An In Silico Model to Examine the Interaction Between Implant Degradation and Fracture Healing Under Mechanical Loading.

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL
Ruisen Fu, Xurun Zhao, Yang Liu, Aike Qiao, Haisheng Yang
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Abstract

Biodegradable implants are promising for fracture fixation but they have not been applied to the load-bearing skeletal sites. A critical issue is how implant degradation and fracture healing affect each other under mechanical loading. To address this issue, we first developed a finite element model of a long bone fracture fixed with a Zn alloy-based screw-plate system, where implant degradation and bone healing were simulated based upon the continuum damage mechanics and mechano-regulated tissue differentiation algorithm, respectively. For comparison, non-degradable Ti alloy implant with normal bone healing and non-healing fracture with normal implant degradation were served as two reference controls. In terms of the effect of implant degradation on bone healing, the results indicated that implant degradation resulted in a greater volume of newly formed bone within the callus (16% for the degradable implant vs 12% for the non-degradable implant) and a better biomechanical recovery of the fractured bone (bone stiffness fraction: 107% vs 95%) at week 8. Regarding the effect of bone healing on implant degradation, fracture healing led to a significant decrease in the degradation rate of the implant (implant stiffness fraction at week 4: 8% for non-healing vs 40% for healing) and an increase in the overall period from 4 to 8 weeks for a complete degradation of the implant. These results together suggest that implant degradation and fracture healing significantly affect each other under mechanical loading. The in silico model developed here may provide a valuable platform to consider interactions between material degradation and bone healing when designing biodegradable implants for orthopaedic internal fixation at the load-bearing sites.

在机械载荷下研究植入物降解与骨折愈合之间相互作用的计算机模型。
可生物降解的植入物在骨折固定方面很有前景,但尚未应用于承重骨骼部位。一个关键的问题是,在机械载荷下,植入物降解和骨折愈合如何相互影响。为了解决这个问题,我们首先开发了一个用锌合金为基础的螺钉板系统固定长骨骨折的有限元模型,其中种植体降解和骨愈合分别基于连续损伤力学和力学调节的组织分化算法进行模拟。作为对照,将骨愈合正常的不可降解钛合金种植体与骨愈合正常的不可降解钛合金种植体作为对照。就植入物降解对骨愈合的影响而言,结果表明,植入物降解导致骨痂内新形成的骨体积更大(可降解植入物为16%,不可降解植入物为12%),骨折骨在第8周的生物力学恢复更好(骨刚度分数:107%对95%)。关于骨愈合对假体降解的影响,骨折愈合导致假体降解率显著降低(第4周时,未愈合的假体刚度分数为8%,而愈合的为40%),并且假体完全降解的总时间从4周到8周增加。这些结果共同表明,在机械载荷下,植入物降解和骨折愈合之间存在着显著的相互影响。在设计用于骨科承重部位内固定的可生物降解植入物时,本文开发的计算机模型可能为考虑材料降解与骨愈合之间的相互作用提供了一个有价值的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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