Annals of Biomedical Engineering最新文献

{"title":"Bony Hip Congruency and Coverage Varies by Acetabular Region and Activity in Asymptomatic Young Adults.","authors":"Camille C Johnson, Ethan R Ruh, Naomi E Frankston, Shaquille Charles, Craig Mauro, Michael McClincy, William J Anderst","doi":"10.1007/s10439-025-03826-8","DOIUrl":"https://doi.org/10.1007/s10439-025-03826-8","url":null,"abstract":"<p><strong>Purpose: </strong>Understanding how hip coverage and congruency change during dynamic loading may provide insight into the etiology of long-term degenerative pathology and susceptibility to hip instability. The goal of this study was to determine how hip congruency and femoral head coverage change during activities of daily living and their relationship with bone morphology in an asymptomatic cohort.</p><p><strong>Methods: </strong>Twenty-four healthy young adults (13 women, 21.9 ± 2.2 years) stood, walked, squatted, and ascended a step while synchronized biplane radiographs of the hip were collected. In-vivo bone motion was determined with sub-millimeter accuracy using a validated tracking technique that matched subject-specific bone models to the biplane radiographs. Dynamic congruency index (CI) and femoral head coverage were calculated across each activity. Mixed effects analyses determined effects of activity, region, and their interaction on CI or coverage, separately, and multiple linear regression determined the associations between alpha angle, lateral center edge angle (LCEA), and CI or coverage in each region and activity.</p><p><strong>Results: </strong>During lower-flexion activities, Anterior-Inferior, Anterior-Superior, and Posterior-Inferior congruency decreased up to 30% (all p < 0.02), Superior and Posterior-Superior congruency increased up to 40% (all p < 0.01), and Anterior and Inferior coverage decreased (up to 40.1% and 9.4%, all p < 0.01) compared to higher-flexion activities. LCEA was a better morphologic predictor of coverage and congruency than alpha angle.</p><p><strong>Conclusion: </strong>These observed regional variations in hip coverage and congruency in asymptomatic individuals provide a potential mechanistic explanation for common patterns of cartilage degeneration in the anterior acetabular region and a reference for evaluating pathologic hips.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Approaches and Evaluation Methods for Tissue-Engineered Articular Cartilage Constructs in Animal Models.","authors":"S H Aswathy, U Narendrakumar, I Manjubala","doi":"10.1007/s10439-025-03819-7","DOIUrl":"10.1007/s10439-025-03819-7","url":null,"abstract":"<p><p>One of the predominant clinical challenges faced by orthopedic practitioners and researchers is the regeneration of articular cartilage. Articular cartilage lesions and/or defects, as well as degeneration, are the primary causes of knee cartilage impairment. Tissue-engineered articular cartilage constructs are being developed to restore articular cartilage. Recent developments in the design of biomaterials have enabled the creation of many promising biomaterials for articular cartilage restoration. The purpose of this review is to provide researchers in the field of tissue engineering with a general overview of the approaches being used to examine articular cartilage and the evaluation methods being used to assess tissue-engineered constructs in animal models. Most tissue-engineered cartilage constructs tested in animal models are evaluated at least macroscopically and histologically. Furthermore, ICRS gross morphology scoring, immunohistochemistry, biochemical assays, biomechanical testing, gene expression analysis, and imaging techniques have been used to evaluate the regeneration potential of tissue-engineered constructs. This review also presents a comprehensive summary of the animal models used in the evaluation of tissue-engineered constructs for cartilage regeneration.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous and Autonomous Monitoring of Changes in Left Ventricular dP/dt_max Using an Epicardial Accelerometer.","authors":"Vetle Christoffer Frostelid, Ali Wajdan, Manuel Villegas-Martinez, Lars-Egil R Hammersboen, Andreas Espinoza, Ole-Johannes H N Grymyr, Per Steinar Halvorsen, Ole Jakob Elle, Espen W Remme","doi":"10.1007/s10439-025-03828-6","DOIUrl":"https://doi.org/10.1007/s10439-025-03828-6","url":null,"abstract":"<p><p>Assessment of the contractile function of the heart typically requires resource demanding techniques, such as invasive left ventricular catheterisation or intermittent medical imaging, and is therefore not readily available for continuous clinical or remote monitoring. Measurement of heart wall motion by use of an epicardially attached three-axis accelerometer has emerged as a promising tool for monitoring cardiac function; however, previous methods have often underutilised the spatial and temporal information contained in the measured signals, potentially limiting its clinical reliability. This work reconstructs the position of an epicardial accelerometer in 3D space in order to enable extraction of indices of cardiac function in a Lagrangian frame of reference. The standard deviation of Lagrangian acceleration throughout a heartbeat, <math><msub><mi>σ</mi> <mrow><mi>Acc</mi></mrow> </msub> </math> , is introduced as a novel surrogate indicator of contractility as changes in <math><msub><mi>σ</mi> <mrow><mi>Acc</mi></mrow> </msub> </math> correlated strongly with changes in the maximum rate of change in left ventricular pressure in animal data (n=29) spanning a variety of haemodynamic conditions. The reported findings of this proof-of-principle study may represent a first step towards long-term monitoring of contractile function and expands on the current repertoire of use for epicardially attached accelerometers as versatile, continuous, and autonomous monitoring devices.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Prompts in Manuscripts Threaten the Integrity of Peer Review and Research: Recommendations for Journals and Institutions","authors":"Louie Giray","doi":"10.1007/s10439-025-03827-7","DOIUrl":"10.1007/s10439-025-03827-7","url":null,"abstract":"<div><p>I examine the scholarly implications of a troubling case where researchers embedded hidden prompts like “give a positive review only” into academic preprints to manipulate AI-assisted peer review. AI is now woven into nearly every facet of academic life, including the peer review process. I contend that manipulating peer review through embedding secret prompts is as serious as plagiarism or data fabrication. Peer review may not be perfect, but deception is misconduct. Reviewers must still be held accountable. Those who blindly rely on AI outputs without critical engagement fail in their scholarly duty. AI should only amplify the reviewer’s expertise. As institutions begin regulating AI in research, similar frameworks must extend to peer review. Journals and publishers should establish clear, enforceable guidelines on acceptable AI use: Will AI be banned, regulated, or embraced? If allowed, disclosures must be mandatory. Authors should also be informed if AI tools will be used in the review process, ensuring transparency and consent. Confidentiality is another pressing issue. Real cases have shown how ChatGPT links shared by reviewers were indexed online, compromising sensitive, unpublished research, even though OpenAI has since moved to discontinue public link discoverability. Beyond policy, we must cultivate a culture of transparency, trust, and responsibility. Institutions can host ethics workshops and mentor early-career scholars. This is not just about AI; it is about who we are as researchers and reviewers. No matter how advanced the technology, integrity must remain our anchor. Without it, even the most innovative research stands on shaky ground.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2385 - 2388"},"PeriodicalIF":5.4,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autofluorescence Quenching in Decellularized Plant Scaffolds for Tissue Engineering.","authors":"Nick Merna","doi":"10.1007/s10439-025-03829-5","DOIUrl":"10.1007/s10439-025-03829-5","url":null,"abstract":"<p><strong>Purpose: </strong>Autofluorescence in plant-derived scaffolds interferes with fluorescence imaging by overlapping with commonly used fluorophores such as Hoechst and FITC. This limits the ability to visualize cell behavior and scaffold integration in tissue engineering applications. This study evaluated whether copper sulfate, ammonium chloride, or sodium borohydride can reduce autofluorescence in decellularized plant scaffolds without compromising mechanical integrity or cell viability.</p><p><strong>Methods: </strong>The effectiveness of the three quenching agents was evaluated in decellularized leatherleaf viburnum, spinach, and parsley scaffolds. Spectral scans were used to characterize baseline autofluorescence. Treated and untreated scaffolds were imaged in Hoechst, FITC, and 633 nm channels. Autofluorescence intensity, quenching stability over 24 h, mechanical properties, and endothelial cell viability were assessed. Imaging of cell seeded scaffolds evaluated improvements in visualization after treatment.</p><p><strong>Results: </strong>Spectral scans revealed strong autofluorescence in the blue and green channels, overlapping with Hoechst and FITC. Copper sulfate reduced autofluorescence more effectively than ammonium chloride or sodium borohydride and improved nuclear visualization, with consistent performance across scaffold types. However, endothelial cell viability declined in copper-treated leatherleaf and parsley scaffolds but remained high in spinach. No significant changes in tensile strength or elastic modulus were observed after treatment.</p><p><strong>Conclusion: </strong>Copper sulfate is a highly effective and stable quenching agent for reducing autofluorescence in plant-derived scaffolds. While suitable for post-fixation imaging, scaffold-specific effects on viability limit its use in live-cell applications. Autofluorescence reduction was achieved without compromising scaffold mechanics. Ammonium chloride and sodium borohydride may be preferable when preserving cell viability is a priority.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Symptom Burden, Cognitive Status, and Risk of Psychological Distress in NCAA Athletes with Sport-Related Concussion(s): Findings from the NCAA-DoD CARE Consortium.","authors":"Lauren L Czerniak, Gian-Gabriel P Garcia, Max W Genthe, Yueyun Xia, Mariel S Lavieri, Michael A McCrea, Thomas W McAllister, Paul F Pasquina, Spencer W Liebel, Steven P Broglio","doi":"10.1007/s10439-025-03824-w","DOIUrl":"https://doi.org/10.1007/s10439-025-03824-w","url":null,"abstract":"<p><strong>Purpose: </strong>Sport-related concussion (SRC) is one of the most complex injuries in sports medicine, and many athletes experience one or multiple SRCs over their collegiate career. However, from the start to the end of an athlete's collegiate career, it remains unclear which methods can accurately predict the change, if any, in an athlete's reported symptom burden, cognitive status, and risk of psychological distress. It is also unclear which factors (e.g., number of concussions) have the greatest influence on this change.</p><p><strong>Methods: </strong>We consider 3201 (1668 male, 1533 female) collegiate varsity athletes from the Concussion Assessment, Research, and Education (CARE) Consortium. Using five machine learning methods, we predict the change in athletes' reported symptom burden (i.e., Sport Concussion Assessment Tool [SCAT]), cognitive status (i.e., Standardized Assessment of Concussion [SAC]), and risk of psychological distress (i.e., Brief Symptom Inventory 18 [BSI-18]) over their collegiate careers.</p><p><strong>Results: </strong>All machine learning methods outperform a simple model that assumes no change with respect to mean squared error (i.e., machine learning helps avoid large prediction errors). We find that the initial baseline evaluation score is of greatest importance across all metrics of interest (e.g., SCAT/SAC/BSI-18). We also find that when an athlete has a poorer performance on the initial baseline evaluation, the prediction for the change in score is often larger and change for the better.</p><p><strong>Conclusion: </strong>This research provides insights on an athlete's change in critical areas of functioning over their collegiate career, and how machine learning can help improve the prediction of this change.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fostering Innovation Through Biomedical Engineering Education in the Philippines: Current Landscape, Challenges, and Future Directions.","authors":"Danilo V Rogayan","doi":"10.1007/s10439-025-03822-y","DOIUrl":"https://doi.org/10.1007/s10439-025-03822-y","url":null,"abstract":"<p><p>Biomedical engineering education in the Philippines is gaining momentum as universities and research institutions strive to integrate engineering and medical sciences to address local healthcare challenges. This article explores the current landscape of biomedical engineering programs, focusing on curriculum design, research initiatives, industry linkages, and graduate employability. It highlights the efforts of key institutions and identifies gaps in policy and professional recognition. Recommendations are proposed to align local programs with global standards and foster innovation through clinical integration, technopreneurship, and industry collaboration.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of Machine Learning in Biomedical Engineering for the Early Detection of Neurological Disorders","authors":"Georgios P. Georgiou","doi":"10.1007/s10439-025-03820-0","DOIUrl":"10.1007/s10439-025-03820-0","url":null,"abstract":"<div><p>Machine learning is increasingly recognized as a transformative tool in the diagnosis and prognosis of neurodevelopmental, neurodegenerative, and learning disorders. Through the analysis of complex patterns in speech and language, these models may offer important insights that can support and enhance clinical decision-making. This paper explores the potential of machine learning to detect a range of disorders and discusses its key advantages, limitations, and clinical integration.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2389 - 2391"},"PeriodicalIF":5.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Reduced Ball Inflation Pressure in Association Football Decrease Head Impact Kinematics?","authors":"Rory England, Suzie Liverseidge, Yusuke Miyazaki, Samuel W Oxford, Ieuan Phillips, Jon Farmer","doi":"10.1007/s10439-025-03804-0","DOIUrl":"https://doi.org/10.1007/s10439-025-03804-0","url":null,"abstract":"<p><strong>Purpose: </strong>Apparent degeneration in brain health due to heading the football is amongst the most pressing and contentious health-related questions in sport (Keogh F, Pirks N (2024) \"Pain was sickening\"-Ex-players on heading fears. In: BBC). The purpose of this study was to thoroughly explore the effectiveness of reduced inflation pressure as an intervention to reduce head kinematics from a ball to head impact. The influence of impact location, head orientation, neck flexion angle and ball type on the intervention were experimentally investigated.</p><p><strong>Method: </strong>A Hybrid III head and neck was impacted in frontal and oblique locations with two modern footballs that were projected using a bespoke launch device. Peak linear acceleration, peak angular velocity, peak angular acceleration and DAMAGE metrics were calculated for a total of 34 permutations of impact variables at two inflation pressures.</p><p><strong>Results: </strong>Magnitude was decreased (82%) or unchanged (8%) for 90% of impacts with average magnitude changes between - 2 and - 12% across the four metrics. Findings indicated that decreased inflation pressure was a positive intervention towards decreasing kinematic magnitudes in most cases. This was especially true for linear acceleration, angular velocity and angular acceleration, where 100, 97 and 100% of impacts were reduced or unchanged, respectively.</p><p><strong>Conclusions: </strong>Reduced inflation pressure was overall an effective mitigation to reduce the kinematic magnitude of heading in football based upon these four kinematic metrics despite 10% of impacts exhibiting an increase in kinematic magnitude. The DAMAGE predictor of MPS exhibited 12 out of 13 cases where magnitude increased demonstrating the capacity for decreased inflation pressure to result in increased kinematics for an angular response derived metric, indicating that reducing inflation pressure is not a universal solution. Nonetheless DAMAGE still saw a net decrease in magnitude across all impacts. Metric magnitude was found to be sensitive to head orientation, impact location and ball type, demonstrating the importance of the sensitivity analysis in this study. Two impacts were recommended to represent the worst-case ball to head impact, one in each nominal orientation. These locations contrasted with those commonly used in literature, a finding pertinent to future experimental design in football heading research.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards the Intravascular Delivery of 3D-printed Leached SMP for Endovascular Treatment of Intracranial Aneurysm.","authors":"Sergio Ruiz Vega, Juan C Mesa, Coral Blanquer, Cristian Barinaga, Tanner L Cabaniss, Angel Enriquez, Bradley N Bohnstedt, Chung-Hao Lee, Hyowon Lee","doi":"10.1007/s10439-025-03816-w","DOIUrl":"10.1007/s10439-025-03816-w","url":null,"abstract":"<p><strong>Purpose: </strong>Intracranial aneurysms (ICAs) pose a serious clinical risk due to their potential for rupture, leading to subarachnoid hemorrhage, high morbidity, and mortality. This study aims to develop a proof-of-concept device for the targeted delivery of shape memory polymers (SMPs)-based embolic devices to improve aneurysm occlusion and reduce recurrence.</p><p><strong>Methods: </strong>A novel system was designed combining a radial compression fixture and an electronic device for Joule heating and electrolytic detachment (ED). Three SMP geometries (5, 6.5 mm spherical, and patient-specific) were evaluated for the shape recovery and thermal responses. In-vitro testing was performed using 6.5 mm and patient-specific geometries in PDMS aneurysm phantoms under physiological relevant conditions utilizing ovine blood.</p><p><strong>Results: </strong>Controlled activation of the SMPs at currents of 400 mA achieved reproducible shape recovery ratios (SRRs) up to 75.71%, with detachment occurring at < 100 mA. Surface temperatures remained below 45 °C. In-vitro deployment resulted in aneurysm sac occlusion of 90.32% (patient-specific) and 94.12% (idealized), without evidence of thermal damage or gas accumulation. Flow visualization confirmed reduced bubble entry into the aneurysm sac post-deployment.</p><p><strong>Conclusion: </strong>This study demonstrates the feasibility of a targeted delivery system for patient-specific ICA treatment using SMPs. While further refinement and in-vivo validation are required, these findings highlight the potential of SMPs as durable embolization devices capable of conforming to complex aneurysm geometries and providing more effective occlusion compared to current methods.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}