Annals of Biomedical Engineering最新文献

{"title":"Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity","authors":"Annika R. Bergstrom,&nbsp;Matthew G. Glimm,&nbsp;Eden A. Houske,&nbsp;Gwendolyn Cooper,&nbsp;Ethan Viles,&nbsp;Marrin Chapman,&nbsp;Katherine Bourekis,&nbsp;Hope D. Welhaven,&nbsp;Priyanka P. Brahmachary,&nbsp;Alyssa K. Hahn,&nbsp;Ronald K. June","doi":"10.1007/s10439-024-03667-x","DOIUrl":"10.1007/s10439-024-03667-x","url":null,"abstract":"<div><p>The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10⁻⁶ g) exposure could lead to osteoarthritis (OA), compromising quality of life post-spaceflight. In this study, we encapsulated human chondrocytes in an agarose gel of similar stiffness to the pericellular matrix to mimic the cartilage microenvironment. We then exposed agarose-chondrocyte constructs to simulated microgravity (SM) for four days using a rotating wall vessel (RWV) bioreactor to better assess the cartilage health risks associated with spaceflight. Metabolites extracted from media and agarose gel constructs were analyzed on liquid chromatography-mass spectrometry. Global metabolomic profiling detected a total of 1205 metabolite features, with 497 significant metabolite features identified by ANOVA (FDR-corrected <i>p</i>-value &lt; 0.05). Specific metabolic shifts detected in response to SM exposure resulted in clusters of co-regulated metabolites, with glutathione, nitrogen, histidine, vitamin B₃, and aminosugars metabolism identified by variable importance in projection scores. Microgravity-induced metabolic shifts in gel constructs and media were indicative of protein synthesis, energy and nucleotide metabolism, and oxidative catabolism. Microgravity associated-metabolic shifts were consistent with our previously published early osteoarthritic metabolomic profiles in human synovial fluid, suggesting that even short-term exposure to microgravity (or other reduced mechanical loading environments) may lead to the development of OA. This work further suggests the potential to detect these metabolic perturbations in synovial fluid <i>in vivo</i> to ascertain osteoarthritis risk in astronauts.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"785 - 797"},"PeriodicalIF":3.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03667-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Impedance and Wave Reflections in Adults with Mitral Stenosis: Immediate and Follow-Up Effects of Balloon Valvuloplasty","authors":"Chih-Tai Ting,&nbsp;Jaw-Wen Chen,&nbsp;Mau-Song Chang,&nbsp;Frank C.-P. Yin","doi":"10.1007/s10439-024-03661-3","DOIUrl":"10.1007/s10439-024-03661-3","url":null,"abstract":"<div><h3>Purpose</h3><p>We compared adults with mitral stenosis (MS) to 8 controls (CONT) to see how pulmonary impedance and wave reflections differ at baseline and after balloon valvuloplasty.</p><h3>Methods</h3><p>We separated the MS patients into groups according to mean pulmonary artery pressure: moderate (MOD; ≤ 26 mmHg, n = 21) and high (HIGH; &gt; 26 mmHg, n = 33). We made baseline high-fidelity measurements in all patients, in the MS groups after vasodilation with nitroprusside, immediately and 4 months after balloon valvuloplasty.</p><h3>Results</h3><p>Comparing MOD vs CONT, using the Kruskal-Wallis test with Bonferroni correction, reveals evidence for higher baseline input resistance (R) (489 vs 205 dyne-sec/cm⁵, P = 0.07); first harmonic of impedance modulus (Z₁) (97.3 vs 27.6 dyne-sec/cm⁵, P = 0.01); first zero crossing of impedance phase angle (F₀) (4.49° vs 2.19°, P = 0.02) but no difference in wave reflection index (P_b/P_f). Baseline HIGH vs CONT comparisons reveal stronger evidence and larger differences than MOD for R (995 vs 205, P &lt; 0.001); Z₁ (151 vs 27.6, P &lt; 0.001); F₀ (5.25 vs 2.19, P &lt; 0.001); as well as P_b/P_f (0.69 vs 0.42, P &lt; 0.001). Responses to nitroprusside and valvuloplasty are also greater in the HIGH than MOD, but the HIGH parameters still differ from the CONT. Four months after valvuloplasty there is evidence for reverse remodeling in both groups. Further analyses reveal that sinus rhythm and younger age are potentially important factors for remodeling.</p><h3>Conclusion</h3><p>MS causes alterations in pulmonary hemodynamics that differ according to pressure levels. These changes are only partially reversed immediately after valvuloplasty. There is evidence for reverse remodeling 4 months afterwards.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"758 - 784"},"PeriodicalIF":3.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03661-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel In Silico–Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures","authors":"Efstathios Stratakos,&nbsp;Linnea Tscheuschner,&nbsp;Lorenzo Vincenzi,&nbsp;Edoardo Pedrinazzi,&nbsp;Fragiska Sigala,&nbsp;Luca D’Andrea,&nbsp;Dario Gastaldi,&nbsp;Francesca Berti,&nbsp;Abraham Rami Tzafriri,&nbsp;Giancarlo Pennati","doi":"10.1007/s10439-024-03634-6","DOIUrl":"10.1007/s10439-024-03634-6","url":null,"abstract":"<div><p>Drug-coated balloons (DCBs) aim to deliver drug-loaded surface coating upon inflation at specific vascular sites, yet the role of inflation pressure remains to be defined. We implement a new approach combining ex vivo stamping experiments with in silico simulations to study acute coating transfer by commercial DCBs. This methodology comprises 3 essential pillars: (I) DCB resin inflation and slicing into cylindrical segments for subsequent stamping onto porcine-excised tissue, (II) Numerical inflation of a full DCB replica in an idealized porcine vessel to predict in vivo interfacial contact pressures (CPs) and subsequent interfacial-level numerical stamping to calculate appropriate benchtop forces that recreate these in vivo CP values, and (III) ex vivo stamping experiments and optical analysis of the stamped surfaces (DCB segment and arterial tissue), using a standard high-resolution camera to visualize coating. High-performance liquid chromatography (HPLC) was employed as a validated assay for quantifying drug in tissue samples post-stamping. HPLC analysis revealed a significant correlation with image processing, confirming the validity of the optical method as a tool to quantify DCB coating. Image and HPLC analysis revealed a statistically significant twofold rise in coating area and drug content to tissue, respectively, when the average CP roughly doubled (0.16–0.35 atm) and a non-statistically significant increase in coating area and drug content with a further rough doubling of average CP (0.35 to 0.75 atm). Imaging of DCB segments pre- and post-stamping showed transfer of partial coating thickness at low CP, contrasting with complete transfer at high CP at the same site. 3D confocal images of DCB surfaces revealed variable thickness in the transferred coating. This study introduces a comprehensive methodology for evaluating the efficacy of commercial DCB coating transfer to arterial tissue—a crucial precursor to drug elution studies—while minimizing the number of DCBs needed and improving variable control and realism.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"740 - 757"},"PeriodicalIF":3.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03634-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Simulation Approaches Used in Finite Element Modelling of a Medial Opening Wedge High Tibial Osteotomy","authors":"Victor A. Carranza,&nbsp;Alan Getgood,&nbsp;Ryan Willing,&nbsp;Timothy A. Burkhart","doi":"10.1007/s10439-024-03662-2","DOIUrl":"10.1007/s10439-024-03662-2","url":null,"abstract":"<div><h3>Purpose</h3><p>Medial opening wedge high tibial osteotomy is a surgical procedure intended to relieve the symptoms of osteoarthritis in the medial compartment of the knee by addressing malalignment within the structures of the knee. In previous studies, the osteotomy cut and wedge opening in a Medial opening wedge high tibial osteotomy finite element model has been represented using either one of two techniques, which we define herein as wedge opening and wedge removal approaches. The purpose of this study is to determine whether the wedge removal for a medial opening wedge high tibial osteotomy finite element modelling study predicts accurate stresses and strains in the plate, screw, and throughout the proximal tibia, in comparison to the wedge opening.</p><h3>Methods</h3><p>Seven tibia models were reconstructed from CT scans of seven cadaveric specimen. Two sets of models were created from the same set of specimens to create the wedge opening (<i>n</i> = 7) and wedge removal (<i>n</i> = 7) dataset.</p><h3>Results</h3><p>A statistically significant difference in the mean plate stresses, screw stresses, and stresses in the tibia at the region around the apex of the osteotomy were found with the wedge removal, resulting in 4–59% greater stresses.</p><h3>Conclusion</h3><p>The wedge removal is not an accurate representation of a medial opening wedge high tibial osteotomy with respect to the wedge opening. Selecting the appropriate modelling method that best represents the clinical scenario is the first crucial step in creating a representative finite element model.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"731 - 739"},"PeriodicalIF":3.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Computational Modeling of Blast Transmission through the Fluid-Filled Cochlea and Hair Cells","authors":"John J. Bradshaw,&nbsp;Marcus A. Brown,&nbsp;Yijie Jiang,&nbsp;Rong Z. Gan","doi":"10.1007/s10439-024-03659-x","DOIUrl":"10.1007/s10439-024-03659-x","url":null,"abstract":"<div><h3>Purpose</h3><p>Veterans commonly suffer from blast-induced hearing disabilities. Injury to the sensitive organ of Corti (OC) or hair cells within the cochlea can directly lead to hearing loss, but is very difficult to measure experimentally. Computational finite element (FE) models of the human ear have been used to predict blast wave transmission through the middle ear and cochlea, but these models lack a representation of the OC. This paper reports a recently developed 3D FE model of the OC to simulate the response of hair cells to blast waves and predict possible injury locations.</p><h3>Methods</h3><p>Components of the OC model consist of the sensory cells, membranes, and supporting cells with endolymphatic fluid surrounding them inside the scala media. Displacement of the basilar membrane induced by a 31-kPa blast overpressure derived from the macroscale model of the human ear was applied as input to the OC model. The fluid–structure interaction coupled analysis in the time domain was conducted in ANSYS.</p><h3>Results</h3><p>Major results derived from the FE model include the strains and displacements of the outer hair cells, stereociliary hair bundles (HBs), reticular lamina, and the tectorial membrane (TcM). The highest structural strain was concentrated around the connecting region of the HBs and the TcM, potentially indicating detachment due to blast exposure. Including the interstitial fluid in the OC created a realistic environment and improved the accuracy of the results compared to the previously published OC model without fluid.</p><h3>Conclusion</h3><p>The microscale model of OC was developed in order to simulate blast overpressure transmission through the fluid-filled cochlea and hair cells. This FE model represents a significant advancement in the study of blast wave transmission through the inner ear, and is an important step toward a comprehensive multi-scale model of the human ear that can predict blast-induced injury and hearing loss.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"718 - 730"},"PeriodicalIF":3.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints","authors":"Lizzie Walker,&nbsp;Daniel Gordon,&nbsp;Alexander Chiaramonti,&nbsp;Shangping Wang,&nbsp;Zhaoxu Meng,&nbsp;Dane Daley,&nbsp;Elizabeth Slate,&nbsp;Hai Yao,&nbsp;Vincent D. Pellegrini Jr.,&nbsp;Yongren Wu","doi":"10.1007/s10439-024-03660-4","DOIUrl":"10.1007/s10439-024-03660-4","url":null,"abstract":"<div><h3>Purpose</h3><p>To identify changes in morphological and mechanical properties in the volar ligament complex (VLC), dorsoradial ligaments (DRL), and posterior oblique ligaments (POL) in healthy and osteoarthritic female trapeziometacarpal (TMC) joints.</p><h3>Methods</h3><p>Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Stress relaxation and load-to-failure testing were performed to characterize mechanical tensile properties. Light imaging and scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS) were performed to further assess enthesis structural integrity.</p><h3>Results</h3><p>The VLC in advanced-stage osteoarthritic TMCs had attenuated mechanical properties in stress relaxation experiments compared to the elder healthy/early-stage osteoarthritic specimens: Young’s modulus at 20% strain (<i>P</i> = 0.044), instantaneous (<i>P</i> = 0.023), relaxed (<i>P</i> = 0.017) moduli. VLCs in advanced-stage osteoarthritic TMCs also had significantly lower properties in the load-to-failure experiments compared to the younger healthy/early-stage osteoarthritic specimens: stiffness (<i>P</i> = 0.048), ultimate load (<i>P</i> = 0.017), toughness (<i>P</i> = 0.003). Light and SEM/EDS imaging revealed partial detachment and loss of enthesis mineral gradient at VLC metacarpal insertion in advanced-stage osteoarthritic specimens. There were no mechanical or structural changes in the DRL and POL between experiment groups.</p><h3>Conclusion</h3><p>VLC morphological and mechanical properties deteriorate across progressively severe osteoarthritis classifications while the DRL and POL remain unchanged. The attenuated mechanical properties of VLCs in advanced-stage osteoarthritic TMCs can be explained by ligament degradation as evidenced by partial detachment and loss of mineral gradient at the metacarpal insertion.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 4","pages":"799 - 811"},"PeriodicalIF":3.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03660-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An OLIF Cage Integrated with a Low-Profile Plate and Cross Screws Could Reduce the Risk of Postoperative Complications Biomechanically","authors":"Ping Cai,&nbsp;Chen Xu,&nbsp;Zifan Zhang,&nbsp;Zhongxin Fang,&nbsp;Chao Deng,&nbsp;Gang Chen,&nbsp;Guoyou Wang,&nbsp;Jingchi Li","doi":"10.1007/s10439-024-03643-5","DOIUrl":"10.1007/s10439-024-03643-5","url":null,"abstract":"<div><h3>Background</h3><p>Stand-alone oblique lumbar interbody fusion (OLIF) cannot provide credible postoperative stability; additional fixation devices (AFDs) have been used to optimize surgical segment stability. Anterior lateral single rod (ALSR) screw fixation can be performed without intraoperative body position changes and additional surgical incisions, but its biomechanical defect may trigger complications. Inspired by the cross screw in other fixation devices, we designed an OLIF cage integrated with a low-profile plate and cross screw (LPCS).</p><h3>Methods</h3><p>This study was designed to investigate whether the biomechanical performance of the LPCS OLIF cage is better than that of OLIF with ALSR fixation. The pullout and bending strength of the newly designed conical screw were tested by comparing it with a clinically used cylindrical screw. Different directional fixation strengths of the LPCS OLIF cage were tested by comparing the failure moment and stiffness with the ALSR fixation model. To test the fixation stability and potential risk for screw loosening in models with LPCS OLIF, we also compared the surgical segment's range of motions (ROMs) and stress distributions on OLIF models without and with different AFD fixation under physiological loading conditions.</p><h3>Results</h3><p>The bending and pullout strength of the conical screw was better than that of the clinically used screw, and the failure moment and stiffness of the LPCS OLIF model were higher than those of the ALSR model, especially under the extension loading conditions. In which, the maximum failure moment of ALSR fixed OLIF model was 0.88 Nm and 0.76 Nm, while that of the LPCS OLIF model was 9.79 Nm and 7.48 Nm in models with normal and osteoporotic BMD, respectively. Compared to the ALSR fixed OLIF model, failure moment of LPCS models increased by 1012.5% and 884.21% in normal and osteoporotic models, respectively. Moreover, under most physiological loading conditions, the ROM and stress values of the LPCS OLIF model were lower than those of the ALSR model and even slightly lower than those of the OLIF model with bilateral pedicle screw fixation under limited loading conditions.</p><h3>Conclusions</h3><p>Compared to OLIF with ALSR fixation, the newly developed LPCS OLIF cage demonstrates inherent biomechanical advantages in establishing immediate postoperative stability and reducing complications related to stress concentration. However, the conclusions of current research should still be validated through in vitro mechanical tests and clinical trials.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"683 - 698"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peaks and Distributions of White Matter Tract-related Strains in Bicycle Helmeted Impacts: Implication for Helmet Ranking and Optimization","authors":"Zhou Zhou,&nbsp;Madelen Fahlstedt,&nbsp;Xiaogai Li,&nbsp;Svein Kleiven","doi":"10.1007/s10439-024-03653-3","DOIUrl":"10.1007/s10439-024-03653-3","url":null,"abstract":"<div><p>Traumatic brain injury (TBI) in cyclists is a growing public health problem, with helmets being the major protection gear. Finite element head models have been increasingly used to engineer safer helmets often by mitigating brain strain peaks. However, how different helmets alter the spatial distribution of brain strain remains largely unknown. Besides, existing research primarily used maximum principal strain (MPS) as the injury parameter, while white matter fiber tract-related strains, increasingly recognized as effective predictors for TBI, have rarely been used for helmet evaluation. To address these research gaps, we used an anatomically detailed head model with embedded fiber tracts to simulate fifty-one helmeted impacts, encompassing seventeen bicycle helmets under three impact locations. We assessed the helmet performance based on four tract-related strains characterizing the normal and shear strain oriented along and perpendicular to the fiber tract, as well as the prevalently used MPS. Our results showed that both the helmet model and impact location affected the strain peaks. Interestingly, we noted that different helmets did not alter strain distribution, except for one helmet under one specific impact location. Moreover, our analyses revealed that helmet ranking outcome based on strain peaks was affected by the choice of injury metrics (Kendall’s Tau coefficient: 0.58–0.93). Significant correlations were noted between tract-related strains and angular motion-based injury metrics. This study provided new insights into computational brain biomechanics and highlighted the helmet ranking outcome was dependent on the choice of injury metrics. Our results also hinted that the performance of helmets could be augmented by mitigating the strain peak and optimizing the strain distribution with accounting the selective vulnerability of brain subregions and more research was needed to develop region-specific injury criteria.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"699 - 717"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03653-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Irradiation Induced Cerebral Water and Hemodynamic Response in Whole Brain Radiotherapy","authors":"Heli Miettinen,&nbsp;Jesse Lohela,&nbsp;Sadegh Moradi,&nbsp;Kalle Inget,&nbsp;Juha Nikkinen,&nbsp;Teemu Myllylä,&nbsp;Sakari S. Karhula,&nbsp;Vesa Korhonen","doi":"10.1007/s10439-024-03663-1","DOIUrl":"10.1007/s10439-024-03663-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Effects of clinical radiotherapy are often studied between or after irradiations. The current study’s aim was to monitor an immediate irradiation response in cerebral water and hemodynamics in patients treated with whole brain radiotherapy (WBRT) and to assess the response’s individuality.</p><h3>Methods</h3><p>We used functional near-infrared spectroscopy (fNIRS) to monitor changes in cerebral water, oxyhemoglobin (HbO), and deoxyhemoglobin (HbR) during the irradiation of 31 patients (age 69.3 ± 12.5 years, 16 females) receiving WBRT. The radiation dose delivered to a patient during a single measurement was 4 Gy (total dose of 20 Gy in five fractions) for most patients and 3 Gy (total dose of 30 Gy in ten fractions) for three patients.</p><h3>Results</h3><p>106 patient recordings were analyzed. They showed an immediate irradiation induced increase in HbO and HbR, and decrease in cerebral water content (<i>P</i> &lt; .001) as soon as 5 s after the start of irradiation. The radiation dose, age, and gender affected recorded signals. A smaller dose resulted in a steeper change in HbR (<i>P</i> &lt; .01), but larger total change in HbO (<i>P</i> &lt; .01). Younger age was associated with a more significant decrease in the water signal (<i>P</i> &lt; .05). In contrast, female gender was associated with a greater total increase in HbO (<i>P</i> &lt; .01) and HbR (<i>P</i> &lt; .001) signals.</p><h3>Conclusion</h3><p>There is an immediate cerebral water and hemodynamic response to irradiation and this response shows dependency on the radiation dose, age, and gender. Better understanding about the immediate radiation response may help improve the patient outcome in clinical radiotherapy.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"673 - 682"},"PeriodicalIF":3.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03663-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Issues in Kinematic Traces from Three Head Impact Sensors in Boxing: Prevalence, Effects, and Implications for Exposure Assessment","authors":"Enora Le Flao,&nbsp;Gunter P. Siegmund,&nbsp;Seth Lenetsky,&nbsp;Robert Borotkanics","doi":"10.1007/s10439-024-03647-1","DOIUrl":"10.1007/s10439-024-03647-1","url":null,"abstract":"<div><h3>Purpose</h3><p>When used in-vivo or in biofidelic environments, many head impact sensors have shown limitations related to the quality and validity of the kinematics measured. The objectives were to assess the quality of kinematic traces from three head impact sensors, determine the effects of signal quality on peak accelerations, and compare measurements across sensors.</p><h3>Methods</h3><p>Head impacts were collected with instrumented mouthguards, skin patches, and headgear patches during boxing sparring. The quality of the raw kinematic traces for 442 events for each sensor was categorized using pre-defined objective criteria into high, questionable, and low-quality classes. The proportion of high-quality recordings was analyzed by participant, type of impact, and impact location. Associations between signal quality and peak kinematics were assessed within each sensor, and peak kinematics (resolved to the head center of gravity) were compared between sensors.</p><h3>Results</h3><p>High-quality criteria were met in 53%, 20%, and 26% of events for the mouthguard, skin patch, and headgear patch, respectively. High-quality recordings were less frequent for impacts occurring close to the sensor (e.g., 30% vs. 61% for the mouthguard) and showed lower peak kinematics than low-quality recordings (<i>p</i> &lt; 0.001). Despite careful selection of high-quality simultaneous recordings, there was little to no association between the sensors’ measurements (Spearman’s <i>p</i> ≥ 0.043).</p><h3>Conclusions</h3><p>The kinematic data often reflected the motion of the sensor itself rather than the motion of the head, overestimating head impact magnitude. Researchers should evaluate data quality prior to analyzing kinematics or injury severity metrics. Comparison of data across studies or in relation to injury risk functions needs to be done with caution when data were acquired from different sensors.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"658 - 672"},"PeriodicalIF":3.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}