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Annual review of cell and developmental biology最新文献

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Bioelectricity in Morphogenesis. 形态发生中的生物电。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-19 DOI: 10.1146/annurev-cellbio-101323-032747
Custodio O Nunes, Elias H Barriga
{"title":"Bioelectricity in Morphogenesis.","authors":"Custodio O Nunes, Elias H Barriga","doi":"10.1146/annurev-cellbio-101323-032747","DOIUrl":"10.1146/annurev-cellbio-101323-032747","url":null,"abstract":"<p><p>Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities influence single-cell and collective cell behaviors in processes such as embryo development, tissue repair, and even disease. Despite the ubiquity of bioelectrical phenomena, most research has focused on bioelectrical control of neural tissues, and as a result, our knowledge of nonneural contexts remains comparatively less understood, scattered, and often misunderstood. Still, there are strong reasons for supporting the idea that bioelectricity contributes to diverse morphogenetic contexts. Thus, in this review we provide an overview of the current knowledge of how cells generate and perceive bioelectrical inputs, and discuss how cells translate these stimuli into responses that influence tissue morphogenesis in physiology and pathology.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zebrafish Gastrulation. 斑马鱼原肠胚形成。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-18 DOI: 10.1146/annurev-cellbio-012125-115503
Miguel L Concha
{"title":"Zebrafish Gastrulation.","authors":"Miguel L Concha","doi":"10.1146/annurev-cellbio-012125-115503","DOIUrl":"10.1146/annurev-cellbio-012125-115503","url":null,"abstract":"<p><p>The primordial body architecture of vertebrates is established during gastrulation, a critical period of development characterized by the emergence of the three germ layers (ectoderm, mesoderm, and endoderm) and the formation of an embryo with clearly identifiable dorso-ventral and anterior-posterior axes. In zebrafish, gastrulation involves molecular and cellular mechanisms that are broadly conserved among vertebrates, with species-specific features imposed by the deterministic role of maternally deposited determinants, the architecture of extraembryonic structures that create a dynamic and physically constrained environment, and the mesenchymal nature of early cells that underpins the migratory nature of mesendoderm internalization. Significant progress has been made in the genetic networks, signaling pathways, and cell dynamics involved, and the unique features of the zebrafish embryo are helping to elucidate the intricate coordination between gene expression, mechanical forces, self-organization, and morphogenetic movements that shape the early embryo. These advances have provided insights into the fundamental principles of vertebrate morphogenesis.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein Storage in Oocytes: Implications for Oocyte Quality, Embryonic Development, and Female Fertility. 卵母细胞中的蛋白质储存：对卵母细胞质量、胚胎发育和女性生育能力的影响。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-13 DOI: 10.1146/annurev-cellbio-101323-031045
Ida Marie Astad Jentoft, Melina Schuh
{"title":"Protein Storage in Oocytes: Implications for Oocyte Quality, Embryonic Development, and Female Fertility.","authors":"Ida Marie Astad Jentoft, Melina Schuh","doi":"10.1146/annurev-cellbio-101323-031045","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-031045","url":null,"abstract":"<p><p>Maternal storage is a fundamental feature of female gametes and is essential for maintaining oocyte quality and preserving developmental competence. Embryonic development relies on maternally deposited proteins, transcripts, and nutrients, yet the mechanisms by which oocytes accumulate and store these critical factors-particularly proteins-remain poorly understood. Across eukaryotes, diverse protein storage strategies have evolved, reflecting both conserved and species-specific adaptations. Here, we review the mechanisms of oocyte protein storage, comparing different species to uncover functional similarities and differences. Additionally, germ cells must clear damaged molecules accumulated during the mother's lifetime to ensure the production of rejuvenated eggs. We examine the conserved proteostasis mechanisms that support this process. By integrating insights from various model organisms and cellular dormancy studies, this review highlights the molecular basis of oocyte protein storage and its vital role in reproductive success.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Cell Membrane Protrusions: A Sensory Organelle. 免疫细胞膜突起：一种感觉细胞器。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-11 DOI: 10.1146/annurev-cellbio-101323-022130
Tamara Zünd, Viola Vogel, Enrico Klotzsch
{"title":"Immune Cell Membrane Protrusions: A Sensory Organelle.","authors":"Tamara Zünd, Viola Vogel, Enrico Klotzsch","doi":"10.1146/annurev-cellbio-101323-022130","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-022130","url":null,"abstract":"<p><p>Immune cells possess a remarkable set of complementary surface protrusions, such as microvilli, podosomes, filopodia, and lamellipodia, which play pivotal roles in the sensing of and responding to varied environmental cues. These dynamic structures maximize the surface area-to-volume ratio of immune cells, which in turn enhances cell-cell and cell-matrix interactions, while generating pulling and pushing forces, allowing immune cells to integrate biochemical and physical cues from their surroundings. This review discusses recent insights into the structures and dynamics of different protrusions, the molecular machinery behind mechanosensing, the differential role of protrusions for different subsets of immune cells, and the cutting-edge technology that has advanced our understanding of those protrusions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nodal Signaling: A Paradigm for TGFβ Signaling in Embryonic Development. 节点信号传导：胚胎发育中tgf - β信号传导的一个范例。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-08 DOI: 10.1146/annurev-cellbio-112122-030209
Jakob El Kholtei, Mireia Codina-Tobias, Alexander F Schier
{"title":"Nodal Signaling: A Paradigm for TGFβ Signaling in Embryonic Development.","authors":"Jakob El Kholtei, Mireia Codina-Tobias, Alexander F Schier","doi":"10.1146/annurev-cellbio-112122-030209","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-112122-030209","url":null,"abstract":"<p><p>Nodal signaling molecules are TGFβ family ligands that arose early during bilaterian evolution and are crucial for several key steps in embryonic development. They regulate the specification of mesoderm and endoderm, body patterning, left-right asymmetry, and pluripotency maintenance. Many of Nodal's effects are tissue specific and achieved through interaction with other signaling pathways. Nodal has become a paradigm for a morphogen that employs multiple mechanisms for tissue patterning, including concentration- and duration-dependent effects, feedback regulation, reaction-diffusion interactions, and scale invariance. Nodal signaling activates a broad set of target genes that specify cell types, remodel the intracellular and extracellular milieu, and drive cell movements and morphogenesis. While Nodal's developmental functions are largely conserved across vertebrates, many facets of the mechanisms that elicit transcriptional responses and pattern embryonic tissues remain to be clarified.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Perils and Promise of Cellular Cannibalism in Development, Homeostasis, and Disease. 细胞同类相食在发育、体内平衡和疾病中的危险和前景。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-06 DOI: 10.1146/annurev-cellbio-101323-121655
Melanie Rodriguez, Abhinava K Mishra, Denise J Montell
{"title":"The Perils and Promise of Cellular Cannibalism in Development, Homeostasis, and Disease.","authors":"Melanie Rodriguez, Abhinava K Mishra, Denise J Montell","doi":"10.1146/annurev-cellbio-101323-121655","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-121655","url":null,"abstract":"<p><p>Cellular cannibalism, defined as one cell eating another, is a widespread cellular behavior in organisms ranging from flies and worms to fish and mammals, where it is essential for development and homeostasis. Some cells nibble on other cells in a process called trogocytosis or grooming. Alternatively, cells can engulf other cells whole, as when macrophages consume stressed stem cells or aged red blood cells. Excessive cellular cannibalism can lead to degenerative disease or immunodeficiency, and cancer cells can hijack this normal behavior to fuel their growth and evade immune attack. Next-generation immunotherapies aim to harness cannibalistic behavior to combat cancer and other diseases, including atherosclerosis. Chimeric antigen receptor macrophage (CAR-M) therapies are in clinical trials for cancer. Elucidating the molecular and cellular mechanisms that drive physiological and pathological cellular cannibalism is likely to inform efforts to improve CAR-M and other therapies that depend on antibody-dependent cellular phagocytosis and tumor-associated macrophage reprogramming.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology. 染色体外环状DNA：塑造宿主生物学的可移动遗传元件。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-08-05 DOI: 10.1146/annurev-cellbio-101323-124454
Shun Yao, Oliver W Chung, Ling Wang, Zz Zhao Zhang
{"title":"Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology.","authors":"Shun Yao, Oliver W Chung, Ling Wang, Zz Zhao Zhang","doi":"10.1146/annurev-cellbio-101323-124454","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-124454","url":null,"abstract":"<p><p>DNA carries genetic information, ensuring the stable transmission of genetic material through generations. However, DNA sequences can be constantly rewritten, allowing evolution and adaptation to occur at both the cellular and species levels. To facilitate this dynamic process, the genome is enriched with mobile genetic elements that can move within DNA sequences. While transposable elements are the classic example of mobile DNA, we propose that extrachromosomal circular DNA (ecDNA) represents another class of mobile genetic elements. This class can also introduce a new layer of genome dynamics, significantly shaping host biology. This review traces the historical discoveries and conceptual evolution of ecDNA, categorizing its diverse forms across organisms and highlighting its life cycle from biogenesis to maintenance and clearance. We discuss ecDNA's pivotal roles in physiological processes, including development, stress adaptation, and species evolution, and emphasize its pathological significance in cancer progression, drug resistance, and viral infections. Finally, we explore therapeutic strategies targeting ecDNA biology, offering a framework for translational advances in oncology and antiviral treatment. Together, these insights position ecDNA as a critical force in shaping genome dynamics and as a promising target for future biomedical interventions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse. 科学、教育、领导与政治：布鲁斯·阿尔伯特和保罗·纳斯访谈。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-10 DOI: 10.1146/annurev-cellbio-101323-034601
Bruce Alberts, Paul Nurse, Alexander F Schier
{"title":"Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse.","authors":"Bruce Alberts, Paul Nurse, Alexander F Schier","doi":"10.1146/annurev-cellbio-101323-034601","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-034601","url":null,"abstract":"<p><p>Science is often portrayed as the objective search for knowledge. However, science is also part of complex societies that shape science and in turn are shaped by scientific findings. In this interview, Bruce Alberts, former president of the US National Academy of Sciences, and Paul Nurse, former and future president of the Royal Society, discuss the roles of science and scientists in society. They share their passion to understand the natural world and the joy of discovery. They emphasize the importance of leadership in building institutions that support science and evidence-based decision-making. They share their frustration that current science education falls short in teaching the way science arrives at a better but incomplete understanding of the world. They urge scientists to organize and make their case to the public and fight misinformation and mistruths.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Developmental Origins of Behavioral Individuality. 行为个性的发展起源。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-06 DOI: 10.1146/annurev-cellbio-101323-025423
Benjamin L de Bivort
{"title":"The Developmental Origins of Behavioral Individuality.","authors":"Benjamin L de Bivort","doi":"10.1146/annurev-cellbio-101323-025423","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-025423","url":null,"abstract":"<p><p>Every individual animal behaves differently, even if they have the same genome and have been raised in the same environment. This diversity in behavior challenges the notion that biological variation derives solely from differences in genetics and environment, and poses the question of what biological processes generate individuality. At very small scales, the dynamics of biological matter are essentially impossible to predict with certainty, and these stochastic fluctuations can ripple out to alter the metabolism, physiology, and behavior of cells and organisms. I review major findings related to the developmental origins of stochastic individuality. These include the multivariate, dynamic organization of individual behavioral differences; control of the extent of individuality by genes, neural activity, and neuromodulation; nanoscale features of neural circuits that predict behavioral biases at the individual level; and experimental and theoretical evidence that behavioral variability may reflect an adaptive bet-hedging strategy. I conclude with a brief discussion of how large datasets like connectomes and long-term behavioral recordings will inform our understanding of the mechanisms underpinning behavioral individuality.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation. 哺乳动物原肠形成时空模型的挑战与机遇。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-04 DOI: 10.1146/annurev-cellbio-101323-125216
Hernan Rubinstein, Yoav Mayshar, Yonatan Stelzer
{"title":"Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation.","authors":"Hernan Rubinstein, Yoav Mayshar, Yonatan Stelzer","doi":"10.1146/annurev-cellbio-101323-125216","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-125216","url":null,"abstract":"<p><p>How cells diversify to form an embryo represents a profound interdisciplinary challenge. Decades of innovative research using model organisms have uncovered principles of lineage specification, morphogenesis, epigenetic mechanisms, and gene regulation that underlie this fundamental process. As biology enters the genomic era, marked by rapid convergence of technological and computational advances, construction of quantitative and heuristic models of development becomes increasingly feasible. In gastrulation, a founding population of equipotent stem cells rapidly diversifies in a highly canonical manner to form the basic body plan. This review discusses considerations required to establish a time-resolved model that reflects the cellular and molecular aspects involved in this process. Building on insights from recent studies and the transformative potential of evolving technologies and experimental frameworks, we discuss how to devise such a model by integrating multiple molecular modalities at the single-cell level within the spatial context as a benchmark for studying cell specification.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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