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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao最新文献

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Studies on esophageal cancer cells in vitro. 食管癌细胞的体外培养研究。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
Q Q Pan
{"title":"Studies on esophageal cancer cells in vitro.","authors":"Q Q Pan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A number of studies on esophageal cancer cells in vitro have been reported since the establishment of a human esophageal epithelial cancer cell line (Eca 109) in China in 1972. Some of these are reviewed here; the heterogeneity of esophageal cancer cells, comparative cytochemical and ultrastructural studies on cancer cells and normal esophageal epithelial cells of primary culture, comparative cytomorphological observation of a cancer cell line and cancer cell smears from patients by balloon technique, establishment of spheroid culture for the study of cancer cell differentiation and invasiveness, and immunological study on esophageal cancer in vitro.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 1","pages":"52-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13795469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of pulse excimer laser irradiation on the human left ventricular wall. 脉冲准分子激光照射对人左室壁的影响。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
M Z Chen, F R Chen, J M Mao, J X Guo, D Y Xie, J R Xu
{"title":"Effects of pulse excimer laser irradiation on the human left ventricular wall.","authors":"M Z Chen,&nbsp;F R Chen,&nbsp;J M Mao,&nbsp;J X Guo,&nbsp;D Y Xie,&nbsp;J R Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study was to assess the potential application of excimer lasers in the ablation of myocardium in vitro for the treatment of constant ventricular tachycardia or hypertrophic cardiomyopathy. A fresh human heart and EMG model 103 XeCl pulse excimer laser machine were used. The pulse repetition rate varied from 1 to 7 Hz. Irradiation directly on the left endocardial and epicardial walls lasted for 10 seconds and was repeated 3 times, creating 3 craters. The histological changes were examined by light microscope. Results showed very close relations between the depth or volume of vaporized craters and the pulse repetition rate on the endocardial (r = 0.9674, P less than 0.001 and r = 0.8962, P less than 0.01, respectively) and epicardial walls (r = 0.9602, P less than 0.001 and r = 0.9612, P less than 0.001, respectively). A sharp, clear border without debris or coagulating necrosis was seen under the microscope. We concluded that the pulse excimer laser, differing from Ar+ or Nd:YAG lasers, might be a powerful tool for manipulating the human ventricular wall, but more work needs to be done before it can be widely applied in the treatment of cardiovascular disease.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 3","pages":"131-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13737385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary vasodilator action of ligustrazine, active principle of a traditional Chinese remedy, in rats and ferrets. 中药活性成分川芎嗪对大鼠和雪貂肺血管扩张的作用。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
Y N Cai, D Bee, G Barer
{"title":"Pulmonary vasodilator action of ligustrazine, active principle of a traditional Chinese remedy, in rats and ferrets.","authors":"Y N Cai,&nbsp;D Bee,&nbsp;G Barer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The action of ligustrazine on the pulmonary circulation was tested in isolated perfused rat lung in vitro and autoperfused ferret lower left lobe preparation in vivo. Ligustrazine reduced hypoxic pulmonary vasoconstriction in a dose-dependent manner. It had a lesser dilator effect on KCl-induced vasoconstriction than verapamil and a relatively small inhibitory effect on the pressor response to angiotensin II. Ligustrazine preferentially inhibited the vasoconstriction caused by hypoxia and almitrine. The increased slope and intercept of the pressure-flow line caused by hypoxic vasoconstriction was reduced to the normal range after administration of ligustrazine (4 mg). Thus ligustrazine proved to be a powerful pulmonary vasodilator; it had a relatively small depressor effect on systemic blood pressure.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 3","pages":"147-52"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13737389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation study of left atrial pressure and pulmonary rheogram. 左房压与肺流变图的相关性研究。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
X Y Zhang, S Y Fu, S Z Teng
{"title":"Correlation study of left atrial pressure and pulmonary rheogram.","authors":"X Y Zhang,&nbsp;S Y Fu,&nbsp;S Z Teng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to observe correlations between LAP and PRG data, we placed small inflated balloons in the left atria of dogs to change LAP. We found good correlations between LAP and Q-6 interval (r = 0.88, P less than 0.001), b-s interval (r = -0.78, P less than 0.001), Hs (r = -0.59, P less than 0.001), Hs X b-s interval (r = -0.65, P less than 0.001), and HD/Hs (r = 0.50, P less than 0.001). The mechanisms of change of these parameters were investigated and corresponding regression equations derived. The authors point out that D wave enlargement and HD/Hs increase are determinant indices of LAP elevation and may be used to estimate LAP and to differentiate LAP elevation from simple pulmonary hypertension. Therefore, we conclude that PRG may reflect changes of pressure or volume in the pulmonary vein and thus provide a noninvasive method of monitoring cardiac preload and the pulmonary cycle. In addition, this research may provide the experimental basis for employing PRG in the study of such pathological processes as mitral valve lesion, left heart failure, etc.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 1","pages":"34-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13852312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative diagnosis and management of pheochromocytoma. 嗜铬细胞瘤的术前诊断与处理。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
L L Wang, L H Liu, L Jin, X H Yue, D J Fan, P Z Zhao, X J Liu, X Z Su
{"title":"Preoperative diagnosis and management of pheochromocytoma.","authors":"L L Wang,&nbsp;L H Liu,&nbsp;L Jin,&nbsp;X H Yue,&nbsp;D J Fan,&nbsp;P Z Zhao,&nbsp;X J Liu,&nbsp;X Z Su","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To improve the diagnosis and management of pheochromocytoma, the results from a comparative study of 34 patients with pheochromocytoma, 33 patients with essential hypertension and 36 normal volunteers are presented. Our data suggest that clinical characteristics indicate the possibility of pheochromocytoma only, while the definite diagnosis of pheochromocytoma must be based on comprehensive analysis of all data obtained from both clinical and laboratory studies. The plasma concentration of free norepinephrine in peripheral veins is helpful in establishing the presence or absence of pheochromocytoma. Both CT scan and meta-I-131-iodobenzylguanidine images are useful noninvasive techniques for localization of pheochromocytoma. Phenoxybenzamine is of benefit in both diagnosis and management of patients with pheochromocytoma.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 1","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13852314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal allergy in China. 中国的鼻腔过敏。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
R J Gu
{"title":"Nasal allergy in China.","authors":"R J Gu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 3","pages":"167-71"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13829348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA sequence analysis of the Hind III M fragment from Chinese vaccine strain of vaccinia virus. 牛痘病毒中国疫苗株HindⅲM片段DNA序列分析。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
V J Liu, Q Jin, D Y Jin, Y D Hou
{"title":"DNA sequence analysis of the Hind III M fragment from Chinese vaccine strain of vaccinia virus.","authors":"V J Liu,&nbsp;Q Jin,&nbsp;D Y Jin,&nbsp;Y D Hou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The complete DNA sequence of the Hind III M fragment of vaccinia virus (VV) Tian Tan strain genome was determined by the dideoxynucleotide chain termination method. Three open reading frames (ORFs) were identified in the complementary strand of the sequence, comprised of 2218bp. Among them, ORF K1 initiates its transcription at -45 of the Hind III K fragment. The deduced peptide encoded by K1 contains 284 amino acids with a calculated molecular weight of 32.48 KDa. Its sequence is homologous to the host range protein of VV Copenhagen strain; the variation is only 2.46% at the amino acid level. ORF M2 could encode a peptide of 21.94 KDa with 196 amino acids. This gene was shown to be homologous to that of the 23 KDa peptide of herpes simplex virus type I. A non-coding region of 204bp located between K1 and M2 is rich in palindromic structures. ORF M1 extends its 3' terminus into the Hind III N fragment. Within the M fragment, M1 can only encode 212 amino acids. The major part of ORF M1 is very similar to the M portion of a possible alpha-amanitin resistance gene isolated from VV-WR strain. This work provides a molecular foundation in the construction of a new insertion vector for the preparation of a recombinant vaccinia virus to be used as a polyvalent live vaccine.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 4","pages":"215-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13773988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of 5 monomers from total glucosides of Tripterygium wilfordii. 雷公藤总苷中5个单体的筛选。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
J R Zheng, J L Fang, K X Gu, W Y Xu
{"title":"Screening of 5 monomers from total glucosides of Tripterygium wilfordii.","authors":"J R Zheng,&nbsp;J L Fang,&nbsp;K X Gu,&nbsp;W Y Xu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 3","pages":"175-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13738103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in cardiac and respiratory function of Antarctic Research Expedition members--preliminary report. 南极科考队员心脏和呼吸功能的变化——初步报告
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
Q F Xue, X X Deng, Y N Cai, C H Li, L Zhao, X J Yuan, R L Qiao, W L Liu, X M Zhou
{"title":"Changes in cardiac and respiratory function of Antarctic Research Expedition members--preliminary report.","authors":"Q F Xue,&nbsp;X X Deng,&nbsp;Y N Cai,&nbsp;C H Li,&nbsp;L Zhao,&nbsp;X J Yuan,&nbsp;R L Qiao,&nbsp;W L Liu,&nbsp;X M Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac and respiratory functions were estimated in 16 Chinese Antarctic Research Expedition members (Third expedition) before and after spending three months in the Antarctic. No significant changes were found in ECG examination. In cardiac function test, prolonged LVET and abbreviated PEP were found. PEP/LVET decreased significantly. Respiratory ventilation function examination showed an increase in FEV1 and FEV25 and a decrease in ERC. Results showed that cardiac and respiratory functions remained almost unchanged in the Expedition members. It is also suggested that a physiological compensation may have occurred in these members' cardiac functions either in the Antarctic or during the return sea voyage.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 2","pages":"112-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13937485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and characterization of two immunoregulatory factors--interleukin 2 inhibitors. 两种免疫调节因子-白细胞介素2抑制剂的分离和鉴定。
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01
Y Y Wu, J Zhang, Y H Zhang
{"title":"Isolation and characterization of two immunoregulatory factors--interleukin 2 inhibitors.","authors":"Y Y Wu,&nbsp;J Zhang,&nbsp;Y H Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Supernatants of cultured gibbon T lymphoma cells MLA144 were shown to contain two suppressive factors (IF50 and IF80) isolated by ammonium sulfate precipitation, ion-exchange chromatography and gel filtration. Both factors had similar activities: inhibition of IL 2 production by human peripheral blood mononuclear cells, inhibition of IL 2 responsiveness of human lymphoblasts and mouse thymocytes, and inhibition of proliferation of Con A-stimulated mouse splenocytes. However, they did not affect E receptors. Fc receptors or phagocytosis. The physico-chemical properties of these two factors were also different. It is of special interest to note that the MLA144 cell line which spontaneously secretes IL 2 also generates IL 2 inhibitors. This offers an experimental model for investigation of the intracellular immunoregulatory mechanism of IL 2 expression.</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"4 2","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13937491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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