Annals of Biomedical Engineering最新文献

{"title":"Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics.","authors":"Kowsar Teimouri, Ahmed Darwish, Wael Saleh, Hoi Dick Ng, Lyes Kadem","doi":"10.1007/s10439-025-03744-9","DOIUrl":"https://doi.org/10.1007/s10439-025-03744-9","url":null,"abstract":"<p><strong>Purpose: </strong>The MitraClip device has emerged as an effective treatment option for patients with mitral regurgitation. However, implementing a MitraClip alters the mitral valve structure and left ventricular flow dynamics. In this study, we experimentally investigate the effects of the MitraClip and the resulting twin pulsed jets on flow dynamics within the left ventricle.</p><p><strong>Methods: </strong>A custom-made left heart pulse duplicator was utilized, considering three different configurations: (1) a healthy mitral valve; (2) a regurgitant mitral valve; and (3) a repaired mitral valve with a MitraClip device. The flow field within the left ventricle was examined using time-resolved particle image velocimetry across different planes. Of particular interest was the analysis of flow structures, viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle.</p><p><strong>Results: </strong>The results indicate that mitral valve regurgitation increases both viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle along with a 45% increase in peak velocity compared to the case with a normal mitral valve. Moreover, while mitral valve repair with a MitraClip alters the flow dynamics in the left ventricle, generating twin pulsed jets, it effectively reduces viscous energy dissipation (by 25 and 36% in the lateral and side planes, respectively) and shear stress accumulation compared to the regurgitant valve. However, these improvements do not fully restore the levels observed in a healthy mitral valve.</p><p><strong>Conclusion: </strong>MitraClip mitigates the adverse effects of mitral regurgitation by restoring key hemodynamic parameters closer to healthy levels, highlighting its potential as a promising treatment.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation of Tentorium and Brainstem Influences on Intracranial Displacements and Strains.","authors":"Sheng Xu, Simon Ouellet, Oren E Petel","doi":"10.1007/s10439-025-03716-z","DOIUrl":"https://doi.org/10.1007/s10439-025-03716-z","url":null,"abstract":"<p><p>Headforms are commonly used as tools in the design and qualification of personal protective equipment. Deformable headforms, containing elastomeric brain models, provide a unique opportunity to directly measure the in situ intracranial strain from an impact; however, these physical models require significant refinement to ensure biofidelity. In the present work, the response and biofidelity of a deformable headform and brain model were investigated, comparing the influence of different boundary conditions on its response. More precisely, the presence or absence of a tentorium or a brainstem model were investigated, focusing on the resulting intracranial displacement and strain fields. The headforms were subjected to a series of linear impacts and deformations within the brain were tracked using embedded radiopaque markers and high-speed X-ray imaging. X-Ray Digital Image Correlation was used to calculate displacement and strain fields within the headform. The biofidelity of the displacement and strain fields within the headform design having both a tentorium and a brainstem were compared to Post-Mortem Human Subject (PMHS) data under identical impact conditions. The biofidelity was ranked using a CORA analysis to provide insight for future design refinements of the headform. The biofidelity ratings for displacement were highest in the frontal and occipital regions (good-excellent) and were worst in the insular region (marginal). Meanwhile, the strain biofidelity rating was best in the frontal (good) and cerebellum (good) regions and worst in the insular region (poor-marginal). This work addresses previous limitations in enhancing the biofidelity of closed headforms and offers opportunities for further improvement through the comparison to PMHS data.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Health Innovation and Entrepreneurship Through an Entrepreneurial Fellowship Program.","authors":"Carter Bloch, Mads Schäfer Bak, Sys Zoffmann Glud","doi":"10.1007/s10439-025-03743-w","DOIUrl":"https://doi.org/10.1007/s10439-025-03743-w","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this paper is to study how the BioMedical Design Programme affects and shapes individual development, group work dynamics among participating fellows and, through these, innovation processes and outcomes.</p><p><strong>Methods: </strong>Drawing on surveys of fellows in the period 2018-2023, it examines changes in fellows' perceived levels of creativity and entrepreneurship and the role of team dynamics through surveys conducted before and after the fellowship.</p><p><strong>Results: </strong>The program led to perceived improvements in being creative, problem solving, collaborating, utilizing networks, and in taking risks. However, at the same time, the program left fellows with a deeper understanding of and respect for the challenges in creating a start-up. One year after the program, fellows reported benefits for their new employment or for their continued start-up ambitions, where around 60% were still involved in an entrepreneurial project.</p><p><strong>Conclusion: </strong>Our results confirm earlier work that shows that entrepreneurial education programs have a positive impact on entrepreneurial attitudes and intentions, where we are also able to explore in greater depth the ways in which the program impacted participating fellows.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication.","authors":"Shamimur R Akanda, Meghan E Kupratis, Arnab Bhattacharjee, Jamie Benson, David L Burris, Christopher Price","doi":"10.1007/s10439-025-03708-z","DOIUrl":"https://doi.org/10.1007/s10439-025-03708-z","url":null,"abstract":"<p><strong>Purpose: </strong>Understanding how obesity-a key risk factor for osteoarthritis-effects articular cartilage function is critical to understand OA pathoetiology. Cartilage, a biphasic material, supports vanishingly low friction coefficients in vivo, but is tribomechanically compromised by load-induced interstitial pressure/lubrication loss. To maintain tribomechanical function, cartilage must recover fluid lost to habitual/average contact stresses, a problem obesity likely exacerbates. Recently, we have shown that articulation/sliding drives robust interstitial fluid recovery and indefinite maintenance of biofidelic tissue strains and frictions through generation of hydrodynamic pressures within cartilage contact interfaces, i.e., via 'tribological rehydration.' However, the impact of elevated contact stresses on tribological rehydration and cartilage's function/lubrication remains unknown.</p><p><strong>Methods: </strong>Using our convergent stationary contact area (cSCA) testing approach on ovine stifle cartilage explants bathed in PBS, we aimed to elucidate several points: (1) the effect of elevated contact stress on tribological rehydration during high-speed articulation, and how (2) cartilage material properties and (3) sliding speed influence contact stress-dependent fluid exudation, rehydration, and lubrication.</p><p><strong>Results: </strong>Overall, we identified that (i) contact stress, across a narrow range, and (ii) static loading time are key controllers of tribological rehydration magnitude, compression accumulation, and equilibrium/total compression under biofidelic cSCA loading and sliding conditions. However, over the range tested (i.e., 0.2-0.8 MPa), (iii) contact stresses had no appreciable effect on cartilage's remarkable lubricity in the cSCA.</p><p><strong>Conclusions: </strong>These results show that obesity is likely to directly physically impair articular cartilage function, and that obesity-driven tissue compression/strain, and not friction per se, may be the primary mechanical driver of cartilage dysfunction and OA risk.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury.","authors":"Declan A Patton, Ciara S Grunig, Jessica R McQuaid, Andrew B Dodd, Mandy K Pacheco, Josef M Ling, Tracey V Wick, Divyasree Sasi Kumar, Vadim Zotev, Rachel E Kinsler, Kristy B Arbogast, Andrew R Mayer","doi":"10.1007/s10439-025-03736-9","DOIUrl":"https://doi.org/10.1007/s10439-025-03736-9","url":null,"abstract":"<p><strong>Purpose: </strong>Large mammal head injury models allow the pathophysiological response associated with traumatic brain injury (TBI) to be studied in vivo with precise control of the physical parameters. However, only some studies have used skull-mounted sensors to measure the kinematics of the animal head rather than relying on measurements of the system delivering the impact. Therefore, the aim of the current study was to compare the kinematics between a rotational injury device (HYGE, Inc., Kittanning, PA) and the head in a swine model of TBI across a range of target peak angular velocities.</p><p><strong>Methods: </strong>Sexually mature Yucatan swine were subjected to a rotational TBI via the HYGE device at one of three targeted peak angular velocities: 110 rad/s (n = 16), 145 rad/s (n = 12) or 170 rad/s (n = 11). Sensor packages were used to measure both the angular kinematics of the animal head and HYGE device swing arm.</p><p><strong>Results: </strong>Peak angular velocity of the animal head was on average 18-33% lower compared to that of the HYGE device swing arm with greater relative differences for greater target peak angular velocities. Similarly, peak angular acceleration of the animal head was lower than that of the HYGE device sing arm by 11-34% on average with greater relative differences for greater target peak angular velocities.</p><p><strong>Conclusions: </strong>This study highlights the importance of directly measuring the head kinematics of the animal in TBI models for the purpose of directional comparisons, finite element simulations, and/or scaling kinematics from human-to-animal to determine boundary conditions or animal-to-human to develop injury criteria.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equestrian STAR: Development of an Experimental Methodology for Assessing the Biomechanical Performance of Equestrian Helmets.","authors":"Lauren A Duma, Mark T Begonia, Barry Miller, Caitlyn Jung, Matthew Wood, Brock G Duma, Steve Rowson","doi":"10.1007/s10439-025-03723-0","DOIUrl":"https://doi.org/10.1007/s10439-025-03723-0","url":null,"abstract":"<p><strong>Purpose: </strong>The current equestrian helmet standards set minimal requirements for passing helmets, highlighting the need for a rating system that differentiates helmets based on their impact performance. This study's objectives were to compare equestrian helmet impact response kinematics between linear-driven and oblique impact conditions and then to evaluate the effect of incorporating oblique drop tests into a previously established equestrian helmet rating system, Equestrian STAR.</p><p><strong>Methods: </strong>Oblique drop tests were conducted with 45 equestrian helmet models at two impact locations, front boss and rear boss, at an impact velocity of 6.56 m/s. The resulting peak linear and rotational head accelerations were compared to those measured during linear-driven pendulum impacts on the same helmet models. A total of 720 impact tests were performed, making this the largest published study on equestrian helmets to date. Equestrian STAR was modified to include both pendulum and oblique impacts by computing and summing weighted concussion risks for each test condition.</p><p><strong>Results: </strong>Oblique impacts had peak linear accelerations ranging from 105.8 to 204.5 g and peak rotational accelerations ranging from 3304 to 13854 rad/s². Between the linear-driven and oblique impacts, peak linear acceleration was weakly correlated (R² = 0.34, p < 0.001), while peak rotational acceleration was not correlated (R² = 0.04, p = 0.21). Equestrian STAR scores calculated using both pendulum and oblique impacts suggested that the worst-performing helmet on both systems had nearly four times the concussion risk as the best-performing.</p><p><strong>Conclusion: </strong>Pendulum and oblique impacts have different methods of generating head rotation, which can highlight different modes of helmet performance. The updated Equestrian STAR helmet rating system differentiates between high-performing and low-performing helmets, enabling equestrians to purchase helmets best at reducing concussion risk and providing companies with a process to compare their helmet designs.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DeepSeek's Readiness for Medical Research and Practice: Prospects, Bottlenecks, and Global Regulatory Constraints.","authors":"ArunSundar MohanaSundaram, Shanmugarajan Thukani Sathanantham, Aleksandar Ivanov, Mohammad Mofatteh","doi":"10.1007/s10439-025-03738-7","DOIUrl":"https://doi.org/10.1007/s10439-025-03738-7","url":null,"abstract":"<p><p>DeepSeek, an open-source multimodal Large Language Model (LLM), was launched by the Chinese startup (Hangzhou DeepSeek Artificial Intelligence Basic Technology Research Co., Ltd.). Despite the lack of advanced artificial intelligence (AI) chips, the performance of its milestone version, \"DeepSeek-V3,\" has set an unprecedented benchmark among LLMs, surpassing existing models. Notably, the opportunity to deploy this model in the local system helps build better-performing \"distilled versions\" suitable for medical research (hypothesis generation, drafting patient consent forms and biostatistical analysis, etc.) and clinical practice (differential diagnosis from symptom clusters, current guideline-based treatment protocol design, interactive medical training, personalized patient education, etc.). However, privacy and security risks, ethical uncertainties, and diversified global AI regulations hinder its potential for sustainable integration into real-world applications.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Low-Profile, Piezoelectric Robot for MR-Guided Abdominal Needle Interventions.","authors":"Samuel Wilcox, Saikat Sengupta, Chuan Huang, Junichi Tokuda, Aiming Lu, David Woodrum, Yue Chen","doi":"10.1007/s10439-025-03719-w","DOIUrl":"https://doi.org/10.1007/s10439-025-03719-w","url":null,"abstract":"<p><strong>Purpose: </strong>Minimally invasive needle-based interventions are commonly used in cancer diagnosis and treatment, including procedures, such as biopsy, brachytherapy, and microwave ablation. Although MR-guided needle placement offers several distinct advantages, such as high-resolution target visualization and accurate device tracking, one of the primary limitations that affect its widespread adoption is the ergonomic constraints of the closed-bore MRI environment, requiring the patients to be frequently moved in and out to perform the needle-based procedures. This paper introduces a low-profile, body-mounted, MR-guided robot designed to address this limitation by streamlining the operation workflow and enabling accurate needle placement within the MRI scanner.</p><p><strong>Methods: </strong>The robot employs piezoelectric linear actuators and stacked Cartesian XY stages to precisely control the position and orientation of a needle guide. A kinematic model and control framework was developed to facilitate accurate targeting. Additionally, clinical workflow for the liver interventions was developed to demonstrate the robot's capability to replicate existing procedures. The proposed system was validated in benchtop environment and 3T MRI scanner to quantify the system performance.</p><p><strong>Results: </strong>Experimental validations conducted in free space demonstrated a position accuracy of 2.38 ± 0.94 mm and orientation error of 1.40 ± 2.89°. Additional tests to confirm MR-conditionality and MR-guided phantom placements were carried out to assess the system's performance and safety in MRI suite, yielding a position error of 2.01 ± 0.77 mm and an orientation error of 1.57 ± 1.31°.</p><p><strong>Conclusion: </strong>The presented robot shows exceptional compatibility with a wide range of patients and bore sizes while maintaining clinically significant accuracy. Future work will focus on the validations in dynamic liver environments.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heparin Coating Decreases the Thrombotic Signature of Flow Diverter Stents.","authors":"Sina Farzaneh, Juan Miguel Jiménez","doi":"10.1007/s10439-025-03724-z","DOIUrl":"https://doi.org/10.1007/s10439-025-03724-z","url":null,"abstract":"<p><strong>Purpose: </strong>Flow diverter stents (FDS) are used to treat aneurysms by modifying the intraaneurysmal hemodynamics and promoting a prothrombotic milieu. Thrombotic in-stent stenosis (ISS) is a common complication of endovascular treatment for intracranial aneurysms with flow diverter stents. The dominant approach to address ISS has been to either increase the dose of antiplatelet therapy agents or extend dual antiplatelet therapy (DAPT) causing ISS to resolve, while potentially exacerbating the side effects associated with DAPT. To decrease the risk of thrombotic ISS, surface coatings have been applied to flow diverter stents with promising results.</p><p><strong>Methods: </strong>The thrombotic signature of a bare metal and a heparin coated FDS was assessed in vitro. The flow diverter stents were exposed to pulsatile blood flow in a one-pass system to assess platelet and fibrin deposition, while flow cytometry was used to assess different markers of platelet activation in blood incubated with flow diverter stents for 30, 60, and 90 minutes.</p><p><strong>Results: </strong>Immunofluorescence and scanning electron microcopy results demonstrated greater fibrin and platelet deposition on bare metal flow diverter stents, while the heparin coated flow diverter stents had less fibrin and platelet deposition. A greater percentage of platelets were not only activated, but also presented higher levels of activation markers, in blood exposed to the bare metal flow diverter stents at the 90 minute time point in comparison to the heparin coated FDS.</p><p><strong>Conclusion: </strong>The findings demonstrate that heparin coated flow diverter stents are characterized by a lower thrombotic signature than bare metal flow diverter stents and raise the possibility of an additional therapeutic option to treat intracranial aneurysms.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Polo Helmet Performance Across Different Impact Test Systems.","authors":"Nicole E-P Stark, Mark T Begonia, Steve Rowson","doi":"10.1007/s10439-025-03731-0","DOIUrl":"https://doi.org/10.1007/s10439-025-03731-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated head impact response between different helmet impact test systems by comparing the performance of ten polo helmets.</p><p><strong>Methods: </strong>Helmets were evaluated using three test systems: a twin-wire guided drop tower, an oblique drop tower, and an impact pendulum. Impact tests were conducted at matched locations (front boss, side, rear boss) and speeds (3.46, 5.46 m/s). We employed a linear mixed model with helmet model as a random effect and calculated the least square mean differences between systems for peak linear acceleration (PLA), peak rotational acceleration (PRA), peak rotational velocity (PRV), and concussion risk. Correlations between systems by impact speed were explored, using linear models of each system as a function of the others, and calculated Spearman rank correlation coefficients between test systems for each dependent variable.</p><p><strong>Results: </strong>Our results found distinct differences in PRA and concussion risk between the oblique and the pendulum impact systems due to the driving force. The acceleration range across helmet models was substantial, and responses differed between test systems at matched impact conditions. However, there were similarities between test systems in the rank order of helmet models. Head acceleration differences between helmets translated to larger differences in concussion risk between helmet models.</p><p><strong>Conclusion: </strong>These trends provide a framework for comparing the headform's response across varying loading conditions. When selecting a test system to evaluate helmets for a specific sport, it is essential to consider the relevant impact conditions and loading patterns to ensure that laboratory tests accurately represent real-world scenarios.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}