Annals of Biomedical Engineering最新文献

{"title":"Fabrication and Properties of Multi-Functional of Tannic Acid-Modified Sodium Alginate/Chitosan Microspheres for Bone Defect Repair","authors":"Zhihui Kuang,&nbsp;Xiangchun Cai,&nbsp;Bo Li,&nbsp;Zhiyou Cao,&nbsp;Yanhua Li,&nbsp;Xiaowei Yang,&nbsp;Jiawei Hu,&nbsp;Xuqiang Liu","doi":"10.1007/s10439-025-03796-x","DOIUrl":"10.1007/s10439-025-03796-x","url":null,"abstract":"<div><h3>Purpose</h3><p>Conventional bone defect treatments face substantial clinical limitations, underscoring the urgent need for innovative bone regeneration materials. While tannic acid (TA) has shown potential in modifying hydrogel properties, its therapeutic implications in sodium alginate (SA)/chitosan (CS) composite hydrogels, particularly regarding bidirectional regulation of bone remodeling processes remain poorly characterized. This investigation tests the hypothesis that TA-modified SA/CS hydrogel microspheres can concurrently enhance antibacterial efficacy, promote osteogenic differentiation of bone mesenchymal stem cells (BMSCs), and suppress osteoclast differentiation of bone marrow macrophages (BMMs), ultimately accelerating bone repair.</p><h3>Methods</h3><p>We engineered SA/CS/TA hydrogel microspheres through ionic crosslinking, followed by comprehensive material characterization using SEM (morphology), UV–Vis (TA release kinetics), and FT-IR (chemical interactions). Antimicrobial efficacy was quantified against common pathogens using plate coating method. For osteogenic assessment, BMSCs were cultured with microspheres and evaluated through qPCR/Western blot for osteogenic markers, ALP activity quantification, and matrix mineralization via ARS. Osteoclastogenesis was analyzed in BMM cultures using TRAP staining, F-actin staining, and osteoclast-specific gene/protein expression. A rat tibial critical-sized defect model with Micro-CT and histomorphometry served for <i>in vivo</i> validation.</p><h3>Results</h3><p>The microspheres exhibited sustained TA release and significant antimicrobial activity compared to control groups. Osteogenic assays demonstrated enhanced ALP activity and calcium deposition, accompanied by upregulation of key osteogenic markers. Conversely, the TA-modified microspheres demonstrated the inhibition of osteoclastogenesis throughout the differentiation process: reduction in TRAP activity reflecting impaired osteoclast maturation, and downregulation of osteoclast-specific markers via qPCR and Western blot analysis. <i>In vivo</i> evaluations revealed substantially improved bone regeneration in microsphere-treated defects compared to untreated controls.</p><h3>Conclusion</h3><p>Our findings confirm the dual functionality of TA-modified SA/CS hydrogel microspheres in bone regeneration, demonstrating simultaneous enhancement of BMSC osteogenesis and suppression of osteoclast differentiation. The coordinated regulation of bone formation and resorption processes, combined with inherent antibacterial properties, establishes SA/CS/TA microspheres as a promising therapeutic platform for critical-sized bone defect reconstruction.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 9","pages":"2080 - 2094"},"PeriodicalIF":5.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Changes of Longitudinal Arch Work Are Related to Energy Expenditure During Long-Distance Running","authors":"Kexin Zhang,&nbsp;Zhaoqi Yan,&nbsp;Yijie Duan,&nbsp;Yan Xu,&nbsp;Zhaowei Chu,&nbsp;Fan Yang,&nbsp;Fang Pu,&nbsp;Weiyan Ren,&nbsp;Yubo Fan","doi":"10.1007/s10439-025-03795-y","DOIUrl":"10.1007/s10439-025-03795-y","url":null,"abstract":"<div><h3>Purpose</h3><p>The medial longitudinal arch of the foot plays a role in energy storage and release during running; however, the relationship between its dynamic mechanical behavior and energy expenditure remains poorly understood. This study aimed to investigate the association between changes in the mechanical work of the longitudinal arch and the energy expenditure during prolonged running.</p><h3>Methods</h3><p>16 male athletes or sports enthusiasts participated in a 60-min treadmill running trial at a constant speed of 10 km/h. Biomechanical data were obtained using force-instrumented treadmill and a motion capture system to compute the positive and negative work of the longitudinal arch. Metabolic data, including oxygen consumption (VO₂), carbon dioxide production (VCO₂), and heart rate (HR), were simultaneously measured with a Cortex cardiopulmonary function tester.</p><h3>Results</h3><p>Positive arch work and metabolic variables increased rapidly during the first 10 min and then stabilized, with inflection points consistently observed at the 10-min mark (<i>p</i> &lt; 0.001). In contrast, no significant main effect of time was found for negative arch work (<i>p</i> = 0.058). Both positive and negative arch work showed significant positive correlations with energy expenditure (positive work: <i>r</i> = 0.588, <i>p</i> = 0.017; negative work: <i>r</i> = 0.514, <i>p</i> = 0.042), indicating that the dynamic function of the longitudinal arch is linked to metabolic demand, especially when adapting to exercise intensity.</p><h3>Conclusion</h3><p>These findings highlight the critical mechanical role of the foot’s longitudinal arch and surrounding soft tissues in regulating energy expenditure during running. Strengthening the longitudinal arch and implementing timely stretching may help improve running efficiency by optimizing energy utilization.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2436 - 2446"},"PeriodicalIF":5.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying Experimental Variability in Shear-Induced Hemolysis to Support Uncertainty-Aware Hemolysis Models","authors":"Christopher Blum,&nbsp;Markus Mous,&nbsp;Ulrich Steinseifer,&nbsp;Johanna C. Clauser,&nbsp;Michael Neidlin","doi":"10.1007/s10439-025-03786-z","DOIUrl":"10.1007/s10439-025-03786-z","url":null,"abstract":"<div><h3>Purpose</h3><p>Numerical hemolysis models rely on experimental data to fit parameters and predict hemolysis under various conditions. However, existing experiments often use few replicates per condition, leaving inherent variability largely unaddressed. This can lead to oversimplified models that fail to capture the true nature of hemolysis. Here, we quantify intra- and inter-donor variability at a single, well-defined shear stress and exposure time and examine how sample size affects measurement precision </p><h3>Methods</h3><p>Human blood from five healthy donors was subjected to a fixed shear stress and exposure time condition. For each donor, 20 independent measurements were performed to calculate a hemolysis index (HI). Intra-donor variability (variation within a single donor’s measurements) and inter-donor variability (variation between donor means) were compared. Additionally, bootstrap analyses were used to explore the effect of the sample size on the confidence intervals of the mean HI. </p><h3>Results</h3><p>Intra-donor variability was approximately four times higher than inter-donor variability, indicating that most of the uncertainty originated from within a single donor’s set of samples rather than between donors. Increasing the sample size from 2 to 20 replicates substantially narrowed the confidence intervals of the mean hemolysis estimate, suggesting that commonly used small sample sizes may underrepresent the true variability in hemolysis measurements.</p><h3>Conclusion</h3><p>Intra-donor variability is a significant driver of uncertainty in hemolysis measurements at a fixed shear stress and exposure time condition, surpassing differences among donors. Obtaining robust and reliable hemolysis estimates requires increasing the number of replicate measurements to reduce uncertainty. Integrating these insights into future experimental designs and uncertainty-aware hemolysis models will improve the reliability of in silico predictions and inform safer, more effective blood-contacting medical device designs.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2551 - 2561"},"PeriodicalIF":5.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03786-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Artery Shear Stress and Oscillatory Shear Index are Associated with Right Ventricular Remodeling in Repaired Tetralogy of Fallot","authors":"Elizabeth W. Thompson,&nbsp;Anindro Bhattacharya,&nbsp;Fengling Hu,&nbsp;Russell T. Shinohara,&nbsp;Paris Perdikaris,&nbsp;Kevin K. Whitehead,&nbsp;Elizabeth Goldmuntz,&nbsp;Mark A. Fogel,&nbsp;Walter R. Witschey","doi":"10.1007/s10439-025-03793-0","DOIUrl":"10.1007/s10439-025-03793-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Right ventricular (RV) remodeling in repaired tetralogy of Fallot (rToF) is a multifactorial process that may be affected by downstream hemodynamics. We therefore sought to characterize hemodynamics in the pulmonary arteries (PAs) of rToF patients using cardiovascular magnetic resonance (CMR)-derived computational fluid dynamics (CFD) and to study these variables in association with RV measurements at follow-up.</p><h3>Methods</h3><p>We selected patients with two CMRs who had magnetic resonance angiography (MRA) performed at baseline. The PA was segmented from the main PA (MPA) through the first bifurcation of the left PA (LPA) and right PA (RPA). Both steady and pulsatile simulations were performed. For each vessel, we calculated curvature, tortuosity, and both average (avg) and peak steady WSS (WSS_steady), time-averaged WSS (taWSS), WSS in systole (WSS_systole), and WSS in diastole (WSS_diastole), as well as oscillatory shear index (OSI). We studied these variables in association with RV metrics at follow-up including: RV end-diastolic volume index (RVEDVi), RV end-systolic volume index (RVESVi), RV stroke volume index (RVSVi), and RV ejection fraction (RVEF), as well as the outcome of pulmonic valve replacement (PVR).</p><h3>Results</h3><p>22 patients met the inclusion criteria. Several focal hemodynamic metrics in the main and branch PAs, including WSS_steady, taWSS, WSS_systole, WSS_diastole, and OSI were associated with RV measurements at follow-up, including RVEDVi, RVESVi, and RVSVi. LPA WSS_steady,avg, RPA WSS_steady,peak, whole vessel OSI_avg, and MPA OSI_avg were associated with likelihood of PVR.</p><h3>Conclusion</h3><p>CFD-derived hemodynamic variables in the PAs of rToF patients are associated with both PVR and RV remodeling.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 9","pages":"2206 - 2222"},"PeriodicalIF":5.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03793-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Collapsing Foot Deformity: Multi-bone Modeling and Joint Level Measurements","authors":"Kassidy Knutson,&nbsp;Andrew C. Peterson,&nbsp;Rich J. Lisonbee,&nbsp;Takuma Miyamoto,&nbsp;Nicola Krähenbühl,&nbsp;Amy L. Lenz","doi":"10.1007/s10439-025-03775-2","DOIUrl":"10.1007/s10439-025-03775-2","url":null,"abstract":"<div><h3>Purpose</h3><p>The objective of this study was to characterize joint level morphology and alignment differences across stages of progressive collapsing foot deformity (PCFD) within the talocrural, subtalar, talonavicular, and calcaneocuboid joints using multi-bone statistical shape modeling (SSM) and joint distance measurements from weightbearing computed tomography (WBCT) scans. This was achieved by employing multi-bone SSM in conjunction with precise joint measurement analysis, utilizing WBCT scans to investigate the intricate changes within the talocrural, subtalar, talonavicular, and calcaneocuboid joints.</p><h3>Methods</h3><p>A retrospective analysis was conducted on patients with PCFD who failed conservative treatment. Two groups of 20 feet each were formed for flexible PCFD and rigid PCFD, with 27 additional feet identified as asymptomatic controls. All 67 participants underwent a WBCT scan, and 3D models were created as inputs for multi-bone SSM and joint distance measures.</p><h3>Results</h3><p>The first principal component analysis mode contained 45.8% of the variation in the population while the second mode contained 13.3% of the variation and the third mode contained 6.4% of variation accounting for 65.6% of the overall variation in the multi-bone model. Joint space distance measurement differences were observed between all three groups for all articulations. The primary difference between flexible PCFD and rigid PCFD multi-bone SSM was a statistically significant medial shift of alignment of the talar neck, resulting in worsened peritalar subluxation.</p><h3>Conclusion</h3><p>PCFD is quantifiably variable across a clinical population when evaluating joint level measurements as well as morphologic and alignment variations. Talonavicular joint malalignment severity may be a clinical key in distinguishing between stages of PCFD.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2426 - 2435"},"PeriodicalIF":5.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Biomedical Sensors for Early Detection of Failure in Hip and Knee Implants: Scoping Review on Potential Sensors for Implant Integration","authors":"P. H. Helene Noordhuis,&nbsp;Paul C. Jutte,&nbsp;Ajay G. P. Kottapalli,&nbsp;Claudine J. C. Lamoth,&nbsp;C. C. Charissa Roossien","doi":"10.1007/s10439-025-03780-5","DOIUrl":"10.1007/s10439-025-03780-5","url":null,"abstract":"<div><h3>Purpose</h3><p>Despite significant advancements in hip and knee joint implant technology, 6.4% of implants fail within the first ten years due to aseptic loosening, instability, and/or infection. Implants equipped with sensors show promise in early failure detection, enabling early and reduced intervention. This scoping review aims to provide an overview of biomedical sensors and their potential for integration into hip- and knee implants.</p><h3>Methods</h3><p>A comprehensive search of databases PubMed and Embase was performed. Inclusion criteria were sensors to detect failure causes infection, inflammation, loosening or wear; developed for biomedical applications; ex vivo, in vivo and/or in vitro studies. The sensors were analysed based on criteria per sensor characteristics (e.g. accuracy, durability, response time) relevant for implant integration.</p><h3>Results</h3><p>49 articles were included presenting 52 sensors: 24 pressure and force, 6 strain, 15 acidity, 4 temperature, and 3 bacterial detection (3 dual sensing elements). Among these, three sensors were specifically designed for hip- and knee implants. The remaining 46 were developed for other biomedical applications. Our analysis identified two strain and seven acidity sensors that met the criteria for detecting hip- and knee implant failure. Two bacteria sensors showed potential for short-term use post-implantation, aligning with the critical period for periprosthetic infection, but the reporting frequency was too low to draw proper conclusions. No wear (particle) sensor was found.</p><h3>Conclusion</h3><p>We found a significant gap in sensors that can detect wear particles. Future work on continuous implant monitoring should focus on reducing risk and the enhancement of sensor durability and longevity.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 10","pages":"2392 - 2407"},"PeriodicalIF":5.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03780-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons Learned from Liver-on-Chip Platform","authors":"Zahra Sadat Razavi,&nbsp;Fateme Sadat Razavi,&nbsp;Madjid Soltani,&nbsp;Hamidreza Pazoki-Toroudi,&nbsp;Simin Farokhi,&nbsp;Iraj Azimi,&nbsp;Nahid Ahmadi","doi":"10.1007/s10439-025-03779-y","DOIUrl":"10.1007/s10439-025-03779-y","url":null,"abstract":"<div><p>The liver is one of the most studied human organs due to its central role in the metabolism of xenobiotics and pharmaceuticals. In vitro liver models that can mimic liver activities for the goal of studying pathophysiological hints in high-throughput and repeatable conditions have received a lot of attention during the past few decades. Two-dimensional (2D) models have been widely used in the process of screening potentially dangerous substances; nevertheless, these models have been unable to accurately depict the hepatic milieu's three-dimensionality (3D). To get around these limitations, scientists have developed better strategies for three-dimensional culturing that mimic the liver's natural milieu. The major goal of these models is to replicate the structure of the liver. They think about the interplay between parenchymal and nonparenchymal cells and the cellular environment. Newer models of the liver, called livers on a chip (LioCs), have been developed with the intention of simulating physiological fluid flow and, hence, performing key hepatic activities. This was done to ensure normal fluid dynamics. Due to their unrivaled capacity to recapture crucial aspects of the cellular microenvironment of the liver, LioC have been widely utilized in pathophysiology modeling. LioCs are now being used in tissue engineering and drug screening, where they have proven to be an effective tool. From 2D hepatocyte models, which are commonly used for liver toxicity screening, to more recent 3D and LioCs culture strategies, which have been adopted to mimic a more physiological microenvironment in order to study liver diseases, we discuss the development of experimental liver models in this article.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 9","pages":"1993 - 2028"},"PeriodicalIF":5.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Redox Imaging Predicts Post-Loading Cartilage Mitochondrial Membrane Potential","authors":"Jingyi Wang,&nbsp;Greta E. Scheidt,&nbsp;Corinne R. Henak","doi":"10.1007/s10439-025-03784-1","DOIUrl":"10.1007/s10439-025-03784-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Disrupted cellular redox balance is associated with various diseases, including osteoarthritis. Although mitochondrial (MT) membrane potential is a proxy for redox balance, the translational potential of this method is limited by exogenous dye. Therefore, the objective of this study was to predict changes in MT membrane potential in response to mechanical loading using dye-free optical redox imaging (ORI). A secondary objective was to determine the effect of loading on ORI metrics.</p><h3>Methods</h3><p>Full-thickness porcine cartilage strips were subjected to tensile loading at one of two strain rates (1.00 s⁻¹ or 0.10 s⁻¹). ORI was done before, immediately after, and 30 minutes after loading. MT membrane potential was then measured using fluorescent dye. A generalized linear mixed-effects model (GLMM) tested main effects (ORI metrics, loading vs. control, loading rate, post-loading time, zone) and their interactions in prediction of MT membrane potential. Significant predictors were retained in a new GLMM that was trained using 70% of the dataset and evaluated using the remaining 30%. Two separate GLMMs evaluated the main effects on ORI metrics.</p><h3>Results</h3><p>In the GLMM using MT red/green ratio as the dependent variable, ORI metrics, loading rate, and loading vs. control were significant main effect. GLMMs to predict MT red/green from ORI that retained significant main effects resulted in an average difference between predicted and actual values of 7.07%. When analyzing the effect of loading vs. control, loading rate, and zone on ORI metrics, only loading rate showed significance.</p><h3>Conclusion</h3><p>ORI can predict MT membrane potential measured by fluorescent dye and has the possibility to be developed as a clinical tool to evaluate cartilage redox balance.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 9","pages":"2111 - 2119"},"PeriodicalIF":5.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03784-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey of Preferences for Sensing Technologies in People with Severe Mental Illness Admitted to an Acute Psychiatric Unit","authors":"Alvaro Barrera,&nbsp;Ana Ghenciulescu,&nbsp;Niamh Owens,&nbsp;Ariana Cortez,&nbsp;Riccardo De Giorgi,&nbsp;Phil Cowen,&nbsp;Jeroen Bergmann","doi":"10.1007/s10439-025-03769-0","DOIUrl":"10.1007/s10439-025-03769-0","url":null,"abstract":"<div><h3>Purpose</h3><p>This study presents the views of patients admitted to an adult acute mental health unit due to an acute episode of severe mental illness, mainly of a psychotic nature, regarding sensing technology.</p><h3>Methods</h3><p>One hundred and twenty five adult inpatients were approached; 31 patients declined to participate whilst eleven patients were missed due to having been discharged from hospital or transferred to a different unit. Eighty three patients consented to participate and were administered a survey, previously validated in people with arthritis and other physical health conditions, about their preferences regarding sensing technology. The participants’ clinical presentation was characterised using standard clinical instruments.</p><h3>Results</h3><p>Ninety percent of participants were on antipsychotic medication and 78% were detained in hospital under the Mental Health Act 1983 of England and Wales. 67.9% exhibited elevated levels of ideas of reference and 61.7% presented a clinical level of persecutory delusions. Patients’ views about wearable digital technology were broadly positive and similar to those previously provided by people with arthritis and physical health conditions, with some specific differences. For example, they agreed to wear a device that is visible to others but less so to wearing one that is concealed in their clothing or implanted or for 24 h monitoring with the data being sent away, analysed or stored.</p><h3>Conclusion</h3><p>This study shows that those who are in the middle of an acute and severe episode of mental ill health are open to using sensing technology, with some specific requirements that would increase the uptake within this patient population. This research shows that this currently underserved patient population has a positive view with regards to sensing technology for healthcare purposes. These findings can inform the design of new wearable systems, which can address the unmet needs in this clinical domain.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 9","pages":"2372 - 2383"},"PeriodicalIF":5.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03769-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Heat Output of Chondrocytes: Implications for Joint Degeneration in Osteoarthritis","authors":"Ayesha Parvaiz Malik,&nbsp;Amna Pervez Malik,&nbsp;Javed Iqbal,&nbsp;Brijesh Sathian,&nbsp;Syed Muhammad Ali","doi":"10.1007/s10439-025-03792-1","DOIUrl":"10.1007/s10439-025-03792-1","url":null,"abstract":"","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 9","pages":"1987 - 1988"},"PeriodicalIF":5.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}