Annals of Transplantation最新文献

{"title":"Brain Death-Induced Systolic Ventricular Dysfunction and Its Association With NLRP3-Related Inflammatory Signaling in a Murine Model.","authors":"Lei Huang, Kevin P Zbierski, Ye Yuan, Siyuan Dong, Jacob Razzouk, David G Rabkin","doi":"10.12659/AOT.951930","DOIUrl":"10.12659/AOT.951930","url":null,"abstract":"<p><p>BACKGROUND Cardiac dysfunction after brain death limits donor heart utilization. We sought to define the incidence and time course of brain death (BD)-induced left ventricular (LV) dysfunction and its association with NLRP3-related inflammatory signaling in a murine model. Upstream regulators of NLRP3 signaling, including P2X7 and PPAR-γ, were also evaluated. MATERIAL AND METHODS Thirty C57BL/6 mice were studied. In phase I, mice were randomized to control (n=8) and BD (n=10) groups. Echocardiography was performed at baseline, and serially for 3 hours. Hemodynamic data were compared. In phase II, mice were randomized to control (n=6) and BD (n=6) groups. Similar measurements were obtained at baseline and periodically for 60 minutes (T60). Mice were killed, and LV tissue samples collected for biochemical analyses. RESULTS In phase I, all BD animals developed significantly depressed LVEF by T60, with no deaths. Six animals in each group survived to T120, and 4 animals to T180. In phase II, all animals survived to T60. Mean LVEF, fractional shortening, and stroke volume were significantly reduced in the BD group. BD group demonstrated significantly greater expression of NLRP3, IL-1ß, TNF-alpha, and IL-6 in LV tissue. P2X7 expression did not differ between groups, while PPAR-γ expression showed a trend toward increase in BD animals. CONCLUSIONS The incidence of depressed LV function was 100% at T60, with no attrition. BD-induced LV dysfunction was associated with increased expression of NLRP3 and pro-inflammatory cytokines in LV tissue, suggesting involvement of NLRP3-related inflammatory signaling. Targeting this pathway may represent a potential strategy to preserve myocardial function following brain death.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e951930"},"PeriodicalIF":1.3,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Internal Validation of a Web-Based Dynamic Nomogram for Dynamic Risk Stratification of Early Bacterial Infection in Liver Transplant Recipients.","authors":"Trung Dinh Ngo, Thu Thi Nguyen, Khanh Nam Le, Anh Hoang Ngoc Nguyen, Trang Thu Do, Huy Xuan Huynh, Khanh Van Le, Nam Van Do","doi":"10.12659/AOT.952951","DOIUrl":"10.12659/AOT.952951","url":null,"abstract":"<p><p>BACKGROUND Early bacterial infections are a common and clinically significant complication after living donor liver transplantation. However, clinically usable tools for early individualized risk stratification remain limited in routine clinical practice. MATERIAL AND METHODS This single-center retrospective cohort study included 205 adult patients who underwent LDLT between October 1, 2017, and October 31, 2025. All patients had complete 30-day follow-up for outcome ascertainment. Early bacterial infection was defined as a microbiologically confirmed infection occurring within 30 days after transplantation. Univariable and multivariable logistic regression analyses were performed to identify independent predictors. Model performance was evaluated using receiver operating characteristic (ROC) analysis, bootstrap-based calibration, and decision curve analysis. Static and web-based dynamic nomograms were constructed based on the final model. RESULTS Early bacterial infections occurred in 45 patients (21.9%). Higher pre-transplant MELD score, post-transplant blood transfusion, bile leakage, and longer intensive care unit (ICU) stay were independently associated with infection risk. The dynamic risk stratification tool demonstrated good discrimination (AUC=0.792, 95% CI 0.716-0.867), good calibration on internal bootstrap validation (MAE and MSE), and favorable net clinical benefit on decision curve analysis. The web-based dynamic nomogram enabled real-time individualized risk estimation using routinely available clinical variables. CONCLUSIONS We developed and internally validated a dynamic risk stratification tool for early bacterial infections after LDLT, implemented as static and web-based dynamic nomograms. The tool reflects evolving postoperative risk rather than prediction at a fixed time point, with good apparent performance. However, its true performance and generalizability remain uncertain, and external validation is required before clinical application.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952951"},"PeriodicalIF":1.3,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Lifeline: Feasibility and Outcomes of Altruistic Donor Programs in Living-Donor Liver Transplantation, A Single Saudi Center Experience.","authors":"Ahmed Zidan, Eyad Gadour, Sultan Zinaulabdin Tawfiq, Hadi Kuriry, Razan M Bader, Hammam Momani, Yahia Saleh, Bodhisatwa Sengupta, Iftikhar Khan, Noora H Al Faraj, Ahla Alkhiliwi, Ibrahim Alraddadi, Nouf Alshammari, Rehab Ahmed Abdullah, Mansour Tawfeeq, Mahmoud Obeid, Khalid Bel'eed-Akkari, Mohammed Ibraheem Alsaghier, Mohammed Alqahtani","doi":"10.12659/AOT.952102","DOIUrl":"10.12659/AOT.952102","url":null,"abstract":"<p><p>BACKGROUND In regions with limited deceased-donor liver transplantation, living-donor liver transplantation is often the only viable option. Altruistic (unrelated, nondirected) living-donor liver donation offers a novel strategy to expand the donor pool, particularly for patients lacking suitable related donors. MATERIAL AND METHODS This retrospective study analyzed all altruistic liver donors and their recipients at King Fahad Specialist Hospital-Dammam between April 2018 and December 2024. Donors underwent medical, psychosocial, and ethical evaluations, with final approval by an independent multidisciplinary committee. Data on donor demographics, hospital stay, complications, and graft type were reviewed. RESULTS Thirty-two altruistic donors (mean age 34.6 years; 68.8% male) successfully donated left lateral liver grafts. Allocation prioritized pediatric and high-urgency recipients. The average donor hospital stay was 4 days. No major complications (Clavien-Dindo grade ≥III) occurred; 81.2% had no complications, and 18.8% had minor (grade I-II) issues. All donors were alive and well at follow-up. CONCLUSIONS Altruistic liver donation is a safe, ethical, and effective strategy to address organ shortages for liver transplantation. With strong oversight and donor screening, this model enables life-saving transplants in vulnerable populations and represents a replicable innovation in transplant care.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952102"},"PeriodicalIF":1.3,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Cardiovascular Risk Indicated by Changes in Triglyceride-Glucose Index After Pancreas Transplantation.","authors":"Paweł Skrzypek, Małgorzata Buksińska-Lisik, Paweł Ziemiański, Antonina Respondek, Kaja Śmigielska, Karol A Sadowski, Justyna Domienik-Karłowicz, Maciej Kosieradzki, Wojciech Lisik","doi":"10.12659/AOT.950940","DOIUrl":"10.12659/AOT.950940","url":null,"abstract":"<p><p>BACKGROUND Pancreas transplantation is the best causal treatment for type I diabetes. The triglyceride-glucose (TyG) index is a validated marker of the long-term risk of cardiovascular episodes. The purpose of this study is to evaluate the potential reduction in cardiovascular risk, using the TyG index as a surrogate marker, in patients undergoing pancreas transplantation. MATERIAL AND METHODS The analysis was conducted on data obtained from 86 patients undergoing pancreas transplantation at the Department of General and Transplantation Surgery, Medical University of Warsaw. Serum triglyceride and glucose levels were recorded at the stage of qualification for transplantation and at 1, 3, 6, and 12 months after transplantation. The repeated measures ANOVA model was applied to the group of patients with complete data (n=14), showing a statistically significant effect of time. The difference between values before and after 12 months was statistically significant. RESULTS The mixed model confirmed the significant effect of time on the TyG index value. The mean TyG index value decreased significantly 1 month after transplantation and remained stable. Trend analysis was performed for the TyG index values at 3 time points: before transplant, early follow-up, and late follow-up. The mean TyG index decreased significantly as early as 1 to 3 months. CONCLUSIONS In this cohort of pancreas transplant recipients, transplantation was strongly associated with a reduction in the TyG index, suggesting a lower long-term risk of cardiovascular events.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e950940"},"PeriodicalIF":1.3,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of 518 Kidney Transplant Recipients to Evaluate the Association of Antiplatelet Therapy With Long-Term Cardiovascular Events and All-Cause Mortality.","authors":"Gavin Christy, Andres Mata, Zalan Shah, Ananta M H Sriram, Diana Pfeiffer, Taylor R Coffman, Madeline K Johnson, Sahita Gandra, Krista L Lentine, Mina M Benjamin","doi":"10.12659/AOT.951325","DOIUrl":"10.12659/AOT.951325","url":null,"abstract":"<p><p>BACKGROUND We investigated the association of single antiplatelet (AP) therapy with reduction of cardiovascular disease (CVD) events in kidney transplantation recipients (KTRs). MATERIAL AND METHODS This retrospective single-center study included KTRs from our institution between 2015 and 2024. Patients receiving anticoagulation or dual AP therapy were excluded. Patients were divided into those receiving AP therapy after kidney transplantation (AP group) and those not receiving such therapy (NoAP group). A separate analysis was performed for patients without known CVD. The primary outcome was a composite of all-cause mortality and major adverse cardiovascular events (MACE). Major bleeding events were also recorded. Kaplan-Meier survival curves and Cox proportional hazards models were constructed. RESULTS Overall, 518 KTRs met the study criteria (175 AP, 343 NoAP). The AP group was significantly older and had higher prevalences of diabetes and coronary artery disease. Over a median follow-up of 52.5 months (interquartile range: 33.1-71.1), 41 (24%) patients in the AP group and 76 (22%) patients in the NoAP group experienced the composite study outcome. After adjustment for confounders, AP therapy was independently associated with a lower risk of the outcome (hazard ratio 0.67, 95% confidence interval 0.45-0.99, P=0.046). AP therapy was not associated with major bleeding events. No significant association between AP therapy and outcomes was observed among patients without known CVD. CONCLUSIONS AP therapy after kidney transplantation was associated with lower risk of the composite outcome (MACE and all-cause mortality) in the overall cohort. No significant association was observed among patients without known CVD.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e951325"},"PeriodicalIF":1.3,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Pre-Transplant Stress Echocardiography Findings in 354 Kidney Transplant Recipients With Posttransplant Major Adverse Cardiovascular Events.","authors":"Spencer H Hobbs, Ava R DeLonais-Parker, Barbara C Okeke, Rushda F Mansuri, Krista L Lentine, Mina M Benjamin","doi":"10.12659/AOT.951383","DOIUrl":"10.12659/AOT.951383","url":null,"abstract":"<p><p>BACKGROUND Cardiovascular disease remains the leading cause of morbidity and mortality in kidney transplant (KT) recipients. Stress echocardiography (STE) is frequently used in pretransplant risk stratification, but its prognostic value in predicting posttransplant outcomes is uncertain. This retrospective study from a single center aimed to evaluate pretransplant STE findings in 354 KT recipients and their association with posttransplant major adverse cardiovascular events (MACE). MATERIAL AND METHODS We included KT recipients from our Midwest academic institution between January 2015 and January 2024 who underwent pretransplant STE. STEs were classified as positive (ischemic EKG changes or new wall motion abnormalities) or negative. MACE was defined as cardiovascular death, acute coronary syndrome, heart failure hospitalization, fatal arrhythmia, or stroke. Kaplan-Meier survival curves and Cox regression models were constructed to assess the associations between STE parameters and outcomes. RESULTS Among 354 KT recipients, 58 (16.3%) had a positive STE. Over a mean follow-up of 54±19 months, 67 patients (18.9%) experienced MACE. In unadjusted analyses, age, diabetes, and coronary artery disease were associated with higher MACE risk; however, positive STE was not significantly associated with outcomes. In multivariable models, abnormal STE remained unassociated with MACE or the composite outcome. Kaplan-Meier survival analysis confirmed no difference in MACE-free survival between groups. CONCLUSIONS In this contemporary single-center cohort of KT recipients, abnormal pretransplant STE was not independently associated with posttransplant cardiovascular events. These findings suggest the need to re-evaluate the role of traditional stress testing targeted toward detecting myocardial ischemia in pre-KT evaluation.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e951383"},"PeriodicalIF":1.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Microbiome Characteristics in Kidney Transplant Recipients and Their Clinical Implications: A Narrative Review.","authors":"Shuzhan Sun, Yuhui He, Yisen Deng, Jianfeng Wang","doi":"10.12659/AOT.952286","DOIUrl":"10.12659/AOT.952286","url":null,"abstract":"<p><p>High-throughput sequencing has overturned the long-standing \"sterile urine\" paradigm and revealed a low-biomass yet clinically informative urinary tract microbiota. In kidney transplant recipients, immunosuppression, perioperative instrumentation, and antibiotic exposure can reshape urinary microbial communities; however, reported signatures remain heterogeneous across cohorts and methodologies. This narrative review synthesizes evidence on: (1) baseline urobiome patterns and major determinants of inter-individual variability, (2) post-transplant drivers of dysbiosis, and (3) associations between urobiome dynamics and key transplant outcomes, including urinary tract infection (UTI), acute rejection (AR), and chronic allograft dysfunction such as interstitial fibrosis and tubular atrophy (IF/TA). Across studies, dysbiosis commonly manifests as reduced diversity, depletion of putatively protective taxa, and enrichment of opportunistic pathogens; several longitudinal cohort studies further suggest that microbiome shifts can precede clinical events, supporting a potential window for risk stratification and early surveillance. We also summarize translational research directions, including integration of urinary microbial profiles with host biomarkers and multi-omics readouts, as well as microbiome-sparing strategies (antimicrobial stewardship, targeted probiotics/synbiotics, and dietary modulation). Finally, we highlight methodological challenges unique to low-biomass urine samples - especially contamination control, negative controls, and transparent reporting - that are essential for improving reproducibility and enabling clinical implementation. This review aims to provide an up-to-date, clinically oriented synthesis of the post-transplant urobiome and to propose methodological and translational priorities for future research and implementation.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e952286"},"PeriodicalIF":1.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Post-Transplant Bacterial Infections Predict Long-Term Mortality in Kidney Transplant Recipients: A 10-Year Retrospective Cohort Study.","authors":"İlhan Kılıç, Ersen Karakılıç, Nilay Metilli, Serkan Bakırdöğen, Hasan Anıl Kurt, Işıl Deniz Alıravcı","doi":"10.12659/AOT.951801","DOIUrl":"10.12659/AOT.951801","url":null,"abstract":"<p><p>BACKGROUND Kidney transplant recipients require lifelong immunosuppression, predisposing them to bacterial infections that can impair survival. This study evaluated the impact of early bacterial infections on long-term mortality and sought to identify clinical and procedural predictors of infection. MATERIAL AND METHODS This retrospective study included kidney transplant recipients (2014-2024) with ≥12 months of follow-up. Bacterial infections were classified as early (≤6 months) or late (>6 months). Clinical, laboratory, and microbiological data were analyzed. Cox regression analysis identified independent predictors of mortality, and logistic regression determined factors associated with early infections. RESULTS Early bacterial infections occurred in 35.4% of patients and were independently associated with a 3-fold increase in mortality risk (adjusted hazard ratio [aHR]=3.03, 95% CI: 1.42-6.44, P=0.004). Diabetic nephropathy-related end-stage kidney disease (aHR=4.14, P=0.003) and older recipient age (aHR=1.10 per year, P<0.001) were additional independent predictors. The final Cox model demonstrated good discriminative performance (C-index=0.821). Urinary tract infections were most common (67%), followed by bloodstream infections (25%) and pneumonia (10%). Escherichia coli, Klebsiella spp., and Enterococcus spp. predominated. Low albumin and hemoglobin levels and ureteral stent placement were associated with early infection. Infection episodes were treated using antibiogram-guided therapy, and no multidrug-resistant organisms were identified. CONCLUSIONS Early infections and diabetic nephropathy-related ESKD predict long-term mortality after kidney transplantation. Optimizing nutritional status to improve albumin and hemoglobin levels, ensuring careful use and timely removal of ureteral stents, and implementing strict antibiogram-guided antibiotic stewardship can help reduce early infection risk. Targeted early interventions and closer surveillance of high-risk patients may improve long-term outcomes.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e951801"},"PeriodicalIF":1.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, Clinical Features, and Risk Factors of Early Neurological Complications After Orthotopic Liver Transplantation: A Single-Center Experience.","authors":"Federica Avorio, Giovanna Russelli, Rossella Alduino, Giovanna Panarello, Alessio Provenzani, Antonio Arcadipane, Salvatore Gruttadauria, Vincenzina Lo Re","doi":"10.12659/AOT.946854","DOIUrl":"10.12659/AOT.946854","url":null,"abstract":"<p><p>BACKGROUND Despite improvements in technical and pharmacological expertise, orthotopic liver transplantation (OLT) still leads to potentially serious neurological complications (NCs) with very strong implications for graft survival, functional outcomes, and mortality. MATERIAL AND METHODS We conducted a retrospective study with the aim of defining the incidence, etiology, and clinical features of early post-OLT NCs, and we searched for preoperative, intraoperative and postoperative risk factors associated with their occurrence. RESULTS Among 376 patients who underwent OLT, 97 (25.8%) had at least 1 neurological manifestation and 24 (6.38%) had more than 1 neurological manifestation. Delirium/metabolic encephalopathy was the most frequent (14.1%), followed by seizures (3.7%) and clinical manifestations of neurotoxicity (3.7%), and then by osmotic demyelination syndrome and peripheral nervous system injury (2.9%). NCs were the cause of death in 9/97 patients, and 11 patients had severe sequelae. Having NCs was correlated with more severe liver disease, a history of chronic renal impairment, higher plasma sodium concentrations at postoperative day 2, higher perioperative delta sodium, and a higher probability of having postoperative acute renal impairment, postoperative infections, graft rejection, and more than 3 systemic complications. No preoperative neurological comorbidities were found to be risk factors for developing acute NCs early after OLT. Patients with NCs had worse outcomes: longer in-hospital length of stay, longer intensive care unit (ICU) stay, higher probability of ICU re-admission, higher probability of in-hospital death, and higher probability of needing rehabilitation after hospital discharge. CONCLUSIONS Understanding the pathophysiology of NCs after OLT may lead to the development of prevention strategies for often untreatable neurological diseases.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e946854"},"PeriodicalIF":1.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Obesity, Comorbidities, and Eligibility for Pre-Transplant Bariatric Surgery in 275 Patients Awaiting Kidney Transplant at a Single Center in Germany.","authors":"Helga Oehler, Hanan El Youzouri, Amir Bolooki, Michael Heise, Ursula Pession, Ingeborg A Hauser, Wolf Otto Bechstein, Teresa Schreckenbach","doi":"10.12659/AOT.951621","DOIUrl":"10.12659/AOT.951621","url":null,"abstract":"<p><p>BACKGROUND Obesity contributes to chronic kidney disease (CKD) through various mechanisms and increase morbidity and mortality after kidney transplantation. Bariatric surgery can reduce perioperative risks. This study aimed to determine the prevalence of obesity in kidney transplant candidates, associations with demographic and clinical factors, and to estimate the proportion of patients potentially eligible for bariatric surgery in a German cohort. MATERIAL AND METHODS This retrospective single-center study included 275 patients listed for kidney transplantation between November 2018 and January 2020 at the University Hospital Frankfurt. Prevalence analyses were limited to 271 patients. Variables included body mass index (BMI), comorbidities, cause of kidney disease, dialysis duration, transplant list status, and prior bariatric surgery. The primary endpoint was the prevalence of obesity; secondary endpoints were correlations between obesity and comorbidities. Statistical analyses included Spearman's correlation and Eta coefficient analyses to evaluate associations. Prevalence estimates are reported with 95% confidence intervals. RESULTS The mean BMI was 25.8 kg/m². BMI correlated with arterial hypertension (η=0.121; P=0.047) and diabetes mellitus (η=0.305; P<0.001), while no significant correlation was observed with transplant list status (η=0.051; P=0.704). Among the 56 obese patients, 6 (10.7%) had BMI 35-39.9 kg/m² and 4 (7.1%) had BMI ≥40 kg/m², meeting common eligibility criteria for bariatric surgery. The prevalence of obesity was 20.7% (95% CI, 1.16-1.25). CONCLUSIONS Obesity is prevalent in this population. Given that obesity is a modifiable risk factor, identifying candidates who may benefit from weight-management interventions is clinically relevant; however, this prevalence study does not allow conclusions regarding outcomes or treatment efficacy.</p>","PeriodicalId":7935,"journal":{"name":"Annals of Transplantation","volume":"31 ","pages":"e951621"},"PeriodicalIF":1.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}