骨髓增生异常综合征患者的细胞遗传学分析。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

N Hu, M Bian

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摘要

对46例骨髓增生异常综合征(MDS)患者进行了研究。46例患者中有20例(43%)出现染色体异常。5号染色体异常6例(13%);其中4例染色体长臂缺失[del (5q)]。7号单体4例(8.6%)，8号三体6例(13%)。我们的研究结果表明，染色体异常，缺失(5q)， 7号单体和8号三体可能在MDS的发病机制中起重要作用。

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Cytogenetic analysis in patients with myelodysplastic syndrome.

Forty-six patients with myelodysplastic syndrome (MDS) were studied. Chromosomal abnormalities were observed in 20 of the 46 patients (43%). Abnormalities of chromosome No. 5 occurred in 6 patients (13%); four of them had a deletion of the long arm of this chromosome [del (5q)]. Four patients had monosomy 7 (8.6%), and six patients had trisomy 8 (13%). Our results suggest that chromosomal abnormalities, deletion (5q), monosomy 7 and trisomy 8, might play important roles in the pathogenesis of MDS.

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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

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