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Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification. 适应性细胞辐射与动物神经系统多样化的遗传机制》（Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification）。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-25 DOI: 10.1146/annurev-cellbio-111822-124041
Jenks Hehmeyer, Flora Plessier, Heather Marlow
{"title":"Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification.","authors":"Jenks Hehmeyer, Flora Plessier, Heather Marlow","doi":"10.1146/annurev-cellbio-111822-124041","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111822-124041","url":null,"abstract":"<p><p>In animals, the nervous system evolved as the primary interface between multicellular organisms and the environment. As organisms became larger and more complex, the primary functions of the nervous system expanded to include the modulation and coordination of individual responsive cells via paracrine and synaptic functions as well as to monitor and maintain the organism's own internal environment. This was initially accomplished via paracrine signaling and eventually through the assembly of multicell circuits in some lineages. Cells with similar functions and centralized nervous systems have independently arisen in several lineages. We highlight the molecular mechanisms that underlie parallel diversifications of the nervous system.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalized Protein Binders in Developmental Biology. 发育生物学中的功能化蛋白质粘合剂。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-22 DOI: 10.1146/annurev-cellbio-112122-025214
Sophie T Schnider, M Alessandra Vigano, Markus Affolter, Gustavo Aguilar
{"title":"Functionalized Protein Binders in Developmental Biology.","authors":"Sophie T Schnider, M Alessandra Vigano, Markus Affolter, Gustavo Aguilar","doi":"10.1146/annurev-cellbio-112122-025214","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-112122-025214","url":null,"abstract":"<p><p>Developmental biology has greatly profited from genetic and reverse genetic approaches to indirectly studying protein function. More recently, nanobodies and other protein binders derived from different synthetic scaffolds have been used to directly dissect protein function. Protein binders have been fused to functional domains, such as to lead to protein degradation, relocalization, visualization, or posttranslational modification of the target protein upon binding. The use of such functionalized protein binders has allowed the study of the proteome during development in an unprecedented manner. In the coming years, the advent of the computational design of protein binders, together with further advances in scaffold engineering and synthetic biology, will fuel the development of novel protein binder-based technologies. Studying the proteome with increased precision will contribute to a better understanding of the immense molecular complexities hidden each step along the way to generate form and function during development.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of Sensory Receptors. 感觉受体的进化。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-10 DOI: 10.1146/annurev-cellbio-120123-112853
Wendy A Valencia-Montoya, Naomi E Pierce, Nicholas W Bellono
{"title":"Evolution of Sensory Receptors.","authors":"Wendy A Valencia-Montoya, Naomi E Pierce, Nicholas W Bellono","doi":"10.1146/annurev-cellbio-120123-112853","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-120123-112853","url":null,"abstract":"<p><p>Sensory receptors are at the interface between an organism and its environment and thus represent key sites for biological innovation. Here, we survey major sensory receptor families to uncover emerging evolutionary patterns. Receptors for touch, temperature, and light constitute part of the ancestral sensory toolkit of animals, often predating the evolution of multicellularity and the nervous system. In contrast, chemoreceptors exhibit a dynamic history of lineage-specific expansions and contractions correlated with the disparate complexity of chemical environments. A recurring theme includes independent transitions from neurotransmitter receptors to sensory receptors of diverse stimuli from the outside world. We then provide an overview of the evolutionary mechanisms underlying sensory receptor diversification and highlight examples where signatures of natural selection are used to identify novel sensory adaptations. Finally, we discuss sensory receptors as evolutionary hotspots driving reproductive isolation and speciation, thereby contributing to the stunning diversity of animals.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dormancy, Quiescence, and Diapause: Savings Accounts for Life. 休眠、静止和暂停：生命储蓄账户
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-10 DOI: 10.1146/annurev-cellbio-112122-022528
Hatice Özge Özgüldez, Aydan Bulut-Karslioğlu
{"title":"Dormancy, Quiescence, and Diapause: Savings Accounts for Life.","authors":"Hatice Özge Özgüldez, Aydan Bulut-Karslioğlu","doi":"10.1146/annurev-cellbio-112122-022528","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-112122-022528","url":null,"abstract":"<p><p>Life on Earth has been through numerous challenges over eons and, one way or another, has always triumphed. From mass extinctions to more daily plights to find food, unpredictability is everywhere. The adaptability of life-forms to ever-changing environments is the key that confers life's robustness. Adaptability has become synonymous with Darwinian evolution mediated by heritable genetic changes. The extreme gene-centric view, while being of central significance, at times has clouded our appreciation of the cell as a self-regulating entity informed of, and informing, the genetic data. An essential element that powers adaptability is the ability to regulate cell growth. In this review, we provide an extensive overview of growth regulation spanning species, tissues, and regulatory mechanisms. We aim to highlight the commonalities, as well as differences, of these phenomena and their molecular regulators. Finally, we curate open questions and areas for further exploration.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left-Right Asymmetry in Invertebrates: From Molecules to Organisms. 无脊椎动物的左右不对称：从分子到生物。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-09 DOI: 10.1146/annurev-cellbio-111822-010628
Reiko Kuroda
{"title":"Left-Right Asymmetry in Invertebrates: From Molecules to Organisms.","authors":"Reiko Kuroda","doi":"10.1146/annurev-cellbio-111822-010628","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111822-010628","url":null,"abstract":"<p><p>Although most animals appear symmetric externally, they exhibit chirality within their body cavity, i.e., in terms of asymmetric organ position, directional organ looping, and lateralized organ function. Left-right (LR) asymmetry is determined genetically by intricate molecular interactions that occur during development. Key genes have been elucidated in several species. There are common mechanisms in vertebrates and invertebrates, but some appear to exhibit unique mechanisms. This review focuses on LR asymmetry formation in invertebrates, particularly <i>Drosophila</i>, ascidians, and mollusks. It aims to understand the role of the genes that are key to creating LR asymmetry and how chirality information is converted/transmitted across the hierarchies from molecules to cells and from cells to tissues.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Organism as the Niche: Physiological States Crack the Code of Adult Neural Stem Cell Heterogeneity. 有机体是利基：生理状态破解了成人神经干细胞异质性的密码。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-09 DOI: 10.1146/annurev-cellbio-120320-040213
Zayna Chaker, Eleni Makarouni, Fiona Doetsch
{"title":"The Organism as the Niche: Physiological States Crack the Code of Adult Neural Stem Cell Heterogeneity.","authors":"Zayna Chaker, Eleni Makarouni, Fiona Doetsch","doi":"10.1146/annurev-cellbio-120320-040213","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-120320-040213","url":null,"abstract":"<p><p>Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise to new neurons and glia throughout life. The largest stem cell niche in the adult mouse brain is the ventricular-subventricular zone (V-SVZ) lining the lateral ventricles. Adult NSCs in the V-SVZ coexist in quiescent and actively proliferating states, and they exhibit a regionalized molecular identity. The importance of such spatial diversity is just emerging, as depending on their position within the niche, adult NSCs give rise to distinct subtypes of olfactory bulb interneurons and different types of glia. However, the functional relevance of stem cell heterogeneity in the V-SVZ is still poorly understood. Here, we put into perspective findings highlighting the importance of adult NSC diversity for brain plasticity, and how the body signals to brain stem cells in different physiological states to regulate their behavior.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network. 线粒体结构、动力学和生理学：用光学显微镜解构网络。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-08 DOI: 10.1146/annurev-cellbio-111822-114733
Juan C Landoni, Tatjana Kleele, Julius Winter, Willi Stepp, Suliana Manley
{"title":"Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network.","authors":"Juan C Landoni, Tatjana Kleele, Julius Winter, Willi Stepp, Suliana Manley","doi":"10.1146/annurev-cellbio-111822-114733","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111822-114733","url":null,"abstract":"<p><p>Mitochondria serve as energetic and signaling hubs of the cell: This function results from the complex interplay between their structure, function, dynamics, interactions, and molecular organization. The ability to observe and quantify these properties often represents the puzzle piece critical for deciphering the mechanisms behind mitochondrial function and dysfunction. Fluorescence microscopy addresses this critical need and has become increasingly powerful with the advent of superresolution methods and context-sensitive fluorescent probes. In this review, we delve into advanced light microscopy methods and analyses for studying mitochondrial ultrastructure, dynamics, and physiology, and highlight notable discoveries they enabled.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ Evolution: Emergence of Multicellular Function. 器官进化：多细胞功能的出现。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-03 DOI: 10.1146/annurev-cellbio-111822-121620
Joseph Parker
{"title":"Organ Evolution: Emergence of Multicellular Function.","authors":"Joseph Parker","doi":"10.1146/annurev-cellbio-111822-121620","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111822-121620","url":null,"abstract":"<p><p>Instances of multicellularity across the tree of life have fostered the evolution of complex organs composed of distinct cell types that cooperate, producing emergent biological functions. How organs originate is a fundamental evolutionary problem that has eluded deep mechanistic and conceptual understanding. Here I propose a cell- to organ-level transitions framework, whereby cooperative division of labor originates and becomes entrenched between cell types through a process of functional niche creation, cell type subfunctionalization, and irreversible ratcheting of cell interdependencies. Comprehending this transition hinges on explaining how these processes unfold molecularly in evolving populations. Recent single-cell transcriptomic studies and analyses of terminal fate specification indicate that cellular functions are conferred by modular gene expression programs. These discrete components of functional variation may be deployed or combined within cells to introduce new properties into multicellular niches, or partitioned across cells to establish division of labor. Tracing gene expression program evolution at the level of single cells in populations may reveal transitions toward organ complexity.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of Thylakoid Structural Diversity. 类囊体结构多样性的进化。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-07-01 DOI: 10.1146/annurev-cellbio-120823-022747
Annemarie Perez-Boerema, Benjamin D Engel, Wojciech Wietrzynski
{"title":"Evolution of Thylakoid Structural Diversity.","authors":"Annemarie Perez-Boerema, Benjamin D Engel, Wojciech Wietrzynski","doi":"10.1146/annurev-cellbio-120823-022747","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-120823-022747","url":null,"abstract":"<p><p>Oxygenic photosynthesis evolved billions of years ago, becoming Earth's main source of biologically available carbon and atmospheric oxygen. Since then, phototrophic organisms have diversified from prokaryotic cyanobacteria into several distinct clades of eukaryotic algae and plants through endosymbiosis events. This diversity can be seen in the thylakoid membranes, complex networks of lipids, proteins, and pigments that perform the light-dependent reactions of photosynthesis. In this review, we highlight the structural diversity of thylakoids, following the evolutionary history of phototrophic species. We begin with a molecular inventory of different thylakoid components and then illustrate how these building blocks are integrated to form membrane networks with diverse architectures. We conclude with an outlook on understanding how thylakoids remodel their architecture and molecular organization during dynamic processes such as biogenesis, repair, and environmental adaptation.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microhomology-Mediated End Joining Chronicles: Tracing the Evolutionary Footprints of Genome Protection. 微观同源性介导的末端连接编年史：追踪基因组保护的进化足迹。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-06-10 DOI: 10.1146/annurev-cellbio-111822-014426
Agnel Sfeir, Marcel Tijsterman, Mitch McVey
{"title":"Microhomology-Mediated End Joining Chronicles: Tracing the Evolutionary Footprints of Genome Protection.","authors":"Agnel Sfeir, Marcel Tijsterman, Mitch McVey","doi":"10.1146/annurev-cellbio-111822-014426","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111822-014426","url":null,"abstract":"<p><p>The fidelity of genetic information is essential for cellular function and viability. DNA double-strand breaks (DSBs) pose a significant threat to genome integrity, necessitating efficient repair mechanisms. While the predominant repair strategies are usually accurate, paradoxically, error-prone pathways also exist. This review explores recent advances and our understanding of microhomology-mediated end joining (MMEJ), an intrinsically mutagenic DSB repair pathway conserved across organisms. Central to MMEJ is the activity of DNA polymerase theta (Polθ), a specialized polymerase that fuels MMEJ mutagenicity. We examine the molecular intricacies underlying MMEJ activity and discuss its function during mitosis, where the activity of Polθ emerges as a last-ditch effort to resolve persistent DSBs, especially when homologous recombination is compromised. We explore the promising therapeutic applications of targeting Polθ in cancer treatment and genome editing. Lastly, we discuss the evolutionary consequences of MMEJ, highlighting its delicate balance between protecting genome integrity and driving genomic diversity.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":null,"pages":null},"PeriodicalIF":11.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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