Jack Seifert, Jared Koser, Alok Shah, Lance Frazer, Frank A Pintar, Narayan Yoganandan, Dan Nicolella, Timothy B Bentley, Brian D Stemper
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The objective of this study was to develop blunt impact injury risk curves for in vitro thoraco-abdominal organs and determine their applicability in predicting in situ BABT injuries.</p><p><strong>Methods: </strong>In vitro tests Healthy isolated liver and heart specimens were perfused and placed on a bed of gelatin underneath a drop tower and impacted with a 3-cm hemisphere impactor. Each organ was exposed to an incremental loading protocol, wherein initial displacement of penetration was 2 mm, and increased by 2 mm for each subsequent impact on the organ. Injury was defined as the presence of laceration. Injury probability curves were developed using a generalized mixed linear model (proc GENMOD). Univariate models were analyzed for predictive variables, including peak displacement, percent compression, and peak force. In situ tests An intact postmortem human subject (PMHS) was instrumented and subsequently impacted with an impactor that had a profile representative of BFD and a velocity of 65 m/s. One impact was aimed at the heart and one impact was aimed at the liver.</p><p><strong>Results: </strong>The final predictive models for isolated organ injuries demonstrated 50% probability of injury for impact displacement of 12.4 mm (95% CI [10.1 mm, 17.6 mm]) and 13.8 mm (95% CI [11.5 mm, 16.8 mm]) for the liver and heart, respectively. During the PMHS tests, total impactor displacement into the PMHS was 45.8 mm and 59.2 mm for the impacts aimed at the liver and heat, respectively. Post-rib fracture impactor displacement did correlate to the isolated organ risk curves, equating to an 88% and 86% of liver and heart injury risk, respectively. Despite high risk of injury for both organs, only the liver was lacerated, suggesting that isolated organ risk curves do not fully translate to in situ testing.</p><p><strong>Conclusion: </strong>These experimental tests and developed risk curves can be used as validation and injury risk estimates for future isolated organ and whole body computational models. Simulated BFD impacts with PMHS tests highlight the complexity of BABT injury mechanisms and shows the significant anisotropy of the thoraco-abdominal region that should be considered when developing future protective equipment.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impactor Displacement as a Predictor of Thoraco-Abdominal Organ Injury: Comparison of Isolated Organ to Whole Body Tests.\",\"authors\":\"Jack Seifert, Jared Koser, Alok Shah, Lance Frazer, Frank A Pintar, Narayan Yoganandan, Dan Nicolella, Timothy B Bentley, Brian D Stemper\",\"doi\":\"10.1007/s10439-025-03797-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Body armor is used to protect the wearer from penetrating injuries. However, when the armor defeats the projectile, it deforms at high rates into the wearer, referred to as back face deformation (BFD). This deformation can cause a variety of superficial and internal injuries and consequently should be considered when designing body armor. However, current design standards do not adequately consider the effects of BFD, and new data are necessary to inform future design thresholds for BFD. The objective of this study was to develop blunt impact injury risk curves for in vitro thoraco-abdominal organs and determine their applicability in predicting in situ BABT injuries.</p><p><strong>Methods: </strong>In vitro tests Healthy isolated liver and heart specimens were perfused and placed on a bed of gelatin underneath a drop tower and impacted with a 3-cm hemisphere impactor. Each organ was exposed to an incremental loading protocol, wherein initial displacement of penetration was 2 mm, and increased by 2 mm for each subsequent impact on the organ. Injury was defined as the presence of laceration. Injury probability curves were developed using a generalized mixed linear model (proc GENMOD). Univariate models were analyzed for predictive variables, including peak displacement, percent compression, and peak force. In situ tests An intact postmortem human subject (PMHS) was instrumented and subsequently impacted with an impactor that had a profile representative of BFD and a velocity of 65 m/s. One impact was aimed at the heart and one impact was aimed at the liver.</p><p><strong>Results: </strong>The final predictive models for isolated organ injuries demonstrated 50% probability of injury for impact displacement of 12.4 mm (95% CI [10.1 mm, 17.6 mm]) and 13.8 mm (95% CI [11.5 mm, 16.8 mm]) for the liver and heart, respectively. During the PMHS tests, total impactor displacement into the PMHS was 45.8 mm and 59.2 mm for the impacts aimed at the liver and heat, respectively. Post-rib fracture impactor displacement did correlate to the isolated organ risk curves, equating to an 88% and 86% of liver and heart injury risk, respectively. Despite high risk of injury for both organs, only the liver was lacerated, suggesting that isolated organ risk curves do not fully translate to in situ testing.</p><p><strong>Conclusion: </strong>These experimental tests and developed risk curves can be used as validation and injury risk estimates for future isolated organ and whole body computational models. 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引用次数: 0
摘要
用途:防弹衣用于保护穿戴者免受穿透性伤害。然而,当盔甲击败投射物时,它会快速变形成穿戴者,称为背面变形(BFD)。这种变形会导致各种表面和内部损伤,因此在设计防弹衣时应该考虑到这一点。然而,目前的设计标准没有充分考虑到BFD的影响,需要新的数据来指导未来BFD的设计阈值。本研究的目的是建立体外胸腹器官钝性撞击损伤风险曲线,并确定其在预测原位BABT损伤中的适用性。方法:将健康的离体肝脏和心脏标本灌注,置于一个滴塔下的明胶床上,用一个3厘米的半球撞击器撞击。每个器官暴露于增量加载方案中,其中初始穿透位移为2mm,随后每次对器官的冲击增加2mm。损伤定义为存在撕裂伤。采用广义混合线性模型(proc GENMOD)绘制损伤概率曲线。单变量模型分析了预测变量,包括峰值位移,压缩百分比和峰值力。原位测试对一个完整的死后人体(PMHS)进行仪器检测,随后用一个具有代表BFD的轮廓和65 m/s速度的撞击器进行撞击。一个撞击目标是心脏,另一个撞击目标是肝脏。结果:孤立器官损伤的最终预测模型显示,肝脏和心脏的冲击位移分别为12.4 mm (95% CI [10.1 mm, 17.6 mm])和13.8 mm (95% CI [11.5 mm, 16.8 mm]),损伤的概率为50%。在PMHS试验中,针对肝脏和热量的冲击器进入PMHS的总位移分别为45.8 mm和59.2 mm。肋骨骨折后冲击物移位确实与孤立器官风险曲线相关,分别相当于肝脏和心脏损伤风险的88%和86%。尽管两个器官的损伤风险都很高,但只有肝脏被撕裂,这表明孤立器官的风险曲线不能完全转化为原位测试。结论:这些实验结果和建立的风险曲线可作为未来离体器官和全身计算模型的验证和损伤风险估计。通过PMHS试验模拟BFD冲击,突出了BABT损伤机制的复杂性,并显示了胸腹区域的显著各向异性,在开发未来的防护设备时应考虑到这一点。
Impactor Displacement as a Predictor of Thoraco-Abdominal Organ Injury: Comparison of Isolated Organ to Whole Body Tests.
Purpose: Body armor is used to protect the wearer from penetrating injuries. However, when the armor defeats the projectile, it deforms at high rates into the wearer, referred to as back face deformation (BFD). This deformation can cause a variety of superficial and internal injuries and consequently should be considered when designing body armor. However, current design standards do not adequately consider the effects of BFD, and new data are necessary to inform future design thresholds for BFD. The objective of this study was to develop blunt impact injury risk curves for in vitro thoraco-abdominal organs and determine their applicability in predicting in situ BABT injuries.
Methods: In vitro tests Healthy isolated liver and heart specimens were perfused and placed on a bed of gelatin underneath a drop tower and impacted with a 3-cm hemisphere impactor. Each organ was exposed to an incremental loading protocol, wherein initial displacement of penetration was 2 mm, and increased by 2 mm for each subsequent impact on the organ. Injury was defined as the presence of laceration. Injury probability curves were developed using a generalized mixed linear model (proc GENMOD). Univariate models were analyzed for predictive variables, including peak displacement, percent compression, and peak force. In situ tests An intact postmortem human subject (PMHS) was instrumented and subsequently impacted with an impactor that had a profile representative of BFD and a velocity of 65 m/s. One impact was aimed at the heart and one impact was aimed at the liver.
Results: The final predictive models for isolated organ injuries demonstrated 50% probability of injury for impact displacement of 12.4 mm (95% CI [10.1 mm, 17.6 mm]) and 13.8 mm (95% CI [11.5 mm, 16.8 mm]) for the liver and heart, respectively. During the PMHS tests, total impactor displacement into the PMHS was 45.8 mm and 59.2 mm for the impacts aimed at the liver and heat, respectively. Post-rib fracture impactor displacement did correlate to the isolated organ risk curves, equating to an 88% and 86% of liver and heart injury risk, respectively. Despite high risk of injury for both organs, only the liver was lacerated, suggesting that isolated organ risk curves do not fully translate to in situ testing.
Conclusion: These experimental tests and developed risk curves can be used as validation and injury risk estimates for future isolated organ and whole body computational models. Simulated BFD impacts with PMHS tests highlight the complexity of BABT injury mechanisms and shows the significant anisotropy of the thoraco-abdominal region that should be considered when developing future protective equipment.
期刊介绍:
Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.