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Annual review of cell and developmental biology最新文献

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Intercellular Spread of Protein Aggregates in Neurodegenerative Disease. 神经退行性疾病中蛋白质聚集体的细胞间扩散
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2018-10-06 Epub Date: 2018-07-25 DOI: 10.1146/annurev-cellbio-100617-062636
Albert A Davis, Cheryl E G Leyns, David M Holtzman
{"title":"Intercellular Spread of Protein Aggregates in Neurodegenerative Disease.","authors":"Albert A Davis, Cheryl E G Leyns, David M Holtzman","doi":"10.1146/annurev-cellbio-100617-062636","DOIUrl":"10.1146/annurev-cellbio-100617-062636","url":null,"abstract":"<p><p>Most neurodegenerative diseases are characterized by the accumulation of protein aggregates, some of which are toxic to cells. Mounting evidence demonstrates that in several diseases, protein aggregates can pass from neuron to neuron along connected networks, although the role of this spreading phenomenon in disease pathogenesis is not completely understood. Here we briefly review the molecular and histopathological features of protein aggregation in neurodegenerative disease, we summarize the evidence for release of proteins from donor cells into the extracellular space, and we highlight some other mechanisms by which protein aggregates might be transmitted to recipient cells. We also discuss the evidence that supports a role for spreading of protein aggregates in neurodegenerative disease pathogenesis and some limitations of this model. Finally, we consider potential therapeutic strategies to target spreading of protein aggregates in the treatment of neurodegenerative diseases.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"34 ","pages":"545-568"},"PeriodicalIF":11.3,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350082/pdf/nihms-1005040.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36343837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specialized Intercellular Communications via Cytonemes and Nanotubes. 通过细胞素和纳米管的特化细胞间通讯。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2018-10-06 Epub Date: 2018-08-03 DOI: 10.1146/annurev-cellbio-100617-062932
Yukiko M Yamashita, Mayu Inaba, Michael Buszczak
{"title":"Specialized Intercellular Communications via Cytonemes and Nanotubes.","authors":"Yukiko M Yamashita,&nbsp;Mayu Inaba,&nbsp;Michael Buszczak","doi":"10.1146/annurev-cellbio-100617-062932","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100617-062932","url":null,"abstract":"<p><p>In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communication. Protrusion-based cellular interactions allow for specific communication between participating cells and have a distinct spectrum of advantages compared to secretion- and diffusion-based intercellular communication. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communication is often involved in pathogenesis, including cancers and infections. Here we review our current understanding of protrusion-based intercellular communication.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"34 ","pages":"59-84"},"PeriodicalIF":11.3,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100617-062932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36365832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease. 非传统的生与死方式:细胞在发育、体内平衡和疾病中的死亡与存活。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2018-10-06 Epub Date: 2018-08-08 DOI: 10.1146/annurev-cellbio-100616-060748
Swapna A Gudipaty, Christopher M Conner, Jody Rosenblatt, Denise J Montell
{"title":"Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease.","authors":"Swapna A Gudipaty,&nbsp;Christopher M Conner,&nbsp;Jody Rosenblatt,&nbsp;Denise J Montell","doi":"10.1146/annurev-cellbio-100616-060748","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100616-060748","url":null,"abstract":"<p><p>Balancing cell death and survival is essential for normal development and homeostasis and for preventing diseases, especially cancer. Conventional cell death pathways include apoptosis, a form of programmed cell death controlled by a well-defined biochemical pathway, and necrosis, the lysis of acutely injured cells. New types of regulated cell death include necroptosis, pyroptosis, ferroptosis, phagoptosis, and entosis. Autophagy can promote survival or can cause death. Newly described processes of anastasis and resuscitation show that, remarkably, cells can recover from the brink of apoptosis or necroptosis. Important new work shows that epithelia achieve homeostasis by extruding excess cells, which then die by anoikis due to loss of survival signals. This mechanically regulated process both maintains barrier function as cells die and matches rates of proliferation and death. In this review, we describe these unconventional ways in which cells have evolved to die or survive, as well as the contributions that these processes make to homeostasis and cancer.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"34 ","pages":"311-332"},"PeriodicalIF":11.3,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100616-060748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36382038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 103
Symmetry Breaking in the Mammalian Embryo. 哺乳动物胚胎中的对称性破坏。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2018-10-06 Epub Date: 2018-08-10 DOI: 10.1146/annurev-cellbio-100617-062616
Hui Ting Zhang, Takashi Hiiragi
{"title":"Symmetry Breaking in the Mammalian Embryo.","authors":"Hui Ting Zhang,&nbsp;Takashi Hiiragi","doi":"10.1146/annurev-cellbio-100617-062616","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100617-062616","url":null,"abstract":"<p><p>We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development. Although we primarily discuss embryonic development of the mouse, as it is the best-studied mammalian model system to date, we also highlight the shared and distinct aspects between different mammalian species. Finally, we discuss how insights gained from studying mammalian development can be generalized in light of self-organization principles. With this review, we hope to highlight new perspectives in studying symmetry breaking and self-organization in multicellular systems.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"34 ","pages":"405-426"},"PeriodicalIF":11.3,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100617-062616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36383321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
Regulation of Division and Differentiation of Plant Stem Cells. 植物干细胞的分裂和分化调控。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2018-10-06 Epub Date: 2018-08-22 DOI: 10.1146/annurev-cellbio-100617-062459
Edith Pierre-Jerome, Colleen Drapek, Philip N Benfey
{"title":"Regulation of Division and Differentiation of Plant Stem Cells.","authors":"Edith Pierre-Jerome,&nbsp;Colleen Drapek,&nbsp;Philip N Benfey","doi":"10.1146/annurev-cellbio-100617-062459","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100617-062459","url":null,"abstract":"<p><p>A major challenge in developmental biology is unraveling the precise regulation of plant stem cell maintenance and the transition to a fully differentiated cell. In this review, we highlight major themes coordinating the acquisition of cell identity and subsequent differentiation in plants. Plant cells are immobile and establish position-dependent cell lineages that rely heavily on external cues. Central players are the hormones auxin and cytokinin, which balance cell division and differentiation during organogenesis. Transcription factors and miRNAs, many of which are mobile in plants, establish gene regulatory networks that communicate cell position and fate. Small peptide signaling also provides positional cues as new cell types emerge from stem cell division and progress through differentiation. These pathways recruit similar players for patterning different organs, emphasizing the modular nature of gene regulatory networks. Finally, we speculate on the outstanding questions in the field and discuss how they may be addressed by emerging technologies.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"34 ","pages":"289-310"},"PeriodicalIF":11.3,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100617-062459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36419833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 61
Ribosomal Stalling During Translation: Providing Substrates for Ribosome-Associated Protein Quality Control. 翻译过程中的核糖体停滞:为核糖体相关蛋白质量控制提供底物。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2017-10-06 Epub Date: 2017-07-17 DOI: 10.1146/annurev-cellbio-111315-125249
Claudio A P Joazeiro
{"title":"Ribosomal Stalling During Translation: Providing Substrates for Ribosome-Associated Protein Quality Control.","authors":"Claudio A P Joazeiro","doi":"10.1146/annurev-cellbio-111315-125249","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111315-125249","url":null,"abstract":"<p><p>Cells of all organisms survey problems during translation elongation, which may happen as a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes, ribosome-associated quality control (RQC) senses elongation-stalled ribosomes and promotes dissociation of ribosomal subunits. This so-called ribosomal rescue releases the mRNA for degradation and allows 40S subunits to be recycled for new rounds of translation. However, the nascent polypeptide chains remain linked to tRNA and associated with the rescued 60S subunits. As a final critical step in this pathway, the Ltn1/Listerin E3 ligase subunit of the RQC complex (RQCc) ubiquitylates the nascent chain, which promotes clearance of the 60S subunit while simultaneously marking the nascent chain for elimination. Here we review the ribosomal stalling and rescue steps upstream of the RQCc, where one witnesses intersection with cellular machineries implicated in translation elongation, translation termination, ribosomal subunit recycling, and mRNA quality control. We emphasize both recent progress and future directions in this area, as well as examples linking ribosomal rescue with the production of Ltn1-RQCc substrates.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"33 ","pages":"343-368"},"PeriodicalIF":11.3,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-111315-125249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35178049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 143
How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology. 单细胞基因组学如何改变进化和发育生物学》（How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology）。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2017-10-06 Epub Date: 2017-08-16 DOI: 10.1146/annurev-cellbio-100616-060818
John C Marioni, Detlev Arendt
{"title":"How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology.","authors":"John C Marioni, Detlev Arendt","doi":"10.1146/annurev-cellbio-100616-060818","DOIUrl":"10.1146/annurev-cellbio-100616-060818","url":null,"abstract":"<p><p>The recent flood of single-cell data not only boosts our knowledge of cells and cell types, but also provides new insight into development and evolution from a cellular perspective. For example, assaying the genomes of multiple cells during development reveals developmental lineage trees-the kinship lineage-whereas cellular transcriptomes inform us about the regulatory state of cells and their gradual restriction in potency-the Waddington lineage. Beyond that, the comparison of single-cell data across species allows evolutionary changes to be tracked at all stages of development from the zygote, via different kinds of stem cells, to the differentiating cells. We discuss recent insights into the evolution of stem cells and initial attempts to reconstruct the evolutionary cell type tree of the mammalian forebrain, for example, by the comparative analysis of neuron types in the mesencephalic floor. These studies illustrate the immense potential of single-cell genomics to open up a new era in developmental and evolutionary research.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"33 ","pages":"537-553"},"PeriodicalIF":11.3,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35327603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex and Gender Differences in the Outcomes of Vaccination over the Life Course. 生命历程中疫苗接种结果的性别差异。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2017-10-06 DOI: 10.1146/annurev-cellbio-100616-060718
Katie L Flanagan, Ashley L Fink, Magdalena Plebanski, Sabra L Klein
{"title":"Sex and Gender Differences in the Outcomes of Vaccination over the Life Course.","authors":"Katie L Flanagan,&nbsp;Ashley L Fink,&nbsp;Magdalena Plebanski,&nbsp;Sabra L Klein","doi":"10.1146/annurev-cellbio-100616-060718","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100616-060718","url":null,"abstract":"<p><p>Both sex (i.e., biological differences) and gender (i.e., social or cultural influences) impact vaccine acceptance, responses, and outcomes. Clinical data illustrate that among children, young adults, and aged individuals, males and females differ in vaccine-induced immune responses, adverse events, and protection. Although males are more likely to receive vaccines, following vaccination, females typically develop higher antibody responses and report more adverse effects of vaccination than do males. Human, nonhuman animal, and in vitro studies reveal numerous immunological, genetic, hormonal, and environmental factors that differ between males and females and contribute to sex- and gender-specific vaccine responses and outcomes. Herein, we address the impact of sex and gender variables that should be considered in preclinical and clinical studies of vaccines.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"33 ","pages":"577-599"},"PeriodicalIF":11.3,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100616-060718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35481566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 319
Assessing the Contributions of Motor Enzymes and Microtubule Dynamics to Mitotic Chromosome Motions. 评估运动酶和微管动力学对有丝分裂染色体运动的贡献。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2017-10-06 DOI: 10.1146/annurev-cellbio-100616-060827
J Richard McIntosh
{"title":"Assessing the Contributions of Motor Enzymes and Microtubule Dynamics to Mitotic Chromosome Motions.","authors":"J Richard McIntosh","doi":"10.1146/annurev-cellbio-100616-060827","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100616-060827","url":null,"abstract":"<p><p>During my graduate work with Keith Porter, I became fascinated by the mitotic spindle, an interest that has motivated much of my scientific work ever since. I began spindle studies by using electron microscopes, instruments that have made significant contributions to our understanding of spindle organization. Such instruments have helped to elucidate the distributions of spindle microtubules, the interactions among them, their molecular polarity, and their associations with both kinetochores and spindle poles. Our lab has also investigated some processes of spindle physiology: microtubule dynamics, the actions of microtubule-associated proteins (including motor enzymes), the character of forces generated by specific spindle components, and factors that control mitotic progression. Here, I give a personal perspective on some of this intellectual history and on what recent discoveries imply about the mechanisms of chromosome motion.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"33 ","pages":"1-22"},"PeriodicalIF":11.3,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100616-060827","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35481568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Temporal Patterning in the Drosophila CNS. 果蝇中枢神经系统的时间模式。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2017-10-06 DOI: 10.1146/annurev-cellbio-111315-125210
Chris Q Doe
{"title":"Temporal Patterning in the Drosophila CNS.","authors":"Chris Q Doe","doi":"10.1146/annurev-cellbio-111315-125210","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111315-125210","url":null,"abstract":"<p><p>A small pool of neural progenitors generates the vast diversity of cell types in the CNS. Spatial patterning specifies progenitor identity, followed by temporal patterning within progenitor lineages to expand neural diversity. Recent work has shown that in Drosophila, all neural progenitors (neuroblasts) sequentially express temporal transcription factors (TTFs) that generate molecular and cellular diversity. Embryonic neuroblasts use a lineage-intrinsic cascade of five TTFs that switch nearly every neuroblast cell division; larval optic lobe neuroblasts also use a rapid cascade of five TTFs, but the factors are completely different. In contrast, larval central brain neuroblasts undergo a major molecular transition midway through larval life, and this transition is regulated by a lineage-extrinsic cue (ecdysone hormone signaling). Overall, every neuroblast lineage uses a TTF cascade to generate diversity, illustrating the widespread importance of temporal patterning.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"33 ","pages":"219-240"},"PeriodicalIF":11.3,"publicationDate":"2017-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-111315-125210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35428555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 166
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