甲状旁腺激素和降钙素对大鼠培养纹状体细胞钙转运的影响。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1990-01-01

Y Hang, P Zuo

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摘要

研究了人甲状旁腺激素(hPTH 1-34)和降钙素对静息大鼠纹状体细胞和kcl去极化培养细胞Ca2+转运的影响。结果表明，在静息细胞中，PTH显著增加Ca2+摄取和外排，而降钙素对两者均无影响。在kcl -去极化细胞中，PTH增加Ca2+摄取，降钙素减少Ca2+摄取，PTH和降钙素都减少Ca2+外排。这些结果表明，这两种激素可能通过调节细胞质Ca2+水平来改变神经元的功能。

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Effects of parathyroid hormone and calcitonin on calcium transport of rat cultured striatum cells.

The effects of human parathyroid hormone (hPTH 1-34) and calcitonin on Ca2+ transport in resting and KCl-depolarized cultured cells of rat striatum were studied. The results showed that in resting cells PTH significantly increased both Ca2+ uptake and efflux, while calcitonin had no effect on either. In KCl-depolarized cells the Ca2+ uptake was increased by PTH and reduced by calcitonin, and the effluxes were reduced by both PTH and calcitonin. These results suggest that the two hormones may alter the functions of neurons by regulating cytoplasmic Ca2+ levels.

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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

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