Annals of Biomedical Engineering最新文献

{"title":"Correction to: Disc Injury and Spine Loads in Low-to-Moderate-Severity Frontal Impacts.","authors":"Richard Kent, Jason Forman","doi":"10.1007/s10439-025-03817-9","DOIUrl":"10.1007/s10439-025-03817-9","url":null,"abstract":"","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal Inverse Kinematics Tool for Inertial Motion Capture Data Based on the Adaptive Unscented Kalman Smoother: An Implementation for OpenSim.","authors":"Matti J Kortelainen, Paavo Vartiainen, Alexander Beattie, Jere Lavikainen, Pasi A Karjalainen","doi":"10.1007/s10439-025-03807-x","DOIUrl":"https://doi.org/10.1007/s10439-025-03807-x","url":null,"abstract":"<p><strong>Purpose: </strong>Conventional tools for human kinematics estimation presume that observations are subject to uncorrelated, zero-mean Gaussian noise, and they provide no estimate for the uncertainty of their solutions. This paper presents AUKSMIKT-a tool for whole-body kinematics estimation in the Bayesian framework to account for these shortcomings.</p><p><strong>Methods: </strong>We implemented AUKSMIKT as a C++ class that extends the OpenSim (v4.5) application programming interface. AUKSMIKT is based on the unscented Kalman filter combined with a run-time estimator of process and observation noises, and a fixed-lag Rauch-Tung-Striebel smoother. We tested the performance of AUKSMIKT using data from a public dataset consisting of both optical and inertial motion capture data recorded from overground walking subjects. We computed the mean absolute errors of estimated angular positions, velocities, and accelerations with respect to the gold standard optical motion capture estimates, and compared these metrics to those obtained from the least squares estimation-based tool native to OpenSim.</p><p><strong>Results: </strong>AUKSMIKT produced smaller errors than the native tool for the angular position of three joints (0.8-1.9%), the velocities of six joints (0.7- <math><mo>-</mo></math> 7.6%), and the accelerations of seven joints (3.0-13.7%). AUKSMIKT produced larger errors in the angular positions of five joints (1.3-7.6%), and the velocities of three joints (4.4-8.3%).</p><p><strong>Conclusion: </strong>With respect to the optical motion capture solution, AUKSMIKT can estimate lower-body kinematics from inertial motion capture data with comparable or higher accuracy than the native OpenSim least squares estimator.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The I-PREDICT 50th Percentile Male Warfighter Finite Element Model: Development and Validation of the Head and Neck.","authors":"Nolan M Norton, Sarah A Crimmins, Zachary S Hostetler, Lance L Frazer, Daniel P Nicolella, Matthew L Davis, Derek A Jones","doi":"10.1007/s10439-025-03814-y","DOIUrl":"https://doi.org/10.1007/s10439-025-03814-y","url":null,"abstract":"<p><p>Military aviators are commonly exposed to scenarios that lead to pain and injury of the head and neck. Postmortem human subjects, human volunteer testing, and anthropomorphic test device experiments can provide useful information for injury risk assessments, but each method has limitations. Finite element human body models are a useful tool for assessing aviator injury risk and generating data that can be used to improve warfighter safety. This study details the head and neck development for such an HBM, the Incapacitation Prediction for Readiness in Expeditionary Domains: an Integrated Computational Tool (I-PREDICT), through a hierarchical framework. A total of 26 cases were included in the hierarchical validation. The validation framework began with identifying and implementing appropriate material models, assessments of functional spinal units (FSUs), progressing to the regional cervical spine and head, and culminated with assessments of the head-neck complex using the BioRank biofidelity scoring system. I-PREDICT FSUs had an overall excellent biofidelity score when assessed in extension, flexion, and tension. The head had an overall excellent biofidelity score when assessed with impacts to the frontal, maxilla, zygomatic, temporal, and parietal regions. The regional cervical spine had an overall good biofidelity score when assessed in compression, extension, flexion, lateral bending, and axial rotation. The head-neck complex had an overall good biofidelity score when assessed in tension, a head drop case, and a rear impact case. The current I-PREDICT model is designed for a 50th percentile male warfighter.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Computational Framework for Investigating the Mechanical Stresses on Breast Implants Under Dynamic Loading Conditions.","authors":"Seungkwan Lee, Ju Yeon Park, Sinwoo Park, Jung-Ju Kim, Il-Seok Jang, Ju-Dong Song, Do-Nyun Kim","doi":"10.1007/s10439-025-03815-x","DOIUrl":"https://doi.org/10.1007/s10439-025-03815-x","url":null,"abstract":"<p><p>The durability and safety of silicone breast implants remain critical concerns due to risk of rupture under long-term and dynamic loading conditions. To address these challenges, this study introduces a Finite Element Analysis (FEA)-based approach to investigate the mechanical behavior of breast implant shells under simulated clinical conditions, including compressive loading and dynamic movements such as walking. The material properties of the implant components in the computational model were characterized through an optimization process integrating 3D scan data and simulation results. Two primary loading scenarios were modeled and analyzed: compressive forces from external pressure like physical manipulation or impact, and dynamic forces induced by walking, representing typical daily activities. Simulation results identified areas of high stress concentration on implant shells, corresponding to clinically observed rupture locations. Specifically, compressive loading simulations revealed high von Mises stress levels, while walking simulations demonstrated periodic stress fluctuations after the initial transient phase, highlighting fatigue-related risks in specific regions of the implant shell. Despite limitations, such as simplified material models and generic body geometries, this study provides a robust framework for analyzing implant performance under realistic conditions. These findings offer valuable insights for improving implant design and durability, paving the way for safer, patient-specific solutions.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Simulation of Respiration-Induced Deformation of Renal Arteries After EVAR.","authors":"Alessandra Corvo, Stéphane Avril, Alberto Aliseda, Stéphan Haulon, Fanette Chassagne","doi":"10.1007/s10439-025-03806-y","DOIUrl":"https://doi.org/10.1007/s10439-025-03806-y","url":null,"abstract":"<p><strong>Purpose: </strong>Fenestrated endovascular aneurysm repair (fEVAR) is widely used to treat complex abdominal aortic aneurysms, requiring renal artery stenting. However, complications such as occlusion can occur within the renal arteries. This study examines the effect of respiration-induced deformations, using patient-specific models and computational simulations. By investigating the impact of stenting and breathing, this research aims to improve surgical pre-planning and minimize EVAR complications.</p><p><strong>Methods: </strong>Pre-EVAR geometries from CT scans were segmented and meshed. Respiratory-induced displacements were applied to the segmented ends of the renal arteries to simulate breathing. The deployment process was achieved via balloon expansion, testing bridging stent-grafts with different lengths. To evaluate the accuracy of the workflow, simulated results and post-op CT scans were compared using centerline analysis, measuring morphological differences between the patient-specific models and the actual patients.</p><p><strong>Results: </strong>Numerical simulations accurately predicted renal artery movement during respiration, aligning with in vivo measurements. Simulated stent-graft configurations closely matched post-EVAR CT scans. Stent-graft protrusions into the aortic lumen were within the expected range, indicating correct positioning. Longer stent-grafts constrained renal artery movement, affecting branching angle changes, while shorter grafts had a less pronounced impact.</p><p><strong>Conclusions: </strong>Our novel digital twin model accurately simulates fEVAR procedures, including the deployment of renal bridging stent-grafts. Numerical simulations capture the bending of the renal arteries during breathing and their morphological changes following stenting in the post-operative configurations. Future research aims to expand the patient cohort and combine the solid mechanics simulations with CFD analysis.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Method for Functional Assessment of the Stenosis of the Anterior Cerebral Circulation.","authors":"Long Yu, Deyuan Zhu, Yunhan Cai, Yibin Fang, Shengzhang Wang","doi":"10.1007/s10439-025-03810-2","DOIUrl":"https://doi.org/10.1007/s10439-025-03810-2","url":null,"abstract":"<p><strong>Purpose: </strong>The cerebral anterior circulation arteries are the primary vessels supplying blood to the brain, and severe stenosis in these arteries can lead to ischemic stroke. Traditional imaging-based methods for assessing stenosis severity primarily focus on the diameter reduction at the narrowest point, which often fails to accurately reflect the functional severity of arterial stenosis. The FFR is considered the gold standard for assessing coronary artery stenosis. This study aims to revisit the original definition of FFR and develop a method for functionally assessing stenosis in the cerebral anterior circulation arteries.</p><p><strong>Methods: </strong>Patient-specific artery models representing both stenosed and post-repair conditions were generated based on clinical data. Numerical simulation models were then developed, and BFFR was calculated as an assessment metric. The accuracy of the numerical simulation model was validated through in vitro experiments.</p><p><strong>Results: </strong>The average bifurcation coefficient across the 9 cases was 2.82. The numerical simulation results for all cases were consistent with the clinical CTP measurements, accurately distinguishing the relative blood flow between the left and right arteries. The mean BFFR <math><mmultiscripts><mrow></mrow> <mrow><mi>min</mi></mrow> <mrow></mrow></mmultiscripts> </math> for patients with mild stenosis was 1.53 times higher than that of patients with moderate and severe stenosis. The relative error between the total flow obtained from the numerical simulations and the experimental measurements was less than 3%.</p><p><strong>Conclusion: </strong>Compared to traditional diameter stenosis rates, BFFR offers a significant advantage in evaluating cerebral artery stenosis. Furthermore, the numerical simulation model developed in this study demonstrated high accuracy.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Kinematics or Muscle Function During Sit-to-Stand Change Following a Primary Total Knee Arthroplasty?","authors":"Kathryn S. Blessinger,&nbsp;Sarah A. Roelker,&nbsp;Reese A. Lloyd,&nbsp;Laura C. Schmitt,&nbsp;Ajit M. W. Chaudhari,&nbsp;Robert A. Siston","doi":"10.1007/s10439-025-03782-3","DOIUrl":"10.1007/s10439-025-03782-3","url":null,"abstract":"<div><p>Sit-to-stand (STS) transfer is essential for independent living and mobility in daily life but challenging for individuals before and after total knee arthroplasty (TKA). It remains unclear whether deficits in individual muscle function contribute to the lack of improvement in STS performance following TKA. The objective of this study was to determine whether lower extremity kinematics, muscle function during STS (quantified by muscle forces and muscle contributions to acceleration), and knee extension strength change following TKA. Dynamic musculoskeletal simulations of STS were performed for seven individuals before and six months after surgery. Computed muscle control and induced acceleration analysis were used to determine individual muscle forces and contributions to center of mass acceleration, respectively. Overall kinematic strategy did not largely change following TKA, and we found no change in muscle forces, muscle contributions, or knee extension strength following TKA, suggesting a consistent movement strategy to compensate for persistent quadriceps weakness. Both before and after TKA, the psoas, gluteus medius, vastus medialis and lateralis, and soleus produced the largest forces, while the gluteus maximus and biceps femoris produced smaller forces. Large braking contributions to acceleration from several muscles and small gluteus maximus contributions to forward and upward acceleration observed at both time points may contribute to the persistent functional performance deficits often observed in patients with a TKA. These findings demonstrate that overall movement strategy during STS (quantified by kinematics and muscle function) and knee extension strength did not change within six months following TKA, which may inform post-operative rehabilitation programs.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2474 - 2488"},"PeriodicalIF":5.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03782-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usability of Speculum-Compatible Injection Devices for Administering Ethyl Cellulose-Ethanol Ablation to Treat Cervical Neoplasia in Low- and Middle-Income Countries","authors":"Taya Lee,&nbsp;Vené Richardson-Powell,&nbsp;Jason Chen,&nbsp;David Garvey,&nbsp;Venkata Sarojasamhita,&nbsp;Kevin Aroom,&nbsp;Martha O. Wang,&nbsp;Brian Crouch,&nbsp;Nimmi Ramanujam,&nbsp;Julie Hurvitz,&nbsp;Jenna Mueller","doi":"10.1007/s10439-025-03799-8","DOIUrl":"10.1007/s10439-025-03799-8","url":null,"abstract":"<div><h3>Purpose</h3><p>Current treatments for cervical neoplasia are often inaccessible in low- and middle-income countries (LMICs), which contributes to high cervical cancer mortality. We previously developed a low-cost ablative therapy using ethanol mixed with ethyl cellulose (EC) to a form an ethanol-retaining gel that reduces injection leakage. To optimize delivery of EC-ethanol into the cervix, we developed and compared three speculum-compatible injectors that each address clinical challenges: 1) a single needle injector, which contained an adjustable depth stop to control the depth of injection, 2) a multi needle injector, which injected three locations in the cervix simultaneously, and 3) an extender injector, which included a needle extender.</p><h3>Methods</h3><p>The variability in EC-ethanol injections was evaluated through bench top and <i>ex vivo</i> swine testing. Usability testing was performed by gynecology (GYN) providers who used each device in a custom pelvic model.</p><h3>Results</h3><p>Both the extender and single needle devices led to consistent ejection volumes in benchtop tests with no variability between injections. All devices achieved spherical depots with minimal leakage in <i>ex vivo</i> tests. In usability testing, 65% of GYN providers preferred the extender device, which achieved significantly shorter injection times in the custom pelvic model compared to other injectors.</p><h3>Conclusion</h3><p>While all devices met clinical constraints, the extender device was preferred by clinicians and achieved repeatable injection distributions. This work presents a clinically informed low-cost intracervical delivery method for LMICs. Future work will include validating performance in clinical trials and assessing feasibility in clinical settings to advance global cervical neoplasia treatment.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2658 - 2668"},"PeriodicalIF":5.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03799-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Bioprinting Technology Utilizing Portable Bioprinters: From Various Device Designs to Dental Applications","authors":"YongJu Chen,&nbsp;MengJie Kong,&nbsp;Tingting Zhang,&nbsp;JiaXin Li","doi":"10.1007/s10439-025-03789-w","DOIUrl":"10.1007/s10439-025-03789-w","url":null,"abstract":"<div><p>Recent advancements in portable bioprinting technology present transformative opportunities for dental applications, enabling handy fabrication of biologically functional tissues. This narrative review examines the current state of portable bioprinting systems, focusing on their potential to address critical challenges in restorative dentistry, periodontal regeneration, and endodontic therapy. We summarize key innovations in handheld bioprinting devices, emphasizing their operational mechanisms, bioink developments, and clinical applicability. Particular attention is given to four-dimensional (4D) bioprinting approaches that leverage stimuli-responsive materials for dynamic tissue reconstruction. While demonstrating promising results in pulp vascularization and defect repair, portable bioprinters face significant limitations in precision, scalability, and reproducibility due to their manual operation and environmental sensitivity. We evaluate these technical constraints and propose solutions through emerging technologies such as robotic-assisted printing, artificial intelligence-driven process optimization, and smart bioink formulations. The discussion extends to standardization protocols and regulatory considerations necessary for clinical translation. Looking forward, we highlight interdisciplinary strategies to bridge existing gaps between laboratory innovation and clinical implementation. By addressing current challenges in automation, material science, and quality control, portable bioprinting could revolutionize personalized dental care, offering biologically integrated solutions that surpass conventional synthetic alternatives. This narrative review provides both a comprehensive assessment of the progress in this field and a roadmap for future development toward clinically viable systems.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2408 - 2425"},"PeriodicalIF":5.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hybrid Approach Combining Dual-Energy and Inpainting Methods for Metal Artifact Reduction in Dentomaxillofacial CBCT: A Proof-of-Concept Phantom Study","authors":"Dinidu Jayakody,&nbsp;Harshit Agrawal,&nbsp;Ella Räinä,&nbsp;Annina Sipola,&nbsp;Ritva Näpänkangas,&nbsp;Sampo Ylisiurua,&nbsp;Miika T. Nieminen,&nbsp;Mikael Brix","doi":"10.1007/s10439-025-03811-1","DOIUrl":"10.1007/s10439-025-03811-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Image inaccuracies and distortions are amplified in cone-beam computed tomography (CBCT), with beam hardening and metal artifacts being particularly pronounced, thereby complicating diagnostic interpretation. An approach, combining dual-energy CBCT based projection-domain material decomposition with virtual monochromatic imaging (VMI) technique, was leveraged to mitigate beam hardening artifacts originating from dental restorative and prosthetic materials on a diagnostic CBCT scanner in a phantom setting.</p><h3>Methods</h3><p>Severe artifact-causing dental restorative and prosthetic materials were identified from the literature and six of them were selected for the study. Six different phantoms were developed using selected materials, and 3D-printed cylindrical molds filled with gelatine. Three different tube voltages, such as 80 kilovoltage (kV), 100 kV, 120 kV were selected for scanning and the phantoms were scanned using a commercial CBCT scanner (Viso G7, Planmeca Oy., Helsinki, Finland). A custom-developed material decomposition algorithm, based on polychromatic projection domain modeling, was employed to separate the dual-energy data into water and iron basis materials. VMIs were then synthesized at 200 keV using the decomposed data. For comparison, the 100 kV acquisition (routine protocol) with and without the vendor’s inpainting-based MAR algorithm was used to assess VMI techniques’ performance for artifact reduction.</p><h3>Results</h3><p>Both subjectively and quantitatively, the VMI technique offered better image quality than the routine 100 kV protocol. Further, combining the VMI technique with an inpainting-based MAR algorithm offered superior artifact reduction (<i>p</i> &lt; 0.01) for all tested materials compared to using the routine protocol and the MAR algorithm.</p><h3>Conclusions</h3><p>The proposed VMI + MAR technique offered superior artifact reduction compared to a commercial MAR algorithm.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2638 - 2647"},"PeriodicalIF":5.4,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03811-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}