Mechanisms of Regeneration and Fibrosis in the Endometrium.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Claire J Ang, Taylor D Skokan, Kara L McKinley
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引用次数: 0

Abstract

The uterine lining (endometrium) regenerates repeatedly over the life span as part of its normal physiology. Substantial portions of the endometrium are shed during childbirth (parturition) and, in some species, menstruation, but the tissue is rapidly rebuilt without scarring, rendering it a powerful model of regeneration in mammals. Nonetheless, following some assaults, including medical procedures and infections, the endometrium fails to regenerate and instead forms scars that may interfere with normal endometrial function and contribute to infertility. Thus, the endometrium provides an exceptional platform to answer a central question of regenerative medicine: Why do some systems regenerate while others scar? Here, we review our current understanding of diverse endometrial disruption events in humans, nonhuman primates, and rodents, and the associated mechanisms of regenerative success and failure. Elucidating the determinants of these disparate repair processes promises insights into fundamental mechanisms of mammalian regeneration with substantial implications for reproductive health.

子宫内膜再生和纤维化的机制。
子宫内膜(子宫内膜)在整个生命周期内反复再生,这是其正常生理学的一部分。在分娩(分娩)和某些物种的月经期间,子宫内膜的大部分都会脱落,但组织会迅速重建,不会留下疤痕,这使其成为哺乳动物强大的再生模式。尽管如此,在一些攻击之后,包括医疗程序和感染,子宫内膜无法再生,反而形成了可能干扰正常子宫内膜功能并导致不孕的疤痕。因此,子宫内膜提供了一个特殊的平台来回答再生医学的一个核心问题:为什么有些系统会再生,而另一些系统会留下疤痕?在这里,我们回顾了我们目前对人类、非人灵长类动物和啮齿类动物不同子宫内膜破坏事件的理解,以及再生成功和失败的相关机制。阐明这些不同修复过程的决定因素,有望深入了解哺乳动物再生的基本机制,对生殖健康产生重大影响。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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