Annals of Biomedical Engineering最新文献

{"title":"Impact of Residual Intimal Flap Displacement Post-TEVAR on TBAD Haemodynamics in Compliant, Patient-specific CFD Simulations Informed by MRI.","authors":"Louis Girardin, Niklas Lind, Hendrik von Tengg-Kobligk, Stavroula Balabani, Vanessa Díaz-Zuccarini","doi":"10.1007/s10439-025-03739-6","DOIUrl":"https://doi.org/10.1007/s10439-025-03739-6","url":null,"abstract":"<p><p>We propose a novel formulation of a moving boundary method to account for the motion of the intimal flap (IF) in a TBAD post-thoracic endovascular aortic repair using patient-specific compliant computational fluid dynamics simulations. The simulations were informed by non-invasive 4D flow MRI sequences. Predicted flow waveforms, aortic wall, and IF displacements were validated against in vivo 4D flow MRI and cine-MRI data. The patient-specific simulation showed that at peak systole, the dynamic interplay between high IF displacement and high transmural pressures promoted true lumen compression and false lumen expansion, whilst luminal patterns were reversed at the deceleration phase. High vorticity and swirling flow patterns were observed throughout the cardiac cycle at the primary entry tear, the descending aorta and proximal to the visceral aortic branches, correlating with high relative residence time, which could indicate an increased localised risk of aortic growth proximal to the IF. A rigid IF simulation revealed significant discrepancies in haemodynamic metrics, highlighting the potential mispredictions when using a rigid wall assumption to assess disease progression. Simulations assuming a more compliant IF highlighted potential increased risks of visceral branches malperfusion and localised aortic wall degeneration. The study underscores the necessity of patient-specific compliant IF simulations for accurate TBAD haemodynamic assessments. These insights can improve disease understanding and inform future treatment strategies.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle Moment Arm-Joint Angle Relations in the Hip, Knee, and Ankle: A Visualization of Datasets.","authors":"Ziyu Chen, David W Franklin","doi":"10.1007/s10439-025-03735-w","DOIUrl":"https://doi.org/10.1007/s10439-025-03735-w","url":null,"abstract":"<p><p>Muscle moment arm is a property that associates muscle force with joint moment and is crucial to biomechanical analysis. In musculoskeletal simulations, the accuracy of moment arm is as important as that of muscle force, and calibrating moment arms in a musculoskeletal model requires data from anatomical measurements. Nonetheless, such data are elusive, and the complex relation between moment arm and joint angle can be unclear. Using common techniques in systematic review, we collected a total of 300 moment arm datasets from literature and visualized the muscle moment arm-joint angle relations in the human hip, knee, and ankle. The findings contribute to the analysis of musculoskeletal mechanics and providing reference regarding the experimental design for future moment arm measurements.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static Precision of Instrumented Pointers for Anatomical Landmark Calibration in CAST-Like Motion Analysis Measurements.","authors":"Kristóf Rácz, Beáta Seregély, Rita M Kiss","doi":"10.1007/s10439-025-03753-8","DOIUrl":"https://doi.org/10.1007/s10439-025-03753-8","url":null,"abstract":"<p><strong>Purpose: </strong>The Calibrated Anatomical Systems Technique is an integral part of modern motion analysis systems. However, the calibration of anatomical landmarks is shown to have large variations in intra- and inter-examiner accuracy, which can result in both offset type errors or changes in the characteristics of joint angles and other parameters. This paper is the first instalment in a series of articles aiming to characterize and minimize all of the different factors contributing to these inconsistent calibrations by examining and optimizing the performance of the instrumented pointers used for landmark calibration. A complete characterisation of all aspects of instrumented pointer precision has not been done before.</p><p><strong>Methods: </strong>This paper focuses on examining four different pointers used with an optical OptiTrack motion capture system to establish the expected variability when measuring pointer tip location. Four different pointers were measured at three different locations within the motion capture system's measurement volume, in a distinct orientation at each of these location.</p><p><strong>Results: </strong>A single stationary marker can be measured with less than 0.06 mm variation with 95% confidence, whilst the variation of the tip of a stationary pointer is 0.2 mm. If the pointer markers are located closer than what the motion capture system is able to resolve, these variations can more than double, but pointer geometry has limited effect on precision apart from this.</p><p><strong>Conclusion: </strong>Thanks to improvement of motion capture technology in the last 20 years, static precision is already excellent. Robustness of tracking can likely be improved, but it's effect on overall pointer precision would be minimal and likely inconsequential.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics Associated with Walking Speed in Postoperative Patients with Adult Spinal Deformity Extracted by Machine Learning.","authors":"Naoto Mano, Kimihiko Mori, Tomohiro Ushikubo, Takayuki Konishi, Shun Ito, Jin Kuramoto, Masayuki Ishihara, Kimitaka Hase","doi":"10.1007/s10439-025-03750-x","DOIUrl":"https://doi.org/10.1007/s10439-025-03750-x","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with adult spinal deformity (ASD) are unable to walk faster even after spinal fixation. Gait rehabilitation that focuses on movements associated with reduced speed may help improve gait function. This study aimed to identify the gait characteristics associated with walking velocity in postoperative patients with ASD.</p><p><strong>Methods: </strong>Three-dimensional gait analysis was performed in 62 postoperative patients with ASD and 105 healthy volunteers. A dimensionality reduction method, based on data from the healthy cohort, was applied to 194 gait characteristics of the patients. Then, the Markov Chain Monte Carlo method sampled the gait characteristics related to speed, and k-means clustering categorized the gait patterns. The relationships between the extracted gait characteristics and velocity were assessed using multiple regression analysis within each cluster.</p><p><strong>Results: </strong>Hip sagittal angle and moment (β = - 0.47 to 0.42) were significantly associated with postoperative velocity in all the patients (R² = 0.834). Two clusters were identified, and hip sagittal moments at contralateral contact and toe-off (β = - 0.58 and 0.68, respectively) were associated with velocity in the group that walked faster (R² = 0.634). Maximum ankle plantarflexion moment and hip flexion power (β = 0.53 and 0.33, respectively) were associated with velocity in the group that walked slowly (R² = 0.448).</p><p><strong>Conclusion: </strong>Larger hip joint movement may play a crucial role in enhancing gait velocity because the spinal fixation limits spino-pelvic movement. To improve gait speed, postoperative older adults with ASD who walk slowly may require new rehabilitation strategies that exert more ankle plantarflexion moment and develop an adequate stance phase to facilitate hip extension.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico, Patient-Specific Assessment of Local Hemodynamic Predictors and Neointimal Hyperplasia Localisation in an Arteriovenous Graft.","authors":"Federica Ninno, Catriona Stokes, Edouard Aboian, Alan Dardik, David Strosberg, Stavroula Balabani, Vanessa Díaz-Zuccarini","doi":"10.1007/s10439-025-03737-8","DOIUrl":"https://doi.org/10.1007/s10439-025-03737-8","url":null,"abstract":"<p><strong>Purpose: </strong>Most computational fluid dynamics (CFD) studies on arteriovenous grafts (AVGs) adopt idealised geometries and simplified boundary conditions (BCs), potentially resulting in misleading conclusions when attempting to predict neointimal hyperplasia (NIH) development. Moreover, they often analyse a limited range of hemodynamic indices, lack verification, and fail to link the graft-altered hemodynamics with follow-up data. This study develops a novel patient-specific CFD workflow for AVGs using pathophysiological BCs. It verifies the CFD results with patient medical data and assesses the co-localisation between CFD results and NIH regions at follow-up.</p><p><strong>Methods: </strong>Contrast-enhanced computed tomography angiography images were used to segment the patient's AVG geometry. A uniform Doppler ultrasound (DUS)-derived velocity profile was imposed at the inlet, and three-element Windkessel models were applied at the arterial outlets of the domain. Transient, rigid-wall simulations were performed using the k-ω SST turbulence model. The CFD-derived flow waveform was compared with the patient's DUS image to ensure verification. Turbulent kinetic energy (TKE), helicity and near-wall hemodynamic descriptors were calculated and linked with regions presenting NIH from a 4-month follow-up fistulogram.</p><p><strong>Results: </strong>In the analysed patient, areas presenting high TKE and balanced helical flow structures at baseline exhibit NIH growth at follow-up. Transverse wall shear stress index is a stronger predictor of NIH than other commonly analysed near-wall hemodynamic indices, since luminal areas subjected to high values greatly co-localise with observed areas of remodelling.</p><p><strong>Conclusion: </strong>This patient-specific computational workflow for AVGs could be applied to a larger cohort to unravel the link between altered hemodynamics and NIH progression in vascular access.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of In Situ Ulnar Nerve Strain and Constraint Tension in the Forearm.","authors":"Mark Carl Miller, Patrick J Schimoler, Harsh Shah, Alexander Kharlamov, R David Graham, Carol Armstrong, Andrew Wroblewski, Yue Yin, Peter Tang","doi":"10.1007/s10439-025-03733-y","DOIUrl":"https://doi.org/10.1007/s10439-025-03733-y","url":null,"abstract":"<p><strong>Background: </strong>Surgical interventions for ulnar neuropathy are typically identified as releases or decompressions. With the expectation that ulnar nerve strain contributes to cubital tunnel syndrome and with the basic hypothesis that nerve tension will most significantly increase in positions of highest elbow flexion, wrist extension, and classic sites of compression, we initiated a new experimental technique to quantify strain and tension in the ulnar nerve.</p><p><strong>Methods: </strong>In five fresh-frozen cadaveric upper extremities from the spine to the wrist, we percutaneously placed small radiopaque spheres into the ulnar nerve using ultrasound guidance to allow tracking of ulnar nerve motion and elongation under fluoroscopy. This technique caused minimal disruption to the soft tissues tethering the nerve. In a custom jig, the forearm was fixed in space while varying elbow and wrist range of motion. After removal of the hand, we measured nerve motion and the tensions constraining the nerve using proportional techniques with application of loads at four standardized locations between the radiocarpal joint and elbow.</p><p><strong>Results: </strong>Means of all in situ tensions varied from 0.54 to 4.28 N. There were significant differences in these constraints tensions among the different elbow flexion angles (p = 0.020). There were differences in in situ tension at the sites of constraint but consistent strains across all four sites.</p><p><strong>Conclusion: </strong>The fluoroscopic technique with percutaneous marker placement successfully allowed strain and tension measurements. The differences in tensions but consistent strains suggest that surgical repair with attention to the attachment of the nerve might restore native nerve gliding and mechanical behavior.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure Between Residual Limb and Transtibial Prosthesis Socket Considering Muscle Contraction: A Finite Element Study.","authors":"Manuel Lucas Sampaio de Oliveira, Thomas K Uchida","doi":"10.1007/s10439-025-03742-x","DOIUrl":"https://doi.org/10.1007/s10439-025-03742-x","url":null,"abstract":"<p><strong>Purpose: </strong>A lower-limb prosthesis is a mechanical device that replaces part of a biological limb to restore mobility. The tissues in the residual limb (the \"residuum\") experience atypical stresses. Importantly, the distal end of the residuum must bear the load that would typically be borne by the foot. To avoid pain and tissue damage, the part of the prosthesis that interfaces with the residuum (the \"socket\") must be designed to fit properly not only at rest but also during walking and other daily activities. The shape of the residuum changes during movement as muscles contract, which can affect the fit of the socket.</p><p><strong>Methods: </strong>To study the residuum-socket interface, we created the first finite element model that considers the effect of muscle contraction on the residuum-socket interfacial pressure.</p><p><strong>Results: </strong>During gait, the interfacial pressure at heel strike and toe off was greater in key regions of the residuum when the gastrocnemius muscle was active rather than passive. The greatest difference was observed in the popliteal fossa region during heel strike, where the pressure was 42% greater when the muscle was fully active than when passive.</p><p><strong>Conclusion: </strong>Our results provide insight into how muscle contraction affects socket fit throughout the gait cycle, potentially leading to improvements in the design and manufacture of prosthesis sockets.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics.","authors":"Kowsar Teimouri, Ahmed Darwish, Wael Saleh, Hoi Dick Ng, Lyes Kadem","doi":"10.1007/s10439-025-03744-9","DOIUrl":"https://doi.org/10.1007/s10439-025-03744-9","url":null,"abstract":"<p><strong>Purpose: </strong>The MitraClip device has emerged as an effective treatment option for patients with mitral regurgitation. However, implementing a MitraClip alters the mitral valve structure and left ventricular flow dynamics. In this study, we experimentally investigate the effects of the MitraClip and the resulting twin pulsed jets on flow dynamics within the left ventricle.</p><p><strong>Methods: </strong>A custom-made left heart pulse duplicator was utilized, considering three different configurations: (1) a healthy mitral valve; (2) a regurgitant mitral valve; and (3) a repaired mitral valve with a MitraClip device. The flow field within the left ventricle was examined using time-resolved particle image velocimetry across different planes. Of particular interest was the analysis of flow structures, viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle.</p><p><strong>Results: </strong>The results indicate that mitral valve regurgitation increases both viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle along with a 45% increase in peak velocity compared to the case with a normal mitral valve. Moreover, while mitral valve repair with a MitraClip alters the flow dynamics in the left ventricle, generating twin pulsed jets, it effectively reduces viscous energy dissipation (by 25 and 36% in the lateral and side planes, respectively) and shear stress accumulation compared to the regurgitant valve. However, these improvements do not fully restore the levels observed in a healthy mitral valve.</p><p><strong>Conclusion: </strong>MitraClip mitigates the adverse effects of mitral regurgitation by restoring key hemodynamic parameters closer to healthy levels, highlighting its potential as a promising treatment.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation of Tentorium and Brainstem Influences on Intracranial Displacements and Strains.","authors":"Sheng Xu, Simon Ouellet, Oren E Petel","doi":"10.1007/s10439-025-03716-z","DOIUrl":"https://doi.org/10.1007/s10439-025-03716-z","url":null,"abstract":"<p><p>Headforms are commonly used as tools in the design and qualification of personal protective equipment. Deformable headforms, containing elastomeric brain models, provide a unique opportunity to directly measure the in situ intracranial strain from an impact; however, these physical models require significant refinement to ensure biofidelity. In the present work, the response and biofidelity of a deformable headform and brain model were investigated, comparing the influence of different boundary conditions on its response. More precisely, the presence or absence of a tentorium or a brainstem model were investigated, focusing on the resulting intracranial displacement and strain fields. The headforms were subjected to a series of linear impacts and deformations within the brain were tracked using embedded radiopaque markers and high-speed X-ray imaging. X-Ray Digital Image Correlation was used to calculate displacement and strain fields within the headform. The biofidelity of the displacement and strain fields within the headform design having both a tentorium and a brainstem were compared to Post-Mortem Human Subject (PMHS) data under identical impact conditions. The biofidelity was ranked using a CORA analysis to provide insight for future design refinements of the headform. The biofidelity ratings for displacement were highest in the frontal and occipital regions (good-excellent) and were worst in the insular region (marginal). Meanwhile, the strain biofidelity rating was best in the frontal (good) and cerebellum (good) regions and worst in the insular region (poor-marginal). This work addresses previous limitations in enhancing the biofidelity of closed headforms and offers opportunities for further improvement through the comparison to PMHS data.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Health Innovation and Entrepreneurship Through an Entrepreneurial Fellowship Program.","authors":"Carter Bloch, Mads Schäfer Bak, Sys Zoffmann Glud","doi":"10.1007/s10439-025-03743-w","DOIUrl":"https://doi.org/10.1007/s10439-025-03743-w","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this paper is to study how the BioMedical Design Programme affects and shapes individual development, group work dynamics among participating fellows and, through these, innovation processes and outcomes.</p><p><strong>Methods: </strong>Drawing on surveys of fellows in the period 2018-2023, it examines changes in fellows' perceived levels of creativity and entrepreneurship and the role of team dynamics through surveys conducted before and after the fellowship.</p><p><strong>Results: </strong>The program led to perceived improvements in being creative, problem solving, collaborating, utilizing networks, and in taking risks. However, at the same time, the program left fellows with a deeper understanding of and respect for the challenges in creating a start-up. One year after the program, fellows reported benefits for their new employment or for their continued start-up ambitions, where around 60% were still involved in an entrepreneurial project.</p><p><strong>Conclusion: </strong>Our results confirm earlier work that shows that entrepreneurial education programs have a positive impact on entrepreneurial attitudes and intentions, where we are also able to explore in greater depth the ways in which the program impacted participating fellows.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}