Annual review of cell and developmental biology最新文献_第3页

Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology. 染色体外环状DNA：塑造宿主生物学的可移动遗传元件。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1146/annurev-cellbio-101323-124454

Shun Yao, Oliver W Chung, Ling Wang, Zz Zhao Zhang

{"title":"Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology.","authors":"Shun Yao, Oliver W Chung, Ling Wang, Zz Zhao Zhang","doi":"10.1146/annurev-cellbio-101323-124454","DOIUrl":"10.1146/annurev-cellbio-101323-124454","url":null,"abstract":"DNA carries genetic information, ensuring the stable transmission of genetic material through generations. However, DNA sequences can be constantly rewritten, allowing evolution and adaptation to occur at both the cellular and species levels. To facilitate this dynamic process, the genome is enriched with mobile genetic elements that can move within DNA sequences. While transposable elements are the classic example of mobile DNA, we propose that extrachromosomal circular DNA (ecDNA) represents another class of mobile genetic elements. This class can also introduce a new layer of genome dynamics, significantly shaping host biology. This review traces the historical discoveries and conceptual evolution of ecDNA, categorizing its diverse forms across organisms and highlighting its life cycle from biogenesis to maintenance and clearance. We discuss ecDNA's pivotal roles in physiological processes, including development, stress adaptation, and species evolution, and emphasize its pathological significance in cancer progression, drug resistance, and viral infections. Finally, we explore therapeutic strategies targeting ecDNA biology, offering a framework for translational advances in oncology and antiviral treatment. Together, these insights position ecDNA as a critical force in shaping genome dynamics and as a promising target for future biomedical interventions.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"553-578"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Developmental Origins of Behavioral Individuality. 行为个性的发展起源。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-06-06 DOI: 10.1146/annurev-cellbio-101323-025423

Benjamin L de Bivort

{"title":"The Developmental Origins of Behavioral Individuality.","authors":"Benjamin L de Bivort","doi":"10.1146/annurev-cellbio-101323-025423","DOIUrl":"10.1146/annurev-cellbio-101323-025423","url":null,"abstract":"Every individual animal behaves differently, even if they have the same genome and have been raised in the same environment. This diversity in behavior challenges the notion that biological variation derives solely from differences in genetics and environment, and poses the question of what biological processes generate individuality. At very small scales, the dynamics of biological matter are essentially impossible to predict with certainty, and these stochastic fluctuations can ripple out to alter the metabolism, physiology, and behavior of cells and organisms. I review major findings related to the developmental origins of stochastic individuality. These include the multivariate, dynamic organization of individual behavioral differences; control of the extent of individuality by genes, neural activity, and neuromodulation; nanoscale features of neural circuits that predict behavioral biases at the individual level; and experimental and theoretical evidence that behavioral variability may reflect an adaptive bet-hedging strategy. I conclude with a brief discussion of how large datasets like connectomes and long-term behavioral recordings will inform our understanding of the mechanisms underpinning behavioral individuality.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"331-352"},"PeriodicalIF":11.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Storage in Oocytes: Implications for Oocyte Quality, Embryonic Development, and Female Fertility. 卵母细胞中的蛋白质储存：对卵母细胞质量、胚胎发育和女性生育能力的影响。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1146/annurev-cellbio-101323-031045

Ida Marie Astad Jentoft, Melina Schuh

引用次数: 0

The Archaeal Cell Cycle. 古细胞周期

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1146/annurev-cellbio-111822-120242

Alice Cezanne, Sherman Foo, Yin-Wei Kuo, Buzz Baum

引用次数: 0

Lipid Droplets Big and Small: Basic Mechanisms That Make Them All. 大小脂滴：造就它们的基本机制

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 DOI: 10.1146/annurev-cellbio-012624-031419

Robin W Klemm, Pedro Carvalho

引用次数: 0

Diversification of Antibodies: From V(D)J Recombination to Somatic Exon Shuffling. 抗体的多样化：从 V(D)J 重组到体细胞外显子洗牌。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 DOI: 10.1146/annurev-cellbio-112122-030835

Mikhail Lebedin, Kathrin de la Rosa

{"title":"Diversification of Antibodies: From V(D)J Recombination to Somatic Exon Shuffling.","authors":"Mikhail Lebedin, Kathrin de la Rosa","doi":"10.1146/annurev-cellbio-112122-030835","DOIUrl":"10.1146/annurev-cellbio-112122-030835","url":null,"abstract":"Antibodies that gain specificity by a large insert encoding for an extra domain were described for the first time in 2016. In malaria-exposed individuals, an exon deriving from the leukocyte-associated immunoglobulin-like 1 (LAIR1) gene integrated via a copy-and-paste insertion into the immunoglobulin heavy chain encoding region. A few years later, a second example was identified, namely a dual exon integration from the leukocyte immunoglobulin-like receptor B1 (LILRB1) gene that is located in close proximity to LAIR1. A dedicated high-throughput characterization of chimeric immunoglobulin heavy chain transcripts unraveled, that insertions from distant genomic regions (including mitochondrial DNA) can contribute to human antibody diversity. This review describes the modalities of insert-containing antibodies. The role of known DNA mobility aspects, such as genomic translocation, gene conversion, and DNA fragility, is discussed in the context of insert-antibody generation. Finally, the review covers why insert antibodies were omitted from the past repertoire analyses and how insert antibodies can contribute to protective immunity or an autoreactive response.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"40 1","pages":"265-281"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated. 单细胞生物学时代的植物细胞类型是什么？很复杂

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1146/annurev-cellbio-111323-102412

Byron Rusnak, Frances K Clark, Batthula Vijaya Lakshmi Vadde, Adrienne H K Roeder

{"title":"What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.","authors":"Byron Rusnak, Frances K Clark, Batthula Vijaya Lakshmi Vadde, Adrienne H K Roeder","doi":"10.1146/annurev-cellbio-111323-102412","DOIUrl":"10.1146/annurev-cellbio-111323-102412","url":null,"abstract":"One of the fundamental questions in developmental biology is how a cell is specified to differentiate as a specialized cell type. Traditionally, plant cell types were defined based on their function, location, morphology, and lineage. Currently, in the age of single-cell biology, researchers typically attempt to assign plant cells to cell types by clustering them based on their transcriptomes. However, because cells are dynamic entities that progress through the cell cycle and respond to signals, the transcriptome also reflects the state of the cell at a particular moment in time, raising questions about how to define a cell type. We suggest that these complexities and dynamics of cell states are of interest and further consider the roles signaling, stochasticity, cell cycle, and mechanical forces play in plant cell fate specification. Once established, cell identity must also be maintained. With the wealth of single-cell data coming out, the field is poised to elucidate both the complexity and dynamics of cell states.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"301-328"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microhomology-Mediated End-Joining Chronicles: Tracing the Evolutionary Footprints of Genome Protection. 微观同源性介导的末端连接编年史：追踪基因组保护的进化足迹。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1146/annurev-cellbio-111822-014426

Agnel Sfeir, Marcel Tijsterman, Mitch McVey

{"title":"Microhomology-Mediated End-Joining Chronicles: Tracing the Evolutionary Footprints of Genome Protection.","authors":"Agnel Sfeir, Marcel Tijsterman, Mitch McVey","doi":"10.1146/annurev-cellbio-111822-014426","DOIUrl":"10.1146/annurev-cellbio-111822-014426","url":null,"abstract":"The fidelity of genetic information is essential for cellular function and viability. DNA double-strand breaks (DSBs) pose a significant threat to genome integrity, necessitating efficient repair mechanisms. While the predominant repair strategies are usually accurate, paradoxically, error-prone pathways also exist. This review explores recent advances and our understanding of microhomology-mediated end joining (MMEJ), an intrinsically mutagenic DSB repair pathway conserved across organisms. Central to MMEJ is the activity of DNA polymerase theta (Polθ), a specialized polymerase that fuels MMEJ mutagenicity. We examine the molecular intricacies underlying MMEJ activity and discuss its function during mitosis, where the activity of Polθ emerges as a last-ditch effort to resolve persistent DSBs, especially when homologous recombination is compromised. We explore the promising therapeutic applications of targeting Polθ in cancer treatment and genome editing. Lastly, we discuss the evolutionary consequences of MMEJ, highlighting its delicate balance between protecting genome integrity and driving genomic diversity.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"195-218"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ Evolution: Emergence of Multicellular Function. 器官进化：多细胞功能的出现。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1146/annurev-cellbio-111822-121620

Joseph Parker

{"title":"Organ Evolution: Emergence of Multicellular Function.","authors":"Joseph Parker","doi":"10.1146/annurev-cellbio-111822-121620","DOIUrl":"10.1146/annurev-cellbio-111822-121620","url":null,"abstract":"Instances of multicellularity across the tree of life have fostered the evolution of complex organs composed of distinct cell types that cooperate, producing emergent biological functions. How organs originate is a fundamental evolutionary problem that has eluded deep mechanistic and conceptual understanding. Here I propose a cell- to organ-level transitions framework, whereby cooperative division of labor originates and becomes entrenched between cell types through a process of functional niche creation, cell-type subfunctionalization, and irreversible ratcheting of cell interdependencies. Comprehending this transition hinges on explaining how these processes unfold molecularly in evolving populations. Recent single-cell transcriptomic studies and analyses of terminal fate specification indicate that cellular functions are conferred by modular gene expression programs. These discrete components of functional variation may be deployed or combined within cells to introduce new properties into multicellular niches, or partitioned across cells to establish division of labor. Tracing gene expression program evolution at the level of single cells in populations may reveal transitions toward organ complexity.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"51-74"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification. 适应性细胞辐射与动物神经系统多样化的遗传机制》（Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification）。

IF 11.4 1区生物学

Annual review of cell and developmental biology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1146/annurev-cellbio-111822-124041

Jenks Hehmeyer, Flora Plessier, Heather Marlow

引用次数: 0