Annals of Transplantation最新文献

Early Post-Transplant Serum Ferritin Levels as Predictive Biomarkers for Severe Acute Graft-Versus-Host Disease in Pediatric Umbilical Cord Blood Transplantation for Acute Leukemia. 移植后早期血清铁蛋白水平作为小儿脐带血移植治疗急性白血病过程中严重急性移植物抗宿主病的预测生物标志物。

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-08-27 DOI: 10.12659/AOT.944156

Zhiqi Zhang, Bohan Li, Lu Liu, Ruolan Xiong, Senlin Zhang, Minyuan Liu, Zihao Xia, Shuran Wang, Jie Li, Shaoyan Hu

{"title":"Early Post-Transplant Serum Ferritin Levels as Predictive Biomarkers for Severe Acute Graft-Versus-Host Disease in Pediatric Umbilical Cord Blood Transplantation for Acute Leukemia.","authors":"Zhiqi Zhang, Bohan Li, Lu Liu, Ruolan Xiong, Senlin Zhang, Minyuan Liu, Zihao Xia, Shuran Wang, Jie Li, Shaoyan Hu","doi":"10.12659/AOT.944156","DOIUrl":"10.12659/AOT.944156","url":null,"abstract":"BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo-HSCT) using umbilical cord blood is a valuable therapy option for patients with acute leukemia (AL). Acute graft-versus-host disease (aGVHD) remains the most frequently encountered complication. This study investigated risk factors for aGVHD and assessed whether post-transplant serum ferritin (SF) within 2 weeks is a potential biomarker for aGVHD in pediatric patients with AL undergoing umbilical cord blood transplantation (UCBT). MATERIAL AND METHODS We conducted a retrospective cohort study of 71 patients with AL who underwent UCBT at the Children's Hospital of Soochow University between 2017 and 2022. We evaluated several factors related to aGVHD. Univariate and multivariate analyses were performed using the proportional subdistribution hazard regression model of Fine and Gray. Analyses of overall survival (OS) were performed using the Kaplan-Meier method, and differences were compared using log-rank tests. RESULTS Of the 71 patients, 23 (32.4%) experienced grade II-IV aGVHD, of whom 18 (25.4%) developed grade III-IV aGVHD. Patients with grade II-IV and III-IV aGVHD had worse 5-year OS (69.4±10%, p=0.01; and 60.6±11.6, P=0.007, respectively). Conditioning intensity was a risk factor for grade III-IV aGVHD (HR: 0.34, 95% CI: 0.13-0.89, P=0.027). An SF level >1650 ng/mL within 2 weeks post-transplant was associated with an increased risk of severe aGVHD (HR: 3.61, 95% CI: 1.09-11.97, P=0.036). CONCLUSIONS Post-transplant SF within 2 weeks was a potential biomarker for developing severe aGVHD. Higher levels of post-transplant SF are associated with a higher incidence of grade II-IV aGVHD and grade III-IV aGVHD.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Year Mortality After Lung Transplantation: Experience of a Single French Center Between 2012 and 2021. 肺移植术后一年的死亡率：2012年至2021年法国一家中心的经验。

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-08-20 DOI: 10.12659/AOT.944420

Thi Cam Tu Hoang, Lien Han, Sandrine Hirschi, Tristan Degot, Justine Leroux, Pierre-Emmanuel Falcoz, Anne Olland, Nicola Santelmo, Marion Villard, Olivier Collange, Gauthier Appere, Romain Kessler, Benjamin Renaud-Picard

{"title":"One-Year Mortality After Lung Transplantation: Experience of a Single French Center Between 2012 and 2021.","authors":"Thi Cam Tu Hoang, Lien Han, Sandrine Hirschi, Tristan Degot, Justine Leroux, Pierre-Emmanuel Falcoz, Anne Olland, Nicola Santelmo, Marion Villard, Olivier Collange, Gauthier Appere, Romain Kessler, Benjamin Renaud-Picard","doi":"10.12659/AOT.944420","DOIUrl":"10.12659/AOT.944420","url":null,"abstract":"BACKGROUND Lung transplantation (LTx) is a life-extending therapy for specific patients with terminal lung diseases. This study aimed to evaluate the associations and causes of 1-year mortality after lung transplantation at Strasbourg University Hospital, France, between 2012 and 2021. MATERIAL AND METHODS We carried out a retrospective analysis on 425 patients who underwent LTx at Strasbourg University Hospital between January 1, 2012, and December 31, 2021. Pre-transplant, perioperative, and postoperative data were collected from the electronic medical records. RESULTS Among all patients, 94.6% had a LTx, 4.0% a heart-lung transplantation, and 1.4% underwent pancreatic islet-lung transplantation. The median age at transplantation was 57 years, with 55.3% male patients. The main native lung disease leading to LTx was chronic obstructive pulmonary disease in 51.1% of patients; 16.2% needed super-urgent LTx. The 1-year mortality rate was 11.5%. Most deaths were either caused by multi-organ failure or septic shock. In our multivariate analysis, we identified 3 risk factors significantly related to 1-year mortality after LTx: body mass index (BMI) between 25 and 30 kg/m² vs BMI between 18.5 and 25 kg/m² (P=0.032), postoperative extracorporeal membrane oxygenation support (P=0.034), and intensive care unit length of stay after transplantation (P<0.001). Two other factors were associated with a significantly lower 1-year mortality risk: longer hospital stay after LTx (P=0.024) and tacrolimus prescription (P=0.004). CONCLUSIONS Our study reported a 1-year mortality rate of 11.5% after LTx. Although LTx candidates are carefully selected, additional data are required to improve understanding of the risk factors for post-LTx mortality.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney After Lung Transplants or Combined Kidney-Lung Transplantation: A Single-Center Retrospective Cohort Study. 肺移植或肾肺联合移植后的肾脏：单中心回顾性队列研究

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-08-13 DOI: 10.12659/AOT.944049

Benoît Mesnard, Matthieu Glorion, Arwa Jalal Eddine, Antoine Roux, Julien Branchereau, Yann Neuzillet, Edouard Sage, Thierry Lebret, Alexandre Hertig, François-Xavier Madec, Yanish Soorojebally

{"title":"Kidney After Lung Transplants or Combined Kidney-Lung Transplantation: A Single-Center Retrospective Cohort Study.","authors":"Benoît Mesnard, Matthieu Glorion, Arwa Jalal Eddine, Antoine Roux, Julien Branchereau, Yann Neuzillet, Edouard Sage, Thierry Lebret, Alexandre Hertig, François-Xavier Madec, Yanish Soorojebally","doi":"10.12659/AOT.944049","DOIUrl":"10.12659/AOT.944049","url":null,"abstract":"BACKGROUND End-stage renal disease is a major issue in the management of patients undergoing lung transplantation. Combined kidney-lung transplantation (CKLT) and kidney after lung transplantation (KALT) are the 2 preferred solutions to manage this situation. To evaluate these strategies, we describe kidney and lung graft outcomes and patient survival in patients managed with CKLT and KALT. MATERIAL AND METHODS We conducted a retrospective single-center cohort study. Patients who underwent a CKLT or a KALT were included in this study. Retrospective extraction of data from medical records was performed. RESULTS Seventeen patients underwent CKLT and 9 underwent KALT. Most of the patients had cystic fibrosis and presented renal failure related to anti-calcineurin toxicity. The 30-day and 1-year survival of CKLT recipients were both 75.6%. No patients with KALT died during the follow-up. Kidney graft prognosis was almost exclusively influenced by patient survival in relation to postoperative lung transplant complications. The rate of severe surgical complications was close to 60% for CKLT compared with 30% for KALT. The kidney graft function (estimated kidney graft function) did not differ according to the transplantation strategy. CONCLUSIONS KALT is a safe option, with postoperative morbidity and renal graft function identical to those of kidney transplantation in non-lung-transplanted patients. The results of CKLT depend mainly on the morbidity associated with lung transplantation but remain an attractive option for patients with respiratory failure associated with end-stage renal disease. The choice of transplant strategy must also take into account the most ethical and efficient allocation of kidney grafts.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare? 小儿肝移植中供体移植物的异常肝活检：他们的表现如何？

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-08-06 DOI: 10.12659/AOT.944245

Jason Guo, Jorge A Sanchez-Vivaldi, Madhukar S Patel, Benjamin K Wang, Andrew D Shubin, Yash Kadakia, Jigesh A Shah, Malcolm MacConmara, Steven Hanish, Parsia A Vagefi, Christine S Hwang

{"title":"Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?","authors":"Jason Guo, Jorge A Sanchez-Vivaldi, Madhukar S Patel, Benjamin K Wang, Andrew D Shubin, Yash Kadakia, Jigesh A Shah, Malcolm MacConmara, Steven Hanish, Parsia A Vagefi, Christine S Hwang","doi":"10.12659/AOT.944245","DOIUrl":"10.12659/AOT.944245","url":null,"abstract":"BACKGROUND Little is known about outcomes of pediatric patients transplanted using donor liver grafts with abnormal biopsy results. We assessed donor liver biopsy data to report characteristics and outcomes of abnormal livers transplanted in pediatric patients. MATERIAL AND METHODS We identified pediatric patients who received a liver transplant from a biopsied deceased donor between 2015 and 2022 using the national database UNOS Standard Transplant Analysis and Research files. Recipients were excluded if they received multi-organ transplants or were lost to follow-up. Livers with ≤5% macrosteatosis, no fibrosis, and no inflammation were classified as normal livers (NL). Allografts with >5% macrosteatosis, any fibrosis, or any inflammation were considered abnormal livers (AL). Donor and recipient demographic data and outcomes were examined. RESULTS Of the 3808 total pediatric liver transplants in the study period, there were 213 biopsied donor liver allografts transplanted into pediatric recipients. Of those, 114 were NL and 99 were AL. 35.4% (35/99) of the AL had >5% macrosteatosis with a mean of 7.6±11.4%, 64.6% (64/99) had any inflammation, and 18.2% (18/99) had any fibrosis. AL donors were significantly older than NL donors. AL recipients had higher PELD scores. There were no significant differences in length of stay, rejection rates and causes, or allograft survival between AL and NL. Multivariable analysis revealed that inflammation was independently associated with a significantly greater risk for graft failure. CONCLUSIONS Outcomes of abnormal livers are excellent. Inflammation was an independent risk factor for poor graft prognosis. Donor biopsies in pediatric liver transplantation can be a useful adjunct to assess outcomes.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of Acute Kidney Injury in Liver Transplantation: Donation after Circulatory Death versus Brain Death. 肝移植中急性肾损伤的比较研究：循环死亡后捐献与脑死亡后捐献的比较研究

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-07-30 DOI: 10.12659/AOT.944077

Benedikt Hilger, Katja Frick, Rolf Erlebach, Philipp Dutkowski, Rea Andermatt, Sascha David, Reto A Schüpbach, Stephanie Klinzing

{"title":"Comparative Study of Acute Kidney Injury in Liver Transplantation: Donation after Circulatory Death versus Brain Death.","authors":"Benedikt Hilger, Katja Frick, Rolf Erlebach, Philipp Dutkowski, Rea Andermatt, Sascha David, Reto A Schüpbach, Stephanie Klinzing","doi":"10.12659/AOT.944077","DOIUrl":"10.12659/AOT.944077","url":null,"abstract":"BACKGROUND Acute kidney injury (AKI) after orthotopic liver transplantation (OLT) contributes to morbidity and mortality. Donation after circulatory death (DCD) has been established to increase the pool of organs. While surgical complications are reported to be comparable in DCD and donation after brain death (DBD) OLT, there is a knowledge gap concerning adverse kidney events in these 2 groups. MATERIAL AND METHODS In this retrospective cohort study, 154 patients received a DBD and 68 received a DCD organ (2016-2020). The primary outcome was a major adverse kidney event within 30 days (MAKE-30). The secondary outcome was dynamics of AKI and kidney replacement therapy (KRT) during the first postoperative week and on postoperative day 30. Incidence and resolution from AKI and KRT and patient survival (PS) 30 days after OLT were compared between the DCD and DBD recipients. RESULTS MAKE-30 incidence after OLT was comparable in DCD (n=27, 40%) vs DBD (n=41, 27%) recipients (risk ratio 1.49 [95% CI 1.01, 2.21], p=0.073). AKI incidence was comparable in DCD (n=58, 94%) vs DBD (n=95, 82%) recipients (risk ratio 1.14 [95% CI: 1.03, 1.27], P=0.057). Overall, 40% (n=88) of patients required KRT, with no difference between DCD (n=27, 40%) vs DBD (n=61, 40%) recipients (risk ratio 1.00 [95% CI 0.71, 1.43], P>0.999). Resolution of AKI by day 30 was lower in DCD (n=29, 50%) than in DBD (n=66, 69%) recipients (risk ratio 0.71 [95% CI: 0.53, 0.95], P=0.032). Survival after 30 days (DCD: n=64, 94% vs DBD: n=146, 95%, risk ratio 0.99 [95% CI 0.93, 1.06], P>0.999) was also comparable. CONCLUSIONS MAKE-30, short-term renal outcome, and survival did not significantly differ between DBD and DCD-OLT. Resolution of AKI by day 30 was lower in DCD than in DBD recipients.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Graft Failure After Penetrating Keratoplasty in Eastern China from 2018 to 2021 2018 至 2021 年华东地区穿透性角膜移植术后移植失败的风险因素

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-07-22 DOI: 10.12659/aot.945388

Yun Yang, Hongya Zeng, Lan Gong, Tong Lin

引用次数: 0

Urinary Chemokines CXCL9 and CXCL10 Are Non-Invasive Biomarkers of Kidney Transplant Rejection 尿化学因子 CXCL9 和 CXCL10 是肾移植排斥反应的非侵入性生物标志物

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-07-17 DOI: 10.12659/aot.944762

E. Mačionienė, Martynas Simanavičius, M. Vitkauskaitė, A. Vickienė, Roberta Staučė, A. Vinikovas, Marius Miglinas

引用次数: 0

Ginkgetin Pretreatment Reduces Inflammatory Response in DCD Donor Liver via JAK2/STAT3 Signaling Pathway. 银杏黄酮预处理通过 JAK2/STAT3 信号通路降低 DCD 供体肝脏的炎症反应

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-07-16 DOI: 10.12659/AOT.944153

Jia Liu, Jiansheng Xiao, Qin Deng, ZhiHui Fu, Qi Xiao

{"title":"Ginkgetin Pretreatment Reduces Inflammatory Response in DCD Donor Liver via JAK2/STAT3 Signaling Pathway.","authors":"Jia Liu, Jiansheng Xiao, Qin Deng, ZhiHui Fu, Qi Xiao","doi":"10.12659/AOT.944153","DOIUrl":"10.12659/AOT.944153","url":null,"abstract":"BACKGROUND Ginkgetin inhibits growth of tumor cells, reducing blood lipids, and improving atherosclerosis, but the protective effect of ginkgetin in donation after cardiac death (DCD) livers is still unknown. The aim of this study was to determine whether pretreatment of DCD donor livers with ginkgetin can reduce inflammatory response through the JAK2/STAT3 signaling pathway. MATERIAL AND METHODS Twenty male Sprague-Dawley rats (200-250 g) were randomly divided into 4 groups: Sham, DCD, Ginkgetin (0.6 mg/kg) pretreatment 1 h before surgery, and Ginkgetin (0.6 mg/kg) plus broussonin E (0.3 mg/kg) (JAK2/STAT3 signaling agonist) pretreatment 1 h before surgery. Rat livers were subjected to 30 min warm ischemia and 24 h cold storage to simulate the preservation process of DCD donor livers, followed by normothermic machine perfusion for 1 h to simulate liver reperfusion in vivo. Liver tissues and perfusate samples were collected for further studies. RESULTS Ginkgetin pretreatment significantly decreased the values of ALT and AST (P<0.05), and improved histological alterations according to improved Suzuki's Score (P<0.05). Ginkgetin also inhibited the protein expression levels of p-JAK2/JAK2 and p-STAT3/STAT3 (P<0.05). Furthermore, ginkgetin pretreatment inhibited levels of interleukin-1β, interleukin-6 and tumor necrosis factor a (P<0.05) to suppress inflammatory response. In addition, broussonin E reversed the improvement of ginkgetin on DCD donor livers. CONCLUSIONS Ginkgetin can inhibit the inflammatory response through the JAK2/STAT3 signaling pathway to improve the quality of DCD donor livers.","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Interventional Therapy for Portal Vein Stenosis after Ex Vivo Liver Resection and Autotransplantation in End-Stage Hepatic Alveolar Echinococcosis with Cavernous Transformation 末期肝泡型棘球蚴病伴腔隙变的体外肝脏切除和自体移植术后门静脉狭窄的成功介入疗法

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-07-16 DOI: 10.12659/aot.944851

Yierfan Yilihaer, Maolin Wang, T. Aji, Yingmei Shao, Ainiwaer Aikebaer, Ahmad Mahmood

引用次数: 0

Impact of Donor-Recipient Relationship on Long-Term Outcomes in Living-Related Donor Kidney Transplantation 供体与受体关系对活体肾移植长期疗效的影响

IF 1.1 4区医学

Annals of Transplantation Pub Date : 2024-07-12 DOI: 10.12659/aot.945065

Liping Chen, Huaiyong Li, Tianyu Zhang, Hongmei Dong, Hongwei Bai

引用次数: 0