Annals of Biomedical Engineering最新文献

{"title":"Hemodynamic Characterization of Peripheral Arterio-Venous Malformations Using Rapid Contrast-Enhanced MR Imaging: An In Vitro and In Vivo Study.","authors":"Camilla Giulia Calastra, Marika Bono, Aloma Blanch Granada, Aleksandra Tuleja, Sarah Maike Bernhard, Vanessa Diaz-Zuccarini, Stavroula Balabani, Dominik Obrist, Hendrik von Tengg-Kobligk, Bernd Jung","doi":"10.1007/s10439-025-03766-3","DOIUrl":"https://doi.org/10.1007/s10439-025-03766-3","url":null,"abstract":"<p><strong>Purpose: </strong>Peripheral arterio-venous malformations (pAVMs) are vascular defects often requiring extensive medical treatment. To improve disease management, hemodynamic markers based on 2D Digital Subtraction Angiography (DSA) data were previously defined to classify pAVMs. However, DSA offers only 2D information, involves ionizing radiation, and requires intra-arterial intervention. We hypothesized that pAVMs could be classified with the same approach with 3D dynamic contrast-enhanced MR-based data. To this end, the present work aims to develop a computational classification system for pAVMs using 3D dynamic contrast-enhanced MR-based data.</p><p><strong>Methods: </strong>A pAVM phantom was imaged using both DSA and MRI to validate the methodology, which was then applied to 10 MR-based in vivo datasets. A semi-automated vessel detection algorithm, based on the standard deviation of each voxel or pixel in time, was used. Classification was performed by identifying the time of arrival (CA_ToA) of contrast agent (CA) and the maximum time derivative of the CA transport in each pixel or voxel (CA_si).</p><p><strong>Results: </strong>Normalized CA_ToA and CA_si histograms showed no significant difference between in vitro DSA and MRI (respectively χ² = 0.20, p = 0.65 and χ² = 0.21, p = 0.65), validating the methodology to classify pAVMs. CA_ToA histograms for type II-IV AVMs derived from in vivo MR-based data aligned with DSA patterns and known hemodynamics. CA_ToA histograms of capillary-venulous AVMs were distinct, with non-zero values at later times than other AVM types, representing late venous drainage. Type IV AVMs histograms for CA_si were more right-skewed than those derived from types II and III pAVMs.</p><p><strong>Conclusions: </strong>MR image quality and temporal resolution are sufficient to allow a classification of pAVMs. This classification method has the potential to become a diagnostic tool for the surgical navigation of pAVMs for clinicians.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and Robustness of Bone Volume Fraction Assessment by Photon-Counting, Dual-Energy, and Quantitative CT using Micro-CT as Standard of Reference.","authors":"Patrik Wili, Dominic Gascho, Alice Dudle, Roy P Marcus, Daniel Nanz, Michael Thali, Philippe Zysset","doi":"10.1007/s10439-025-03732-z","DOIUrl":"https://doi.org/10.1007/s10439-025-03732-z","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to quantitatively compare different computed tomography (CT)-based bone volume fraction (BV/TV) measurements. We hypothesize that phantom-less measurement using virtual monochromatic images (VMI) reconstructed form dual-energy CT (DECT) or photon counting CT (PCT) is less affected by tissue variations in trabecular bone than quantitative CT (QCT) and that PCT allows measurements with a lower radiation dose.</p><p><strong>Method: </strong>The BV/TV of bovine trabecular bone samples were measured using four CT scanning methods. Eight different measurements were compared using three soft tissue substitutes (air, saline solution, and fat) to investigate its effect on BV/TV estimation. For this purpose, the samples' bone marrow was removed and replaced with one of the three substitutes in succession for CT scanning. For QCT, a standard bone phantom was used to derive BV/TV form CT values. While DECT- and PCT-based measurements were based on a system of energy-dependent equations established by reconstructing VMIs for specific photon energies. T-test, ANOVA tests and pairwise comparison were performed using the micro-CT (µCT) measurements as reference standard.</p><p><strong>Results: </strong>QCT showed a significant difference between the fat, saline solution, and air. DECT and especially PCT showed no differences between the substitutes. PCT showed no significant differences between radiation doses.</p><p><strong>Conclusion: </strong>Our results highlight the complexity of BV/TV measurements and emphasize the impact of the trabecular bone components on measurement accuracy. Despite these challenges, VMIs from \"low\" dose PCT provide a reliable alternative to standard QCT. They have the potential to improve the estimation of bone conditions, as well offering valuable insights for clinical, and forensic applications.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Stress Conditioning Promotes a Pro-Inflammatory Response in Porcine Endocardial Endothelial Cells.","authors":"Pengfei Ji, Kathryn Jane Grande-Allen, Swathi Balaji, Ravi K Birla, Sundeep G Keswani","doi":"10.1007/s10439-025-03751-w","DOIUrl":"https://doi.org/10.1007/s10439-025-03751-w","url":null,"abstract":"<p><strong>Purpose: </strong>Discrete subaortic stenosis (DSS) is a congenital heart disease characterized by a narrowing of the passage below the aortic valve in the left ventricular outflow tract (LVOT). While endocardial endothelial cells (EECs) are known to play a role in DSS, the response of these cells to shear stress is not known. In this study, we hypothesize that the response of EECs to shear stress in the LVOT is a mediator of DSS.</p><p><strong>Methods: </strong>To test this hypothesis, we conditioned porcine EECs to controlled shear stress regimes using cone-and-plate bioreactors. Subsequently, we quantified the concentration of proinflammatory cytokine in the conditioned media using the Luminex assay. Bulk-RNA sequencing was used to quantify changes in the genotype of the shear stress-conditioned EECs.</p><p><strong>Results: </strong>The expression of CD31 was knocked down, and subsequently, the changes in release of shear stress-induced proinflammatory cytokines released by EECs were quantified using the Luminex assay. The results of these studies show that the inflammatory cytokines were highly selected in the conditioning medium, and under bioreactor treatment, the cell activated the PI3K-AKT and TNF-a signaling, which also triggered the other immune cell responses through Th1, Th2, and Th17 cell differentiation pathways. Furthermore, CD31 was identified as a potential mediator of the proinflammatory response of shear stress-conditioned EECs.</p><p><strong>Conclusions: </strong>The studies provide a potential link between shear stress and the subsequent proinflammatory response of EECs as a mediator of DSS.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Analysis of Inconsistencies in the Brain's Conventional Ex Vivo Mechanical Experiments.","authors":"Hadi Nosrati, Mehdi Shafieian, Nabiollah Abolfathi","doi":"10.1007/s10439-025-03765-4","DOIUrl":"https://doi.org/10.1007/s10439-025-03765-4","url":null,"abstract":"<p><p>In 2020, a review titled Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue was published, offering a comprehensive overview of brain mechanics. While this work stands out for its insightful analysis of brain mechanics, there are certain points it did not fully address, as well as key areas that require more detailed examination. The goal of this review is not merely to summarize and report on previous studies but to highlight discrepancies in the root causes of the extensive data reported in the literature. By examining the wide-ranging data, the progression of research over six decades, and the knowledge developed during this period, we aim to identify the sources of these discrepancies and propose feasible directions for future research. Additionally, while micromechanical models have attracted significant attention in recent years, we provide evidence to emphasize that, despite their advantages, these models are not yet reliable enough to replace conventional mechanical experiments and macro-scale models. By compiling, visualizing, and analyzing data from the past six decades and integrating challenging issues into a cohesive framework, this approach provides a more actionable analysis. It simplifies navigation through the field and equips researchers with a clearer understanding of its historical progression, challenges, and opportunities.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Fidelity Finite Element Modeling Technique to Improve Sensitivity to Bone Tissue Changes of Older Adults with Obesity undergoing Intensive Lifestyle Intervention.","authors":"Michael A K Liebschner, Daeseung Kim, Nina Klonis, Giulia Gregori, Reina Armamento-Villareal, Clifford Qualls, Dennis T Villareal","doi":"10.1007/s10439-025-03763-6","DOIUrl":"https://doi.org/10.1007/s10439-025-03763-6","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity presents a significant health risk for the aging population. Research shows that weight loss and regular exercise can greatly improve the functional status of older adults who are obese. However, weight loss may also result in a decrease in bone mass. To properly assess changes in fracture risk due to lifestyle interventions, a direct biomechanical evaluation of bone strength and fracture risk at metabolically active sites is essential.</p><p><strong>Methods: </strong>Computed tomography scans taken at two different time points of ten human volunteers provided the foundation for this study. A high-fidelity segmentation and modeling approach was taken to generate finite element models. Fracture risk before and after lifestyle intervention was compared using well-established hip and spine fracture models. In this study, two modeling techniques for generating finite element analyses were compared for their ability to detect minor changes in bone strength.</p><p><strong>Results: </strong>An uncertainty analysis of methodologies indicated that a high-fidelity anatomically detailed modeling technique would be more sensitive than state-of-the-art voxel-based techniques to detect changes in bone strength and subsequent fracture risk due to lifestyle intervention.</p><p><strong>Conclusion: </strong>The presented study demonstrated the ability to generate high-fidelity finite element models with unparalleled precision by capturing individual anatomical variations and material properties.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Bone Scaffold Fabrication: A Comparative Study of Manual Casting and Automated 3D Bioprinting.","authors":"Yasser Ahmed, Ali S Alshami, Ashraf Al-Goraee, Collins P Obeng, Rebecca Kennedy, Hesham Abdelaziz, Ryan Striker","doi":"10.1007/s10439-025-03752-9","DOIUrl":"https://doi.org/10.1007/s10439-025-03752-9","url":null,"abstract":"<p><p>While fabrication of bone scaffolds is important for the development of tissue engineering, traditional techniques have typically been prone to either scaling or reproducibility issues. This paper highlights a strategy for automated 3D printing and bioprinting techniques that enhance precision and efficiency in the production of PLGA-HA scaffolds. We realized significant improvements in efficiency, reproducibility, and scalability through optimization of 3D printing parameters, improvement of material handling, and refinement of the fabrication process. Precise measurement consequently minimized material waste; the introduction of a mesh filter allowed for high-throughput experimentation without compromising the integrity of individual scaffolds, streamlining the workflow. Combining automated casting with state-of-the-art 3D bioprinting, our experimental methodology precisely applied the bioactive materials, reducing the processing time fivefold and enhancing precision. Besides, automated casting produced thicker, better-quality scaffolds averaging 0.02354 g, which is against 0.01169 g using the manual approach, effectively doubling the retention of the PLGA-HA coating on a PVA mold. Excellent cell viability and adhesion on automated scaffolds have been further underlined for application in tissue engineering during in vitro studies using multipotent mesenchymal stromal cells. Although conventional techniques, such as injection molding, are standard for large lots, 3D printing has advantages in scaffold fabrication regarding control over geometry and homogeneous material properties. Equally important, these characteristics are necessary to achieve repeatable and up-scaled experimental results.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Augmented Full-Body Model that Improves Upper Body Tracking and Reduces Dynamic Inconsistency in Complex Motion.","authors":"Xiao Hu, Evan A Dooley, Darren J Stefanyshyn, John W Wannop, Shawn D Russell","doi":"10.1007/s10439-025-03762-7","DOIUrl":"https://doi.org/10.1007/s10439-025-03762-7","url":null,"abstract":"<p><strong>Purpose: </strong>In recent years, the applications of musculoskeletal simulations have been expanded from simple walking to complex movements in various kinds of sports. The goal of this study was to augment the capability of the currently widely used full-body model (Rajagopal (2016) IEEE Trans. Biomed. Eng. 63:2068-2079) to improve the tracking of the kinematics of the head, shoulder, arms, and torso during complex full-body motion.</p><p><strong>Methods: </strong>Based on the testing of different modeling choices of neck, shoulder, and torso segments, the original Rajagopal full-body model was augmented by adding three joints in the spine and two sternoclavicular joints. The inverse kinematics and inverse dynamics of sports-related movements from 16 collegiate athletes were compared between the original Rajagopal and augmented full-body model.</p><p><strong>Results: </strong>Our results showed that the augmented full-body model had significant improvements in tracking errors of the markers on the head, arm, torso, and pelvis during inverse kinematics, which led to reduced dynamic inconsistency in inverse dynamics, compared to the Rajagopal model.</p><p><strong>Conclusion: </strong>With a significant improvement in tracking the kinematics of the upper body, the augmented full-body model is a more suitable model to perform simulations involving complex full-body movements and is available for research use upon request from simtk.org.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Investigation of Osteogenesis and Angiogenesis of Modified Polycaprolactone-Hydroxyapatite-Zinc Oxide Electrospun Nanofibers Loaded with Metformin.","authors":"Zahra Kazemian-Najafabadi, Sameereh Hashemi-Najafabadi, Mohamadreza Baghaban-Eslaminejad, Fatemeh Bagheri","doi":"10.1007/s10439-025-03761-8","DOIUrl":"https://doi.org/10.1007/s10439-025-03761-8","url":null,"abstract":"<p><p>Critical bone defects pose significant challenges to effective treatment. However, drug loading within scaffold structures has emerged as an advanced strategy for successful bone tissue regeneration.</p><p><strong>Purpose: </strong>This study investigates the effects of nano-zinc oxide (nZnO) and metformin (MET) on angiogenesis and osteogenesis in electrospun scaffolds under both in vitro and in vivo conditions.</p><p><strong>Methods: </strong>Electrospun scaffolds, composed of poly(ε-caprolactone), nano-hydroxyapatite, and nZnO, were ultrasonicated to modify pore sizes and enhance bone regeneration. Subsequently, gelatin nanoparticles containing metformin (MET/GNPs) were covalently bonded to the scaffolds. MET/GNP-loaded scaffolds were co-cultured with human umbilical vein endothelial cells and rat bone marrow mesenchymal stem cells. In vitro assays, including MTT, ALP, and alizarin red staining, were performed to assess cytotoxicity, differentiation, and mineralization, respectively. Angiogenesis and osteogenesis were further evaluated in vivo using a rat calvarial defect model through CT imaging, hematoxylin and eosin staining, Masson's trichrome staining, and immunohistochemistry (IHC).</p><p><strong>Results: </strong>Scanning electron microscopy revealed nano-scale dimensions of the fibers and nanoparticles, while dynamic light scattering confirmed nanoparticle properties. The loading content and loading efficiency of MET/GNPs were calculated as 56.4% and 12.5%, respectively. Results demonstrated significantly enhanced cell viability in MET/GNP-loaded scaffolds, along with increased ALP activity and mineralization capacity. Histological and IHC analyses confirmed successful stimulation of angiogenesis and osteogenesis in vivo.</p><p><strong>Conclusion: </strong>These scaffolds show significant potential for promoting osteogenesis and angiogenesis in bone tissue engineering.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondrocytes Embedded in Agarose Generate Distinct Metabolic Heat Profiles Based on Media Carbon Sources.","authors":"Erik Myers, Priyanka Brahmachary, Sarah Mensah, Campbell Putnam, Ross P Carlson, Mark Greenwood, Ronald K June","doi":"10.1007/s10439-025-03755-6","DOIUrl":"https://doi.org/10.1007/s10439-025-03755-6","url":null,"abstract":"<p><p>Human chondrocytes are responsible for cartilage repair and homeostasis through metabolic production of precursors to collagen and other matrix components. This metabolism is sensitive both to the availability of media energy sources as well as the local temperature. Central carbon metabolites such as glucose and glutamine are essential not only for producing energetic compounds such as ATP and NADH, but also for assembling collagen and aggrecan from non-essential amino acid precursors. The rate at which this metabolism takes place directly relates to temperature: a moderate increase in temperature results in faster enzyme kinetics and faster metabolic processes. Furthermore, these biological processes are exothermic and will generate heat as a byproduct, further heating the local environment of the cell. Prior studies suggest that mechanical stimuli affect levels of central metabolites in three-dimensionally cultured articular chondrocytes. But these prior studies have not determined if articular chondrocytes produce measurable heat. Thus, the goal of this study is to determine if three-dimensionally encapsulated chondrocytes are capable of heat production which will improve our knowledge of chondrocyte central metabolism and further validate in vitro methods. Here we show the results of microcalorimetric measurements of heat generated by chondrocytes suspended in agarose hydrogels over a 2-day period in PBS, glucose, and glutamine media. The results show that a significant amount of heat is generated by cells (Cells Only: 3.033 ± 0.574 µJ/cell, Glucose: 2.791 ± 0.819 µJ/cell, Glutamine: 1.900 ± 0.650 µJ/cell) versus the absence of cells (No Cells: 0.374 ± 0.251 µJ/cell). This suggests that cells which have access to carbon sources in the media or as intracellular reserves will generate a significant amount of heat as they process these metabolites, produce cellular energy, and synthesize collagen precursors. The length of the microcalorimeter experiment (48 h) also suggests that the metabolism of articular chondrocytes is slower than many other cells, such as human melanoma cells, which can produce similar quantities of heat in less than an hour. These data broadly suggest that chondrocyte metabolism is sensitive to the available nutrients and has the potential to alter cartilage temperature through metabolic activity.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-contoured Plate Fit Assessment for Acetabular Fractures.","authors":"Willemina A van Veldhuizen, Nick Assink, Richte C L Schuurmann, Reza Firoozabadi, Kaj Ten Duis, Jean-Paul P M de Vries, Jelmer M Wolterink, Frank F A IJpma","doi":"10.1007/s10439-025-03760-9","DOIUrl":"https://doi.org/10.1007/s10439-025-03760-9","url":null,"abstract":"<p><strong>Purpose: </strong>Insufficient fitting of pre-contoured plates for acetabular fractures might lead to inadequate fracture reduction, but it is unclear in which patients pre-contoured plates fit adequately. The aims of this study were to assess plate fitting in sex- and height-specific anatomical variations of the hemipelvis, and categorizing the outcomes as moderate or good fit.</p><p><strong>Methods: </strong>3D models from computed tomography (CT) scans were obtained from a dataset of 200 patients with an intact left hemipelvis. This dataset was divided into eight subgroups, based on sex and body height, and the plate was virtually fitted on each shape. Plate fitting was assessed by computing the iliopectineal line, the quadrilateral slope, and the root mean square distance (RMSD) between each coordinate of the plate and its closest coordinate on the hemipelvis.</p><p><strong>Results: </strong>The mean age was 56 ± 16 years, and the mean height was 173 ± 10 cm. All female pelves had a moderate fit, mainly because the plate length either exceeded the iliopectineal line length, or the plate's anterior aspect was directed too ventrally. Three out of four male pelves had a good fit. Only the small height subgroup (<175 cm) showed a moderate fit due to the plate length exceeding the iliopectineal line length and a relatively high median RMSD value (1.5 [0.8-2.0] mm) in mid-section of the plate.</p><p><strong>Conclusions: </strong>In acetabular fracture surgery, both visual and quantitative evaluation of suprapectineal plate fitting in sex- and body height-specific subgroups showed moderate fitting in female pelvic shapes, indicating a need for substantial intraoperative bending. This suggests the need for different sizes and contours of future suprapectineal plates in acetabular fracture surgery.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}