Annals of Transplantation最新文献_第2页

Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients With Posttransplant Lymphoproliferative Disorder: A Single-Center Retrospective Study. 儿童肝移植后淋巴增生性疾病的免疫抑制戒断：一项单中心回顾性研究

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-08-18 DOI: 10.12659/AOT.952021

Ying Liu, Ru-Zhou Cai, Wei Qu, Lin Wei, Zhi-Gui Zeng, Zhi-Jun Zhu, Li-Ying Sun

{"title":"Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients With Posttransplant Lymphoproliferative Disorder: A Single-Center Retrospective Study.","authors":"Ying Liu, Ru-Zhou Cai, Wei Qu, Lin Wei, Zhi-Gui Zeng, Zhi-Jun Zhu, Li-Ying Sun","doi":"10.12659/AOT.952021","DOIUrl":"10.12659/AOT.952021","url":null,"abstract":"BACKGROUND Posttransplant lymphoproliferative disorder (PTLD) is a serious complication following pediatric liver transplantation. Reduction of immunosuppression is a cornerstone of PTLD management; however, the feasibility and safety of complete immunosuppression withdrawal (ISW) in this setting remain unclear. MATERIAL AND METHODS We retrospectively reviewed 6 pediatric liver transplant recipients diagnosed with PTLD who subsequently underwent complete ISW at our center between 2013 and 2019. Demographic characteristics, clinical features, pathological classification, treatments, and follow-up outcomes were analyzed. RESULTS The cohort included 6 children (4 females and 2 males) who underwent liver transplantation at a median age of 8 months. PTLD subtypes included infectious mononucleosis-type (n=3), polymorphic PTLD (n=1), Burkitt lymphoma (n=1), and classical Hodgkin lymphoma-like PTLD (n=1). All patients achieved complete remission following multimodal therapy. The median interval from transplantation to initiation of ISW was 35 months. During a median follow-up of 52 months after ISW, 4 patients maintained stable graft function without biopsy-proven rejection, whereas 2 developed rejection-related complications, both of which resolved after restart of low-dose immunosuppressive therapy. No graft loss or PTLD recurrence occurred. CONCLUSIONS In carefully selected pediatric liver transplant recipients with PTLD, supervised ISW may be achieved without irreversible graft injury. However, a substantial risk of rejection remains, highlighting the importance of close clinical and histological monitoring.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952021"},"PeriodicalIF":1.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased Ventilation Duration and ICU Stay Associated With Early Percutaneous Dilatational Tracheostomy After Liver Transplantation. 肝移植术后早期经皮气管扩张造瘘术与通气时间和ICU住院时间的关系。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-08-11 DOI: 10.12659/AOT.953143

Miroslav Jalc, Dieter Paul Hoyer, Ulf Peter Neumann, Juergen Walter Treckmann, Jassin Rashidi-Alavijeh, Katharina Willuweit, Eugen Malamutmann

{"title":"Decreased Ventilation Duration and ICU Stay Associated With Early Percutaneous Dilatational Tracheostomy After Liver Transplantation.","authors":"Miroslav Jalc, Dieter Paul Hoyer, Ulf Peter Neumann, Juergen Walter Treckmann, Jassin Rashidi-Alavijeh, Katharina Willuweit, Eugen Malamutmann","doi":"10.12659/AOT.953143","DOIUrl":"10.12659/AOT.953143","url":null,"abstract":"BACKGROUND Liver transplantation in critically ill patients with advanced cirrhosis frequently leads to prolonged ventilation. Percutaneous dilatational tracheostomy is widely used to facilitate weaning, yet the optimal timing after liver transplantation remains uncertain. MATERIAL AND METHODS This retrospective single-center study analyzed 83 of 1352 liver transplant recipients (6.1%) who underwent percutaneous dilatational tracheostomy between December 2010 and June 2024. Patients were retrospectively categorized as early (≤7 days) or late (≥8 days) according to the interval from liver transplantation to tracheostomy. Clinical and laboratory parameters were assessed using group comparisons, multivariable linear regression (with and without log-transformed outcomes), Cox regression, and Kaplan-Meier survival analysis. RESULTS Patients who underwent early percutaneous dilatational tracheostomy had lower platelet counts (57 vs 97×109/L; P=0.047) and higher aspartate aminotransferase (72 vs 46 U/L; P=0.022), alanine aminotransferase (249 vs 67 U/L; P<0.001), and creatinine levels (175 vs 141 μmol/L; P=0.033). Early percutaneous dilatational tracheostomy was independently associated with a shorter intensive care unit stay (ß=-0.651; 95% CI, -1.087 to -0.214; P=0.004; 47.8% reduction) and shorter mechanical ventilation duration (ß=-0.560; 95% CI, -1.027 to -0.093; P=0.020; 42.9% reduction). No significant survival difference was found between early and late percutaneous dilatational tracheostomy (Cox hazard ratio, 0.76; 95% CI, 0.41-1.40; P=0.37). CONCLUSIONS Early percutaneous dilatational tracheostomy was associated with reduced intensive care unit and ventilation times but did not confer a survival benefit. These findings should be interpreted cautiously, given the retrospective single-center design.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e953143"},"PeriodicalIF":1.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13476976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Anatomical Landscape of Living Donor Livers: A 101-Case Retrospective Single-Center Study in Indonesia From 2010 to 2025. 活体供肝解剖景观：2010年至2025年印度尼西亚101例回顾性单中心研究

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-08-04 DOI: 10.12659/AOT.952031

Arnetta Naomi Louise Lalisang, Toar Jean Maurice Lalisang, Yarman Mazni, Ridho Ardhi Syaiful, Lam Sihardo, Vania Myralda Giamour Marbun, Anisa Ayu Maharani, Nathaniel Jason Zacharia, Afid Brilliana Putra, Taufik Agung Wibowo

{"title":"The Anatomical Landscape of Living Donor Livers: A 101-Case Retrospective Single-Center Study in Indonesia From 2010 to 2025.","authors":"Arnetta Naomi Louise Lalisang, Toar Jean Maurice Lalisang, Yarman Mazni, Ridho Ardhi Syaiful, Lam Sihardo, Vania Myralda Giamour Marbun, Anisa Ayu Maharani, Nathaniel Jason Zacharia, Afid Brilliana Putra, Taufik Agung Wibowo","doi":"10.12659/AOT.952031","DOIUrl":"10.12659/AOT.952031","url":null,"abstract":"BACKGROUND Anatomical variations of the hepatic vasculature and bile ducts are critical considerations in living donor liver transplantation (LDLT), yet population-specific data remain limited. This retrospective study aimed to evaluate hepatic artery, portal vein, hepatic vein, and intrahepatic bile duct anatomy in 101 living liver donors at a single center in Indonesia from 2010 to 2025, and to identify donor characteristics associated with these variations. MATERIAL AND METHODS A retrospective review was performed on 101 living liver donors at Cipto Mangunkusumo Hospital, Indonesia (2010-2025). Hepatic artery and portal/hepatic vein anatomy were assessed using computed tomography angiography (CTA), and biliary anatomy using magnetic resonance cholangiopancreatography (MRCP). Variations were classified according to the Michel, Nakamura, and Huang systems. Logistic and multinomial regression analyses evaluated demographic predictors, and linear regression assessed operative time. RESULTS Donors (mean age 31.8±6.2 years; body mass index [BMI] 22.6 kg/m²; 62.5% female) were predominantly Javanese and Sumatran. Canonical anatomy predominated (Michel I 70.8%; Nakamura I 71.9%; Huang A1 59.7%). Sumatran donors demonstrated higher frequencies of hepatic artery and portal vein variants. Increasing age predicted hepatic artery variation (aOR 1.08/year, P=0.046), while BMI influenced portal vein subtypes (P=0.006). No factors affected operative time. CONCLUSIONS Canonical anatomy predominated, with ethnic variations seen in Sumatran donors. Age and BMI predicted vascular variations, while biliary anatomy remained stable. Anatomical variations did not affect operative time, highlighting the importance of preoperative imaging and planning.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952031"},"PeriodicalIF":1.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Risk Factors of Hepatic Steatosis in Kidney Transplant Recipients. 肾移植受者肝脂肪变性的患病率及危险因素。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-07-28 DOI: 10.12659/AOT.952251

Monika Górska, Filip Wróbel, Marta Rząsa, Ilona Kurnatowska

{"title":"Prevalence and Risk Factors of Hepatic Steatosis in Kidney Transplant Recipients.","authors":"Monika Górska, Filip Wróbel, Marta Rząsa, Ilona Kurnatowska","doi":"10.12659/AOT.952251","DOIUrl":"10.12659/AOT.952251","url":null,"abstract":"BACKGROUND Kidney failure and hepatic steatosis (HS) are core elements of cardiovascular-renal-metabolic syndrome. Evidence of HS in kidney transplant (KTx) recipients remains limited. We evaluated the prevalence and determinants of de novo hepatic steatosis (dnHS) after KTx. MATERIAL AND METHODS We retrospectively analyzed adult KTx recipients from a single outpatient center without HS prior to transplantation. Anthropometric data, laboratory results, comorbidities, and medication use were evaluated. HS was diagnosed based on ultrasonography. RESULTS In 127 (53 female) KTx recipients with median age of 56.91 (44.91-64.62) years and median estimated glomerular filtration rate of 39.6 (29.76-48.51) mL/min/1.73 m², 44 patients (30.1%) had dnHS. Patients in the dnHS and nonHS groups were of comparable age, sex, and graft function. Patients in the dnHS group had significantly higher body mass index (BMI) before (25.5±3.29 vs 23.26±3.55 kg/m²; P<0.001) and after KTx (27.86±4.06 vs 24.71±3.69 kg/m²; P<0.001), and dnHS was associated with higher rates of hyperlipidemia (77.3% vs 54.2%; P=0.012), hyperuricemia (52.3% vs 28.9%; P=0.009), and ischemic heart disease (34.1% vs 13.1%, P=0.006). In multivariable logistic regression, higher post-KTx BMI (OR=1.21; 95% CI, 1.08-1.37; P=0.002) and history of ischemic heart disease (OR=3.40; 95% CI, 1.18-9.74; P=0.023) were independently associated with the presence of dnHS. CONCLUSIONS Hepatic steatosis is common among KTx recipients and is strongly associated with metabolic comorbidity, particularly higher BMI and ischemic heart disease.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952251"},"PeriodicalIF":1.3,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148597855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tongue Carcinoma in Immunosuppressed Patients After Liver and Kidney Transplantation: A Case Series. 肝、肾移植后免疫抑制患者的舌癌：一个病例系列。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-07-21 DOI: 10.12659/AOT.951715

Barbora Hocková, Svetlana Adamcová Selčanová, Rastislav Slávik, Dušan Poruban, Martina Hanzelová, Yu-Chi Cheng, Ľubomír Skladaný, Adam Stebel

{"title":"Tongue Carcinoma in Immunosuppressed Patients After Liver and Kidney Transplantation: A Case Series.","authors":"Barbora Hocková, Svetlana Adamcová Selčanová, Rastislav Slávik, Dušan Poruban, Martina Hanzelová, Yu-Chi Cheng, Ľubomír Skladaný, Adam Stebel","doi":"10.12659/AOT.951715","DOIUrl":"10.12659/AOT.951715","url":null,"abstract":"BACKGROUND Solid organ transplant recipients carry an elevated risk of de novo malignancies under chronic immunosuppression, including aggressive squamous cell carcinoma (SCC) of the oral cavity and oropharynx. Practical, evidence-based guidance for maxillofacial management in this population remains limited. CASE REPORT Case 1 involved a 44-year-old man who developed T1N0 SCC of the lateral tongue 23 months after orthotopic liver transplantation for alcoholic cirrhosis. He was treated with partial glossectomy and selective neck dissection, followed by re-excision for a positive deep margin; he remains disease-free at 2 years, with mild residual tongue hypomobility. Case 2 involved a 59-year-old man who developed T2N1M0 SCC of the tongue 8 months after kidney transplantation. He underwent extended hemiglossectomy with neck dissection, anterolateral thigh free flap reconstruction, and adjuvant chemoradiotherapy; suspected locoregional recurrence required limited resection, and he remains disease-free at 5 years. Case 3 involved a 62-year-old woman who developed T1N0M0 SCC of the floor of the mouth 12 years after liver transplantation. She was treated via local excision followed by block neck dissection without adjuvant therapy and remains disease-free at 1 year, with preserved function. CONCLUSIONS Oral SCC in transplant recipients can arise early or late after transplantation and requires meticulous surgical clearance, judicious use of adjuvant therapy, and vigilant surveillance. Close multidisciplinary coordination with transplant teams to optimize and, when feasible, de-escalate immunosuppression is essential, along with routine oral cancer screening and risk factor modification. Larger multicenter studies are needed to refine screening intervals and peri-oncologic immunosuppressive strategies.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e951715"},"PeriodicalIF":1.3,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver Transplantation. 基于iTRAQ和mrm的蛋白质组学鉴定肝移植后原发性功能障碍的早期损伤生物标志物。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-07-14 DOI: 10.12659/AOT.952366

Xiaohong Lin, Wanzhen Cai, Xitao Hong, Ziming Ye, Yuqi Dong, Shuai Wang, Xiaoshun He, Donghong Li, Weiqiang Ju, Maogen Chen

{"title":"iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver Transplantation.","authors":"Xiaohong Lin, Wanzhen Cai, Xitao Hong, Ziming Ye, Yuqi Dong, Shuai Wang, Xiaoshun He, Donghong Li, Weiqiang Ju, Maogen Chen","doi":"10.12659/AOT.952366","DOIUrl":"10.12659/AOT.952366","url":null,"abstract":"BACKGROUND Primary nonfunction (PNF) is a severe complication following liver transplantation (LT), yet precise molecular biomarkers for early identification of patients at risk remain lacking, which can delay timely therapeutic intervention. MATERIAL AND METHODS Liver biopsies were collected from patients and classified into 4 groups: control, optimal graft (OG), early allograft dysfunction (EAD), and PNF. Samples were obtained at 3 time points: T0 (pre-cold perfusion), T1 (pre-reperfusion), and T2 (post-reperfusion). Isobaric tags for relative and absolute quantitation (iTRAQ) and multiple reaction monitoring (MRM) were used for proteomic analysis and biomarker verification. RESULTS Baseline characteristics of the patients showed no significant differences between groups. A total of 6505 proteins were identified in human liver samples. There were 160 differentially expressed proteins (67 upregulated and 93 downregulated) found in the PNF group compared to the control, while 54 and 36 proteins were identified in the EAD and OG groups, respectively. Ten proteins were selected for MRM verification, confirming the significant upregulation of VWF and downregulation of PRDX1, HGD, THIO, 6PGD, and HPPD, consistent with the iTRAQ results. CONCLUSIONS PRDX1, HGD, THIO, 6PGD, HPPD, and VWF were identified as candidate proteins associated with PNF and ischemia-reperfusion injury (IRI) after LT. These findings are hypothesis-generating and require validation in larger, independent cohorts to determine their potential clinical value.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952366"},"PeriodicalIF":1.3,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Reported Asian Cases of Robot-Assisted Simultaneous Bilateral Nephrectomy With Kidney Transplantation in Autosomal Dominant Polycystic Kidney Disease: A Case Series. 亚洲首次报道的机器人辅助双侧肾切除术合并肾移植治疗常染色体显性多囊肾病的病例系列。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-07-07 DOI: 10.12659/AOT.952581

Jin-Myung Kim, Hye Eun Kwon, Youngmin Ko, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Sung Shin

{"title":"First Reported Asian Cases of Robot-Assisted Simultaneous Bilateral Nephrectomy With Kidney Transplantation in Autosomal Dominant Polycystic Kidney Disease: A Case Series.","authors":"Jin-Myung Kim, Hye Eun Kwon, Youngmin Ko, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Sung Shin","doi":"10.12659/AOT.952581","DOIUrl":"10.12659/AOT.952581","url":null,"abstract":"BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is frequently associated with massive kidney enlargement, which complicates kidney transplantation by limiting intra-abdominal space. Simultaneous bilateral nephrectomy with kidney transplantation can reduce surgical burden and avoid staged procedures, but it is technically demanding and rarely performed using robotic surgery. No such cases have been reported previously in Asian patients. CASE REPORT Two adult patients with end-stage kidney disease due to ADPKD presented with severe abdominal distension, pain, early satiety, and impaired quality of life caused by massively enlarged kidneys extending into the pelvis. Robot-assisted simultaneous bilateral nephrectomy was performed using a transperitoneal approach, followed by living-donor kidney transplantation during the same operation. Despite distorted anatomy, limited working space, and extensive vascular adhesions, robotic nephrectomy allowed precise dissection and safe completion of bilateral kidney removal. After repositioning, graft implantation in the iliac fossa was successfully achieved. Operative times were prolonged (approximately 10 hours and 9 hours), reflecting the complexity of simultaneous bilateral nephrectomy and transplantation, while estimated blood loss remained low and no transfusions were required. Both patients demonstrated immediate graft function, early ambulation, and uneventful recovery without intraoperative or postoperative complications. CONCLUSIONS Robot-assisted simultaneous bilateral nephrectomy with kidney transplantation is feasible and safe in selected patients with severely enlarged polycystic kidneys. These first reported Asian cases suggest that this approach may offer perioperative and recovery advantages while avoiding the risks of staged operations.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952581"},"PeriodicalIF":1.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Health-Related Quality of Life After Pure Laparoscopic vs Open Donor Hepatectomy in a Low-Volume Living Donor Liver Transplantation Center: A Retrospective Cohort Study. 小容量活体肝移植中心纯腹腔镜与开放式供肝切除术后健康相关生活质量的比较：一项回顾性队列研究

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-06-30 DOI: 10.12659/AOT.952469

Kanya Udomsin, Asara Thepbunchonchai, Sunhawit Junrungsee, Anon Chotirosniramit, Phuriphong Chanthima, Warangkana Lapisatepun, Worakitti Lapisatepun

{"title":"Comparison of Health-Related Quality of Life After Pure Laparoscopic vs Open Donor Hepatectomy in a Low-Volume Living Donor Liver Transplantation Center: A Retrospective Cohort Study.","authors":"Kanya Udomsin, Asara Thepbunchonchai, Sunhawit Junrungsee, Anon Chotirosniramit, Phuriphong Chanthima, Warangkana Lapisatepun, Worakitti Lapisatepun","doi":"10.12659/AOT.952469","DOIUrl":"10.12659/AOT.952469","url":null,"abstract":"BACKGROUND Pure laparoscopic donor hepatectomy (PLDH) is increasingly adopted in living donor liver transplantation (LDLT) to enhance donor recovery. However, evidence on long-term health-related quality of life (HRQoL) following PLDRH is scarce, particularly in low-volume centers. This study aimed to compare perioperative outcomes and longitudinal HRQoL between PLDH and conventional open donor hepatectomy (CODH) in a single low-volume LDLT center. MATERIAL AND METHODS A retrospective cohort study was conducted between March 2010 and July 2023, including 50 living liver donors who underwent donor hepatectomy (27 CODH; 23 PLDH). Donor demographics, operative details, complications, and liver function test results were retrieved from the institutional database. HRQoL was assessed using the 36-Item Short Form Health Survey (SF-36) at 1, 3, 6, and 12 months postoperatively, prospectively administered during follow-up visits and retrospectively reviewed. Statistical analyses included the t test, Fisher exact test, Mann-Whitney U test, and repeated-measures ANOVA. RESULTS Baseline characteristics were similar between groups except for higher education levels among PLDH donors (P<0.001). PLDH group showed a trend toward shorter hospital stay (6.83 vs 8.44 days; P=0.055). Postoperative complications and liver function test results were similar. PLDH donors reported significantly higher HRQoL scores in physical function, role physical, general health, and social function domains (P<0.05), with favorable trends in other domains. CONCLUSIONS In this low-volume LDLT center, PLDH demonstrated perioperative safety comparable to CODH, while achieving superior recovery in multiple HRQoL domains and reduced transfusion requirements. These findings support PLDH as the preferred donor approach when expertise is available.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952469"},"PeriodicalIF":1.3,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of an Early Post-Liver Transplant Activity Knowledge, Attitude, and Practice Questionnaire for Intensive Care Unit Nurses: A Multicenter Study. 重症监护室护士早期肝移植后活动知识、态度和实践问卷的开发和验证：一项多中心研究。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-06-23 DOI: 10.12659/AOT.952175

Shuo Li, Lixia Zhong, Yulin Zheng, Yanhong Jin

{"title":"Development and Validation of an Early Post-Liver Transplant Activity Knowledge, Attitude, and Practice Questionnaire for Intensive Care Unit Nurses: A Multicenter Study.","authors":"Shuo Li, Lixia Zhong, Yulin Zheng, Yanhong Jin","doi":"10.12659/AOT.952175","DOIUrl":"10.12659/AOT.952175","url":null,"abstract":"BACKGROUND We developed and validated a questionnaire assessing intensive care unit (ICU) nurses' knowledge, attitude, and practice (KAP) regarding early mobilization of patients who are critically ill following liver transplantation. MATERIAL AND METHODS Using KAP theory, an initial questionnaire was formed via a literature review, Delphi expert consultation, and pre-survey. In January 2024, ICU nurses from 7 Chinese tertiary hospitals conducting liver transplants were surveyed, yielding 334 valid responses. RESULTS The Early Activity Assessment Tools for ICU Nurses after Liver Transplantation Based on the Theory of Knowledge, Attitude, and Practice contains 3 dimensions and 40 entries, including 17 entries in the knowledge dimension, 10 entries in the attitude dimension, and 13 entries in the practice dimension. The content validity index (CVI) of the questionnaire was 0.937, and the CVI of each entry ranged from 0.800 to 1.000. The exploratory factor analysis extracted 3 male factors, accounting for a cumulative variance contribution of 86.852%. The Cronbach's alpha coefficient of the questionnaire was 0.976, the folded half reliability was 0.772, and the retest reliability was 0.784. CONCLUSIONS The reliability of the Early Activity Assessment Tools for ICU Nurses after Liver Transplantation Based on the Theory of Knowledge, Attitude, and Practice is good, and the tool can support the preliminary verification of the knowledge, attitude, and practice level of ICU nurses on early activities of patients who are critically ill following liver transplantation.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952175"},"PeriodicalIF":1.3,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid-Sparing Effects of Peripheral Nerve Blocks in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis. 肾移植受者周围神经阻滞的阿片保留作用：系统回顾和荟萃分析。

IF 1.3 4区医学

Annals of Transplantation Pub Date : 2026-06-16 DOI: 10.12659/AOT.952211

Hye Joo Yun, Dong Hyun Kim, Mee Young Chung, Ji Young Min

{"title":"Opioid-Sparing Effects of Peripheral Nerve Blocks in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis.","authors":"Hye Joo Yun, Dong Hyun Kim, Mee Young Chung, Ji Young Min","doi":"10.12659/AOT.952211","DOIUrl":"10.12659/AOT.952211","url":null,"abstract":"BACKGROUND Kidney transplantation (KT) is frequently associated with substantial postoperative pain, while opioid use in these patients increases the risk of adverse outcomes. Peripheral nerve blocks (PNBs) have been proposed as opioid-sparing strategies; however, evidence in kidney transplant recipients remains inconsistent, likely due to heterogeneity in block techniques, variability in perioperative analgesic regimens, and differences in study design and methodological rigor. This systematic review and meta-analysis aimed to evaluate the impact of PNBs on postoperative analgesia in kidney transplant recipients. MATERIAL AND METHODS A systematic search of PubMed, EMBASE, the Cochrane Library, and Web of Science was conducted through April 2025 following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies reporting 24-h postoperative opioid consumption in adult kidney transplant recipients were included. The primary outcome was cumulative opioid use within 24 hours after surgery, expressed as intravenous morphine or fentanyl. RESULTS Twelve studies met the inclusion criteria, of which 10 contributed to the quantitative synthesis. Pooled analysis showed that PNBs significantly reduced 24-h morphine consumption compared with control analgesia (pooled mean difference=-16.20 mg of intravenous morphine equivalents, 95% confidence interval -24.66 to -7.74; P=0.0002). Heterogeneity was high (I²=99%), but no study reported higher opioid use or increased adverse events in the PNB groups. CONCLUSIONS PNBs appear to be an effective opioid-sparing adjunct for postoperative analgesia in kidney transplant recipients. However, the available evidence remains limited, and further well-designed comparative trials are needed to define their role within multimodal analgesic strategies in this population.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952211"},"PeriodicalIF":1.3,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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