Annals of Biomedical Engineering最新文献

{"title":"The Potential of Sound Analysis to Reveal Hemodynamic Conditions of Arteriovenous Fistulae for Hemodialysis.","authors":"Sofia Poloni, Luca Soliveri, Anna Caroli, Andrea Remuzzi, Michela Bozzetto","doi":"10.1007/s10439-024-03638-2","DOIUrl":"https://doi.org/10.1007/s10439-024-03638-2","url":null,"abstract":"<p><strong>Purpose: </strong>Arteriovenous fistula (AVF), the preferred vascular access for hemodialysis, is associated with high failure rate. The aim of this study was to investigate the potential of AVF sound auscultation in providing quantitative information on AVF hemodynamic conditions.</p><p><strong>Methods: </strong>This single-center prospective study involved six patients with native radio-cephalic AVFs who underwent multiple follow-up visits. Doppler Ultrasound blood flow volume (BFV) assessment and electronic stethoscope-based sound recordings were performed during each visit, whereas MRIs were acquired 3 days, 3 weeks and 1 year after surgery. Computational fluid dynamic (CFD) simulations were performed on patient-specific MRI-derived geometrical models.</p><p><strong>Results: </strong>Higher values of median peak amplitudes ratios (high-low peak ratio-HLPR) were found to be associated with complex blood flow and velocity streamlines recirculation at systolic peak, and corresponding extended regions of high oscillatory shear index (OSI). On the contrary, lower values of HLPR were associated with laminar flow pattern and low values of OSI. Significant differences were observed in HLPR between subgroups with extended or limited areas with OSI > 0.1 (0.67 vs 0.31, respectively). Significant relationships were found between AVF sound intensity and brachial BFV (slope = 0.103, p < 0.01) as well as between longitudinal changes in brachial BFV and HLPR (slope = - 0.001, p < 0.01).</p><p><strong>Conclusion: </strong>Our results show that AVF sound can be exploited to extract fundamental information on AVF hemodynamic conditions, providing indication of the presence of complex hemodynamic and adequate BFV to perform hemodialysis. Sound analysis has therefore the potential to improve clinical AVF surveillance and to ameliorate outcome.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Machine Learning for Pre-procedural Prediction of Time-Varying Boundary Condition After Fontan Procedure Using Generative Adversarial Networks.","authors":"Wenyuan Song, David Frakes, Lakshmi Prasad Dasi","doi":"10.1007/s10439-024-03640-8","DOIUrl":"10.1007/s10439-024-03640-8","url":null,"abstract":"<p><p>The Fontan procedure is the definitive palliation for pediatric patients born with single ventricles. Surgical planning for the Fontan procedure has emerged as a promising vehicle toward optimizing outcomes, where pre-operative measurements are used prospectively as post-operative boundary conditions for simulation. Nevertheless, actual post-operative measurements can be very different from pre-operative states, which raises questions for the accuracy of surgical planning. The goal of this study is to apply machine leaning techniques to describing pre-operative and post-operative vena caval flow conditions in Fontan patients in order to develop predictions of post-operative boundary conditions to be used in surgical planning. Based on a virtual cohort synthesized by lumped-parameter models, we proposed a novel diversity-aware generative adversarial active learning framework to successfully train predictive deep neural networks on very limited amount of cases that are generally faced by cardiovascular studies. Results of 14 groups of experiments uniquely combining different data query strategies, metrics, and data augmentation options with generative adversarial networks demonstrated that the highest overall prediction accuracy and coefficient of determination were exhibited by the proposed method. This framework serves as a first step toward deep learning for cardiovascular flow prediction/regression with reduced labeling requirements and augmented learning space.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulating Pelvis Kinematics from Belt and Seat Loading in Frontal Car Crash Scenarios: Important Boundary Conditions that Influence the Outcome.","authors":"Erik Brynskog, Johan Iraeus, Bengt Pipkorn, Johan Davidsson","doi":"10.1007/s10439-024-03631-9","DOIUrl":"https://doi.org/10.1007/s10439-024-03631-9","url":null,"abstract":"<p><strong>Purpose: </strong>The risk of submarining during automotive crashes, defined by the lap belt sliding off the pelvis to load the abdomen, is predicted to increase in future autonomous vehicles as greater variation in seating position is enabled. Biofidelic tools are required to efficiently design and evaluate new and/or improved safety systems. This study aims to evaluate the pelvis response sensitivity to variations in boundary conditions that directly influence the pelvis loads, deemed important for the submarining outcome, to facilitate a more precise comparison between finite element human body models (FE-HBMs) and post-mortem human subjects (PMHSs).</p><p><strong>Methods: </strong>A parameter study, using a one-variable-at-a-time analysis (low/high) of belt friction, seat friction, seat stiffness, and (on/off) for added belt bending stiffness, was performed using a state-of-the-art FE-HBM in four different test scenarios; one stationary, two sleds with upright occupant posture, and one sled with reclined occupant posture.</p><p><strong>Results: </strong>In the stationary scenario, both belt friction and belt bending stiffness influenced the belt folding behavior, which consequently affected the belt-to-pelvis angle at submarining. In the sled scenarios, only seat friction was found to influence the pelvis kinematics and submarining outcome, with the most biofidelic response resulting from both the low (0.2) and high (0.5) friction coefficient depending on the scenario.</p><p><strong>Conclusion: </strong>To reduce uncertainty in boundary conditions affecting the external pelvis loads and increase confidence in FE-HBM to PMHS comparisons, it is recommended that future experiments evaluate the PMHS to seat friction coefficient and that new belt modeling methods that accurately capture belt folding when interacting with soft tissues are developed.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar Spine Orientation Affects Compressive Fracture Outcome.","authors":"Rachel Cutlan, Muhammad Khokhar, Nader Shammout, Alok S Shah, Lance Frazer, Narayan Yoganandan, Barry S Shender, James Sheehy, Glenn Paskoff, Daniel Nicolella, Timothy Bentley, Saman Shabani, Brian D Stemper","doi":"10.1007/s10439-024-03604-y","DOIUrl":"https://doi.org/10.1007/s10439-024-03604-y","url":null,"abstract":"<p><strong>Purpose: </strong>Understanding how spinal orientation affects injury outcome is essential to understand lumbar injury biomechanics associated with high-rate vertical loading.</p><p><strong>Methods: </strong>Whole-column human lumbar spines (T12-L5) were dynamically loaded using a drop tower to simulate peak axial forces associated with high-speed aircraft ejections and helicopter crashes. Spines were allowed to maintain natural lordotic curvature for loading, resulting in a range of orientations. Pre-test X-rays were used to quantify specimen orientation at the time of loading. Primary fracture types were identified (wedge, n = 6; burst, n = 4; hyperextension, n = 4) and compared for loading parameters and lumbar orientation.</p><p><strong>Results: </strong>Fracture type was dependent on peak acceleration, bending moment, Cobb angle, sagittal spinal tilt, and location of the applied load.</p><p><strong>Conclusions: </strong>Lumbar spine orientation under high-rate axial acceleration affected the resulting fracture type. Analysis of pre-test X-rays revealed that spines that sustained wedge and burst fractures were oriented straighter at the time of loading. The load was applied centrally to T12 in spines with burst fractures, and anteriorly to T12 in spines with wedge fractures. Spines that sustained hyperextension fracture had lower peak accelerations, larger Cobb angles at the time of loading, and sustained larger extension moments. Fracture presentation is an important and understudied factor that influences biomechanical stability, clinical course, and long-term patient outcomes.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In vivo Pilot Study to Estimate the Swelling of the Aneurysm Wall Rabbit Model Generated with Pulsed Fluid Against the Aneurysm Wall.","authors":"Guillaume Plet, Jolan Raviol, Jean-Baptiste Langlois, Salim Si-Mohamed, Hélène Magoariec, Cyril Pailler-Mattei","doi":"10.1007/s10439-024-03633-7","DOIUrl":"10.1007/s10439-024-03633-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study addresses the critical issue of evaluating the risk of rupture of unruptured intracranial aneurysms (UIAs) through the assessment of the mechanical properties of the aneurysm wall. To achieve this, an original approach based on the development of an in vivo deformation device prototype (DDP) of the vascular wall is proposed. The DDP operates by pulsing a physiological fluid onto the vascular wall and measuring the resulting deformation using spectral photon counting computed tomography (SPCCT) imaging.</p><p><strong>Methods: </strong>In this preliminary study conducted on a rabbit animal model, an aneurysm was induced on the carotid artery, followed by deformation of the aneurysm sac wall using the DDP. The change in luminal volume of the aneurysm sac induced by the deformation of the vascular wall was then quantified.</p><p><strong>Results: </strong>The initial experimental results demonstrated an increase in the luminal volume of the aneurysm sac in relation to the increased flow rate of the fluid pulsed by the DDP onto the arterial wall. Measurement of the pressure generated by the DDP in relation to the different flow rate values imposed by the pulsation system revealed experimental values of the same order of magnitude as dynamic blood pressure. Furthermore, theoretical pressure values on the deformed area, calculated using Euler's theorem, appeared to be correlated with experimental pressure measurements.</p><p><strong>Conclusion: </strong>This equivalence between theory and experiment is a key element in the use of the DDP for estimating the mechanical properties of the vascular wall, particularly for the use of finite element models to characterise the stress state of the deformed vascular wall. This preliminary work thus presents a novel, innovative, and promising approach for the evaluation and management of the risk of rupture of unruptured intracranial aneurysms.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Bioreactor Design for Non-invasive Longitudinal Monitoring of Tissue-Engineered Heart Valves in 7T MRI and Ultrasound.","authors":"Saurav Ranjan Mohapatra, Elena Rama, Maximillian P Werner, Tobias Call, Tanja Loewenberg, Alexander Loewen, Christian Apel, Fabian Kiessling, Stefan Jockenhoevel","doi":"10.1007/s10439-024-03632-8","DOIUrl":"https://doi.org/10.1007/s10439-024-03632-8","url":null,"abstract":"<p><p>The development of cardiovascular implants is abundant, yet their clinical adoption remains a significant challenge in the treatment of valvular diseases. Tissue-engineered heart valves (TEHV) have emerged as a promising solution due to their remodeling capabilities, which have been extensively studied in recent years. However, ensuring reproducible production and clinical translation of TEHV requires robust longitudinal monitoring methods.Cardiovascular magnetic resonance imaging (MRI) is a non-invasive, radiation-free technique providing detailed valvular imaging and functional assessment. To facilitate this, we designed a state-of-the-art metal-free bioreactor enabling dynamic MRI and ultrasound imaging. Our compact bioreactor, tailored to fit a 72 mm bore 7 T MRI coil, features an integrated backflow design ensuring MRI compatibility. A pneumatic drive system operates the bioreactor, minimizing potential MRI interference. The bioreactor was digitally designed and constructed using polymethyl methacrylate, utilizing only polyether ether ketone screws for secure fastening. Our biohybrid TEHV incorporates a non-degradable polyethylene terephthalate textile scaffold with fibrin matrix hydrogel and human arterial smooth muscle cells.As a result, the bioreactor was successfully proven to be MRI compatible, with no blooming artifacts detected. The dynamic movement of the TEHVs was observed using gated MRI motion artifact compensation and ultrasound imaging techniques. In addition, the conditioning of TEHVs in the bioreactor enhanced ECM production. Immunohistology demonstrated abundant collagen, α-smooth muscle actin, and a monolayer of endothelial cells throughout the valve cusp. Our innovative methodology provides a physiologically relevant environment for TEHV conditioning and development, enabling accurate monitoring and assessment of functionality, thus accelerating clinical acceptance.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage Tissue Engineering in Multilayer Tissue Regeneration.","authors":"Hilal Yilmaz, Israa F Abdulazez, Sevda Gursoy, Yagmur Kazancioglu, Cem Bulent Ustundag","doi":"10.1007/s10439-024-03626-6","DOIUrl":"https://doi.org/10.1007/s10439-024-03626-6","url":null,"abstract":"<p><p>The functional and structural integrity of the tissue/organ can be compromised in multilayer reconstructive applications involving cartilage tissue. Therefore, multilayer structures are needed for cartilage applications. In this review, we have examined multilayer scaffolds for use in the treatment of damage to organs such as the trachea, joint, nose, and ear, including the multilayer cartilage structure, but we have generally seen that they have potential applications in trachea and joint regeneration. In conclusion, when the existing studies are examined, the results are promising for the trachea and joint connections, but are still limited for the nasal and ear. It may have promising implications in the future in terms of reducing the invasiveness of existing grafting techniques used in the reconstruction of tissues with multilayered layers.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiration-Induced Organ Motion Compensation: A Review.","authors":"Samuel Wilcox, Zhefeng Huang, Jay Shah, Xiaofeng Yang, Yue Chen","doi":"10.1007/s10439-024-03630-w","DOIUrl":"https://doi.org/10.1007/s10439-024-03630-w","url":null,"abstract":"<p><strong>Purpose: </strong>Motion of organs in the abdominal and thoracic cavity caused by respiration is a major issue that affects a wide range of clinical diagnoses or treatment outcomes, including radiotherapy, high-intensity focused ultrasound ablation, and many generalized percutaneous needle interventions. These motions pose significant challenges in accurately reaching the target even for the experienced clinician.</p><p><strong>Methods: </strong>This review was conducted through comprehensive search on IEEE Explore, Google Scholar, and PubMed.</p><p><strong>Results: </strong>Diverse methods have been proposed to compensate for this motion effect to enable effective surgical operations. This review paper aims to examine the current respiratory motion compensation techniques used across the clinical procedures of radiotherapy, high-intensity focused ultrasound, and percutaneous needle procedures.</p><p><strong>Conclusion: </strong>The complexity of respiratory-induced organ motion and diversity of areas for which compensation can be applied allows for a variety of methods to be implemented. This review aims to serve as inspiration for the future development of new systems to achieve clinical relevance.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling Biomedical Devices Using Pneumatic Logic.","authors":"Shane Hoang, Mabel Shehada, Konstantinos Karydis, Philip Brisk, William H Grover","doi":"10.1007/s10439-024-03628-4","DOIUrl":"https://doi.org/10.1007/s10439-024-03628-4","url":null,"abstract":"<p><p>Many biomedical devices are powered and controlled by electrical components. These electronics add to the cost of a device (possibly making the device too expensive for use in resource-limited or point-of-care settings) and can also render the device unsuitable for use in some environments (for example, high-humidity areas such as incubators where condensation could cause electrical short circuits, ovens where electronic components may overheat, or explosive or flammable environments where electric sparks could cause serious accidents). In this work, we show that pneumatic logic can be used to power and control biomedical devices without the need for electricity or electric components. Originally developed for controlling microfluidic \"lab-on-a-chip\" devices, these circuits use microfluidic valves like transistors in air-powered logic \"circuits.\" We show that a modification to the basic valve design-adding additional air channels in parallel through the valve-creates a \"high-flow\" valve that is suitable for controlling a broad range of bioinstruments, not just microfluidics. As a proof-of-concept, we developed a high-flow pneumatic oscillator that uses five high-flow Boolean NOT gates arranged in a loop. Powered by a single constant vacuum source, the oscillator provides five out-of-phase pneumatic outputs that switch between vacuum and atmospheric pressure every 1.3 s. Additionally, a user can adjust the frequency of the oscillator by squeezing a bellows attached to one of the pneumatic outputs. We then used the pneumatic oscillator to power a low-cost 3D-printed laboratory rocker/shaker commonly used to keep blood products, cell cultures, and other heterogeneous samples in suspension. Our air-powered rocker costs around $12 USD to build and performs as well as conventional electronic rockers that cost $1000 USD or more. This is the first of many biomedical devices that can be made cheaper and safer using pneumatic logic.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Markerless Motion Capture for Soldier Movement Patterns Assessment Under Varying Body-Borne Loads.","authors":"Isabel Coll, Matthew P Mavor, Thomas Karakolis, Ryan B Graham, Allison L Clouthier","doi":"10.1007/s10439-024-03622-w","DOIUrl":"https://doi.org/10.1007/s10439-024-03622-w","url":null,"abstract":"<p><p>Field performance of modern soldiers is affected by an increase in body-borne load due to technological advancements related to their armour and equipment. In this project, the Theia3D markerless motion capture system was compared to the marker-based gold standard for capturing movement patterns of participants wearing various body-borne loads. The aim was to estimate lower body joint kinematics, gastrocnemius lateralis and medialis muscle activation patterns, and lower body joint reaction forces from the two motion capture systems. Data were collected on 16 participants performing three repetitions of walking and running under four body-borne load conditions by both motion capture systems simultaneously. A complete musculoskeletal analysis was completed in OpenSim. Strong correlations ( <math><mrow><mtext>r</mtext> <mo>></mo> <mn>0.8</mn></mrow> </math> ) and acceptable differences were observed between the kinematics of the marker-based and markerless systems. Timing of muscle activations of the gastrocnemius lateralis and medialis, as estimated through OpenSim from both systems, agreed with the ones measured using electromyography. Joint reaction force results showed a very strong correlation ( <math><mrow><mtext>r</mtext> <mo>></mo> <mn>0.9</mn></mrow> </math> ) between the systems; however, the markerless model estimated greater joint reaction forces when compared the marker-based model due to differences in muscle recruitment strategy. Overall, this research highlights the potential of markerless motion capture to track participants wearing body-borne loads.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}