Annals of Biomedical Engineering最新文献_第4页

Optimized FDA Blood Pump: A Case Study in System-Level Customized Ventricular Assist Device Designs. 优化FDA血泵：系统级定制心室辅助装置设计的案例研究。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-09-09 DOI: 10.1007/s10439-025-03834-8

Canberk Yıldırım, Kağan Uçak, Ali Madayen, Tansu Gölcez, Hakan Ertürk, Özgür Uğraş Baran, Kerem Pekkan

{"title":"Optimized FDA Blood Pump: A Case Study in System-Level Customized Ventricular Assist Device Designs.","authors":"Canberk Yıldırım, Kağan Uçak, Ali Madayen, Tansu Gölcez, Hakan Ertürk, Özgür Uğraş Baran, Kerem Pekkan","doi":"10.1007/s10439-025-03834-8","DOIUrl":"https://doi.org/10.1007/s10439-025-03834-8","url":null,"abstract":"Purpose: The design and development of ventricular assist devices have heavily relied on computational tools, particularly computational fluid dynamics (CFD), since the early 2000s. However, traditional CFD-based optimization requires costly trial-and-error approaches involving multiple design cycles. This study aims to propose a more efficient VAD design and optimization framework that overcomes these limitations.Methods: We developed a system- and component-level ventricle assist device optimization approach by coupling a lumped parameter cardiovascular physiology model with parametric turbomachinery, volute design, and blade path generation packages. The framework incorporates pump hydrodynamic losses and is validated against experimental data from six distinct blood pump designs and CFD simulations. The optimization framework allows for the specification of both physiology-related and device-related objective functions to generate optimized blood pump configurations over a large parameter space.Results: The optimization was applied to the U.S. Food and Drug Administration (FDA) benchmark blood pump as the baseline design. Results showed that an optimized FDA pump, maintaining the same cardiac output and aortic pressure, achieved a ~ 32% reduction in blade tip velocity compared to the baseline, resulting in an ~ 88% reduction in hemolysis. Additionally, an alternative design with a 40% reduction in blood-wetted area was generated while preserving the baseline pressure and flow.Conclusion: The proposed optimization framework improves device development efficiency by shortening the design cycle and enabling hydrodynamically optimized pumps that perform well across diverse patient hemodynamics. The optimized pump designs are available as open-source resources for further research and development.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Trade-Offs of Regulatory Mechanisms in the Management of Body Energy, Frontal Plane Angular Momentum and Mediolateral Margin of Stability During Hole Negotiation Gait. 孔洞步态中身体能量、正面角动量和中外侧稳定缘管理调节机制的功能权衡。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-09-08 DOI: 10.1007/s10439-025-03835-7

Adamantios Arampatzis, Maria-Elissavet Nikolaidou, Christos Theodorakis, Morteza Ghasemi, Falk Mersmann, Sebastian Bohm

{"title":"Functional Trade-Offs of Regulatory Mechanisms in the Management of Body Energy, Frontal Plane Angular Momentum and Mediolateral Margin of Stability During Hole Negotiation Gait.","authors":"Adamantios Arampatzis, Maria-Elissavet Nikolaidou, Christos Theodorakis, Morteza Ghasemi, Falk Mersmann, Sebastian Bohm","doi":"10.1007/s10439-025-03835-7","DOIUrl":"https://doi.org/10.1007/s10439-025-03835-7","url":null,"abstract":"The functional interaction of regulatory mechanisms that manage total centre of mass (CoM) energy, frontal plane whole-body angular momentum and mediolateral margin of stability (MoS) during hole negotiation gait was investigated. Joint kinematics, leg posture, total CoM energy, frontal plane whole-body angular momentum, mediolateral MoS and muscle activation patterns of seven bilateral lower leg muscles were assessed in 18 participants. During hole negotiation, we found an increase in the peak-to-peak range of total CoM energy and frontal plane whole-body angular momentum during the preparation, hole and recovery steps, and a decrease in mediolateral MoS at touch-down during the preparation and hole steps compared to level walking, providing evidence of an increased challenge in stability control. Anticipatory adjustments in CoM trajectories, joint kinematics and muscle activation patterns regulated mechanisms that primarily supported the management of total CoM energy at the expense of whole-body angular momentum in the frontal plane. We identified an anticipatory foot placement strategy during the step in the hole that significantly reduced the moment arm of the vertical ground reaction force (p = 0.011, d = 0.81), thereby favouring the control of frontal plane whole-body angular momentum. Conversely, this foot placement strategy significantly reduced (p < 0.001, d = 1.05) the mediolateral MoS. The mutual influence between the regulatory mechanisms that control total CoM energy, frontal plane angular momentum and mediolateral MoS represent trade-offs rooted in the nature of the hole negotiation gait and demonstrate the challenge of moving on uneven terrain.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model. 脊髓损伤研究的精确性：一种用于一致性猪模型的新型电磁冲击器。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-09-05 DOI: 10.1007/s10439-025-03836-6

Leonard Steger, Abdul Karim Ghaith, Carly Weber-Levine, Kayla Robinson, Christina Krueger, Constantin Smit, Siddharth Krishnan, Kelley M Kempski Leadingham, Daniel Davidar, Denis Routkevitch, Kelly Jiang, Victor Quiroz, Stuart Bauer, Ruixing Liang, Max Kerensky, Ian Suk, Betty Tyler, Joshua C Doloff, Nicholas Theodore, Amir Manbachi

{"title":"Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model.","authors":"Leonard Steger, Abdul Karim Ghaith, Carly Weber-Levine, Kayla Robinson, Christina Krueger, Constantin Smit, Siddharth Krishnan, Kelley M Kempski Leadingham, Daniel Davidar, Denis Routkevitch, Kelly Jiang, Victor Quiroz, Stuart Bauer, Ruixing Liang, Max Kerensky, Ian Suk, Betty Tyler, Joshua C Doloff, Nicholas Theodore, Amir Manbachi","doi":"10.1007/s10439-025-03836-6","DOIUrl":"10.1007/s10439-025-03836-6","url":null,"abstract":"Purpose: Replicating spinal cord injury (SCI) in large animals is necessary for evaluating translational therapeutics, yet there is currently no commercial, standardized device for inducing SCI. We present the fabrication and testing of a custom impactor device for producing repeatable contusion SCI in porcine models.Methods: The device was built, and mechanical modeling was utilized for calibration. Benchtop verification measured impact force. Impact velocity and kinetic energy were calculated. The device was used to generate a contusion SCI model in 2 pigs and the results were compared to an uninjured pig. Ultrasound imaging and Hematoxylin-eosin (H&E) staining were used to confirm injury presence. The device was utilized in survival studies requiring a porcine SCI model and motor scores were collected at postoperative day 1 in 4 pigs.Results: Characterization revealed distinct impact velocities for each dial turn. This device further demonstrated repeatability and the potential for modulating injury severity on the benchtop. Impactor forces were demonstrated across a range from 12.8 to 67.6 N, with error between 0.2 and 0.7 N. Kinetic energy ranged from 0.045 to 0.338 J, with error between 0.0009 to 0.003 J. Intraoperative ultrasound imaging and histology of the spinal cord confirmed two injuries of different severity. The device produced a variety of injury severities through parameter modifications in survival studies assessed by the porcine neurological motor (PNM) score.Conclusion: This impactor device is a major advancement towards titratable contusions in large animal SCI models.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Musculoskeletal Modeling of the Thoraco-Lumbar Spine: A Comprehensive Systematic Review. 胸腰椎肌肉骨骼模型的研究进展：一个全面的系统综述。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-09-05 DOI: 10.1007/s10439-025-03818-8

Linda Carpenedo, Dominika Ignasiak, Robin Remus, Luigi La Barbera

{"title":"Advances in Musculoskeletal Modeling of the Thoraco-Lumbar Spine: A Comprehensive Systematic Review.","authors":"Linda Carpenedo, Dominika Ignasiak, Robin Remus, Luigi La Barbera","doi":"10.1007/s10439-025-03818-8","DOIUrl":"https://doi.org/10.1007/s10439-025-03818-8","url":null,"abstract":"Understanding spine biomechanics is essential for maintaining posture under static and dynamic conditions, relying on a balance of muscular and gravitational forces. Computational musculoskeletal (MSK) models are increasingly being used in biomechanical research as non-invasive alternatives to in vivo and in vitro methods. Two main MSK modeling strategies are multibody (MB) models, which simplify the spine using rigid vertebrae and intervertebral joints to study muscle recruitment, and finite element (FE) models, which provide detailed tissue representation but often rely on oversimplified loading conditions. Recently, coupled (C) models integrating MB and FE approaches have emerged, though they face technical integration challenges. This literature review examines thoracolumbar MSK modeling methods-MB, FE, and C-to outline current practices, evaluate model capabilities, and inform future research and development. Most reviewed models have been published since 2016, reflecting the growing interest and advances in computational spine biomechanics. While certain modeling choices (e.g., the representation of body weight) are consistent across studies, considerable variability remains in other aspects (e.g., the depiction of muscular architecture, including the selection of muscle groups and the number of fascicles used). Despite being critical for model credibility, validation is often constrained by the limited availability of experimental data. Finally, the review highlights emerging directions such as modeling more complex functional tasks, personalizing anatomical and mechanical properties, and promoting Open Science to enhance reproducibility and collaboration in the field.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Contusion Risk Assessment in Astronauts During Off-Nominal Earth-Return Capsule Landings. 非标称返回舱着陆过程中宇航员肺挫伤风险评估。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-09-04 DOI: 10.1007/s10439-025-03839-3

Xin Ma, Dongmei Wang, Yutan Wang, Fang Wang, Aili Qu

{"title":"Pulmonary Contusion Risk Assessment in Astronauts During Off-Nominal Earth-Return Capsule Landings.","authors":"Xin Ma, Dongmei Wang, Yutan Wang, Fang Wang, Aili Qu","doi":"10.1007/s10439-025-03839-3","DOIUrl":"https://doi.org/10.1007/s10439-025-03839-3","url":null,"abstract":"Purpose: To investigate injury mechanisms and vulnerable regions for severe pulmonary contusion (PC) in astronauts during off-nominal capsule landings, establishing critical injury thresholds.Methods: Six distinct high-intensity landing scenarios (≤52.1 g) were simulated using a drop-tower test stand and a Hybrid III anthropometric test device(ATD). The Total Human Model for Safety (THUMS) finite element model (FEM) was utilized to simulate thorax-pulmonary dynamics at a 40° supine posture. Injury risk was assessed using the Viscous Criterion (VC), strain/strain-rate thresholds, and Abbreviated Injury Scale (AIS) criteria.Results: At 37.1 g impact (VCmax 0.98 m/s), the probability of life-threatening AIS 4 + PC surged to 25%, concurrent with a 19.5% probability of 3 + rib fractures(RF). The medial segment of the right middle lobe (S5) was the most severely affected region, primarily due to compression by the costal arch and liver. Injury to the right lung was more severe compared to the left, and fractures of the 1st, 9th, and 10th ribs exacerbated the lung injury.Conclusion: This study defines 37.1 g as the critical threshold for AIS 4 + thoraco-pulmonary trauma, elucidating the S5 compression mechanism and its association with high-risk RFs (1st, 9th, 10th). These findings provide a biomechanical foundation for enhancing astronaut survival protocols, enabling rapid post-impact triage, targeted pulmonary intervention (focus right S5 segment), and the design of energy-absorbing countermeasures to mitigate visceral compression.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image-Guided Adaptive Cryotherapy for Prostate Cancer Treatment. 影像引导下的适应性冷冻治疗前列腺癌。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-08-29 DOI: 10.1007/s10439-025-03833-9

Eva Beek, Nobuhiko Hata, Kemal Tuncali, Pedro Moreira

{"title":"Image-Guided Adaptive Cryotherapy for Prostate Cancer Treatment.","authors":"Eva Beek, Nobuhiko Hata, Kemal Tuncali, Pedro Moreira","doi":"10.1007/s10439-025-03833-9","DOIUrl":"10.1007/s10439-025-03833-9","url":null,"abstract":"Purpose: Focal cryoablation is an effective treatment for localized and recurrent prostate cancer, offering reduced risks of side effects. However, treatment success depends on physician experience, as intraprocedural adjustments are required due to needle deflection. To determine whether an image-guided adaptive treatment strategy could reduce the required years of experience, we developed Image-guided Adaptive Cryotherapy (ImAC). We hypothesize that ImAC can be successfully implemented in MRI-guided cryotherapy to optimize needle placement. To test this hypothesis, we conducted a retrospective study comparing the performance of an experienced physician to that of ImAC.Methods: ImAC was designed to calculate the best subsequent needle location while accounting for needle deflection and iceball formation. After development, its performance was evaluated by simulating 21 needle insertions.Results: We found that ImAC achieved a higher median minimum ablation margin than the physician (5.0 vs 3.4 mm) while maintaining similar needle placement adjustments (± 7.5 mm).Conclusion: These results suggest that ImAC has the potential to optimize needle placement and may reduce the years of experience required for effective cryoablation.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast Cancer. 局部重编程肿瘤相关巨噬细胞与装载细胞因子的可注射冷冻细胞治疗乳腺癌。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-08-29 DOI: 10.1007/s10439-025-03823-x

Sydney R Henriques, Evan B Glass, Kristen L Hoek, Ori Z Chalom, Abigail E Manning, Sohini Roy, Diana K Graves, Sarah M Goldstein, Benjamin C Hacker, Renjie Jin, Marjan Rafat, Paula J Hurley, Laura C Kennedy, Young J Kim, Andrew J Wilson, Fiona E Yull, Todd D Giorgio

{"title":"Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast Cancer.","authors":"Sydney R Henriques, Evan B Glass, Kristen L Hoek, Ori Z Chalom, Abigail E Manning, Sohini Roy, Diana K Graves, Sarah M Goldstein, Benjamin C Hacker, Renjie Jin, Marjan Rafat, Paula J Hurley, Laura C Kennedy, Young J Kim, Andrew J Wilson, Fiona E Yull, Todd D Giorgio","doi":"10.1007/s10439-025-03823-x","DOIUrl":"10.1007/s10439-025-03823-x","url":null,"abstract":"Purpose: Tumor-associated macrophages (TAMs) are the most abundant immune cells in primary solid tumors, including breast cancer, and typically exhibit an M2-like, immunosuppressive phenotype that promotes tumor growth. Given that TAMs can be repolarized through cytokine signaling, we propose a localized cytokine delivery depot using an injectable alginate cryogel to reprogram TAMs and create an inflammatory, anti-tumor TME.Methods: The cryogels were fabricated using cryogelation to generate a macroporous structure, followed by ionic crosslinking to enhance mechanical integrity while preserving pore size distribution. In vitro studies were conducted using bone marrow-derived macrophages, tumor-associated macrophages, and tumor explants. In vivo studies were conducted by orthotopically implanting breast tumors in the fat pads of FVB mice. Cell makeup and tissue composition were analyzed using qRT-PCR, flow cytometry, and Luminex panels. Statistical significance was determined using ANOVA and t-tests.Results: In vitro, cryogels released chemokines and cytokines, attracted M2 macrophages, and repolarized them toward M1-like activities. In vivo, cryogel treatment increased the presence of M1 macrophages relative to M2 macrophages in both the primary tumor and lungs, reduced primary tumor growth, and decreased T-cell exhaustion.Conclusions: A localized, injectable cryogel depot successfully induces an inflammatory TME, leading to reduced tumor burden and T-cell exhaustion while avoiding systemic toxicities associated with cytokine delivery.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies. 保留射血分数的心力衰竭临床前模型：推进器械治疗的知识。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-08-25 DOI: 10.1007/s10439-025-03821-z

Nina Langer, Andreas Escher, Caglar Ozturk, Andrew F Stephens, Ellen T Roche, Marcus Granegger, David M Kaye, Shaun D Gregory

{"title":"Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies.","authors":"Nina Langer, Andreas Escher, Caglar Ozturk, Andrew F Stephens, Ellen T Roche, Marcus Granegger, David M Kaye, Shaun D Gregory","doi":"10.1007/s10439-025-03821-z","DOIUrl":"https://doi.org/10.1007/s10439-025-03821-z","url":null,"abstract":"Heart failure with preserved ejection fraction (HFpEF) is a growing health problem worldwide, accounting for half of all heart failure cases. HFpEF patients present with diverse underlying causes and symptoms, making diagnosis and treatment challenging. Current pharmacological therapies are inadequate, while approved device-based therapies have shown limited success due to patient heterogeneity. This underscores the need for improved pre-clinical models, critical for guiding the design and development of effective therapeutic devices. This paper presents an overview of current pre-clinical HFpEF models, including in-silico, in-vitro, ex-vivo, and in-vivo approaches, aimed at advancing the understanding of HFpEF physiology and the development of device-based therapies. We examined each model's ability to replicate key HFpEF characteristics, discuss their respective strengths and limitations, and highlight their role in supporting the creation of clinically relevant solutions. Additionally, the potential of emerging advancements is explored.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy and Reliability of Synthetic Computed Tomography for Model-Based Tracking of Biplane Videoradiography Data. 基于模型的双翼放射成像数据跟踪的合成计算机断层扫描的准确性和可靠性。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-08-23 DOI: 10.1007/s10439-025-03831-x

Seth J Kussow, Jared L Zitnay, Penny R Atkins, Andrew E Anderson

{"title":"Accuracy and Reliability of Synthetic Computed Tomography for Model-Based Tracking of Biplane Videoradiography Data.","authors":"Seth J Kussow, Jared L Zitnay, Penny R Atkins, Andrew E Anderson","doi":"10.1007/s10439-025-03831-x","DOIUrl":"https://doi.org/10.1007/s10439-025-03831-x","url":null,"abstract":"Purpose: Biplane videoradiography (BVR) accurately measures hip kinematics in vivo. One downside of BVR is that it typically requires a pelvic computed tomography (CT) scan to reconstruct surfaces for model-based tracking (MBT), increasing the radiation burden to participants. Synthetic CT (sCT) from magnetic resonance imaging (MRI) provides similar volumetric image-based data. The purpose of this study was to assess the effect sCT has on the accuracy and reliability of in vivo hip kinematics from BVR data.Methods: Three asymptomatic participants received CT and MRI scans and were imaged with BVR while standing and during gait. Kinematics were calculated from femur and pelvis surfaces reconstructed from CT and sCT scans. Accuracy and inter-/intra-reviewer reliability of hip kinematics using sCT were assessed against CT as the reference using mean absolute error (MAE), mean difference (MD), precision, and inter-/intra-class correlation coefficients (ICCs). Kinematics were represented with and without correction for standing posture.Results: MAE, MD, and precision of posture-corrected sCT kinematic results were 0.85, 0.60, and 0.71° for rotations and 0.40, 0.23, and 0.39 mm for translations, respectively. Accuracy of posture-corrected joint angles was within 0.17° of prior MBT validation in the hip, while translation accuracy and precision were greater herein. Kinematic results using CT and sCT had similar reliability.Conclusion: The results of this study establish novel reliability metrics for in vivo hip kinematics from BVR. Findings indicate that sCT can be used in lieu of CT to measure in vivo hip kinematics, reducing radiation burden of BVR hip kinematic protocols by up to 73%.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lap belt-induced Iliac Wing Fracture Risk Curve Development for Female PMHS in Frontal Sled Tests. 正面台车试验中女性PMHS系带诱导髂翼断裂风险曲线的发展。

IF 5.4 2区医学

Annals of Biomedical Engineering Pub Date : 2025-08-22 DOI: 10.1007/s10439-025-03830-y

Karthik Somasundaram, Narayan Yoganandan, Frank Pintar

{"title":"Lap belt-induced Iliac Wing Fracture Risk Curve Development for Female PMHS in Frontal Sled Tests.","authors":"Karthik Somasundaram, Narayan Yoganandan, Frank Pintar","doi":"10.1007/s10439-025-03830-y","DOIUrl":"https://doi.org/10.1007/s10439-025-03830-y","url":null,"abstract":"Purpose: This study estimates the tolerance of the female pelvis iliac wing under lap belt loading in frontal impacts. With future autonomous vehicles relying on seatbelts as the primary restraint, understanding pelvic injury biomechanics is crucial. The goal was to investigate pelvis fracture patterns resulting from seat belt loading among female specimens in MCW series and develop injury risk curves (IRCs) for iliac bone fracture.Methods: Twenty-seven postmortem human subject (PMHS) frontal sled tests were conducted using a spring-controlled seat system. Tests included small and obese female surrogates at delta V levels of 32 kph and 50 kph, with variations in seatback recline angles, seat stiffness, and the presence of knee bolsters. Pelvic injury outcomes were analyzed, and IRCs were developed based on lap belt force, considering age, body mass index (BMI), and hip bone mineral density (BMD) as covariates.Results: The test produced iliac wing fracture coincided with the real-world report pattern in frontal collision. Two sets of IRCs were developed: Cohort A (small females) and Cohort B (all females). At 50% probability level, lap belt forces of 5.55 kN and 6.24 kN for cohort A and B, respectively. Age, BMI, and hip BMD significantly influenced fracture risk independently, but only for Cohort B.Conclusion: The developed IRCs reflect the characteristics of the tested female specimens from the current dataset. The findings indicate that increased age and declining hip BMD are associated with elevated injury risk, whereas a higher BMI may confer a protective effect.","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0