Adhesion-Based Self-Organization in Tissue Patterning.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Tony Y-C Tsai, Rikki M Garner, Sean G Megason
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引用次数: 14

Abstract

Since the proposal of the differential adhesion hypothesis, scientists have been fascinated by how cell adhesion mediates cellular self-organization to form spatial patterns during development. The search for molecular tool kits with homophilic binding specificity resulted in a diverse repertoire of adhesion molecules. Recent understanding of the dominant role of cortical tension over adhesion binding redirects the focus of differential adhesion studies to the signaling function of adhesion proteins to regulate actomyosin contractility. The broader framework of differential interfacial tension encompasses both adhesion and nonadhesion molecules, sharing the common function of modulating interfacial tension during cell sorting to generate diverse tissue patterns. Robust adhesion-based patterning requires close coordination between morphogen signaling, cell fate decisions, and changes in adhesion. Current advances in bridging theoretical and experimental approaches present exciting opportunities to understand molecular, cellular, and tissue dynamics during adhesion-based tissue patterning across multiple time and length scales.

组织图案化中基于粘附的自组织。
自从差异粘附假说提出以来,科学家们一直着迷于细胞粘附如何介导细胞自组织在发育过程中形成空间模式。寻找具有同源性结合特异性的分子工具包产生了多种粘附分子。最近对皮层张力在粘附结合中的主导作用的理解将差异粘附研究的重点转向了粘附蛋白调节肌动蛋白收缩性的信号功能。微分界面张力的更广泛框架包括粘附分子和非粘附分子,在细胞分选过程中共享调节界面张力以产生不同组织模式的共同功能。稳健的基于粘附的图案化需要形态发生信号、细胞命运决定和粘附变化之间的密切协调。桥接理论和实验方法的当前进展为理解跨多个时间和长度尺度的基于粘附的组织图案化过程中的分子、细胞和组织动力学提供了令人兴奋的机会。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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