Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao最新文献_第3页

Gossypol-induced alterations of aminophospholipid composition in human sperm. 棉酚诱导的人类精子中氨基磷脂组成的改变。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

T Huang, Q Fan, R Liu, J Lin, C Yang

{"title":"Gossypol-induced alterations of aminophospholipid composition in human sperm.","authors":"T Huang, Q Fan, R Liu, J Lin, C Yang","doi":"","DOIUrl":"","url":null,"abstract":"Gossypol-induced alterations of aminophospholipid composition in human sperm were observed and the effects of some factors on these alterations were investigated. The alterations of aminophospholipid composition of human sperm induced by gossypol included a progressive decrease in the levels of phosphatidylethanolamine (PE) and phosphatidylserine (PS) when gossypol concentrations ranged from 5-500 mumol/L, and a progressive increase in the level of (LPE) at lower gossypol concentrations (5-50 mumol/L). The conversion of PE into lysophosphatidylethanolamine (LPE) was strongly enhanced by Ca2+ and inhibited by 0.5 mmol/L EDTA, while PMSF, NEM, iodoacetamide and Zn2+ had no effect. This conversion was weaker in sperm with stripped surface proteins than in normal sperm. In addition, three surface proteins (MW 80, 60 and 40 kD) were fixed on the plasma membrane by gossypol treatment. The significance of gossypol action and the possibility that sperm PLA2, PE and some surface proteins might play an important role in the physiological acrosome reaction of human sperm, as well as in oocyte penetration, are discussed.","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 1","pages":"25-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13519845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation of sclerofasciitis and progressive systemic sclerosis: clinico-pathologic considerations of 51 cases of sclerofasciitis. 硬筋膜炎与进行性系统性硬化症的鉴别:51例硬筋膜炎的临床病理分析。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

X Yuan, Y Yang, B Zhang, H Wang, H Yan, Y Shao

引用次数: 0

Early and late results of total gastrectomy in treatment of advanced adenocarcinoma of the cardia. 全胃切除术治疗晚期贲门腺癌的早期和晚期效果。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

Z J Li, L T Xu, C F Sun, L H Wu, Z Y Zhang

引用次数: 0

Preliminary observations on the phenotypes of lymphoid cells in mycosis fungoides using anti-human-thymocyte monoclonal antibodies. 抗人胸腺细胞单克隆抗体对蕈样真菌病淋巴样细胞表型的初步观察。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

J Liu, Y Shi, Q Kong, Q Zhang, J Huang, X Zeng, X Wang, J Li, H Sang, A Li

引用次数: 0

Cytogenetic analysis in patients with myelodysplastic syndrome. 骨髓增生异常综合征患者的细胞遗传学分析。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

N Hu, M Bian

引用次数: 0

The differences of serum cholesterol and lipoproteins in animals susceptible and nonsusceptible to atherosclerosis. 动脉粥样硬化易感和非易感动物血清胆固醇和脂蛋白的差异。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

K Q Wang, Z G Li, Q L Hao, J L He, X Z Li, H Z Zhang, J J Tang, G Wu, B S Chen, J M Wang

{"title":"The differences of serum cholesterol and lipoproteins in animals susceptible and nonsusceptible to atherosclerosis.","authors":"K Q Wang, Z G Li, Q L Hao, J L He, X Z Li, H Z Zhang, J J Tang, G Wu, B S Chen, J M Wang","doi":"","DOIUrl":"","url":null,"abstract":"The differences of serum lipid and lipoprotein (LP, profiles of animals susceptible (rabbit) and nonsusceptible (Beijing duck) to atherosclerosis as well as the distribution of apolipoprotein (apo) A-I and its catabolism in vivo were studied. Eight items, i.e. total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride, percentage of alpha-LP and beta-LP, beta-LP concentration, lecithin cholesterol acyl transferase (LCAT), and agarose and polyacrylamide gel electrophoresis of both species were assayed before and after feeding a high fat, high cholesterol diet. Results indicate that the exogenous cholesterol consumed by Beijing ducks was carried and transported by HDL, while that in rabbits was transported by low density lipoprotein (LDL). The biological half lives of apo A-I in serum and in HDL were 41.1 +/- 2.4 and 42.8 +/- 1.7 h respectively, and its distribution in different organs was in the order of liver greater than kidney greater than spleen greater than lung greater than heart greater than intestine greater than muscles greater than aorta. These results show that the liver is the major organ for metabolizing HDL apo A-I, and the kidney is also important. The results also imply that in Beijing ducks the cholesterol carried by HDL may be catabolized through apo A-I receptors in the liver and kidney. The differences in cholesterol binding and in lipoprotein and apolipoprotein metabolism of the two species provide important clues for the elucidation of the pathogenesis of atherosclerosis.","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 2","pages":"112-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13277297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of three-year multidrug therapy in multibacillary leprosy patients. 多菌性麻风患者三年多药治疗的疗效。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

W Li, G Ye, Z Yang, M Tao, J Luo, C Wang, F Ji

引用次数: 0

Effects of parathyroid hormone and calcitonin on calcium transport of rat cultured striatum cells. 甲状旁腺激素和降钙素对大鼠培养纹状体细胞钙转运的影响。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

Y Hang, P Zuo

引用次数: 0

Leukemia among medical diagnostic X-ray workers in China. 中国医学诊断x射线工作者中的白血病。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

J Wang, J D Boice, P D Inskip, B Li, J Zhang, J F Fraumeni

{"title":"Leukemia among medical diagnostic X-ray workers in China.","authors":"J Wang, J D Boice, P D Inskip, B Li, J Zhang, J F Fraumeni","doi":"","DOIUrl":"","url":null,"abstract":"The incidence of leukemia among 27,011 medical diagnostic X-ray workers was compared with that among 25,782 other medical specialists employed between 1950 and 1985 in China. A significantly elevated risk of leukemia was seen among diagnostic X-ray workers. The relative risk (RR) of leukemia was 2.4 (95% CI = 1.3-4.1) based on the rate observed in the comparison group, and 2.3 when the rate in a Shanghai population was used. The elevated incidence of leukemia was restricted to male X-ray workers, and the relative risk of leukemia was higher for X-ray workers who began employment before 1970 than for those who started work more recently. The RR for leukemia was highest among workers who had been employed for 10-15 years, but the incidence was not apparently elevated further among those who had been employed for more than 20 years. The risk was more pronounced in workers who had begun their jobs before the age of 20 years, and it appeared to decrease with increasing age at first employment. The variation in risk with the duration of employment, age and the calendar time when diagnostic radiological work began indicates that the elevated incidence of leukemia is attributable to occupational exposure to X-rays.","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 4","pages":"194-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13443644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of uterine cytosol and nuclear sex steroid receptors in aging female ICR mice. 衰老雌性ICR小鼠子宫细胞质和核性类固醇受体的表征。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

Z Xu, J Clark

{"title":"Characterization of uterine cytosol and nuclear sex steroid receptors in aging female ICR mice.","authors":"Z Xu, J Clark","doi":"","DOIUrl":"","url":null,"abstract":"Changes in uterine wet weight and estrogen receptor levels were studied in aging female ovariectomized ICR mice. A marked increase in uterine wet weight was observed in 18-month-old mice after injection of estradiol-17 beta (E2), from 67.6 +/- 3.1 mg (control, no injection) to 98.2 +/- 14.8 mg (1 h after injection of 1.0 microgram E2) and to 125.2 +/- 15.8 mg (4 h after injection of 1.0 microgram E2). The response to E2 in old mice was greater than that in young. This observation suggests that the uteri of old mice are still sensitive to gonadal steroids up to the post-reproductive age of 18 months. A 2.7-fold age-related increase in uterine estrogen receptor content was also noted in aging ovariectomized female mice, from 0.38 pmol/uterus in young mice to 1.01 pmol/uterus in old mice (1 h after injection of E2). Both cytoplasmic estrogen receptor content and receptor concentration (expressed as estrogen binding sites/cell) increased with advancing age. In contrast, no age-related change in the dissociation constant of estrogen receptors was detected (Kd = 1.0 +/- 0.5 x 10(-9) mol/L). The progesterone receptor content also increased with advancing age. This study demonstrates a marked increase of uterine estrogen receptor content in aging mice, suggesting that the uterus is not responsible for the increased incidence of pregnancy failure in old mice.","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 4","pages":"207-12"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13443646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0