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Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse. 科学、教育、领导与政治：布鲁斯·阿尔伯特和保罗·纳斯访谈。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-10 DOI: 10.1146/annurev-cellbio-101323-034601
Bruce Alberts, Paul Nurse, Alexander F Schier
{"title":"Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse.","authors":"Bruce Alberts, Paul Nurse, Alexander F Schier","doi":"10.1146/annurev-cellbio-101323-034601","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-034601","url":null,"abstract":"<p><p>Science is often portrayed as the objective search for knowledge. However, science is also part of complex societies that shape science and in turn are shaped by scientific findings. In this interview, Bruce Alberts, former president of the US National Academy of Sciences, and Paul Nurse, former and future president of the Royal Society, discuss the roles of science and scientists in society. They share their passion to understand the natural world and the joy of discovery. They emphasize the importance of leadership in building institutions that support science and evidence-based decision-making. They share their frustration that current science education falls short in teaching the way science arrives at a better but incomplete understanding of the world. They urge scientists to organize and make their case to the public and fight misinformation and mistruths.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting to the Route: The Evolution of Nitrogen-Fixing Nodules. 到达路线：固氮结核的进化。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-06 DOI: 10.1146/annurev-cellbio-101123-093247
Anindya Kundu, Thiago Alexandre Moraes, R Jordan Price, Richard J Harrison, Giles E D Oldroyd
{"title":"Getting to the Route: The Evolution of Nitrogen-Fixing Nodules.","authors":"Anindya Kundu, Thiago Alexandre Moraes, R Jordan Price, Richard J Harrison, Giles E D Oldroyd","doi":"10.1146/annurev-cellbio-101123-093247","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101123-093247","url":null,"abstract":"<p><p>Root nodule symbiosis allows for plant acquisition of reactive nitrogen through fixation of atmospheric molecular dinitrogen by nitrogen-fixing bacteria. Nodulation is a complex trait, with diverse modes of bacterial infection and nodule morphologies across species, reflecting evolutionary adaptation. Understanding ancient forms of this trait may carry advantages for its current utilization, since basal states likely reflect the least complexity. In this review we focus on the evolution of nodule development, particularly on events that have led to increased complexity of this symbiosis in later adaptations. We hypothesize that the ancestral form of nodulation comprises of an evolutionary coupling of nutrient-dependent lateral root development with apoplastic intercellular bacterial growth, alongside the acquisition or evolution of an ancestral chitinaceous signaling molecule by the microbial symbiont. Uncovering the evolutionary adaptations underpinning the extant diversity of this trait allows for a better understanding of the simplest ancestral state.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Developmental Origins of Behavioral Individuality. 行为个性的发展起源。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-06 DOI: 10.1146/annurev-cellbio-101323-025423
Benjamin L de Bivort
{"title":"The Developmental Origins of Behavioral Individuality.","authors":"Benjamin L de Bivort","doi":"10.1146/annurev-cellbio-101323-025423","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-025423","url":null,"abstract":"<p><p>Every individual animal behaves differently, even if they have the same genome and have been raised in the same environment. This diversity in behavior challenges the notion that biological variation derives solely from differences in genetics and environment, and poses the question of what biological processes generate individuality. At very small scales, the dynamics of biological matter are essentially impossible to predict with certainty, and these stochastic fluctuations can ripple out to alter the metabolism, physiology, and behavior of cells and organisms. I review major findings related to the developmental origins of stochastic individuality. These include the multivariate, dynamic organization of individual behavioral differences; control of the extent of individuality by genes, neural activity, and neuromodulation; nanoscale features of neural circuits that predict behavioral biases at the individual level; and experimental and theoretical evidence that behavioral variability may reflect an adaptive bet-hedging strategy. I conclude with a brief discussion of how large datasets like connectomes and long-term behavioral recordings will inform our understanding of the mechanisms underpinning behavioral individuality.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation. 哺乳动物原肠形成时空模型的挑战与机遇。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-04 DOI: 10.1146/annurev-cellbio-101323-125216
Hernan Rubinstein, Yoav Mayshar, Yonatan Stelzer
{"title":"Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation.","authors":"Hernan Rubinstein, Yoav Mayshar, Yonatan Stelzer","doi":"10.1146/annurev-cellbio-101323-125216","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-125216","url":null,"abstract":"<p><p>How cells diversify to form an embryo represents a profound interdisciplinary challenge. Decades of innovative research using model organisms have uncovered principles of lineage specification, morphogenesis, epigenetic mechanisms, and gene regulation that underlie this fundamental process. As biology enters the genomic era, marked by rapid convergence of technological and computational advances, construction of quantitative and heuristic models of development becomes increasingly feasible. In gastrulation, a founding population of equipotent stem cells rapidly diversifies in a highly canonical manner to form the basic body plan. This review discusses considerations required to establish a time-resolved model that reflects the cellular and molecular aspects involved in this process. Building on insights from recent studies and the transformative potential of evolving technologies and experimental frameworks, we discuss how to devise such a model by integrating multiple molecular modalities at the single-cell level within the spatial context as a benchmark for studying cell specification.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting Enemies in Every Which Way. 以各种方式与敌人战斗。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-06-02 DOI: 10.1146/annurev-cellbio-101123-091853
Jian-Min Zhou, Hongze Wang, Wei Wang
{"title":"Fighting Enemies in Every Which Way.","authors":"Jian-Min Zhou, Hongze Wang, Wei Wang","doi":"10.1146/annurev-cellbio-101123-091853","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101123-091853","url":null,"abstract":"<p><p>Plants are subject to assault from numerous pathogens that colonize different tissues and organs that vary greatly in structure, nutrient availability, water status, and responsiveness to pathogens. Past research has focused on how plant immune receptors sense danger signals during infection and signaling mechanisms. How pathogens, particularly those that infect flowers and roots, breach physical barriers of different host tissues and establish niches for proliferation has received less attention. Recent advances indicate that different pathogens employ specialized mechanisms to manipulate the physiology, metabolism, growth, and development of specific host cells to breach various physical barriers and create a microenvironment suitable for pathogen proliferation and dissemination. Importantly, the plant immune system actively engages these processes to counter pathogenesis. Furthermore, emerging evidence increasingly points to different roles of specific plant cells in sensing the pathogen and cell-cell communication that is important for the establishment of immunity at the organism level.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphogenesis of the Vertebrate Intestine: From Form to Function. 脊椎动物肠的形态发生：从形态到功能。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-04-23 DOI: 10.1146/annurev-cellbio-101123-044600
Bhargav D Sanketi, Liqing Huang, Natasza A Kurpios
{"title":"Morphogenesis of the Vertebrate Intestine: From Form to Function.","authors":"Bhargav D Sanketi, Liqing Huang, Natasza A Kurpios","doi":"10.1146/annurev-cellbio-101123-044600","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101123-044600","url":null,"abstract":"<p><p>Vertebrate gut morphogenesis involves complex tissue transformations that convert a simple gut tube into a functionally sophisticated organ with a multilayer architecture optimized for nutrient absorption. The formation of the functional gut requires coordinated development at multiple scales, from cellular behaviors to tissue-level deformations. In this review, we examine recent advances in our understanding of three fundamental aspects of gut development: the formation of the primitive gut tube from embryonic germ layers, establishment of left-right asymmetry driving gut rotation and looping, and radial patterning that generates functional structures like villi and muscles. We discuss how mechanical forces and molecular signals integrate to orchestrate these processes, and we highlight open questions guiding future studies of gut morphogenesis. These insights are critical for understanding congenital gut malformations and developing therapeutic approaches.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA-Degrading Exosome Complexes: Molecular Mechanisms and Structural Insights. rna降解外泌体复合物：分子机制和结构见解。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-04-17 DOI: 10.1146/annurev-cellbio-111822-115115
Achim Keidel, Courtney L Long, Janet Iwasa, Elena Conti
{"title":"RNA-Degrading Exosome Complexes: Molecular Mechanisms and Structural Insights.","authors":"Achim Keidel, Courtney L Long, Janet Iwasa, Elena Conti","doi":"10.1146/annurev-cellbio-111822-115115","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111822-115115","url":null,"abstract":"<p><p>The RNA exosome is a conserved multiprotein complex essential for 3'-to-5' RNA degradation in eukaryotic cells. In the cytoplasm, the exosome participates in messenger RNA surveillance and decay, while in the nucleus and nucleolus it performs a broader range of functions, from fully degrading cryptic RNAs generated by faulty or pervasive transcription to precisely trimming structured RNAs. An extended network of obligate cofactors and transient RNA helicase complexes has evolved to handle the large variety of substrates in each subcellular compartment. This network organizes in layers around the exosome core and regulates the irreversible 3'-to-5' degradative action in synergy with the features of the substrates. In this review, we discuss findings derived from genetic, cellular, biochemical, and structural analyses of nuclear and cytoplasmic exosome complexes, and integrate them into molecular movies that illustrate the mechanistic principles of this versatile and dynamic machine in RNA processing and RNA decay.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid Droplets Big and Small: Basic Mechanisms That Make Them All. 大小脂滴：造就它们的基本机制
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-10-01 DOI: 10.1146/annurev-cellbio-012624-031419
Robin W Klemm, Pedro Carvalho
{"title":"Lipid Droplets Big and Small: Basic Mechanisms That Make Them All.","authors":"Robin W Klemm, Pedro Carvalho","doi":"10.1146/annurev-cellbio-012624-031419","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-012624-031419","url":null,"abstract":"<p><p>Lipid droplets (LDs) are dynamic storage organelles with central roles in lipid and energy metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is surrounded by a monolayer of phospholipids and specialized surface proteins. The surface composition determines many of the LD properties, such as size, subcellular distribution, and interaction with partner organelles. Considering the diverse energetic and metabolic demands of various cell types, it is not surprising that LDs are highly heterogeneous within and between cell types. Despite their diversity, all LDs share a common biogenesis mechanism. However, adipocytes have evolved specific adaptations of these basic mechanisms, enabling the regulation of lipid and energy metabolism at both the cellular and organismal levels. Here, we discuss recent advances in the understanding of both the general mechanisms of LD biogenesis and the adipocyte-specific adaptations controlling these fascinating organelles.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"40 1","pages":"143-168"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Archaeal Cell Cycle. 古细胞周期
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1146/annurev-cellbio-111822-120242
Alice Cezanne, Sherman Foo, Yin-Wei Kuo, Buzz Baum
{"title":"The Archaeal Cell Cycle.","authors":"Alice Cezanne, Sherman Foo, Yin-Wei Kuo, Buzz Baum","doi":"10.1146/annurev-cellbio-111822-120242","DOIUrl":"10.1146/annurev-cellbio-111822-120242","url":null,"abstract":"<p><p>Since first identified as a separate domain of life in the 1970s, it has become clear that archaea differ profoundly from both eukaryotes and bacteria. In this review, we look across the archaeal domain and discuss the diverse mechanisms by which archaea control cell cycle progression, DNA replication, and cell division. While the molecular and cellular processes archaea use to govern these critical cell biological processes often differ markedly from those described in bacteria and eukaryotes, there are also striking similarities that highlight both unique and common principles of cell cycle control across the different domains of life. Since much of the eukaryotic cell cycle machinery has its origins in archaea, exploration of the mechanisms of archaeal cell division also promises to illuminate the evolution of the eukaryotic cell cycle.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"1-23"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversification of Antibodies: From V(D)J Recombination to Somatic Exon Shuffling. 抗体的多样化：从 V(D)J 重组到体细胞外显子洗牌。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-10-01 DOI: 10.1146/annurev-cellbio-112122-030835
Mikhail Lebedin, Kathrin de la Rosa
{"title":"Diversification of Antibodies: From V(D)J Recombination to Somatic Exon Shuffling.","authors":"Mikhail Lebedin, Kathrin de la Rosa","doi":"10.1146/annurev-cellbio-112122-030835","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-112122-030835","url":null,"abstract":"<p><p>Antibodies that gain specificity by a large insert encoding for an extra domain were described for the first time in 2016. In malaria-exposed individuals, an exon deriving from the leukocyte-associated immunoglobulin-like 1 (<i>LAIR1</i>) gene integrated via a copy-and-paste insertion into the immunoglobulin heavy chain encoding region. A few years later, a second example was identified, namely a dual exon integration from the leukocyte immunoglobulin-like receptor B1 (<i>LILRB1</i>) gene that is located in close proximity to <i>LAIR1</i>. A dedicated high-throughput characterization of chimeric immunoglobulin heavy chain transcripts unraveled, that insertions from distant genomic regions (including mitochondrial DNA) can contribute to human antibody diversity. This review describes the modalities of insert-containing antibodies. The role of known DNA mobility aspects, such as genomic translocation, gene conversion, and DNA fragility, is discussed in the context of insert-antibody generation. Finally, the review covers why insert antibodies were omitted from the past repertoire analyses and how insert antibodies can contribute to protective immunity or an autoreactive response.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"40 1","pages":"265-281"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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