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Annual review of cell and developmental biology最新文献

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The Mexican Tetra, Astyanax mexicanus, as a Model System in Cell and Developmental Biology. 墨西哥毒蜥Astyanax mexicanus，作为细胞和发育生物学的模型系统。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-12 DOI: 10.1146/annurev-cellbio-012023-014003
Pavani Ponnimbaduge Perera, David Perez Guerra, Misty R Riddle
{"title":"The Mexican Tetra, <i>Astyanax mexicanus,</i> as a Model System in Cell and Developmental Biology.","authors":"Pavani Ponnimbaduge Perera, David Perez Guerra, Misty R Riddle","doi":"10.1146/annurev-cellbio-012023-014003","DOIUrl":"10.1146/annurev-cellbio-012023-014003","url":null,"abstract":"<p><p>Our understanding of cell and developmental biology has been greatly aided by a focus on a small number of model organisms. However, we are now in an era where techniques to investigate gene function can be applied across phyla, allowing scientists to explore the diversity and flexibility of developmental mechanisms and gain a deeper understanding of life. Researchers comparing the eyeless cave-adapted Mexican tetra, <i>Astyanax mexicanus</i>, with its river-dwelling counterpart are revealing how the development of the eyes, pigment, brain, cranium, blood, and digestive system evolves as animals adapt to new environments. Breakthroughs in our understanding of the genetic and developmental basis of regressive and constructive trait evolution have come from <i>A. mexicanus</i> research. They include understanding the types of mutations that alter traits, which cellular and developmental processes they affect, and how they lead to pleiotropy. We review recent progress in the field and highlight areas for future investigations that include evolution of sex differentiation, neural crest development, and metabolic regulation of embryogenesis.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"23-44"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
tRNA Dysregulation in Neurodevelopmental and Neurodegenerative Diseases. 神经发育和神经退行性疾病中的tRNA失调。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-06-20 DOI: 10.1146/annurev-cellbio-021623-124009
Robert W Burgess, Erik Storkebaum
{"title":"tRNA Dysregulation in Neurodevelopmental and Neurodegenerative Diseases.","authors":"Robert W Burgess,&nbsp;Erik Storkebaum","doi":"10.1146/annurev-cellbio-021623-124009","DOIUrl":"10.1146/annurev-cellbio-021623-124009","url":null,"abstract":"<p><p>Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The nuclear genome contains many tRNA genes for each amino acid and even each anticodon. Recent evidence indicates that expression of these tRNAs in neurons is regulated, and they are not functionally redundant. When specific tRNA genes are nonfunctional, this results in an imbalance between codon demand and tRNA availability. Furthermore, tRNAs are spliced, processed, and posttranscriptionally modified. Defects in these processes lead to neurological disorders. Finally, mutations in the aminoacyl tRNA synthetases (aaRSs) also lead to disease. Recessive mutations in several aaRSs cause syndromic disorders, while dominant mutations in a subset of aaRSs lead to peripheral neuropathy, again due to an imbalance between tRNA supply and codon demand. While it is clear that disrupting tRNA biology often leads to neurological disease, additional research is needed to understand the sensitivity of neurons to these changes.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"223-252"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Control of Tissue Development by Morphogens. 形态发生素对组织发育的控制。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-07 DOI: 10.1146/annurev-cellbio-020823-011522
Anna Kicheva, James Briscoe
{"title":"Control of Tissue Development by Morphogens.","authors":"Anna Kicheva,&nbsp;James Briscoe","doi":"10.1146/annurev-cellbio-020823-011522","DOIUrl":"10.1146/annurev-cellbio-020823-011522","url":null,"abstract":"<p><p>Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"91-121"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Tubulin Code, from Molecules to Health and Disease. 微管蛋白密码，从分子到健康和疾病。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 DOI: 10.1146/annurev-cellbio-030123-032748
Elizabeth D McKenna, Stephanie L Sarbanes, Steven W Cummings, Antonina Roll-Mecak
{"title":"The Tubulin Code, from Molecules to Health and Disease.","authors":"Elizabeth D McKenna, Stephanie L Sarbanes, Steven W Cummings, Antonina Roll-Mecak","doi":"10.1146/annurev-cellbio-030123-032748","DOIUrl":"10.1146/annurev-cellbio-030123-032748","url":null,"abstract":"<p><p>Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They support intracellular trafficking, cell division, cellular motility, and other essential cellular processes. In many species, both α-tubulin and β-tubulin are encoded by multiple genes with distinct expression profiles and functionality. Microtubules are further diversified through abundant posttranslational modifications, which are added and removed by a suite of enzymes to form complex, stereotyped cellular arrays. The genetic and chemical diversity of tubulin constitute a tubulin code that regulates intrinsic microtubule properties and is read by cellular effectors, such as molecular motors and microtubule-associated proteins, to provide spatial and temporal specificity to microtubules in cells. In this review, we synthesize the rapidly expanding tubulin code literature and highlight limitations and opportunities for the field. As complex microtubule arrays underlie essential physiological processes, a better understanding of how cells employ the tubulin code has important implications for human disease ranging from cancer to neurological disorders.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"39 ","pages":"331-361"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neofunctionalization of Toll Signaling in Insects: From Immunity to Dorsoventral Patterning. 昆虫Toll信号的新功能化：从免疫到背腔模式。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 DOI: 10.1146/annurev-cellbio-120319-120223
Siegfried Roth
{"title":"Neofunctionalization of Toll Signaling in Insects: From Immunity to Dorsoventral Patterning.","authors":"Siegfried Roth","doi":"10.1146/annurev-cellbio-120319-120223","DOIUrl":"10.1146/annurev-cellbio-120319-120223","url":null,"abstract":"<p><p>Toll signaling plays a crucial role in pathogen defense throughout the animal kingdom. It was discovered, however, for its function in dorsoventral (DV) axis formation in <i>Drosophila</i>. In all other insects studied so far, but not outside the insects, Toll is also required for DV patterning. However, in insects more distantly related to <i>Drosophila</i>, Toll's patterning role is frequently reduced and substituted by an expanded influence of BMP signaling, the pathway implicated in DV axis formation in all major metazoan lineages. This suggests that Toll was integrated into an ancestral BMP-based patterning system at the base of the insects or during insect evolution. The observation that Toll signaling has an immune function in the extraembryonic serosa, an early differentiating tissue of most insect embryos, suggests a scenario of how Toll was co-opted from an ancestral immune function for its new role in axis formation.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"39 ","pages":"1-22"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of TORC2 Function and Localization in Yeast. TORC2功能的调控及其在酵母中的定位。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-06-20 DOI: 10.1146/annurev-cellbio-011723-030346
Anita Emmerstorfer-Augustin, Jeremy Thorner
{"title":"Regulation of TORC2 Function and Localization in Yeast.","authors":"Anita Emmerstorfer-Augustin,&nbsp;Jeremy Thorner","doi":"10.1146/annurev-cellbio-011723-030346","DOIUrl":"10.1146/annurev-cellbio-011723-030346","url":null,"abstract":"<p><p>Every eukaryotic cell contains two distinct multisubunit protein kinase complexes that each contain a TOR (target of rapamycin) protein as the catalytic subunit. These ensembles, designated TORC1 and TORC2, serve as nutrient and stress sensors, signal integrators, and regulators of cell growth and homeostasis, but they differ in their composition, localization, and function. TORC1, activated on the cytosolic surface of the vacuole (or, in mammalian cells, on the cytosolic surface of the lysosome), promotes biosynthesis and suppresses autophagy. TORC2, located primarily at the plasma membrane (PM), maintains the proper levels and bilayer distribution of all PM components (sphingolipids, glycerophospholipids, sterols, and integral membrane proteins), which are needed for the membrane expansion that accompanies cell growth and division and for combating insults to PM integrity. This review summarizes our current understanding of the assembly, structural features, subcellular distribution, and function and regulation of TORC2, obtained largely through studies conducted with <i>Saccharomyces cerevisiae</i>.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"363-389"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10042890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and Open Questions. RBG基序桥状脂质转运蛋白：结构、功能和悬而未决的问题。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-05 DOI: 10.1146/annurev-cellbio-120420-014634
Michael Hanna, Andrés Guillén-Samander, Pietro De Camilli
{"title":"RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and Open Questions.","authors":"Michael Hanna, Andrés Guillén-Samander, Pietro De Camilli","doi":"10.1146/annurev-cellbio-120420-014634","DOIUrl":"10.1146/annurev-cellbio-120420-014634","url":null,"abstract":"<p><p>The life of eukaryotic cells requires the transport of lipids between membranes, which are separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the secretory and endocytic pathways and lipid transfer proteins (LTPs) cooperate in this transport. Until recently, known LTPs were shown to carry one or a few lipids at a time and were thought to mediate transport by shuttle-like mechanisms. Over the last few years, a new family of LTPs has been discovered that is defined by a repeating β-groove (RBG) rod-like structure with a hydrophobic channel running along their entire length. This structure and the localization of these proteins at membrane contact sites suggest a bridge-like mechanism of lipid transport. Mutations in some of these proteins result in neurodegenerative and developmental disorders. Here we review the known properties and well-established or putative physiological roles of these proteins, and we highlight the many questions that remain open about their functions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"409-434"},"PeriodicalIF":11.4,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Fish Eye View: Retinal Morphogenesis from Optic Cup to Neuronal Lamination. 鱼眼观：从视杯到神经元层积的视网膜形态发生。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-07 DOI: 10.1146/annurev-cellbio-012023-013036
Caren Norden
{"title":"A Fish Eye View: Retinal Morphogenesis from Optic Cup to Neuronal Lamination.","authors":"Caren Norden","doi":"10.1146/annurev-cellbio-012023-013036","DOIUrl":"10.1146/annurev-cellbio-012023-013036","url":null,"abstract":"<p><p>The neural retina, at the back of the eye, is a fascinating system to use to discover how cells form tissues in the context of the developing nervous system. The retina is the tissue responsible for perception and transmission of visual information from the environment. It consists of five types of neurons and one type of glia cells that are arranged in a highly organized, layered structure to assure visual information flow. To reach this highly ordered arrangement, intricate morphogenic movements are occurring at the cell and tissue levels. I here discuss recent advances made to understand retinal development, from optic cup formation to neuronal layering. It becomes clear that these complex morphogenetic processes must be studied by taking the cellular as well as the tissue-wide aspects into account. The loop has to be closed between exploring how cell behavior influences tissue development and how the surrounding tissue itself influences single cells. Furthermore, it was recently revealed that the retina is a great system to study neuronal migration phenomena, and more is yet to be discovered in this aspect. Constantly developing imaging and image analysis toolboxes as well as the use of machine learning and synthetic biology make the retina the perfect system to explore more of its exciting neurodevelopmental biology.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"175-196"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue Biology: In Search of a New Paradigm. 组织生物学：寻找新的范式。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-08-22 DOI: 10.1146/annurev-cellbio-120420-113830
Miri Adler, Arun R Chavan, Ruslan Medzhitov
{"title":"Tissue Biology: In Search of a New Paradigm.","authors":"Miri Adler, Arun R Chavan, Ruslan Medzhitov","doi":"10.1146/annurev-cellbio-120420-113830","DOIUrl":"10.1146/annurev-cellbio-120420-113830","url":null,"abstract":"<p><p>Animal tissues are made up of multiple cell types that are increasingly well-characterized, yet our understanding of the core principles that govern tissue organization is still incomplete. This is in part because many observable tissue characteristics, such as cellular composition and spatial patterns, are emergent properties, and as such, they cannot be explained through the knowledge of individual cells alone. Here we propose a complex systems theory perspective to address this fundamental gap in our understanding of tissue biology. We introduce the concept of cell categories, which is based on cell relations rather than cell identity. Based on these notions we then discuss common principles of tissue modularity, introducing compositional, structural, and functional tissue modules. Cell diversity and cell relations provide a basis for a new perspective on the underlying principles of tissue organization in health and disease.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"67-89"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Regeneration and Fibrosis in the Endometrium. 子宫内膜再生和纤维化的机制。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 DOI: 10.1146/annurev-cellbio-011723-021442
Claire J Ang, Taylor D Skokan, Kara L McKinley
{"title":"Mechanisms of Regeneration and Fibrosis in the Endometrium.","authors":"Claire J Ang, Taylor D Skokan, Kara L McKinley","doi":"10.1146/annurev-cellbio-011723-021442","DOIUrl":"10.1146/annurev-cellbio-011723-021442","url":null,"abstract":"<p><p>The uterine lining (endometrium) regenerates repeatedly over the life span as part of its normal physiology. Substantial portions of the endometrium are shed during childbirth (parturition) and, in some species, menstruation, but the tissue is rapidly rebuilt without scarring, rendering it a powerful model of regeneration in mammals. Nonetheless, following some assaults, including medical procedures and infections, the endometrium fails to regenerate and instead forms scars that may interfere with normal endometrial function and contribute to infertility. Thus, the endometrium provides an exceptional platform to answer a central question of regenerative medicine: Why do some systems regenerate while others scar? Here, we review our current understanding of diverse endometrial disruption events in humans, nonhuman primates, and rodents, and the associated mechanisms of regenerative success and failure. Elucidating the determinants of these disparate repair processes promises insights into fundamental mechanisms of mammalian regeneration with substantial implications for reproductive health.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"39 ","pages":"197-221"},"PeriodicalIF":11.4,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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