The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Joseph Lewis Bedont, Daniel Maxim Iascone, Amita Sehgal
{"title":"The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.","authors":"Joseph Lewis Bedont, Daniel Maxim Iascone, Amita Sehgal","doi":"10.1146/annurev-cellbio-100818-125454","DOIUrl":null,"url":null,"abstract":"<p><p>Diverse factors including metabolism, chromatin remodeling, and mitotic kinetics influence development at the cellular level. These factors are well known to interact with the circadian transcriptional-translational feedback loop (TTFL) after its emergence. What is only recently becoming clear, however, is how metabolism, mitosis, and epigenetics may become organized in a coordinated cyclical precursor signaling module in pluripotent cells prior to the onset of TTFL cycling. We propose that both the precursor module and the TTFL module constrain cellular identity when they are active during development, and that the emergence of these modules themselves is a key lineage marker. Here we review the component pathways underlying these ideas; how proliferation, specification, and differentiation decisions in both developmental and adult stem cell populations are or are not regulated by the classical TTFL; and emerging evidence that we propose implies a primordial clock that precedes the classical TTFL and influences early developmental decisions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"469-509"},"PeriodicalIF":11.4000,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826104/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of cell and developmental biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-cellbio-100818-125454","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Diverse factors including metabolism, chromatin remodeling, and mitotic kinetics influence development at the cellular level. These factors are well known to interact with the circadian transcriptional-translational feedback loop (TTFL) after its emergence. What is only recently becoming clear, however, is how metabolism, mitosis, and epigenetics may become organized in a coordinated cyclical precursor signaling module in pluripotent cells prior to the onset of TTFL cycling. We propose that both the precursor module and the TTFL module constrain cellular identity when they are active during development, and that the emergence of these modules themselves is a key lineage marker. Here we review the component pathways underlying these ideas; how proliferation, specification, and differentiation decisions in both developmental and adult stem cell populations are or are not regulated by the classical TTFL; and emerging evidence that we propose implies a primordial clock that precedes the classical TTFL and influences early developmental decisions.

时间之前的血统:昼夜节律和非经典时钟对发育的影响》(The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development)。
新陈代谢、染色质重塑和有丝分裂动力学等多种因素在细胞水平上影响着发育。众所周知,这些因素在昼夜节律转录-翻译反馈环(TTFL)出现后会相互作用。然而,最近才逐渐清楚的是,在TTFL循环开始之前,多能细胞中的新陈代谢、有丝分裂和表观遗传学是如何在一个协调的循环前体信号模块中组织起来的。我们提出,前体模块和 TTFL 模块在发育过程中活跃时会制约细胞特性,而这些模块本身的出现是一个关键的品系标志。在此,我们回顾了这些观点的组成途径;发育和成体干细胞群的增殖、规格化和分化决定是如何受或不受经典TTFL调控的;以及我们提出的暗示原始时钟先于经典TTFL并影响早期发育决定的新证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信