Annals of Biomedical Engineering最新文献

{"title":"Dynamic Fracture Fixation Plates: A Systematic Review of Evolving Design Approaches.","authors":"Connor Huxman, April Armstrong, Gary Updegrove, Gregory S Lewis, Jared Butler","doi":"10.1007/s10439-025-03714-1","DOIUrl":"https://doi.org/10.1007/s10439-025-03714-1","url":null,"abstract":"<p><p>Fracture fixation with standard locked plates can suppress interfragmentary motion beneficial for secondary bone healing. To address this limitation, dynamic fracture fixation plates have been developed which seek to maintain bending and torsional rigidity while providing controlled axial micromotion. This article provides a comprehensive systematic review of the history and current state of proposed dynamic plating technologies to better inform future development. 59 records (51 articles, 8 patents) describing 26 unique dynamic plating devices were identified across three literature and patent databases using PRISMA review guidelines. Concepts were grouped into one of 9 engineering approach categories, including plates that incorporate sliding mechanisms, elastic inserts, lattice structures, and mechanically compliant flexures, among others. Devices are compared in their technological characteristics, ranges of axial motion, stiffnesses, and levels of development. Despite many dynamic technologies demonstrating good healing results experimentally and clinically, widespread clinical adoption has not occurred. Some explanations for this are provided, including production costs for complex designs and the current co-existence of both rigid and flexible fixation approaches. Overall, dynamic plating offers a promising area of innovation to address the ongoing concerns of non-union rates associated with standard locked plating of long bone fractures.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies.","authors":"Shumaila Riaz, Shaukat Ali, Muhammad Summer, Urva Akhtar, Shehzeen Noor, Rimsha Haqqi, Muhammad Adeel Farooq, Iqra Sardar","doi":"10.1007/s10439-025-03712-3","DOIUrl":"https://doi.org/10.1007/s10439-025-03712-3","url":null,"abstract":"<p><p>Magnetic nanoparticles (MNPs) have revolutionized cancer therapy by serving as effective drug transporters through active and passive targeting of tumor sites in conjugation with external alternating magnetic fields (AMFs), thus minimizing off-target effects. This precise targeting strategy guarantees a focused and controlled drug release at the tumor site, reducing the drawbacks of standard drug delivery systems and enhancing treatment effectiveness. Magnetic nanoparticles usually follow in magnetic hyperthermia (MHT) therapy, where AMFs raise the temperature at the tumor site, efficiently eliminating cancer cells and presenting a hopeful complement to conventional cancer treatments. In addition, side effects are reduced by launching a smart drug delivery system (SDDSs) in which treatment efficacy is enhanced by reducing the dosage frequency. Intrinsic properties of MNPs are measured when they serve as contrast agents in magnetic resonance imaging (MRI), providing a diagnostic aspect to their therapeutic capabilities and enabling medical professionals to monitor and record treatment outcomes with precision and higher accuracy. This comprehensive review highlights the multifaceted potential of MNPs in reshaping cancer treatment, emphasizing their role in targeted drug delivery, hyperthermia therapy, and imaging applications, and underscoring their transformative impact on the future of oncological care.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EMG-Informed Neuromusculoskeletal Simulations Increase the Accuracy of the Estimation of Knee Joint Contact Forces During Sub-optimal Level Walking.","authors":"Domitille Princelle, Marco Viceconti, Giorgio Davico","doi":"10.1007/s10439-025-03713-2","DOIUrl":"https://doi.org/10.1007/s10439-025-03713-2","url":null,"abstract":"<p><strong>Purpose: </strong>Personalized musculoskeletal models are crucial to get insights into the mechanisms underpinning neuromusculoskeletal disorders and have the potential to support clinicians in the daily management and evaluation of patients. However, their use is still limited due to the lack of validation studies, which hinders people's trust in these technologies. The current study aims to assess the predictive accuracy of two common approaches to estimate knee joint contact forces, when employing musculoskeletal models.</p><p><strong>Methods: </strong>Subject-specific musculoskeletal models were developed for four elderly subjects, exploiting the freely accessible Knee Grand Challenge datasets, and used to perform biomechanical simulations of level walking to estimate knee joint contact forces. The classical static optimization and EMG-assisted approaches were implemented to resolve the muscle redundancy problem. Their estimates were compared, in terms of predictive accuracy, against the experimental recordings from an instrumented knee implant and against one another. Spatiotemporal differences were identified through Statistical Parametrical Mapping, to complement traditional similarity metrics (R², RMSE, 95th percentile, and the maximal error).</p><p><strong>Results: </strong>Both methods allowed to estimate the experimental knee joint contact forces experienced during walking with a high level of accuracy (R² > 0.82, RMSE < 0.56 BW). The EMG-assisted approach further enabled to highlight subject-specific features that were not captured otherwise, such as a prolonged or anticipated muscle-co-contraction.</p><p><strong>Conclusion: </strong>While the static optimization approach provides reasonable estimates for subjects exhibiting typical gait, the EMG-assisted approach should be preferred and employed when studying clinical populations or patients exhibiting abnormal walking patterns.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical and Compositional Changes in the Murine Uterus with Age.","authors":"Mari J E Domingo, Triniti N Vanoven, Raffaella De Vita, Maria E Florian Rodriguez, Kristin S Miller, Isaac J Pence","doi":"10.1007/s10439-025-03709-y","DOIUrl":"https://doi.org/10.1007/s10439-025-03709-y","url":null,"abstract":"<p><p>The uterus is a hollow, fibromuscular organ involved in physiological processes such as menstruation and pregnancy. The content and organization of extracellular matrix constituents such as fibrillar collagen dictate passive (non-contractile) biomechanical tissue function; however, how extracellular matrix composition and biomechanical function change with age in the uterus remains unknown. This study utilizes Raman spectroscopy coupled with biaxial inflation testing to investigate changes in the murine uterus with age (2-3 months, 4-6 months, 10-12 months, and 20-24 months). Linear and toe moduli significantly decreased with reproductive aging (2 to 12 months); however, both moduli increased in the oldest age group (20-24 months). The optical concentration of the combined elastin and collagen spectrum was significantly higher in the oldest group (20-24 month), while the glycogen contribution was the highest in the 2-3 month murine uterus. The presented workflow couples biaxial inflation testing and Raman spectroscopy, representing a critical first step to correlating biomechanics and optical signatures in the aging uterus with the potential for clinical translation. Further, this study may provide critical compositional and structure-function information regarding age-related uterine disorders.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Parameterisation and Prediction of Intra-canal Cochlear Structures.","authors":"Joshua Thiselton, Tania Hanekom","doi":"10.1007/s10439-025-03711-4","DOIUrl":"https://doi.org/10.1007/s10439-025-03711-4","url":null,"abstract":"","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Semi-automatic Finite Element Modeling Workflow for the Evaluation of Cranial Suture-Bone Complex Temporal Strain Evolution During Growth.","authors":"Tsolmonbaatar Khurelbaatar, Mahzad Sadati, Rachel Schultz, Leah Fisher, Emilie Robertson, Curtis Budden, Tracy Popowics, Michael R Doschak, Christopher R Dennison, Lindsey Westover, Dan L Romanyk","doi":"10.1007/s10439-025-03710-5","DOIUrl":"https://doi.org/10.1007/s10439-025-03710-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a semi-automatic workflow for medical image segmentation and finite element (FE) modeling. The workflow was subsequently used to investigate the temporal evolution of the localized mechanical strain in the rat coronal suture during normal growth.</p><p><strong>Methods: </strong>The subject-specific FE models were created based on in vivo longitudinal micro-computed tomography images acquired from n = 4 rats (AUP00003759, 11/04/2021). The FE models were created through a semi-automatic workflow that consisted of a semi-automatic segmentation of the rat cranial sutures, a simplified full skull model, and the detailed coronal suture model. Simulated intracranial pressure loading was implemented, and the localized equivalent, maximum principal, and minimum principal strains were estimated at volumes of interest (VOIs) selected along the suture-bone interface.</p><p><strong>Results: </strong>The semi-automatic segmentations were consistent among operators with a coefficient of variation of 1.8% and showed good agreement compared to the manual segmentation, with maximum differences of 4.1% and 2.0% in terms of suture volume and surface area, respectively. The estimated strains evolved with a trend increasing from 7 to 9 week and 9 to 11 week time intervals and decreasing from 11 to 16 week time interval for all VOIs. The results showed that strains at VOIs significantly changed (p < 0.05) over time. The concave regions of the suture experienced the highest magnitude of strains.</p><p><strong>Conclusion: </strong>The presented research has developed an appropriate semi-automatic FE workflow capable of evaluating temporal changes in mechanical strain of cranial sutures during growth, and was utilized to demonstrate transient and location-specific changes in the rat coronal suture.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The I-PREDICT 50th Percentile Male Finite Element Model: Development and Validation of the Torso.","authors":"Zachary S Hostetler, Drew DiSerafino, Alex Kalmar-Gonzalo, Derek Jones, Lance Frazer, Dan Nicolella, Matthew Davis","doi":"10.1007/s10439-025-03704-3","DOIUrl":"https://doi.org/10.1007/s10439-025-03704-3","url":null,"abstract":"<p><p>Behind Armor Blunt Trauma (BABT) is a phenomenon that occurs when energy is transferred from Personal Protective Equipment (PPE) to the human body and can range from minor to fatal injuries. The current standard to evaluate PPE uses Roma Plastilina No. 1 clay and has a poor correlation to human injuries. To provide a more suitable human surrogate for evaluating risk of injury and functional incapacitation due to BABT, the Incapacitation Prediction for Readiness in Expeditionary Domains: an Integrated Computational Tool (I-PREDICT) has developed a 50th percentile male human body model (HBM) to better understand injury mechanisms in the BABT environment. The model was developed using a hierarchical validation approach including component, regional, and whole torso level tests. Material properties were sourced from literature and I-PREDICT experimental test data, and the model was simulated in 25 different validation cases ranging from component level quasi-static tests to high-rate BABT impacts. The model was stable in all 25 simulations. CORrelation and Analysis (CORA) and BioRank were used to objectively quantify the model response. The average CORA and BioRank across all validation cases were 0.78 ± 0.18 and 0.68 ± 0.27, respectively, indicating 'good' agreement by CORA standards and 'excellent' by BioRank standards. When compared to high-rate BABT experimental impacts on post-mortem human subjects, the I-PREDICT HBM accurately predicted rib fracture probability. The ultimate goal of the I-PREDICT model is to predict injury and functional incapacitation for various in theater military applications. This study highlights the development and validation of the I-PREDICT torso and highlights initial BABT use cases.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscles Functioning as Primary Shoulder Movers Aid the Rotator Cuff Muscles in Increasing Active Glenohumeral Stiffness.","authors":"Constantine P Nicolozakes, Julia S Schmulewitz, Daniel Ludvig, Emma M Baillargeon, Margaret S Danziger, Amee L Seitz, Eric J Perreault","doi":"10.1007/s10439-025-03683-5","DOIUrl":"https://doi.org/10.1007/s10439-025-03683-5","url":null,"abstract":"<p><strong>Purpose: </strong>Active stability is essential to preventing dislocations and the focus of rehabilitation following dislocations. This is thought to arise from shoulder muscles compressing the humeral head into the glenoid (called concavity compression). However, shoulder muscles may also resist humeral head translation through increases in intrinsic muscle stiffness, an unexplored mechanism. Our objective was to quantify shoulder muscles' contributions to changes in glenohumeral stiffness, or the resistance to humeral head translation. We hypothesized that primary shoulder movers (e.g., the pectoralis major or deltoid) would differ from rotator cuff muscles in how much they increase glenohumeral stiffness because they leverage their intrinsic stiffness in addition to concavity compression.</p><p><strong>Methods: </strong>We measured glenohumeral stiffness across a range of isometric muscle activation levels in shoulder abduction and used electromyography to estimate the contributions of rotator cuff muscles and primary shoulder movers. We then created a musculoskeletal model to evaluate individual muscle contributions to glenohumeral stiffness through both concavity compression and intrinsic muscle stiffness.</p><p><strong>Results: </strong>We found that muscle activity in primary shoulder movers was a better predictor of active glenohumeral stiffness than in rotator cuff muscles (R² = 0.81 vs 0.36, P < 0.001). Our musculoskeletal model demonstrated that concavity compression is the primary stabilizing mechanism for most shoulder muscles, yet the muscles that increase glenohumeral stiffness the most also do so considerably through their intrinsic muscle stiffness.</p><p><strong>Conclusion: </strong>Our results emphasize the importance of primary shoulder movers as active stabilizers of the glenohumeral joint and highlight their potential importance in preventing shoulder dislocations.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling Negative and Positive Power for Efficiency Enhancement and Muscle Strain Mitigation During Squatting with a Portable Knee Exoskeleton.","authors":"Shuangyue Yu, Lu Liu, Sainan Zhang, Antonio Di Lallo, Junxi Zhu, Qifei Wu, Guoyu Zuo, Xianlian Zhou, Hao Su","doi":"10.1007/s10439-025-03696-0","DOIUrl":"https://doi.org/10.1007/s10439-025-03696-0","url":null,"abstract":"<p><strong>Purpose: </strong>Workers face a notable risk of musculoskeletal injuries when performing squatting tasks. Knee exoskeletons offer a promising solution to mitigate muscle strain through squat assistance. However, existing studies on knee exoskeletons lack a comprehensive study that meets the multifaceted requirements of squatting assistance in terms of portability, efficiency, and muscle strain mitigation. Furthermore, another open research question pertains to the control strategy of squat assistance, which should be adaptable to various postures and cadences for different individuals. In particular, the effect of controlling negative power assistance during the squat-down phase is not studied.</p><p><strong>Methods: </strong>To fill these two gaps, first, we develop a simple (computationally efficient and implementable in a microcontroller) and generalizable (for different postures, cadences, and individuals) torque controller for portable knee exoskeletons that delivers both negative and positive power. Our portable knee exoskeleton can benefit users by enhancing efficiency (reducing metabolic cost, heart rate, breathing ventilation), mitigating muscle strain (reducing EMG), and reducing perceived exertion (reducing Borg 6-20 scale) during squatting. Second, we study the effect of three levels of negative power assistance during the squat-down phase.</p><p><strong>Results: </strong>This study integrates comprehensive biomechanics and physiology analyses that evaluate our exoskeleton's effectiveness using four objective and two subjective metrics with a group of able-bodied subjects (n = 7). The exoskeleton reduced metabolic cost by 12.8%, heart rate by 13.8%, breathing ventilation by 8.9%, and reduced extensor muscle activity by 39.4-43.2%, flexor muscle activity by 18.9-20.3%, and Borg perceived exertion rate by 1.8 during squatting compare with not wearing the robot.</p><p><strong>Conclusion: </strong>Different from the musculoskeletal model predictions that suggest increasing benefit with a higher level of negative power assistance, we find that the best performances were achieved with a moderate level of negative power assistance, followed by no assistance and then high assistance.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Rigid-Flexible Multibody Analysis Reveals Reduced Pedicle Screw Loads in Short-Segment Fixation for Decompressed Lumbar Spine Stabilization.","authors":"Simone Borrelli, Giovanni Putame, Stefano Marone, Andrea Ferro, Alberto L Audenino, Mara Terzini","doi":"10.1007/s10439-025-03706-1","DOIUrl":"https://doi.org/10.1007/s10439-025-03706-1","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord compression in patients with vertebral metastases often requires surgical decompression with spinal fixation. Recent studies reported increased implant failures due to mechanical complications, raising concerns about current clinical practices. Long-segment fixation (Lf) is commonly employed to enhance mechanical stability and reduce the severity of pedicle screw failure. The study investigates how the number of vertebral levels involved in fixation affects the loads on pedicle screw anchorages in a fatigue-related displacement domain.</p><p><strong>Method: </strong>Using a rigid-flexible multibody approach, a non-linear T12-S1 model was employed to simulate two fixation types following L3 posterior decompression surgery: Lf spanning two levels above and below the decompression site (L1, L2, L4, and L5) and a short-segment fixation (Sf) involving only adjacent vertebrae. Internal reactions at the rod-pedicle screw anchorages were estimated in terms of pullout, shear forces, and bending moments. The range of motion analysed (flexion: 22°, extension: 8°, lateral bending: 12°, axial rotation: 5°) was confined to the \"Cone of Economy\", representing a small-displacement volume where loads are assumed cyclically exchanged.</p><p><strong>Results: </strong>Lf exhibited up to fivefold higher reactions than Sf, with a heterogeneous shear force distribution: middle screws appeared shielded, while extremity screws were overloaded (~400 N, comparable to experimental fatigue strength). Pullout forces remained within safe limits (< 150 N).</p><p><strong>Conclusions: </strong>The rigid-flexible multibody approach effectively estimated internal loads in the implant-spine constructs under dynamic conditions. The findings highlight the long-term implications of Lf, demonstrating that involving more vertebral levels triggers adverse loads on pedicle screws, potentially compromising implant durability.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}