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Annual review of cell and developmental biology最新文献

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Structural Biophysics of Cytoskeletal Force Transduction. 细胞骨架力转导的结构生物物理学。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-05-18 DOI: 10.1146/annurev-cellbio-101223-022717
Gregory M Alushin, Sarah M Connolly, Blessing C Njoku
{"title":"Structural Biophysics of Cytoskeletal Force Transduction.","authors":"Gregory M Alushin, Sarah M Connolly, Blessing C Njoku","doi":"10.1146/annurev-cellbio-101223-022717","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101223-022717","url":null,"abstract":"<p><p>Cells mechanically interface with their surroundings through the actin cytoskeleton, a network of dynamic actin filaments, force-generating myosin motor proteins, and hundreds of associated binding proteins. The cytoskeleton plays a central role in the capacity of cells to sense and respond to physical forces and the mechanical properties of their environments (mechanosensing). Mechanosensing is essential for development and tissue homeostasis, and it is frequently disrupted in hereditary developmental disorders and cancers. Mechanistic studies of cytoskeletal mechanosensing have uncovered mechanically regulated binding interactions between cytoskeletal proteins, as well as force-sensitive dynamics of subcellular cytoskeletal networks that emerge at the scale of hundreds to thousands of molecules. Here, we review recent efforts to decipher the biophysical and protein structural bases of cytoskeletal mechanosensing, emphasizing emerging approaches for directly visualizing active force transduction from the angstrom to micrometer scale.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microproteins at the Frontiers of Biology and Medicine. 生物学和医学前沿的微蛋白。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-05-13 DOI: 10.1146/annurev-cellbio-101323-122347
Andrea Rocha, Alan Saghatelian
{"title":"Microproteins at the Frontiers of Biology and Medicine.","authors":"Andrea Rocha, Alan Saghatelian","doi":"10.1146/annurev-cellbio-101323-122347","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-101323-122347","url":null,"abstract":"<p><p>Small proteins, known as microproteins, typically consisting of fewer than 150 amino acids, have recently emerged as a previously unrecognized class of functional genes in biology. Advances in ribosome profiling, proteogenomics, and genome-wide functional screens have revealed that thousands of small open reading frames are actively translated, producing microproteins, some of which regulate essential processes in metabolism, immunity, cancer, and neurodegeneration. These discoveries have challenged long-held assumptions that gene function is confined to large, conserved proteins and have underscored microproteins as critical modulators. Dysregulation or mutation of small open reading frame-encoding microproteins contributes to a diverse range of biology, and in some cases links the noncanonical proteome to pathophysiological biology. In this review, we summarize current knowledge of microprotein discovery and function, describe key examples connecting microproteins to human disease, and discuss the opportunities and challenges that define this rapidly evolving field.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic Inheritance Through Replication-Coupled Parental Histone Recycling. 通过复制偶联亲本组蛋白循环的表观遗传。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-04-20 DOI: 10.1146/annurev-cellbio-111524-044608
Juntao Yu, Danesh Moazed
{"title":"Epigenetic Inheritance Through Replication-Coupled Parental Histone Recycling.","authors":"Juntao Yu, Danesh Moazed","doi":"10.1146/annurev-cellbio-111524-044608","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111524-044608","url":null,"abstract":"<p><p>Epigenetic inheritance of repressed chromatin domains plays a central role in the stable silencing of cell type-specific genes and transposons in eukaryotes. Silent chromatin domains are associated with repressive histone modifications, and their propagation requires a read-write mechanism involving recognition of histone modifications by enzymes that also catalyze them. The recycling of parental histones during DNA replication plays a crucial role in maintaining chromatin states by providing the substrate for read-write enzymes. Here we describe recent advances in understanding how the DNA replication machinery and its associated histone chaperones mediate symmetrical parental histone transfer to newly replicated daughter DNA strands and evidence that this process is required for the epigenetic inheritance of silent chromatin domains.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oscillatory Gene Expression During Cell Differentiation. 细胞分化过程中的振荡基因表达。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-04-06 DOI: 10.1146/annurev-cellbio-111524-093438
Ryoichiro Kageyama, Akihiro Isomura
{"title":"Oscillatory Gene Expression During Cell Differentiation.","authors":"Ryoichiro Kageyama, Akihiro Isomura","doi":"10.1146/annurev-cellbio-111524-093438","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111524-093438","url":null,"abstract":"<p><p>Both the levels and duration of gene expression play critical roles in many biological processes. Recent studies have further revealed that the dynamics of oscillatory versus sustained gene expression also provide essential regulatory information during cell proliferation and differentiation. Oscillatory expression, governed by intracellular negative feedback loops and intercellular coupling with appropriate delays, promotes the proliferation of stem cells, whereas sustained expression typically drives cells toward quiescence or differentiation. Over time, oscillations can result in the gradual upregulation or downregulation of downstream factors or shifts in phase relationships between distinct oscillators, thereby functioning as a timer for cell state transition. Moreover, oscillation frequency encodes critical cues for cell fate choice. Thus, oscillatory dynamics add an extra dimension to the informational landscape of gene expression. Here, we discuss recent advances in our understanding of how oscillatory gene expression is regulated and how it influences the proliferation and differentiation of stem cells.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specification of Ciliated Cells. 纤毛细胞的规格。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-04-03 DOI: 10.1146/annurev-cellbio-111524-094101
Hao Lu, Govind Yadav, Sudipto Roy
{"title":"Specification of Ciliated Cells.","authors":"Hao Lu, Govind Yadav, Sudipto Roy","doi":"10.1146/annurev-cellbio-111524-094101","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111524-094101","url":null,"abstract":"<p><p>It is believed that the last common eukaryotic ancestor was a ciliated organism that used cilia for locomotion and sensation. Many extant ciliated protozoans exemplify this archetypal condition. However, in metazoans, particularly vertebrates, there appears to be a demarcation of cilia types. Thus, immotile primary cilia function in sensory neurons for the perception of environmental stimuli and in many other cells for the transduction of morphogenetic and physiological signals. By contrast, motile cilia are more restricted in their distribution, and their rhythmic beating drives fluid flow over epithelia or cellular locomotion. Here, we review the mechanisms that regulate ciliated cell specification, focusing principally on ciliogenic transcriptional networks and inductive signals that activate them in different cell lineages. We also highlight human disorders that arise from misspecification of ciliated cells and conclude with a discussion on how ciliated cell specification pathways could be utilized for the amelioration of disease phenotypes in ciliopathies.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in the Arabidopsis thaliana Root Meristem. 通过根的周期调控：拟南芥根分生组织细胞周期进程的发育调控。
IF 12.5 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-03-30 DOI: 10.1146/annurev-cellbio-111524-085650
Anna T DiBattista, Laura R Lee, Zachary L Nimchuk
{"title":"Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in the <i>Arabidopsis thaliana</i> Root Meristem.","authors":"Anna T DiBattista, Laura R Lee, Zachary L Nimchuk","doi":"10.1146/annurev-cellbio-111524-085650","DOIUrl":"10.1146/annurev-cellbio-111524-085650","url":null,"abstract":"<p><p>A plant's indeterminate growth requires constant cell proliferation and stem cell maintenance to support its developmental plasticity. The root meristem is an excellent system to study the developmental control of plant cell cycles due to the organ's accessibility and the tight link between cell cycle and developmental regulation. Studies have uncovered diverse pathways that shape root tissue patterning and cell identity, but how these mechanistically connect to cell cycle components remains unclear. Recent work and new approaches are starting to bridge this gap. In this review, we synthesize recent findings on the developmental regulation of cell cycle progression across distinct cell types and developmental zones in the <i>Arabidopsis thaliana</i> root apical meristem, highlighting cells and regions of the root where these processes have been thoroughly studied, and others where we know little. These discoveries reveal a nuanced relationship between cell identity and cell cycle regulation that implies an active role for cell cycle modulation in the patterning and developmental plasticity that are integral to plant growth.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13037681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local Translation in Glial Cells of the Brain. 脑胶质细胞的局部翻译。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2026-03-16 DOI: 10.1146/annurev-cellbio-111524-124159
Martine Cohen-Salmon
{"title":"Local Translation in Glial Cells of the Brain.","authors":"Martine Cohen-Salmon","doi":"10.1146/annurev-cellbio-111524-124159","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-111524-124159","url":null,"abstract":"<p><p>Local protein synthesis is a conserved mechanism that allows cells with intricate architectures to perform compartment-specific functions. By translating messenger RNAs (mRNAs) at distinct subcellular locations, cells can respond swiftly and precisely to localized stimuli. This strategy is crucial in neurons, whose long processes extend far from the cell body. Disruptions in neuronal local translation have been implicated in neurological disorders, including fragile X syndrome, amyotrophic lateral sclerosis, and spinal muscular atrophy. While much of the spotlight has been on neurons, glial cells-microglia, astrocytes, oligodendrocytes, and radial glia-are increasingly recognized for their own dynamic use of local translation. These support cells exhibit asymmetric mRNA localization, suggesting that local protein synthesis plays key roles in their diverse functions. This review explores the emerging landscape of local translation in glial cells and examines how this finely tuned process contributes to both normal brain function and the development of neurological disease.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation. 哺乳动物原肠形成时空模型的挑战与机遇。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-06-04 DOI: 10.1146/annurev-cellbio-101323-125216
Hernan Rubinstein, Yoav Mayshar, Yonatan Stelzer
{"title":"Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation.","authors":"Hernan Rubinstein, Yoav Mayshar, Yonatan Stelzer","doi":"10.1146/annurev-cellbio-101323-125216","DOIUrl":"10.1146/annurev-cellbio-101323-125216","url":null,"abstract":"<p><p>How cells diversify to form an embryo represents a profound interdisciplinary challenge. Decades of innovative research using model organisms have uncovered principles of lineage specification, morphogenesis, epigenetic mechanisms, and gene regulation that underlie this fundamental process. As biology enters the genomic era, marked by rapid convergence of technological and computational advances, construction of quantitative and heuristic models of development becomes increasingly feasible. In gastrulation, a founding population of equipotent stem cells rapidly diversifies in a highly canonical manner to form the basic body plan. This review discusses considerations required to establish a time-resolved model that reflects the cellular and molecular aspects involved in this process. Building on insights from recent studies and the transformative potential of evolving technologies and experimental frameworks, we discuss how to devise such a model by integrating multiple molecular modalities at the single-cell level within the spatial context as a benchmark for studying cell specification.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"135-158"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zebrafish Gastrulation. 斑马鱼原肠胚形成。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-18 DOI: 10.1146/annurev-cellbio-012125-115503
Miguel L Concha
{"title":"Zebrafish Gastrulation.","authors":"Miguel L Concha","doi":"10.1146/annurev-cellbio-012125-115503","DOIUrl":"10.1146/annurev-cellbio-012125-115503","url":null,"abstract":"<p><p>The primordial body architecture of vertebrates is established during gastrulation, a critical period of development characterized by the emergence of the three germ layers (ectoderm, mesoderm, and endoderm) and the formation of an embryo with clearly identifiable dorso-ventral and anterior-posterior axes. In zebrafish, gastrulation involves molecular and cellular mechanisms that are broadly conserved among vertebrates, with species-specific features imposed by the deterministic role of maternally deposited determinants, the architecture of extraembryonic structures that create a dynamic and physically constrained environment, and the mesenchymal nature of early cells that underpins the migratory nature of mesendoderm internalization. Significant progress has been made in the genetic networks, signaling pathways, and cell dynamics involved, and the unique features of the zebrafish embryo are helping to elucidate the intricate coordination between gene expression, mechanical forces, self-organization, and morphogenetic movements that shape the early embryo. These advances have provided insights into the fundamental principles of vertebrate morphogenesis.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"89-134"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioelectricity in Morphogenesis. 形态发生中的生物电。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-19 DOI: 10.1146/annurev-cellbio-101323-032747
Custodio O Nunes, Elias H Barriga
{"title":"Bioelectricity in Morphogenesis.","authors":"Custodio O Nunes, Elias H Barriga","doi":"10.1146/annurev-cellbio-101323-032747","DOIUrl":"10.1146/annurev-cellbio-101323-032747","url":null,"abstract":"<p><p>Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities influence single-cell and collective cell behaviors in processes such as embryo development, tissue repair, and even disease. Despite the ubiquity of bioelectrical phenomena, most research has focused on bioelectrical control of neural tissues, and as a result, our knowledge of nonneural contexts remains comparatively less understood, scattered, and often misunderstood. Still, there are strong reasons for supporting the idea that bioelectricity contributes to diverse morphogenetic contexts. Thus, in this review we provide an overview of the current knowledge of how cells generate and perceive bioelectrical inputs, and discuss how cells translate these stimuli into responses that influence tissue morphogenesis in physiology and pathology.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"187-208"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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