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Annual review of cell and developmental biology最新文献

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Immune Cell Membrane Protrusions as Sensory Organelles. 免疫细胞膜突起：一种感觉细胞器。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-11 DOI: 10.1146/annurev-cellbio-101323-022130
Tamara Zünd, Viola Vogel, Enrico Klotzsch
{"title":"Immune Cell Membrane Protrusions as Sensory Organelles.","authors":"Tamara Zünd, Viola Vogel, Enrico Klotzsch","doi":"10.1146/annurev-cellbio-101323-022130","DOIUrl":"10.1146/annurev-cellbio-101323-022130","url":null,"abstract":"<p><p>Immune cells possess a remarkable set of complementary surface protrusions, such as microvilli, podosomes, filopodia, and lamellipodia, which play pivotal roles in the sensing of and responding to varied environmental cues. These dynamic structures maximize the surface area-to-volume ratio of immune cells, which in turn enhances cell-cell and cell-matrix interactions, while generating pulling and pushing forces, allowing immune cells to integrate biochemical and physical cues from their surroundings. This review discusses recent insights into the structures and dynamics of different protrusions, the molecular machinery behind mechanosensing, the differential role of protrusions for different subsets of immune cells, and the cutting-edge technology that has advanced our understanding of those protrusions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"433-456"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Messenger RNA Packaging and Export. 信使RNA的包装和输出机制。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 DOI: 10.1146/annurev-cellbio-101123-045256
Rupert Faraway, Daniel Zenklusen, Clemens Plaschka
{"title":"Mechanisms of Messenger RNA Packaging and Export.","authors":"Rupert Faraway, Daniel Zenklusen, Clemens Plaschka","doi":"10.1146/annurev-cellbio-101123-045256","DOIUrl":"10.1146/annurev-cellbio-101123-045256","url":null,"abstract":"<p><p>The packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs are packaged by proteins into mRNA ribonucleoproteins (mRNPs). Other proteins then assist in the export of mRNPs into the cytoplasm for translation. Together, these proteins play critical roles in compacting the mRNA, defining mRNA identity, preventing unwanted interactions, and orchestrating mRNA transport through the nuclear pore complex (NPC). Here, we review decades of genetics and biochemistry alongside recent structural and functional insights and outline a general framework for the late stages of nuclear mRNA biogenesis and export. We also highlight open questions, including the mechanisms of mRNP packaging, mRNP export through the NPC, and the regulation, quality control, and exploitation of the pathway.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"41 1","pages":"479-504"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nodal Signaling: A Paradigm for TGFβ Signaling in Embryonic Development. 节点信号传导：胚胎发育中tgf - β信号传导的一个范例。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1146/annurev-cellbio-112122-030209
Jakob El Kholtei, Mireia Codina-Tobias, Alexander F Schier
{"title":"Nodal Signaling: A Paradigm for TGFβ Signaling in Embryonic Development.","authors":"Jakob El Kholtei, Mireia Codina-Tobias, Alexander F Schier","doi":"10.1146/annurev-cellbio-112122-030209","DOIUrl":"10.1146/annurev-cellbio-112122-030209","url":null,"abstract":"<p><p>Nodal signaling molecules are TGFβ family ligands that arose early during bilaterian evolution and are crucial for several key steps in embryonic development. They regulate the specification of mesoderm and endoderm, body patterning, left-right asymmetry, and pluripotency maintenance. Many of Nodal's effects are tissue specific and achieved through interaction with other signaling pathways. Nodal has become a paradigm for a morphogen that employs multiple mechanisms for tissue patterning, including concentration- and duration-dependent effects, feedback regulation, reaction-diffusion interactions, and scale invariance. Nodal signaling activates a broad set of target genes that specify cell types, remodel the intracellular and extracellular milieu, and drive cell movements and morphogenesis. While Nodal's developmental functions are largely conserved across vertebrates, many facets of the mechanisms that elicit transcriptional responses and pattern embryonic tissues remain to be clarified.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"45-88"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene Clusters Reveal Fundamental Principles of Genome Folding and Transcriptional Regulation. 基因簇揭示基因组折叠和转录调控的基本原理。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 DOI: 10.1146/annurev-cellbio-111822-122324
Alex Buckley, Carlo Vetralla, Daniele Canzio
{"title":"Gene Clusters Reveal Fundamental Principles of Genome Folding and Transcriptional Regulation.","authors":"Alex Buckley, Carlo Vetralla, Daniele Canzio","doi":"10.1146/annurev-cellbio-111822-122324","DOIUrl":"10.1146/annurev-cellbio-111822-122324","url":null,"abstract":"<p><p>Gene clusters generate proteome diversity required for cell fate and function. Given their genomic organization, wherein tandemly arranged genes with nearly identical promoter sequences neighbor shared enhancers, gene clusters present extreme cases of enhancer-promoter specificity, long-range enhancer-promoter communication, and chromatin compartmentalization. Here, we review recent advances in the regulation of protocadherin (Pcdh) and olfactory receptor (OR) gene clusters. These clusters present similar challenges in that cells must express a limited number of each type of gene stochastically. Probabilistic Pcdh and OR choice is accomplished through tunable enhancer-promoter interactions, but these interactions are regulated by distinct mechanisms. At the Pcdh locus, cohesin-mediated DNA loop extrusion dictates enhancer-promoter communication, whereas OR genes communicate with their enhancers through multichromosome assemblies involving the protein LDB1. In reviewing principles of Pcdh and OR regulation, we propose that gene clusters offer valuable paradigms for deciphering principles of gene expression regulation, with broad mechanistic and physiological implications for mammalian genome folding.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"41 1","pages":"579-603"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Crest Migration Orchestrated by Molecular and Mechanical Signals. 由分子和机械信号调控的神经嵴迁移。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 DOI: 10.1146/annurev-cellbio-101323-125749
Kai Weißenbruch, Roberto Mayor
{"title":"Neural Crest Migration Orchestrated by Molecular and Mechanical Signals.","authors":"Kai Weißenbruch, Roberto Mayor","doi":"10.1146/annurev-cellbio-101323-125749","DOIUrl":"10.1146/annurev-cellbio-101323-125749","url":null,"abstract":"<p><p>The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from streams with hundreds of cells delaminating in the cephalic region to chains of single cells that delaminate in a dripping manner in the trunk. Here, we review the guidance mechanisms involved in neural crest migration and stream formation. We first describe established concepts of neural crest chemosensing and then highlight novel insights into biomechanical guidance. Finally, we propose how chemical and mechanical cues might interact and how neural crest cells can self-generate guidance gradients, facilitating robust guidance. Through this, we describe the mechanisms enabling neural crest cells to swarm collectively over large distances in a coordinated and directional manner within the complex in vivo environment of an embryo.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"41 1","pages":"159-185"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Evolution of Biomolecular Condensates: From Prebiotic Origins to Subcellular Diversity. 生物分子凝聚物的进化：从益生元起源到亚细胞多样性。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-31 DOI: 10.1146/annurev-cellbio-101123-051723
Anna Hadarovich, David Kuster, Maria Luisa Romero Romero, Agnes Toth-Petroczy
{"title":"On the Evolution of Biomolecular Condensates: From Prebiotic Origins to Subcellular Diversity.","authors":"Anna Hadarovich, David Kuster, Maria Luisa Romero Romero, Agnes Toth-Petroczy","doi":"10.1146/annurev-cellbio-101123-051723","DOIUrl":"10.1146/annurev-cellbio-101123-051723","url":null,"abstract":"<p><p>Biomolecular condensates provide a way to compartmentalize subcellular components with high temporal and spatial resolution, enabling rapid responses to signals and environmental changes. While the formation, components, and function of some condensates are well-characterized, their presence across organisms, their evolutionary history, and their origin are less well-understood. Here, we review the diversity of condensate components and highlight that not only disordered but also fully structured proteins are capable of driving condensate formation. We compare how proteomes of condensates overlap within and across species, and we present functionally analogous condensates across organisms. Additionally, we discuss the potential role of condensation in early life, suggesting that phase separation could have facilitated the selection and concentration of prebiotic molecules, promoting essential biochemical processes. We conclude that condensate-related organization principles are ubiquitously used across organisms from bacteria to mammals, and they potentially played a key role in prebiotic evolution, serving as primitive compartments for early biochemical processes.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"403-432"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Along the Trajectory to Understanding Cellular Aging: More Lessons from Yeast. 沿着理解细胞衰老的轨迹：酵母的更多经验教训。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1146/annurev-cellbio-112122-023631
Kiyan Shabestary, Reinhard Dechant, Daniel E Gottschling
{"title":"Along the Trajectory to Understanding Cellular Aging: More Lessons from Yeast.","authors":"Kiyan Shabestary, Reinhard Dechant, Daniel E Gottschling","doi":"10.1146/annurev-cellbio-112122-023631","DOIUrl":"10.1146/annurev-cellbio-112122-023631","url":null,"abstract":"<p><p>Aging is a universal biological phenomenon that affects all biological systems. It is characterized by the inability to remain in a balanced physiological state, leading to a functional decline of the organism and, in metazoa, an increased risk of age-related diseases. Identifying causal drivers of aging is a major challenge at the cellular level, but in the model organism <i>Saccharomyces cerevisiae</i>, recent technical advances enabling the full observation of its replicative lifespan have revealed a heterogeneous aging process characterized by unique temporal and functional dependencies between cellular subprocesses. Specifically, cellular aging progresses through different trajectories, representing successive stages of homeostatic loss throughout the organism's life. In this perspective, we review the latest cellular principles as learned from <i>S. cerevisiae</i> that are providing a better understanding of how cellular aging progresses in metazoa.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"353-373"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADAR1: Beyond Just an RNA Editor. ADAR1：超越RNA编辑器。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1146/annurev-cellbio-101323-020352
Martin Marônek, Valentina Lacovich, Anna Cherian, Damiano Amoruso, Pavla Linhartova, Qiupei Du, Janka Melicherová, Liam P Keegan, Mary A O'Connell
{"title":"ADAR1: Beyond Just an RNA Editor.","authors":"Martin Marônek, Valentina Lacovich, Anna Cherian, Damiano Amoruso, Pavla Linhartova, Qiupei Du, Janka Melicherová, Liam P Keegan, Mary A O'Connell","doi":"10.1146/annurev-cellbio-101323-020352","DOIUrl":"10.1146/annurev-cellbio-101323-020352","url":null,"abstract":"<p><p>The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) has recently emerged from relative obscurity to be recognized as a key player in a variety of inflammatory diseases, including cancer. This growing recognition has generated interest in developing ADAR1 inhibitors; however, several fundamental questions about the enzyme need to be answered before ADAR1-based therapies can be successful. In this review, we summarize the current understanding of ADAR1, including its protein structure, RNA substrates, and roles in both innate and adaptive immunity. Recent studies have shed light on ADAR1 protein interactions and its RNA editing-independent functions. We also explore the involvement of ADAR1 in human diseases, with a focus on its roles in various cancers. <i>Drosophila</i> lacks an ADAR1 homolog; instead, the ADAR2 homolog is responsible for editing double-stranded RNA to prevent aberrant activation of the innate immune system. Finally, we address major questions in the field that still remain unanswered.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"529-551"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology. 染色体外环状DNA：塑造宿主生物学的可移动遗传元件。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1146/annurev-cellbio-101323-124454
Shun Yao, Oliver W Chung, Ling Wang, Zz Zhao Zhang
{"title":"Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology.","authors":"Shun Yao, Oliver W Chung, Ling Wang, Zz Zhao Zhang","doi":"10.1146/annurev-cellbio-101323-124454","DOIUrl":"10.1146/annurev-cellbio-101323-124454","url":null,"abstract":"<p><p>DNA carries genetic information, ensuring the stable transmission of genetic material through generations. However, DNA sequences can be constantly rewritten, allowing evolution and adaptation to occur at both the cellular and species levels. To facilitate this dynamic process, the genome is enriched with mobile genetic elements that can move within DNA sequences. While transposable elements are the classic example of mobile DNA, we propose that extrachromosomal circular DNA (ecDNA) represents another class of mobile genetic elements. This class can also introduce a new layer of genome dynamics, significantly shaping host biology. This review traces the historical discoveries and conceptual evolution of ecDNA, categorizing its diverse forms across organisms and highlighting its life cycle from biogenesis to maintenance and clearance. We discuss ecDNA's pivotal roles in physiological processes, including development, stress adaptation, and species evolution, and emphasize its pathological significance in cancer progression, drug resistance, and viral infections. Finally, we explore therapeutic strategies targeting ecDNA biology, offering a framework for translational advances in oncology and antiviral treatment. Together, these insights position ecDNA as a critical force in shaping genome dynamics and as a promising target for future biomedical interventions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"553-578"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Developmental Origins of Behavioral Individuality. 行为个性的发展起源。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-06-06 DOI: 10.1146/annurev-cellbio-101323-025423
Benjamin L de Bivort
{"title":"The Developmental Origins of Behavioral Individuality.","authors":"Benjamin L de Bivort","doi":"10.1146/annurev-cellbio-101323-025423","DOIUrl":"10.1146/annurev-cellbio-101323-025423","url":null,"abstract":"<p><p>Every individual animal behaves differently, even if they have the same genome and have been raised in the same environment. This diversity in behavior challenges the notion that biological variation derives solely from differences in genetics and environment, and poses the question of what biological processes generate individuality. At very small scales, the dynamics of biological matter are essentially impossible to predict with certainty, and these stochastic fluctuations can ripple out to alter the metabolism, physiology, and behavior of cells and organisms. I review major findings related to the developmental origins of stochastic individuality. These include the multivariate, dynamic organization of individual behavioral differences; control of the extent of individuality by genes, neural activity, and neuromodulation; nanoscale features of neural circuits that predict behavioral biases at the individual level; and experimental and theoretical evidence that behavioral variability may reflect an adaptive bet-hedging strategy. I conclude with a brief discussion of how large datasets like connectomes and long-term behavioral recordings will inform our understanding of the mechanisms underpinning behavioral individuality.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"331-352"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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