80

自引率

0.00%

发文量

期刊介绍： Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition