Annals of Biomedical Engineering最新文献_第8页

Detecting and Salvaging Head Impacts with Decoupling Artifacts from Instrumented Mouthguards 用仪器护齿器的解耦伪影检测和修复头部撞击。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-02-08 DOI: 10.1007/s10439-025-03689-z

Ryan Gellner, Mark T. Begonia, Matthew Wood, Lewis Rockwell, Taylor Geiman, Caitlyn Jung, Blake Gellner, Allison MacMartin, Sophia Manlapit, Steve Rowson

{"title":"Detecting and Salvaging Head Impacts with Decoupling Artifacts from Instrumented Mouthguards","authors":"Ryan Gellner, Mark T. Begonia, Matthew Wood, Lewis Rockwell, Taylor Geiman, Caitlyn Jung, Blake Gellner, Allison MacMartin, Sophia Manlapit, Steve Rowson","doi":"10.1007/s10439-025-03689-z","DOIUrl":"10.1007/s10439-025-03689-z","url":null,"abstract":"<div><p>In response to growing evidence that repetitive head impact exposure and concussions can lead to long-term health consequences, many research studies are attempting to quantify the frequency and severity of head impacts incurred in various sports and occupations. The most popular apparatus for doing so is the instrumented mouthguard (iMG). While these devices hold greater promise of head kinematic accuracy than their helmet-mounted predecessors, data artifacts related to iMG decoupling still plague results. We recreated iMG decoupling artifacts in a laboratory test series using an iMG fit to a dentition mounted in a NOCSAE headform. With these data, we identified time, frequency, and time-frequency features of decoupled head impacts that we used in a machine learning classification algorithm to predict decoupling in six-degree-of-freedom iMG signals. We compared our machine learning algorithm predictions on the laboratory series and 80 video-verified field head acceleration events to several other proprietary and published methods for predicting iMG decoupling. We also present a salvaging method to remove decoupling artifacts from signals and reduce peak resultant error when decoupling is detected. Future researchers should expand these methods using on-field data to further refine and enable prediction of iMG decoupling during live volunteer use. Combining the presented machine learning model and salvaging technique with other published methods, such as infrared proximity sensing, advanced triggering thresholds, and video review, may enable researchers to identify and salvage data with decoupling artifacts that previously would have had to be discarded.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 5","pages":"1095 - 1112"},"PeriodicalIF":3.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03689-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of Considering Temporal Variations in Pulse Wave Velocity for Accurate Blood Pressure Prediction 考虑脉搏波速度的时间变化对准确预测血压的重要性。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-02-06 DOI: 10.1007/s10439-025-03681-7

Aditya Satishkumar Bantwal, Amit Kumar Bhayadia, Hui Meng

{"title":"Importance of Considering Temporal Variations in Pulse Wave Velocity for Accurate Blood Pressure Prediction","authors":"Aditya Satishkumar Bantwal, Amit Kumar Bhayadia, Hui Meng","doi":"10.1007/s10439-025-03681-7","DOIUrl":"10.1007/s10439-025-03681-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Continuous, cuffless blood pressure (BP) monitoring devices based on measuring pulse wave velocity (PWV) or pulse transit time (PTT) are emerging but are often plagued by large prediction errors. A key issue is that these techniques typically rely on a single PWV value, assuming a linear response and small arterial wall deformations. However, arterial response to BP is inherently nonlinear, with PWV varying over time [PWV(t)] by up to 50% during a cardiac cycle. This study evaluates the impact of assuming a single PWV on BP prediction accuracy.</p><h3>Method</h3><p>Using a Fluid-structure Interaction (FSI) testbed, we simulate the radial and common carotid arteries with the Holzapfel–Gasser–Ogden (HGO) constitutive model to capture nonlinear arterial behavior under a pulsatile physiological blood flow. Pressure data from FSI simulation are used as the ground truth, while inner area A(t) and two PWV values, at diastole and systole, serve as inputs to BP prediction models. Two models are tested: one using a single PWV value, emulating existing PWV-based BP prediction methods; another using the two PWV values to account for PWV(t).</p><h3>Results</h3><p>The single-PWV BP model produced prediction errors of 17.44 mmHg and 6.57 mmHg for the radial and carotid arteries, respectively. The model incorporating two PWV values reduced these errors by 90.6% and 96.8%, respectively.</p><h3>Conclusion</h3><p>Relying on a single PWV in BP prediction models can lead to significant errors. To improve BP accuracy, future efforts should focus on incorporating PWV(t), or at least both diastolic and systolic PWV values, into these models.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 5","pages":"1080 - 1094"},"PeriodicalIF":3.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03681-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Prediction of Intracranial Aneurysm Rupture Status Using Temporal Velocity-Informatics 利用时间速度信息学改进颅内动脉瘤破裂状态的预测。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-02-04 DOI: 10.1007/s10439-025-03686-2

M. Rezaeitaleshmahalleh, Z. Lyu, Nan Mu, Varatharajan Nainamalai, Jinshan Tang, J. J. Gemmete, A. S. Pandey, J. Jiang

引用次数: 0

Multi-Scale Multi-Cell Computational Model of Inflammation-Mediated Aortic Remodeling in Hypertension 高血压炎症介导主动脉重构的多尺度多细胞计算模型。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-02-04 DOI: 10.1007/s10439-025-03685-3

Ana C. Estrada, Jay D. Humphrey

{"title":"Multi-Scale Multi-Cell Computational Model of Inflammation-Mediated Aortic Remodeling in Hypertension","authors":"Ana C. Estrada, Jay D. Humphrey","doi":"10.1007/s10439-025-03685-3","DOIUrl":"10.1007/s10439-025-03685-3","url":null,"abstract":"<div><h3>Purpose</h3><p>Multiple cell types interact within the aortic wall to control development, homeostasis, and adaptation as well as to drive disease progression. Given the complexity of these interactions and their manifestations at the tissue level, there is a pressing need for a new class of computational models that integrate data across scales.</p><h3>Methods</h3><p>We meld logic-based cell signaling models of vascular smooth muscle cells, adventitial fibroblasts, and macrophages and couple this multi-cell model with a tissue level-constrained mixture model of aortic growth and remodeling. The coupled multi-scale model is parameterized using data from the literature and then specialized for the case of angiotensin II-induced hypertensive remodeling of the descending thoracic aorta in wild-type mice.</p><h3>Results</h3><p>We contrast important contributions of chemo- and mechano-stimulation of cell responses and identify critical roles of recruited macrophages in driving the non-homeostatic thickening of the adventitial layer that reduces biaxial wall stress below setpoint values.</p><h3>Conclusion</h3><p>We show the utility of a multi-scale, multi-cell model in delineating effects of different chemo-mechanical stimuli in aortic remodeling in hypertension.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 4","pages":"1014 - 1023"},"PeriodicalIF":3.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Arm Swing During Running Improves Rotational Stability of the Upper Body and Metabolic Energy Efficiency 跑步时主动摆动手臂可以提高上半身的旋转稳定性和代谢能量效率。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-02-03 DOI: 10.1007/s10439-025-03688-0

Young-Jun Koo, Naomichi Ogihara, Seungbum Koo

{"title":"Active Arm Swing During Running Improves Rotational Stability of the Upper Body and Metabolic Energy Efficiency","authors":"Young-Jun Koo, Naomichi Ogihara, Seungbum Koo","doi":"10.1007/s10439-025-03688-0","DOIUrl":"10.1007/s10439-025-03688-0","url":null,"abstract":"<div><h3>Purpose</h3><p>The kinematic benefits of arm swing during running for upper body stability have been previously investigated, while its role in metabolic energy efficiency remains controversial. To address this, this study aimed to test the hypothesis that active arm swing during running reduces both torso angular motion around the longitudinal axis and metabolic energy consumption.</p><h3>Methods</h3><p>We employed forward dynamics musculoskeletal running simulations with different arm conditions to investigate the hypothesis. Full-body musculoskeletal running models, incorporating 150 muscles, were developed using artificial neural network-based running controllers. Three arm conditions were simulated using the running models and controllers: active arm swing, passive arm swing, and fixed arms.</p><h3>Results</h3><p>Our results revealed that the active arm swing model demonstrated the lowest total metabolic energy consumption per traveling distance. The costs of transport were 5.52, 5.73, and 5.82 J/kg-m for active, passive, and fixed arm models, respectively. Interestingly, while metabolic energy consumption in the upper limb muscles was higher during active arm swing, the total energy consumption was lower. Additionally, the longitudinal rotation of the torso was minimal in the active arm swing condition.</p><h3>Conclusion</h3><p>These findings support our hypothesis, demonstrating that active arm swing during running reduces the angular motion of the torso and the metabolic energy consumption. This study provides evidence that arm swing during running is performed actively as an energy-saving mechanism. These results contribute to understanding of running biomechanics and may have implications for performance optimization in sports and rehabilitation settings.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 4","pages":"1003 - 1013"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-025-03688-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Diagnostics: The Role of Wearable Ultrasound and AI in Abdominal Aortic Aneurysm 3D Modeling 新一代诊断：可穿戴超声和人工智能在腹主动脉瘤3D建模中的作用。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-01-31 DOI: 10.1007/s10439-025-03692-4

Michael James, Viren S. Sehgal, Rooshi Parikh

引用次数: 0

Center of Pressure of Medial Knee Contact Force Predicts Future Transition Risk of Knee Surgery in Patients with Knee Osteoarthritis 膝关节内侧接触力压力中心预测膝关节骨性关节炎患者手术过渡风险。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-01-31 DOI: 10.1007/s10439-024-03664-0

Yamagata Momoko, Taniguchi Masashi, Tateuchi Hiroshige, Motomura Yoshiki, Kobayashi Masashi, Ichihashi Noriaki

{"title":"Center of Pressure of Medial Knee Contact Force Predicts Future Transition Risk of Knee Surgery in Patients with Knee Osteoarthritis","authors":"Yamagata Momoko, Taniguchi Masashi, Tateuchi Hiroshige, Motomura Yoshiki, Kobayashi Masashi, Ichihashi Noriaki","doi":"10.1007/s10439-024-03664-0","DOIUrl":"10.1007/s10439-024-03664-0","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to explore whether mechanical load features, including the magnitude of the medial knee contact force (KCFmed) and its center of pressure (KCFcop) during gait, predict future surgery in patients with knee osteoarthritis (OA).</p><h3>Methods</h3><p>Twenty-six patients with knee OA walked three times at a comfortable speed, and the external knee adduction moment (KAM), flexion moment (KFM), and total knee moment of the KAM and KFM (KTM) were assessed. We further evaluated KCFmed and KCFcop using a musculoskeletal model. The values of knee moments and KCFmed were extracted at the first and second peaks, and the average KCFcop location and amount of KCFcop displacement were calculated during the early-, mid-, and late-stance phases. Ten years after data collection, we confirmed whether the patients required knee surgery (Surg_OA) or not (NonSurg_OA).</p><h3>Results</h3><p>Twenty-four patients with complete data were divided into Surg_OA and NonSurg_OA groups. The Surg_OA group had significantly lower KTM, KFM, and KCFmed values at the first peak than the NonSurg_OA group. In the Surg_OA group, KCFcop shifted toward the joint center during the mid- and late-stance phases, and the amount of KCFcop displacement was small during the mid-stance phase. No significant differences were observed in the other parameters.</p><h3>Conclusion</h3><p>Our findings demonstrated that individuals who underwent knee surgery within 10 years showed suppressed KCFmed magnitudes in the first half of the stance phase, whereas they received sustained force on a localized area of the medial compartment during the mid-stance phase.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 4","pages":"994 - 1001"},"PeriodicalIF":3.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03664-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Optimising Instrumented Mouthguard Data Analysis: Video Synchronisation Using a Cross-correlation Approach 修正：优化仪器护齿数据分析：使用相互关联方法的视频同步。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-01-30 DOI: 10.1007/s10439-025-03690-6

James Tooby, Steve Rowson, Kevin Till, David Allan, Melanie Dawn Bussey, Dario Cazzola, Éanna Falvey, Kenzie Friesen, Andrew J. Gardner, Cameron Owen, Gregory Roe, Thomas Sawczuk, Lindsay Starling, Keith Stokes, Gregory Tierney, Ross Tucker, Ben Jones

引用次数: 0

Enhancing Bioactivity of Titanium-Based Materials Through Chitosan Based Coating and Calcitriol Functionalization 壳聚糖包覆及骨化三醇功能化增强钛基材料的生物活性。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-01-27 DOI: 10.1007/s10439-025-03684-4

Burcu Doymuş, Görke Gürel Peközer, Sakip Önder

{"title":"Enhancing Bioactivity of Titanium-Based Materials Through Chitosan Based Coating and Calcitriol Functionalization","authors":"Burcu Doymuş, Görke Gürel Peközer, Sakip Önder","doi":"10.1007/s10439-025-03684-4","DOIUrl":"10.1007/s10439-025-03684-4","url":null,"abstract":"<div><p>Titanium (Ti)-based materials are favored for hard tissue applications, yet their bioinertness limits their success. This study hypothesizes that functionalizing Ti materials with chitosan nano/microspheres and calcitriol (VD) will enhance their bioactivity by improving cellular activities and mineralization. To test this, chitosan particles were applied uniformly onto Ti surfaces using electrophoretic deposition (EPD) at 20 V for 3 minutes. VD was then loaded onto the coated surfaces, and the release profile of VD was monitored. Human fetal osteoblastic cells (hFOB) were cultured on the VD-loaded Ti surfaces. Cellular activities such as proliferation, Alkaline phosphatase (ALP) activity, osteogenic gene expression (runt-related transcription factor 2 (Runx2), collagen type 1 (Col I), osteocalcin ( OCn), osteopontin (OP)), and mineralization were assessed. Von Kossa staining was performed to analyze mineralization, and the expression of cell adhesion proteins (N-cadherin (NC), integrin alpha V (IaV), integrin beta 3, (Ib3)) was measured. The results showed that approximately 50% of the VD released over 50 hours. The chitosan coating increased surface roughness three-fold, and this, combined with VD release, resulted in reduced cell proliferation but increased ALP activity, suggesting enhanced differentiation. VD-functionalized Ti surfaces showed statistically significant differences in osteogenic gene expressions, particularly on rougher surfaces. Additionally, the expression of cell adhesion proteins (NC, IaV, Ib3) was upregulated on VD-containing coated surfaces. Von Kossa analysis revealed that surface roughness significantly enhanced mineralization, particularly on VD-free surfaces by day 7, while mineralization on VD-containing bare surfaces started on day 14. These findings demonstrate that VD-loaded chitosan coatings significantly enhance the biocompatibility and bioactivity of Ti-based materials, highlighting their potential for applications in bone regeneration.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 4","pages":"980 - 993"},"PeriodicalIF":3.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Valveless Pulsatile Flow Pump for Extracorporeal Blood Circulation 一种用于体外血液循环的新型无阀脉动泵。

IF 3 2区医学

Annals of Biomedical Engineering Pub Date : 2025-01-26 DOI: 10.1007/s10439-024-03672-0

Joaquín Anatol, Emanuele Vignali, Emanuele Gasparotti, Francisco Castro-Ruiz, Manuel Rubio, César Barrios-Collado, Jose Sierra-Pallares, Simona Celi

引用次数: 0